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  1. Article ; Online: Rivaroxaban in Peripheral Arterial Disease (PAD) Management.

    Rehman, Zia Ur

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2023  Volume 33, Issue 7, Page(s) 832

    Abstract: Null. ...

    Abstract Null.
    MeSH term(s) Humans ; Rivaroxaban/therapeutic use ; Peripheral Arterial Disease/drug therapy ; Factor Xa Inhibitors/therapeutic use
    Chemical Substances Rivaroxaban (9NDF7JZ4M3) ; Factor Xa Inhibitors
    Language English
    Publishing date 2023-07-04
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2023.07.832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Clinical Characteristics and Etiology of Epilepsy in Children Aged Below Two Years: Perspective From a Tertiary Childcare Hospital in South Punjab, Pakistan.

    Rehman, Zia Ur

    Cureus

    2022  Volume 14, Issue 4, Page(s) e23854

    Abstract: Background Epilepsy is described as an enduring disposition toward recurrent unprovoked seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition. This study aimed to find the clinical characteristics and ... ...

    Abstract Background Epilepsy is described as an enduring disposition toward recurrent unprovoked seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition. This study aimed to find the clinical characteristics and etiology of epilepsy in children aged below two years. Methodology This cross-sectional study was conducted at the department of pediatric neurology, the Children's Hospital and Institute of Child Health, Multan, Pakistan, from February 2021 to July 2021. During the study period, a total of 226 children of both genders, aged below two years, presenting with epilepsy and who underwent electroencephalography (EEG) were included. Socio-demographic and clinical data along with clinical features and radiological/imaging findings were noted. Results In a total of 226 children, 121 (53.5%) were male and 105 (46.5%) female. Overall, the mean age was calculated to be 14.6±5.2 months while 107 (47.3%) children were aged between 13 to 24 months. Residential status was found to be rural in 142 (62.8%) children. Generalized seizures (both primary and secondary) were reported in 205 (90.7%) children while the remaining 21 (9.3%) children had focal seizures. The most common etiology of epilepsy was noted to be structural/metabolic in 122 (54.0%) children. Abnormal EEG findings were observed among 150 (66.4%) children. Developmental delay (p=0.0016), hypotonia (p<0.0001), microcephaly or macrocephaly (p<0.0001), abnormal brain CT or MRI (p<0.0001), and abnormal EEG findings (p=0.0161) were found to have a significant association with etiology of epilepsy. Conclusion Generalized seizures like tonic-clonic and clonic types were the most common findings among children below two years of age with epilepsy. Structural abnormalities were the most common etiology in children with epilepsy. Age between one to two years was the commonest age of onset of seizures among young children.
    Language English
    Publishing date 2022-04-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.23854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mesenteric inflammatory veno-occlusive disease: what is it and why it is important to know it?

    Rehman, Zia Ur

    JPMA. The Journal of the Pakistan Medical Association

    2022  Volume 71, Issue 12, Page(s) 2840–2841

    MeSH term(s) Humans ; Mesentery ; Vascular Diseases
    Language English
    Publishing date 2022-02-09
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.01-747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Identifying the 'Vulnerable Plaque' in Asymptomatic Carotid Artery Disease Patients.

    Rehman, Zia Ur

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2022  Volume 32, Issue 4, Page(s) 552

    Abstract: Null. ...

    Abstract Null.
    MeSH term(s) Carotid Artery Diseases/diagnostic imaging ; Carotid Stenosis/diagnostic imaging ; Humans
    Language English
    Publishing date 2022-03-21
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2022.04.552
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Routine Procedure Getting Complicated: Iliac Artery Injury during Herniated Disc Surgery.

    Rehman, Zia Ur

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2022  Volume 32, Issue 2, Page(s) 272–273

    Abstract: Null. ...

    Abstract Null.
    MeSH term(s) Abdominal Injuries ; Humans ; Iliac Artery/surgery ; Intervertebral Disc Displacement/surgery
    Language English
    Publishing date 2022-02-02
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2022.02.272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Pattern of Chronic Venous Insufficiency among Patients Presenting to a Vascular Surgery Clinic in Low- to Middle-Income Countries (LMIC): A Cross-Sectional Study.

    Rehman, Zia Ur

    Annals of vascular diseases

    2021  Volume 14, Issue 2, Page(s) 118–121

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2021-07-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2394256-3
    ISSN 1881-6428 ; 1881-641X
    ISSN (online) 1881-6428
    ISSN 1881-641X
    DOI 10.3400/avd.oa.20-00088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Frequency of limb salvage after infra-inguinal bypass for chronic limb-threatening ischaemia in diabetics: A retrospective study.

    Rehman, Zia Ur

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 71, Issue 7, Page(s) 1885–1888

    Abstract: A study was conducted to assess the number of limbs salvaged among diabetic patients with chronic limb-threatening ischaemia after infra-inguinal bypass surgeries at a low- to middle-income country (LMIC) hospital. It was a retrospective chart review of ... ...

    Abstract A study was conducted to assess the number of limbs salvaged among diabetic patients with chronic limb-threatening ischaemia after infra-inguinal bypass surgeries at a low- to middle-income country (LMIC) hospital. It was a retrospective chart review of diabetic patients who underwent infra-inguinal bypass for lower leg revascularisation for chronic limb-threatening ischaemia at the Section of Vascular Surgery, Aga Khan University Hospital, Karachi (Pakistan) from January 2008 till April 2019. Diabetic patients with chronic limb-threatening ischaemia had a salvage rate of 90.5%(29/32) after infra-inguinal bypass surgery in our set up which is comparable to those described in the literature.
    MeSH term(s) Amputation ; Diabetes Mellitus/epidemiology ; Humans ; Ischemia/surgery ; Limb Salvage ; Peripheral Arterial Disease ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2021-08-18
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Abdominal vascular injuries- what general/ trauma surgeons should know?

    Rehman, Zia Ur

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 71, Issue 8, Page(s) 2027–2031

    Abstract: Abdominal vascular injuries are the common cause of death post-trauma. These are challenging injuries to manage due to severe haemodynamic instability, other associated injuries and difficulty in accessing and controlling these deep-seated vessels. Early ...

    Abstract Abdominal vascular injuries are the common cause of death post-trauma. These are challenging injuries to manage due to severe haemodynamic instability, other associated injuries and difficulty in accessing and controlling these deep-seated vessels. Early control of bleeding can decrease mortality in these patients. Abdominal vasculature is divided into three zones, each requiring different operative strategy for exposure. Standard vascular surgery principles of achieving proximal and distal control before exploring any haematoma are followed when managing these injuries. Resuscitative endovascular balloon occlusion of aorta is a minimally invasive method of achieving proximal aortic occlusion. This also acts as bridge for definitive intervention or surgery. Endovascular interventions, including angioembolisation and stent-graft, have shown to improve outcomes, especially in patients with blunt abdominal trauma. Updated knowledge is necessary for all those directly involved in managing these patients. The current narrative review was planned to discusses relevant anatomy, principles, different surgical approaches and endovascular techniques to deal with these injuries.
    MeSH term(s) Abdominal Injuries/surgery ; Balloon Occlusion ; Endovascular Procedures ; Humans ; Surgeons ; Vascular System Injuries/surgery
    Language English
    Publishing date 2021-08-21
    Publishing country Pakistan
    Document type Journal Article ; Review
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Endoleaks: Current concepts and treatments - A Narrative Review.

    Rehman, Zia Ur

    JPMA. The Journal of the Pakistan Medical Association

    2021  Volume 71, Issue 9, Page(s) 2224–2229

    Abstract: Endoleaks are the most common complications following endovascular aneurysm repair. Depending upon their origin, there are five types of endoleaks, types I-V, which can also be classified as direct and indirect endoleaks. Direct endoleaks (type I and III) ...

    Abstract Endoleaks are the most common complications following endovascular aneurysm repair. Depending upon their origin, there are five types of endoleaks, types I-V, which can also be classified as direct and indirect endoleaks. Direct endoleaks (type I and III) have higher risk of aneurysm rupture due to rapid sac expansion, and require immediate correction. Indirect endoleaks ( type II, IV and V) have a relatively benign course compared to direct endoleaks. Most of them resolve with time and very few need interventions upon sac enlargement. Type V endotension is a special situation where there is sac enlargement despite no demonstrable endoleak. Proper planning and appropriate selection of stent-graft can prevent most of these endoleaks. With improvement in stent-graft technology, the incidence of endoleaks has been reduced. The current narrative review was planned to describe the pathophysiology, risk factors and treatment options for each type of endoleak.
    MeSH term(s) Aortic Aneurysm, Abdominal/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Endoleak/diagnostic imaging ; Endoleak/etiology ; Endoleak/therapy ; Endovascular Procedures ; Humans ; Retrospective Studies ; Stents ; Treatment Outcome
    Language English
    Publishing date 2021-09-27
    Publishing country Pakistan
    Document type Journal Article ; Review
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.03-345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exploring EGFR inhibitors with the aid of virtual screening, docking, and dynamics simulation studies.

    Rehman, Zia Ur / Najmi, Asim

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–21

    Abstract: In humans, Epidermal Growth Factor Receptor (EGFR) is linked to small-cell lung cancer, breast cancer, and glioblastoma. Receptor kinase inhibitors against EGFR have become a standard treatment option for non-small cell lung cancer (NSCLC), breast cancer ...

    Abstract In humans, Epidermal Growth Factor Receptor (EGFR) is linked to small-cell lung cancer, breast cancer, and glioblastoma. Receptor kinase inhibitors against EGFR have become a standard treatment option for non-small cell lung cancer (NSCLC), breast cancer patients, and even for those with EGFR mutations or resistance. About 2734 FDA-approved medication compounds were subjected to virtual screening for EGFR kinase inhibitory activity. The top 30 molecules were chosen based on the binding affinity scores and subjected to extra-precision docking and binding free energy analysis. The ADMET profile of the top three hit molecules was verified to confirm their druggability nature. Top three hits- compound 1047 (ZINC000001550477), 1302 (ZINC00003781952), and 2332 (ZINC000019632618) were identified on account of their MMGBSA binding affinity values. The top three hit compounds were subjected to molecular dynamics (MD) simulation for 100 ns. The dynamic nature of the ligand-protein complex was analyzed which corroborated the results of molecular docking and MMGBSA analysis studies. All the top three hits were further subjected to steered MD studies for testing the strength of these ligand-receptor binding in the presence of an external force. Compound 2332 (ZINC000019632618) was identified as the best hit molecule that can be used as a lead to develop newer derivatives of EGFR kinase inhibitors.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2256887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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