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  1. Article ; Online: Insights on ErbB glycosylation - contributions to precision oncology.

    Duarte, Henrique O / Reis, Celso A / Gomes, Joana

    Trends in cancer

    2022  Volume 8, Issue 6, Page(s) 448–455

    Abstract: Although the ErbB receptors remain incontrovertible drivers of human neoplastic transformation, the clinical performance of ErbB-directed therapeutics is significantly undermined by the emergence of molecular resistance. The ErbB extracellular region ... ...

    Abstract Although the ErbB receptors remain incontrovertible drivers of human neoplastic transformation, the clinical performance of ErbB-directed therapeutics is significantly undermined by the emergence of molecular resistance. The ErbB extracellular region undergoes extensive post-translational glycosylation, which crucially impacts receptor structure, functionality, and therapeutic response, thereby hindering efforts towards the successful translation of such molecular insights into the clinical setting. The unraveling of the ErbB site-specific glycome will allow for the design of more efficient ErbB-directed therapeutic strategies capable of circumventing molecular resistance, the establishment of novel prognostic and predictive clinical biomarkers supporting improved patient stratification, and the rational guidance of therapeutic decisions.
    MeSH term(s) ErbB Receptors/metabolism ; Glycosylation ; Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Precision Medicine ; Prognosis
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-03-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2022.02.003
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  2. Article ; Online: Editorial: Glycans: Masters of immunity, from cancers to inflammatory disease.

    Beatson, Richard / Läubli, Heinz / Pearce, Oliver M T / Reis, Celso A

    Frontiers in immunology

    2022  Volume 13, Page(s) 1002679

    MeSH term(s) Humans ; Neoplasms ; Polysaccharides
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2022-08-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1002679
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  3. Article: Editorial: Does the golgi complex enable oncogenesis?

    Colanzi, Antonino / Parashuraman, Setharaman / Reis, Celso A / Ungar, Daniel

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 1000946

    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1000946
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  4. Article ; Online: Phenylethyl Isothiocyanate: A Bioactive Agent for Gastrointestinal Health.

    Coscueta, Ezequiel R / Sousa, Ana Sofia / Reis, Celso A / Pintado, Maria Manuela

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 3

    Abstract: The incidence of gastrointestinal pathologies (cancer in particular) has increased progressively, with considerable morbidity and mortality, and a high economic impact on the healthcare system. The dietary intake of natural phytochemicals with certain ... ...

    Abstract The incidence of gastrointestinal pathologies (cancer in particular) has increased progressively, with considerable morbidity and mortality, and a high economic impact on the healthcare system. The dietary intake of natural phytochemicals with certain bioactive properties has shown therapeutic and preventive effects on these pathologies. This includes the cruciferous vegetable derivative phenylethyl isothiocyanate (PEITC), a bioactive compound present in some vegetables, such as watercress. Notably, PEITC has antioxidant, anti-inflammatory, bactericidal, and anticarcinogenic properties. This review summarized the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discussed the safe and recommended dose of PEITC. In addition, we established a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural molecule for industrial use. With PEITC, there is great potential to develop a viable strategy for preventing cancer and other associated diseases of the gastrointestinal tract. However, this topic still needs more scientific studies to help develop new PEITC products for the nutraceutical, pharmaceutical, or food industries.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Cell Line, Tumor ; Dietary Supplements ; Gastrointestinal Tract/drug effects ; Humans ; Isothiocyanates/pharmacology
    Chemical Substances Anti-Inflammatory Agents ; Antioxidants ; Isothiocyanates ; phenethyl isothiocyanate (6U7TFK75KV)
    Language English
    Publishing date 2022-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27030794
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  5. Article ; Online: The role of O-glycosylation in human disease.

    Magalhães, Ana / Duarte, Henrique O / Reis, Celso A

    Molecular aspects of medicine

    2021  Volume 79, Page(s) 100964

    Abstract: O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular ... ...

    Abstract O-glycosylation is a highly frequent post-translation modification of proteins, with important functional implications in both physiological and disease contexts. The biosynthesis of O-glycans depends on several layers of regulation of the cellular glycosylation machinery, being organ-, tissue- and cell-specific. This review provides insights on the molecular mechanism underlying O-glycan biosynthesis and modification, and highlights illustrative examples of diseases that are triggered or modulated by aberrant cellular O-glycosylation. Particular relevance is given to genetic disorders of glycosylation, infectious diseases and cancer. Finally, we address the potential of O-glycans and their biosynthetic pathways as targets for novel therapeutic strategies.
    MeSH term(s) Glycosylation ; Humans ; Neoplasms/genetics ; Polysaccharides ; Protein Processing, Post-Translational
    Chemical Substances Polysaccharides
    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2021.100964
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Glycosylation is a key in SARS-CoV-2 infection.

    Reis, Celso A / Tauber, Rudolf / Blanchard, Véronique

    Journal of molecular medicine (Berlin, Germany)

    2021  Volume 99, Issue 8, Page(s) 1023–1031

    Abstract: SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how ... ...

    Abstract SARS-CoV-2 causes the respiratory syndrome COVID-19 and is responsible for the current pandemic. The S protein of SARS-CoV-2-mediating virus binding to target cells and subsequent viral uptake is extensively glycosylated. Here we focus on how glycosylation of both SARS-CoV-2 and target cells crucially impacts SARS-CoV-2 infection at different levels: (1) virus binding and entry to host cells, with glycosaminoglycans of host cells acting as a necessary co-factor for SARS-CoV-2 infection by interacting with the receptor-binding domain of the SARS-CoV-2 spike glycoprotein, (2) innate and adaptive immune response where glycosylation plays both a protective role and contributes to immune evasion by masking of viral polypeptide epitopes and may add to the cytokine cascade via non-fucosylated IgG, and (3) therapy and vaccination where a monoclonal antibody-neutralizing SARS-CoV-2 was shown to interact also with a distinct glycan epitope on the SARS-CoV-2 spike protein. These evidences highlight the importance of ensuring that glycans are considered when tackling this disease, particularly in the development of vaccines, therapeutic strategies and serological testing.
    MeSH term(s) Adaptive Immunity ; Animals ; Blood Group Antigens/immunology ; Blood Group Antigens/metabolism ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/therapy ; Exocytosis ; Glycosylation ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization ; Virus Replication
    Chemical Substances Blood Group Antigens ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2021-05-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1223802-8
    ISSN 1432-1440 ; 0946-2716
    ISSN (online) 1432-1440
    ISSN 0946-2716
    DOI 10.1007/s00109-021-02092-0
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.36: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: CAR‐Ts: new perspectives in cancer therapy

    Abrantes, Rafaela / Duarte, Henrique O. / Gomes, Catarina / Wälchli, Sébastien / Reis, Celso A.

    FEBS letters. 2022 Feb., v. 596, no. 4

    2022  

    Abstract: Chimeric antigen receptor (CAR)‐T‐cell therapy is a promising anticancer treatment that exploits the host's immune system to fight cancer. CAR‐T cell therapy relies on immune cells being modified to express an artificial receptor targeting cancer‐ ... ...

    Abstract Chimeric antigen receptor (CAR)‐T‐cell therapy is a promising anticancer treatment that exploits the host's immune system to fight cancer. CAR‐T cell therapy relies on immune cells being modified to express an artificial receptor targeting cancer‐specific markers, and infused into the patients where they will recognize and eliminate the tumour. Although CAR‐T cell therapy has produced encouraging outcomes in patients with haematologic malignancies, solid tumours remain challenging to treat, mainly due to the lack of cancer‐specific molecular targets and the hostile, often immunosuppressive, tumour microenvironment. CAR‐T cell therapy also depends on the quality of the injected product, which is closely connected to CAR design. Here, we explain the technology of CAR‐Ts, focusing on the composition of CARs, their application, and limitations in cancer therapy, as well as on the current strategies to overcome the challenges encountered. We also address potential future targets to overcome the flaws of CAR‐T cell technology in the treatment of cancer, emphasizing glycan antigens, the aberrant forms of which attain high tumour‐specific expression, as promising targets for CAR‐T cell therapy.
    Keywords antigens ; cancer therapy ; immune system ; immunosuppression ; neoplasms
    Language English
    Dates of publication 2022-02
    Size p. 403-416.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note REVIEW
    ZDB-ID 212746-5
    ISSN 1873-3468 ; 0014-5793
    ISSN (online) 1873-3468
    ISSN 0014-5793
    DOI 10.1002/1873-3468.14270
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    In stock of ZB MED Bonn / Germany

    Z 2005/702: Show issues
    Z 5.4: Show issues

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  8. Article: Phenylethyl Isothiocyanate Extracted from Watercress By-Products with Aqueous Micellar Systems: Development and Optimisation

    Coscueta, Ezequiel R / Reis, Celso A / Pintado, Manuela

    Antioxidants. 2020 Aug. 03, v. 9, no. 8

    2020  

    Abstract: Phenylethyl isothiocyanate (PEITC) was reported as a useful antioxidant, anti-inflammatory, and chemopreventive agent. Due to technological and stability issues, it is necessary to be able to extract PEITC from its natural matrix (watercress) through ... ...

    Abstract Phenylethyl isothiocyanate (PEITC) was reported as a useful antioxidant, anti-inflammatory, and chemopreventive agent. Due to technological and stability issues, it is necessary to be able to extract PEITC from its natural matrix (watercress) through sustainable and scalable methodologies. In this article, we explored, for the first time, the extractive capacity of aqueous micellar systems (AMSs) of two non-ionic surfactants. For this, we compared the AMSs with conventional organic solvents. Furthermore, we developed and optimised a new integral PEITC production and extraction process by a multifactorial experimental design. Finally, we analysed the antioxidant capacity by the oxygen radical absorbance capacity (ORAC) and ABTS methods. As results, the AMSs were able to extract PEITC at the same level as the tested conventional solvents. In addition, we optimised by response surface methodology the integrated process (2.0% m/m, 25.0 °C, pH 9.0), which was equally effective (ca. 2900 µg PEITC/g watercress), regardless of the surfactant used. The optimal extracts showed greater antioxidant capacity than pure PEITC, due to other antioxidant compounds extracted in the process. In conclusion, by the present work, we developed an innovative cost-effective and low environmental impact process for obtaining PEITC extracts from watercress by-products.
    Keywords antioxidants ; byproducts ; chemoprevention ; cost effectiveness ; environmental impact ; experimental design ; isothiocyanates ; nonionic surfactants ; oxygen radical absorbance capacity ; pH ; response surface methodology ; solvents ; watercress
    Language English
    Dates of publication 2020-0803
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9080698
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Phenylethyl Isothiocyanate Extracted from Watercress By-Products with Aqueous Micellar Systems: Development and Optimisation.

    Coscueta, Ezequiel R / Reis, Celso A / Pintado, Manuela

    Antioxidants (Basel, Switzerland)

    2020  Volume 9, Issue 8

    Abstract: Phenylethyl isothiocyanate (PEITC) was reported as a useful antioxidant, anti-inflammatory, and chemopreventive agent. Due to technological and stability issues, it is necessary to be able to extract PEITC from its natural matrix (watercress) through ... ...

    Abstract Phenylethyl isothiocyanate (PEITC) was reported as a useful antioxidant, anti-inflammatory, and chemopreventive agent. Due to technological and stability issues, it is necessary to be able to extract PEITC from its natural matrix (watercress) through sustainable and scalable methodologies. In this article, we explored, for the first time, the extractive capacity of aqueous micellar systems (AMSs) of two non-ionic surfactants. For this, we compared the AMSs with conventional organic solvents. Furthermore, we developed and optimised a new integral PEITC production and extraction process by a multifactorial experimental design. Finally, we analysed the antioxidant capacity by the oxygen radical absorbance capacity (ORAC) and ABTS methods. As results, the AMSs were able to extract PEITC at the same level as the tested conventional solvents. In addition, we optimised by response surface methodology the integrated process (2.0% m/m, 25.0 °C, pH 9.0), which was equally effective (ca. 2900 µg PEITC/g watercress), regardless of the surfactant used. The optimal extracts showed greater antioxidant capacity than pure PEITC, due to other antioxidant compounds extracted in the process. In conclusion, by the present work, we developed an innovative cost-effective and low environmental impact process for obtaining PEITC extracts from watercress by-products.
    Language English
    Publishing date 2020-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox9080698
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  10. Article ; Online: Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: Optimal formulation.

    Coscueta, Ezequiel R / Sousa, Ana Sofia / Reis, Celso A / Pintado, Manuela

    PloS one

    2021  Volume 16, Issue 5, Page(s) e0248257

    Abstract: Phenylethyl isothiocyanate (PEITC), a chemopreventive compound, is highly reactive due to its considerably electrophilic nature. Furthermore, it is hydrophobic and has low stability, bioavailability and bioaccessibility. This restricts its use in ... ...

    Abstract Phenylethyl isothiocyanate (PEITC), a chemopreventive compound, is highly reactive due to its considerably electrophilic nature. Furthermore, it is hydrophobic and has low stability, bioavailability and bioaccessibility. This restricts its use in biomedical and nutraceutical or food applications. Thus, the encapsulation of this agent has the function of overcoming these limitations, promoting its solubility in water, and stabilizing it, preserving its bioactivity. So, polymeric microparticles were developed using chitosan-olive oil-PEITC systems. For this, an optimisation process (factors: olive oil: chitosan ratio and PEITC: chitosan ratio) was implemented through a 3-level factorial experimental design. The responses were: the particle size, zeta-potential, polydisperse index, and entrapment efficiency. The optimal formulation was further characterised by FTIR and biocompatibility in Caco-2 cells. Optimal conditions were olive oil: chitosan and PEITC: chitosan ratios of 1.46 and 0.25, respectively. These microparticles had a size of 629 nm, a zeta-potential of 32.3 mV, a polydispersity index of 0.329, and entrapment efficiency of 98.49%. We found that the inclusion process affected the optical behaviour of the PEITC, as well as the microparticles themselves and their interaction with the medium. Furthermore, the microparticles did not show cytotoxicity within the therapeutic values of PEITC. Thus, PEITC was microencapsulated with characteristics suitable for potential biomedical, nutraceutical and food applications.
    MeSH term(s) Chitosan/chemistry ; Drug Carriers/chemistry ; Drug Compounding ; Isothiocyanates/chemistry ; Microspheres ; Olive Oil/chemistry ; Solubility ; Water/chemistry
    Chemical Substances Drug Carriers ; Isothiocyanates ; Olive Oil ; Water (059QF0KO0R) ; phenethyl isothiocyanate (6U7TFK75KV) ; Chitosan (9012-76-4)
    Language English
    Publishing date 2021-05-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0248257
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