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Article: 5 minutes pour apprendre. Traitement problématique d’une bactériurie asymptomatique.

Sultan, Rama / Cazaux, Tomas / Regina, Jean

2024 Volume 20, Issue 869, Page(s) 766–767

Abstract: Asymptomatic bacteriuria is frequently encountered in clinical practice and should be treated only in pregnant women and before invasive urological procedures. Inappropriate treatment of asymptomatic bacteriuria is associated with numerous adverse ... ...

Title translation	Inappropriate treatment of asymptomatic bacteriuria.
Abstract	Asymptomatic bacteriuria is frequently encountered in clinical practice and should be treated only in pregnant women and before invasive urological procedures. Inappropriate treatment of asymptomatic bacteriuria is associated with numerous adverse effects including allergic reactions, increased antibiotics resistance and increase risk of Clostridioides difficile infection. Positive urinary culture often leads to antimicrobial treatment, irrespective of urinary symptoms. Therefore, urine analysis and culture should be performed only in symptomatic individuals or in asymptomatic individuals with a clear indication for treatment.
MeSH term(s)	Pregnancy ; Humans ; Female ; Bacteriuria/diagnosis ; Bacteriuria/drug therapy ; Drug-Related Side Effects and Adverse Reactions ; Hypersensitivity
Language	French
Publishing date	2024-03-31
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2024.20.869.766
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Article: [No title information]

Moret Bochatay, Mallory / Regina, Jean

Revue medicale suisse

2022 Volume 18, Issue 787, Page(s) 1283

Title translation	Pas d’amoxicilline sans procalcitonine ?
MeSH term(s)	Amoxicillin ; Calcitonin ; Humans ; Procalcitonin ; Protein Precursors
Chemical Substances	Procalcitonin ; Protein Precursors ; Amoxicillin (804826J2HU) ; Calcitonin (9007-12-9)
Language	French
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	News
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2022.18.787.1283
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Article ; Online: Things We Do for No Reason™: Computed tomography of the head before lumbar puncture in low-risk adults and children.

Regina, Jean / Manuel, Oriol

Journal of hospital medicine

2022 Volume 18, Issue 6, Page(s) 534–537

MeSH term(s)	Humans ; Adult ; Child ; Spinal Puncture ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2233783-0
ISSN	1553-5606 ; 1553-5592
ISSN (online)	1553-5606
ISSN	1553-5592
DOI	10.1002/jhm.12967
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Zs.A 6276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 542: Show issues

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Article: Insuffisance cardiaque à haut débit.

Regina, Jean / Racine, Grégoire / Moalic, Antoine / Moret Bochatay, Mallory

Revue medicale suisse

2022 Volume 18, Issue 794, Page(s) 1656–1661

Abstract: High output heart failure (HOHF) is a particular type of heart failure with multiple etiologies but a similar underlying mechanism, namely a decrease in systemic vascular resistance, in some instances associated with increased metabolic requirements. ... ...

Title translation	High-output heart failure.
Abstract	High output heart failure (HOHF) is a particular type of heart failure with multiple etiologies but a similar underlying mechanism, namely a decrease in systemic vascular resistance, in some instances associated with increased metabolic requirements. This leads to neurohormonal activation, fluid and sodium retention and a chronic hyperdynamic state resulting in a classic congestive state associated with clinical signs of high output. While no clear definition of HOHF exists, such findings and an increase in cardiac output (cardiac index >4 L/min/m2) strongly suggest the diagnosis. This probably under-diagnosed entity should actively be sought, particularly in obese patients and/or patients labelled with heart failure with preserved ejection fraction (HFpEF). Treatment and prognosis depend on the etiology.
MeSH term(s)	Heart Failure/diagnosis ; Heart Failure/drug therapy ; Heart Failure/etiology ; Humans ; Stroke Volume/physiology
Language	French
Publishing date	2022-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2022.18.794.1656
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Article: Démence rapidement progressive : prise en charge par l’interniste.

Jossein, Thibaut / Ruchat, David / Regina, Jean / Salvioni Chiabotti, Paolo / Fisch, Loraine

Revue medicale suisse

2023 Volume 19, Issue 840, Page(s) 1598–1604

Abstract: Rapidly progressive dementia is distinguished from other neurocognitive disorders by its rapid onset (less than two years from first symptoms to diagnosis). It comprises a wide range of etiologies, including Creutzfledt-Jakob disease and Alzheimer's ... ...

Title translation	Rapidly progressive dementia: management by the internist.
Abstract	Rapidly progressive dementia is distinguished from other neurocognitive disorders by its rapid onset (less than two years from first symptoms to diagnosis). It comprises a wide range of etiologies, including Creutzfledt-Jakob disease and Alzheimer's disease. When faced with a recent and rapid onset of major cognitive impairment, it is essential to rule out delirium or any other cause that may lead to rapid cognitive decline (such as stroke, encephalitis, or epileptic seizure). The work-up is based on a detailed history (drugs, exposure, medical history), a thorough clinical examination, and a broad biological work-up including MRI, lumbar puncture and EEG. Management should rapidly involve a neurologist or a specialized center.
MeSH term(s)	Humans ; Dementia ; Physicians ; Alzheimer Disease ; Neurocognitive Disorders ; Cognitive Dysfunction
Language	French
Publishing date	2023-09-06
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2023.19.840.1598
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Article: Insuffisance rénale aiguë associée aux produits de contraste iodés : état des lieux et recommandations pratiques.

Regina, Jean / Christe, Chiara / Lederer, Fabian / Fumeaux, Zina

Revue medicale suisse

2021 Volume 17, Issue 754, Page(s) 1730–1734

Abstract: Iodinated contrast products have been incriminated for a long time in the development of acute renal failure after injected procedures. This trend is now being questioned and this article reviews the current state of knowledge concerning the risk of ... ...

Title translation	Contrast-associated acute kidney injury : state of the art and practical approach.
Abstract	Iodinated contrast products have been incriminated for a long time in the development of acute renal failure after injected procedures. This trend is now being questioned and this article reviews the current state of knowledge concerning the risk of acute renal failure after intra-arterial and intravenous iodinated contrast media injection. It also proposes a review of prophylactic measures for these two modalities as well as a practical attitude to adopt with patients requiring an injected examination.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Contrast Media/adverse effects ; Humans ; Risk Factors
Chemical Substances	Contrast Media
Language	French
Publishing date	2021-10-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
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Article ; Online: Sepsis awareness and knowledge amongst nurses, physicians and paramedics of a tertiary care center in Switzerland: A survey-based cross-sectional study.

Regina, Jean / Le Pogam, Marie-Annick / Niemi, Tapio / Akrour, Rachid / Pepe, Santino / Lehn, Isabelle / Wasserfallen, Jean-Blaise / Calandra, Thierry / Meylan, Sylvain

PloS one

2023 Volume 18, Issue 6, Page(s) e0285151

Abstract: Background: Sepsis is a leading cause of morbidity and mortality. Prompt recognition and management are critical to improve outcomes.: Methods: We conducted a survey among nurses and physicians of all adult departments of the Lausanne University ... ...

Abstract	Background: Sepsis is a leading cause of morbidity and mortality. Prompt recognition and management are critical to improve outcomes. Methods: We conducted a survey among nurses and physicians of all adult departments of the Lausanne University Hospital (LUH) and paramedics transporting patients to our hospital. Measured outcomes included professionals' demographics (age, profession, seniority, unit of activity), quantification of prior sepsis education, self-evaluation, and knowledge of sepsis epidemiology, definition, recognition, and management. Correlation between surveyed personnel and sepsis perceptions and knowledge were assessed with univariable and multivariable logistic regression models. Results: Between January and October 2020, we contacted 1'216 of the 4'417 professionals (27.5%) of the LUH, of whom 1'116 (91.8%) completed the survey, including 619 of 2'463 (25.1%) nurses, 348 of 1'664 (20.9%) physicians and 149 of 290 (51.4%) paramedics. While 98.5% of the participants were familiar with the word "sepsis" (97.4% of nurses, 100% of physicians and 99.3% of paramedics), only 13% of them (physicians: 28.4%, nurses: 5.9%, paramedics: 6.8%) correctly identified the Sepsis-3 consensus definition. Similarly, only 48% and 49.3% of the physicians and 10.1% an 11.9% of the nurses knew that SOFA was a sepsis defining score and that the qSOFA score was a predictor of increased mortality, respectively. Furthermore, 15.8% of the physicians and 1.0% of the nurses knew the three components of the qSOFA score. For patients with suspected sepsis, 96.1%, 91.6% and 75.8% of physicians respectively chose blood cultures, broad-spectrum antibiotics and fluid resuscitation as therapeutic interventions to be initiated within 1 (76.4%) to 3 (18.2%) hours. For nurses and physicians, recent training correlated with knowledge of SOFA score (ORs [95%CI]: 3.956 [2.018-7.752] and 2.617 [1.527-4.485]) and qSOFA (ORs [95%CI]: 5.804 [2.653-9.742] and 2.291 [1.342-3.910]) scores purposes. Furthermore, recent training also correlated with adequate sepsis definition (ORs [95%CI]: 1.839 [1.026-3.295]) and the components of qSOFA (ORs [95%CI]: 2.388 [1.110-5.136]) in physicians. Conclusions: This sepsis survey conducted among physicians, nurses and paramedics of a tertiary Swiss medical center identified a deficit of sepsis awareness and knowledge reflecting a lack of sepsis-specific continuing education requiring immediate corrective measures.
MeSH term(s)	Adult ; Humans ; Switzerland/epidemiology ; Cross-Sectional Studies ; Paramedics ; Tertiary Care Centers ; Hospital Mortality ; Sepsis/diagnosis ; Sepsis/epidemiology ; Sepsis/therapy ; Physicians ; Nurses ; Organ Dysfunction Scores ; Retrospective Studies ; Prognosis ; Intensive Care Units
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285151
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An Early Warning Score to predict ICU admission in COVID-19 positive patients.

Meylan, Sylvain / Akrour, Rachid / Regina, Jean / Bart, Pierre-Alexandre / Dami, Fabrice / Calandra, Thierry

The Journal of infection

2020 Volume 81, Issue 5, Page(s) 816–846

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Betacoronavirus/genetics ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Early Warning Score ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Patient Admission ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Polymerase Chain Reaction ; Prognosis ; Risk Factors ; SARS-CoV-2 ; Sensitivity and Specificity ; Time Factors
Keywords	covid19
Language	English
Publishing date	2020-05-28
Publishing country	England
Document type	Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2020.05.047
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Zs.A 1501: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of 2020 EUCAST criteria on meropenem prescription for the treatment of Pseudomonas aeruginosa infections: an observational study in a university hospital.

Munting, Aline / Regina, Jean / Damas, José / Lhopitallier, Loïc / Kritikos, Antonios / Guery, Benoît / Senn, Laurence / Viala, Benjamin

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2021 Volume 28, Issue 4, Page(s) 558–563

Abstract: Objectives: We aimed to evaluate the impact of the 10th version of European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints table, where most antipseudomonal drugs but meropenem are now categorised as "Susceptible, increased ... ...

Abstract	Objectives: We aimed to evaluate the impact of the 10th version of European Committee on Antimicrobial Susceptibility Testing (EUCAST) breakpoints table, where most antipseudomonal drugs but meropenem are now categorised as "Susceptible, increased exposure" and labelled I, on meropenem prescription for Pseudomonas aeruginosa infections. Methods: In this retrospective single-centre observational study, we analysed antimicrobial therapies prescribed after susceptibility testing in all consecutive adult patients treated for P. aeruginosa infections between 01.08.2019 and 30.07.2020 in Lausanne University Hospital, Switzerland. We collected epidemiological, microbiological, clinical data, antimicrobial therapy, and infectious diseases specialists (IDs) consultations' data. The primary outcome was the prescription of meropenem to treat P. aeruginosa infections after release of susceptibility testing results. Secondary outcomes were: the use of increased dosage for non-meropenem anti-pseudomonal drugs, and IDs' consultations rates after susceptibility testing was made available. Results: Among the 264 patients included, 40 (15.2%) received meropenem, 3.4% (5/148) before EUCAST update versus 30.2% (35/116) after (p < 0.001). Supervision and counselling from IDs and the use of increased dosages of non-carbapenem antibiotics also increased respectively (40.5% (60/148) vs 62.9% (73/116), P < 0.001); (55.5% (76/148) vs 88.9% (72/116), P < 0.001). Factors associated with these increments could not be adequately modelled. Conclusions: The change to 2020 EUCAST criteria might be associated with increased odds of meropenem prescription for the treatment of P. aeruginosa infections stressing the need of prescribers' education and the importance of antibiotic stewardship interventions.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Hospitals ; Humans ; Meropenem/therapeutic use ; Microbial Sensitivity Tests ; Prescriptions ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa ; Retrospective Studies
Chemical Substances	Anti-Bacterial Agents ; Meropenem (FV9J3JU8B1)
Language	English
Publishing date	2021-11-23
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2021.03.034
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Zs.A 4541: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia.

Heinonen, Tytti / Ciarlo, Eleonora / Rigoni, Ersilia / Regina, Jean / Le Roy, Didier / Roger, Thierry

Frontiers in immunology

2019 Volume 10, Page(s) 2713

Abstract: Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation and inflammation pathways and have been implicated in the pathogenesis of neurodegenerative, ... ...

Abstract	Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation and inflammation pathways and have been implicated in the pathogenesis of neurodegenerative, metabolic and oncologic disorders. Both pro- and anti-inflammatory effects have been attributed to SIRT2 and SIRT3, and single deficiency in SIRT2 or SIRT3 had minor or no impact on antimicrobial innate immune responses. Here, we generated a SIRT2/3 double deficient mouse line to study the interactions between SIRT2 and SIRT3. SIRT2/3
MeSH term(s)	Animals ; Cells, Cultured ; Endotoxemia/metabolism ; Female ; Immune Tolerance ; Immunity, Innate ; Inflammation/metabolism ; Macrophages/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Sirtuin 2/genetics ; Sirtuin 2/metabolism ; Sirtuin 3/genetics ; Sirtuin 3/metabolism
Chemical Substances	Sirtuin 2 (EC 3.5.1.-) ; Sirtuin 3 (EC 3.5.1.-)
Language	English
Publishing date	2019-11-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02713
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