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  1. Article: Update in medical treatment of Crohn's disease.

    Regueiro, M D

    Journal of clinical gastroenterology

    2000  Volume 31, Issue 4, Page(s) 282–291

    Abstract: Crohn's disease is an inflammatory bowel disorder that has no known cause. The goal of medical treatment is to control active disease, induce and maintain clinical remission, and treat complications. Anti-inflammatory medications and immunomodulatory ... ...

    Abstract Crohn's disease is an inflammatory bowel disorder that has no known cause. The goal of medical treatment is to control active disease, induce and maintain clinical remission, and treat complications. Anti-inflammatory medications and immunomodulatory therapies are the primary treatment modalities for Crohn's disease. The categories of standard treatment include the 5-aminosalicylic acid compounds, corticosteroids, antibiotics, and immunomodulators. New biologic therapy has been developed to better target the immune mediators that are active in Crohn's disease. Infliximab is the first of the biologic agents approved for the treatment of fistulizing and active Crohn's disease. Despite medical advances in treatment, there is still no cure for Crohn's disease.
    MeSH term(s) Algorithms ; Crohn Disease/drug therapy ; Humans
    Language English
    Publishing date 2000-12-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 448460-5
    ISSN 1539-2031 ; 0192-0790
    ISSN (online) 1539-2031
    ISSN 0192-0790
    DOI 10.1097/00004836-200012000-00004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1523: Show issues Location:
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  2. Article: Will the real 5-aminosalicylic acid please stand up?

    Regueiro, M D

    Inflammatory bowel diseases

    1999  Volume 5, Issue 2, Page(s) 147–148

    MeSH term(s) Aminosalicylic Acids/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Anti-Ulcer Agents/therapeutic use ; Colitis, Ulcerative/drug therapy ; Humans ; Mesalamine/therapeutic use ; Phenylhydrazines
    Chemical Substances Aminosalicylic Acids ; Anti-Inflammatory Agents, Non-Steroidal ; Anti-Ulcer Agents ; Phenylhydrazines ; Mesalamine (4Q81I59GXC) ; balsalazide (P80AL8J7ZP)
    Language English
    Publishing date 1999-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1340971-2
    ISSN 1536-4844 ; 1078-0998
    ISSN (online) 1536-4844
    ISSN 1078-0998
    DOI 10.1097/00054725-199905000-00016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Opioid Analgesics Do Not Improve Abdominal Pain or Quality of Life in Crohn's Disease.

    Coates, M D / Seth, N / Clarke, K / Abdul-Baki, H / Mahoney, N / Walter, V / Regueiro, M D / Ramos-Rivers, C / Koutroubakis, I E / Bielefeldt, K / Binion, D G

    Digestive diseases and sciences

    2019  Volume 65, Issue 8, Page(s) 2379–2387

    Abstract: Background: Abdominal pain and opioid analgesic use are common in Crohn's disease (CD).: Aims: We sought to identify factors associated with abdominal pain in CD and evaluate the impact of opioid analgesics on pain and quality-of-life scores in this ... ...

    Abstract Background: Abdominal pain and opioid analgesic use are common in Crohn's disease (CD).
    Aims: We sought to identify factors associated with abdominal pain in CD and evaluate the impact of opioid analgesics on pain and quality-of-life scores in this setting.
    Methods: We performed a longitudinal cohort study using a prospective, consented IBD natural history registry from a single academic center between 2009 and 2013. Consecutive CD patients were followed for at least 1 year after an index visit. Data were abstracted regarding pain experience (from validated surveys), inflammatory activity (using endoscopic/histologic findings), laboratory studies, coexistent psychiatric disorders, medical therapy, opioid analgesic, and tobacco use.
    Results: Of 542 CD patients (56.6% women), 232 (42.8%) described abdominal pain. Individuals with pain were more likely to undergo surgery and were more frequently prescribed analgesics and/or antidepressants/anxiolytics. Elevated ESR (OR 1.79; 95%CI 1.11-2.87), coexistent anxiety/depression (OR 1.87; 95%CI 1.13-3.09), smoking (OR 2.08; 95%CI 1.27-3.40), and opioid use (OR 2.46; 95%CI 1.33-4.57) were independently associated with abdominal pain. Eighty patients (14.8%) were prescribed opioids, while 31 began taking them at or after the index visit. Patients started on opioids demonstrated no improvement in abdominal pain or quality-of-life scores on follow-up compared to patients not taking opioids.
    Conclusions: Abdominal pain is common in CD and is associated with significant opioid analgesic utilization and increased incidence of anxiety/depression, smoking, and elevated inflammatory markers. Importantly, opioid use in CD was not associated with improvement in pain or quality-of-life scores. These findings reinforce the limitations of currently available analgesics in IBD and support exploration of alternative therapies.
    MeSH term(s) Abdominal Pain/drug therapy ; Abdominal Pain/epidemiology ; Abdominal Pain/etiology ; Adult ; Analgesics, Opioid/therapeutic use ; Crohn Disease/complications ; Crohn Disease/psychology ; Female ; Humans ; Incidence ; Longitudinal Studies ; Male ; Pennsylvania/epidemiology ; Quality of Life ; Registries
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2019-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-019-05968-x
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  4. Article: Fine needle aspiration cytology of a pancreatic cyst in a patient with autosomal dominant polycystic kidney disease. A case report.

    Silverman, J F / Prichard, J / Regueiro, M D

    Acta cytologica

    2001  Volume 45, Issue 3, Page(s) 415–419

    Abstract: Background: Solitary cysts occur in approximately 10% of patients with autosomal dominant polycystic kidney disease (ADPKD), and fine needle aspiration cytology (FNAC) can be beneficial in evaluating complications related to the cysts and in excluding ... ...

    Abstract Background: Solitary cysts occur in approximately 10% of patients with autosomal dominant polycystic kidney disease (ADPKD), and fine needle aspiration cytology (FNAC) can be beneficial in evaluating complications related to the cysts and in excluding malignancies and other cystic lesions that can occur in these patients.
    Case: FNAC was performed on a benign epithelial cyst in a symptomatic, 25-year-old, white female with ADPKD. The aspirate consisted of scattered small, flat groups of uniform epithelial cells arranged in a honey-comb fashion.
    Conclusion: To the best of our knowledge, this is the first FNAC report of a pancreatic cyst in ADPKD.
    MeSH term(s) Adult ; Biopsy, Needle ; Diagnosis, Differential ; Female ; Humans ; Pancreatic Cyst/complications ; Pancreatic Cyst/pathology ; Polycystic Kidney, Autosomal Dominant/complications
    Language English
    Publishing date 2001-05
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 80003-x
    ISSN 1938-2650 ; 0001-5547
    ISSN (online) 1938-2650
    ISSN 0001-5547
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    Zs.A 358: Show issues Location:
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  5. Book ; Online: The underscreened Kondo lattice model applied to heavy fermion uranium compounds

    Perkins, N. B. / Nunez-Regueiro, M. D. / Coqblin, B. / Iglesias, J. R.

    2007  

    Abstract: We present theoretical results for the underscreened Kondo lattice model with localized S=1 spins coupled to a conduction band through a Kondo coupling, $J_K$, and interacting among them ferromagnetically. We use a fermionic representation for the spin ... ...

    Abstract We present theoretical results for the underscreened Kondo lattice model with localized S=1 spins coupled to a conduction band through a Kondo coupling, $J_K$, and interacting among them ferromagnetically. We use a fermionic representation for the spin operators and expand the Hamiltonian in terms of bosonic fields. For large values of $J_K$, we obtain a ferromagnetically ordered solution and a Kondo regime with a Kondo temperature, $T_K$, larger than the Curie temperature, $T_C$. This finding suggests a scenario for a coexistence of Kondo effect and ferromagnetic order. In some uranium compounds, like $UTe$ or $UCu_{0.9}Sb_{2}$, this kind of coexistence has been experimentally observed: they order ferromagnetically with a Curie temperature of order $T_C \sim 100K$ and exhibit a Kondo behavior for $T > T_C$. The proposed underscreened Kondo lattice model accounts well for the coexistence between magnetic order and Kondo behavior and yields to a new ``ferromagnetic Doniach diagram''.
    Keywords Condensed Matter - Strongly Correlated Electrons ; Condensed Matter - Materials Science
    Subject code 530
    Publishing date 2007-11-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Management of Patients With Crohn's Disease and Ulcerative Colitis During the Coronavirus Disease-2019 Pandemic

    Rubin, D.T. / Abreu, M.T. / Rai, V. / Siegel, C.A. / Ahuja, V. / Allez, M. / Ananthakrishnan, A.N. / Bernstein, C.N. / Braun, J.G. / Chowers, Y. / Colombel, J.-F. / Danese, S. / D'Haens, G. / D'Hoore, A. / Dignass, A. / Dotan, I. / Dubinsky, M.C. / Ekbom, A. / Fleshner, P.R. /
    Gassull, M.A. / Gearry, R.B. / Ghosh, S. / Griffiths, A.M. / Halfvarson, J. / Hanauer, S.B. / Harpaz, N. / Hart, A. / Kamm, M.A. / Kaplan, G.G. / Koutroubakis, I. / Lakatos, P.L. / Levine, A. / Lewis, J.D. / Lindsay, J.O. / Loftus, E.V., Jr. / Louis, E. / Lukas, M. / Magro, F. / Mahadevan, U. / Mantzaris, G.J. / McGovern, D.P. / Moum, B.A. / Munkholm, P. / Neurath, M.F. / Ng, S.C. / O'Morain, C. / Panaccione, R. / Panes, J. / Peyrin-Biroulet, L. / Prantera, C. / Ran, Z. / Reinisch, W. / Remzi, F.H. / Sachar, D.B. / Sandborn, W.J. / Sartor, R.B. / Schoelmerich, J. / Schreiber, S. / Siegmund, B. / Silverberg, M.S. / Soederholm, J.D. / Stange, E.F. / Steinwurz, F. / Turner, D. / Vatn, M.H. / Vermeire, S. / Brenner, E.J. / Christensen, B. / D'Amico, F. / Griffiths, C.M. / Higgins, P.D. / Kappelman, M.D. / Lees, C. / Regueiro, M.D. / Rosh, J.R. / Ungaro, R. / International Organization for the Study of Inflammatory Bowel Disease

    Gastroenterology, 159(1)

    Results of an International Meeting

    2020  

    Abstract: The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is the only global organization devoted to the study of and management of the inflammatory bowel diseases (IBDs), namely, Crohn?s disease and ulcerative colitis. ... ...

    Abstract The International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) is the only global organization devoted to the study of and management of the inflammatory bowel diseases (IBDs), namely, Crohn?s disease and ulcerative colitis. Membership is composed of physician-scientists who have established expertise in these diseases. The organization hosts an annual meeting and a number of working groups addressing issues of the epidemiology of IBD, diet and nutrition, and the development and use of treatments for IBD. There are currently 89 members of IOIBD representing 26 different countries. The organization has taken particular interest in the coronavirus disease-2019 (COVID-19) pandemic and how it may affect the IBD patient population. This document summarizes the results of 2 recent virtual meetings of the group and subsequent expert guidance for patients and providers.
    Keywords Severe acute respiratory syndrome coronavirus 2 ; health care organization ; Crohn disease ; practice guideline ; coronavirus disease 2019 ; pandemic ; inflammatory bowel disease ; ulcerative colitis ; immune response ; nonhuman ; human ; patient care ; methodology ; covid19
    Subject code 610
    Language English
    Publisher W.B. Saunders
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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