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  1. Article ; Online: The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells.

    Reisbeck, Lisa / Linder, Benedikt / Tascher, Georg / Bozkurt, Süleyman / Weber, Katharina J / Herold-Mende, Christel / van Wijk, Sjoerd J L / Marschalek, Rolf / Schaefer, Liliana / Münch, Christian / Kögel, Donat

    American journal of physiology. Cell physiology

    2023  Volume 325, Issue 6, Page(s) C1451–C1469

    Abstract: Induction of alternative, non-apoptotic cell death programs such as cell-lethal autophagy and mitophagy represent possible strategies to combat glioblastoma (GBM). Here we report that VLX600, a novel iron chelator and oxidative phosphorylation (OXPHOS) ... ...

    Abstract Induction of alternative, non-apoptotic cell death programs such as cell-lethal autophagy and mitophagy represent possible strategies to combat glioblastoma (GBM). Here we report that VLX600, a novel iron chelator and oxidative phosphorylation (OXPHOS) inhibitor, induces a caspase-independent type of cell death that is partially rescued in adherent U251
    MeSH term(s) Humans ; Mitophagy/physiology ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/pathology ; Autophagy ; Antineoplastic Agents/pharmacology ; Apoptosis ; Mitochondrial Proteins/metabolism ; Iron Chelating Agents/pharmacology ; Iron ; Proto-Oncogene Proteins c-bcl-2 ; Cell Line, Tumor
    Chemical Substances VLX600 ; Antineoplastic Agents ; Mitochondrial Proteins ; Iron Chelating Agents ; Iron (E1UOL152H7) ; Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00293.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A New Pentafluorothio-Substituted Curcuminoid with Superior Antitumor Activity.

    Linder, Benedikt / Köhler, Leonhard H F / Reisbeck, Lisa / Menger, Dominic / Subramaniam, Dharmalingam / Herold-Mende, Christel / Anant, Shrikant / Schobert, Rainer / Biersack, Bernhard / Kögel, Donat

    Biomolecules

    2021  Volume 11, Issue 7

    Abstract: A new and readily available pentafluorothiophenyl-substituted N-methyl-piperidone ... ...

    Abstract A new and readily available pentafluorothiophenyl-substituted N-methyl-piperidone curcuminoid
    MeSH term(s) Animals ; Animals, Genetically Modified ; Antineoplastic Agents, Phytogenic/chemical synthesis ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Curcumin/chemical synthesis ; Curcumin/pharmacology ; Diarylheptanoids/chemical synthesis ; Diarylheptanoids/pharmacology ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor/methods ; HCT116 Cells ; HT29 Cells ; Humans ; MCF-7 Cells ; Zebrafish
    Chemical Substances Antineoplastic Agents, Phytogenic ; Diarylheptanoids ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2021-06-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11070947
    Database MEDical Literature Analysis and Retrieval System OnLINE

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