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  1. Book: Proteomics in systems biology

    Reinders, Jörg

    methods and protocols

    (Methods in molecular biology ; 1394 ; Springer protocols)

    2016  

    Author's details edited by Jörg Reinders
    Series title Methods in molecular biology ; 1394
    Springer protocols
    Collection
    Language English
    Size xii, 313 Seiten, Illustrationen, Diagramme
    Publisher Humana Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT019149927
    ISBN 978-1-4939-3339-6 ; 9781493933419 ; 1-4939-3339-6 ; 1493933418
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1394- verfügbar in Königswinter Königswinter

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  2. Book: Proteomics

    Reinders, Jörg

    methods and protocols

    (Methods in molecular biology ; 564 ; Springer protocols)

    2009  

    Author's details ed. by Jörg Reinders
    Series title Methods in molecular biology ; 564
    Springer protocols
    Collection
    Language English
    Size XII, 441 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015984458
    ISBN 978-1-60761-156-1 ; 1-60761-156-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 4254 order for loan Magazin

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  3. Book: Proteomics in systems biology

    Reinders, Jörg

    methods and protocols

    (Methods in molecular biology ; 1394 ; Springer protocols)

    2016  

    Abstract: This volume presents an overview of contemporary quantitative proteomics methods along with instructions on data interpretation, while providing examples on how to implement proteomics into systems biology. Written in the highly successful Methods in ... ...

    Author's details edited by Jörg Reinders, Institute of Functional Genomics, University of Regensburg, Regensburg, Germany
    Series title Methods in molecular biology ; 1394
    Springer protocols
    Abstract This volume presents an overview of contemporary quantitative proteomics methods along with instructions on data interpretation, while providing examples on how to implement proteomics into systems biology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Proteomics in Systems Biology: Methods and Protocols is a valuable resource for researchers who are interested in using proteomics techniques to help answer biological and medical questions
    MeSH term(s) Proteomics/methods ; Systems Biology/methods
    Keywords Proteomics ; Systems biology ; Proteomanalyse ; Systembiologie
    Language English
    Size xii, 313 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York ; Heidelberg ; Dordrecht ; London
    Document type Book
    Note Includes bibliographical references and index
    ISBN 9781493933396 ; 9781493933419 ; 1493933396 ; 1493933418
    Database Leibniz Institute of Plant Genetics and Crop Plant Research

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  4. Book: Proteomics in systems biology

    Reinders, Jörg

    methods and protocols

    (Methods in molecular biology, ; 1394 ; Springer protocols)

    2016  

    Author's details edited by Jörg Reinders
    Series title Methods in molecular biology, ; 1394
    Springer protocols
    MeSH term(s) Proteomics/methods ; Systems Biology/methods
    Language English
    Size xii, 313 pages :, illustrations.
    Document type Book
    ISBN 9781493933396 ; 9781493933419 ; 1493933396 ; 1493933418
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article ; Online: Activation of the non-neuronal cholinergic cardiac system by hypoxic preconditioning protects isolated adult cardiomyocytes from hypoxia/reoxygenation injury.

    Braczko, Felix / Fischl, Sara Romina / Reinders, Jörg / Lieder, Helmut Raphael / Kleinbongard, Petra

    American journal of physiology. Heart and circulatory physiology

    2024  

    Abstract: Background: Activation of the vagus nerve mediates cardioprotection and attenuates myocardial ischemia/reperfusion (I/R) injury. In response to vagal activation, acetylcholine (ACh) is released from the intracardiac nervous system (ICNS) and activates ... ...

    Abstract Background: Activation of the vagus nerve mediates cardioprotection and attenuates myocardial ischemia/reperfusion (I/R) injury. In response to vagal activation, acetylcholine (ACh) is released from the intracardiac nervous system (ICNS) and activates intracellular cardioprotective signaling cascades. Recently, however, a non-neuronal cholinergic cardiac system (NNCCS) in cardiomyocytes has been described as an additional source of ACh.
    Aim: To investigate whether the NNCCS mediates cardioprotection in absence of vagal and ICNS activation. For that, we used a reductionist approach of isolated adult rat ventricular cardiomyocytes in absence of neuronal cells with hypoxic preconditioning (HPC) as protective stimulus.
    Methods: Adult rat ventricular cardiomyocytes were isolated, absence of neuronal cells was confirmed, HPC was induced by 10/20 min hypoxia/reoxygenation (H/R) before subjection to 30/5 min H/R to simulate I/R injury. Cardiomyocyte viability was assessed by trypan blue staining. Intra- and extracellular ACh was quantified using liquid chromatography-coupled mass spectrometry at baseline, after HPC, after hypoxia, and after reoxygenation, respectively. In a subset of experiments, muscarinic/nicotinic ACh receptor (mAChR/nAChR) antagonists were added during HPC or during H/R.
    Results: Cardiomyocyte viability at baseline (69±4%) was reduced by H/R (10±3%). With HPC cardiomyocyte viability was preserved after H/R (25±6%). Intra- and extracellular ACh increased during hypoxia, HPC further increased both intra- and extracellular ACh (from 0.9±0.7 to 1.5±1.0 nmol/mg; from 0.7±0.6 to 1.1±0.7 nmol/mg). Addition of mAChR and nAChR antagonists during HPC had no impact on HPC´s protection, however protection was abrogated when antagonists were added during H/R (cardiomyocyte viability after H/R: 23±5%; 13±4%).
    Conclusion: Activation of the NNCCS is involved in cardiomyocyte protection: HPC increases intra- and extracellular ACh during H/R, and m-/nAChRs are causally involved in HPC´s cardiomyocyte protection during H/R. The interplay between upstream ICNS activation and the NNCCS activation to myocardial cholinergic metabolism and cardioprotection needs to be investigated in future studies.
    Language English
    Publishing date 2024-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00211.2024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.89: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Chronic

    Getzmann, Stephan / Golka, Klaus / Bröde, Peter / Reinders, Jörg / Kadhum, Thura / Hengstler, Jan G / Wascher, Edmund / Gajewski, Patrick D

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 2

    Abstract: While several studies have shown associations between hearing disorders and congenital toxoplasmosis, the present study investigated the impact of chronic, ... ...

    Abstract While several studies have shown associations between hearing disorders and congenital toxoplasmosis, the present study investigated the impact of chronic, latent
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14020194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Immediate and Delayed Salivary Cytokine Responses during Repeated Exposures to Cold Pressor Stress.

    Larra, Mauro F / Capellino, Silvia / Schwendich, Elena / von Haugwitz, Leon / Reinders, Jörg / Wascher, Edmund

    Neuroimmunomodulation

    2023  Volume 30, Issue 1, Page(s) 81–92

    Abstract: Introduction: Excessive stress is increasingly recognized as an important trigger of many diseases prevalent in modern societies, and monitoring such stress-related effects could aid prevention. The measurement of salivary markers of inflammation is ... ...

    Abstract Introduction: Excessive stress is increasingly recognized as an important trigger of many diseases prevalent in modern societies, and monitoring such stress-related effects could aid prevention. The measurement of salivary markers of inflammation is emerging as a promising tool to non-invasively quantify stress' effects on immune processes in everyday life and thereby detect early aberrations before the manifestation of serious health problems. However, more laboratory-controlled research is needed in order to establish the timescale and determinants of salivary cytokine responses to acute stress.
    Methods: We repeatedly exposed participants to Cold Pressor Stress Test (CPT) or a control procedure and measured a wide array of salivary cytokines as well as subjective, cardiovascular, and cortisol stress reactions. CPT exposure was repeated every 15 min, 3 times in total, with a duration of 3 min each. Saliva was sampled immediately after the first two exposures as well as in 15-min intervals until 60 min after the onset of the first intervention.
    Results: We found that many cytokines were detectable in saliva. Specific stress effects were limited to IL-8 and IL-6, however, which decreased immediately or 15 min after stress onset, respectively. Moreover, IL-8 was negatively correlated to cortisol output in the stress but not in the control group. Significant increases were also observed in salivary TNFα and IFNγ; however, these effects were similar under both stress and control conditions.
    Discussion: Our results show that particular salivary cytokines may be sensitive to immediate effects of acute CPT-induced stress and also highlight the importance of employing control procedures to discern stress effects from unrelated variations in salivary cytokines.
    MeSH term(s) Humans ; Cytokines ; Hydrocortisone ; Interleukin-8 ; Stress, Psychological ; Saliva ; Hypothalamo-Hypophyseal System
    Chemical Substances Cytokines ; Hydrocortisone (WI4X0X7BPJ) ; Interleukin-8
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1184368-8
    ISSN 1423-0216 ; 1021-7401
    ISSN (online) 1423-0216
    ISSN 1021-7401
    DOI 10.1159/000529625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3975: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Dopamine receptor 1 expressing B cells exert a proinflammatory role in female patients with rheumatoid arthritis.

    Wieber, Karolin / Fleige, Leonie / Tsiami, Styliani / Reinders, Jörg / Braun, Jürgen / Baraliakos, Xenofon / Capellino, Silvia

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 5985

    Abstract: Rheumatoid arthritis (RA) is a chronic rheumatic disease with a clear sex-bias. Recent data indicated a role for dopamine in RA pathogenesis, while dopaminergic pathways can be modulated by estrogens. As defined mechanism of action of dopamine on B cell ... ...

    Abstract Rheumatoid arthritis (RA) is a chronic rheumatic disease with a clear sex-bias. Recent data indicated a role for dopamine in RA pathogenesis, while dopaminergic pathways can be modulated by estrogens. As defined mechanism of action of dopamine on B cell function in RA are unclear, we aimed to elucidate this, with special focus on sex-differences. Healthy controls (HC, n = 64) and RA patients (n = 61) were recruited. Expression of D
    MeSH term(s) Arthritis, Rheumatoid/pathology ; B-Lymphocytes/metabolism ; Cytokines/metabolism ; Dopamine/metabolism ; Female ; Humans ; Leukocytes, Mononuclear/metabolism ; Male ; Receptors, Dopamine/metabolism ; Receptors, Dopamine D1
    Chemical Substances Cytokines ; DRD1 protein, human ; Receptors, Dopamine ; Receptors, Dopamine D1 ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-09891-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain.

    Salehinejad, Mohammad Ali / Ghanavati, Elham / Reinders, Jörg / Hengstler, Jan G / Kuo, Min-Fang / Nitsche, Michael A

    eLife

    2022  Volume 11

    Abstract: Sleep strongly affects synaptic strength, making it critical for cognition, especially learning and memory formation. Whether ... ...

    Abstract Sleep strongly affects synaptic strength, making it critical for cognition, especially learning and memory formation. Whether and
    MeSH term(s) Brain ; Cognition ; Evoked Potentials, Motor/physiology ; Humans ; Motor Cortex/physiology ; Neuronal Plasticity/physiology ; Sleep ; Sleep Deprivation ; Transcranial Direct Current Stimulation/methods ; Transcranial Magnetic Stimulation
    Language English
    Publishing date 2022-06-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.69308
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Acetaminophen overdose causes a breach of the blood-bile barrier in mice but not in rats.

    Hassan, Reham / Hobloss, Zaynab / Myllys, Maiju / González, Daniela / Begher-Tibbe, Brigitte / Reinders, Joerg / Friebel, Adrian / Hoehme, Stefan / Abdelmageed, Noha / Abbas, Aya A / Seddek, Abdel-Latief / Morad, Samy A F / Hengstler, Jan G / Ghallab, Ahmed

    Archives of toxicology

    2024  Volume 98, Issue 5, Page(s) 1533–1542

    Abstract: Acetaminophen (APAP) is known to cause a breach of the blood-bile barrier in mice that, via a mechanism called futile bile acid (BA) cycling, increases BA concentrations in hepatocytes above cytotoxic thresholds. Here, we compared this mechanism in mice ... ...

    Abstract Acetaminophen (APAP) is known to cause a breach of the blood-bile barrier in mice that, via a mechanism called futile bile acid (BA) cycling, increases BA concentrations in hepatocytes above cytotoxic thresholds. Here, we compared this mechanism in mice and rats, because both species differ massively in their susceptibility to APAP and compared the results to available human data. Dose and time-dependent APAP experiments were performed in male C57BL6/N mice and Wistar rats. The time course of BA concentrations in liver tissue and in blood was analyzed by MALDI-MSI and LC-MS/MS. APAP and its derivatives were measured in the blood by LC-MS. APAP-induced liver damage was analyzed by histopathology, immunohistochemistry, and by clinical chemistry. In mice, a transient increase of BA in blood and in peri-central hepatocytes preceded hepatocyte death. The BA increase coincided with oxidative stress in liver tissue and a compromised morphology of bile canaliculi and immunohistochemically visualized tight junction proteins. Rats showed a reduced metabolic activation of APAP compared to mice. However, even at very high doses that caused cell death of hepatocytes, no increase of BA concentrations was observed neither in liver tissue nor in the blood. Correspondingly, no oxidative stress was detectable, and the morphology of bile canaliculi and tight junction proteins remained unaltered. In conclusion, different mechanisms cause cell death in rats and mice, whereby oxidative stress and a breach of the blood-bile barrier are seen only in mice. Since transient cholestasis also occurs in human patients with APAP overdose, mice are a clinically relevant species to study APAP hepatotoxicity but not rats.
    MeSH term(s) Mice ; Rats ; Humans ; Male ; Animals ; Acetaminophen/toxicity ; Acetaminophen/metabolism ; Bile/metabolism ; Chromatography, Liquid ; Chemical and Drug Induced Liver Injury/pathology ; Rats, Wistar ; Tandem Mass Spectrometry ; Liver/metabolism ; Hepatocytes/metabolism ; Mice, Inbred C57BL ; Tight Junction Proteins/metabolism
    Chemical Substances Acetaminophen (362O9ITL9D) ; Tight Junction Proteins
    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124992-7
    ISSN 1432-0738 ; 0340-5761
    ISSN (online) 1432-0738
    ISSN 0340-5761
    DOI 10.1007/s00204-024-03705-6
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    Uf I Zs.90: Show issues Location:
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