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  1. Book: Diagnosis of Alzheimer's disease

    Reisberg, Barry

    [product of a special meeting of the International Psychogeriatric Association ... held in Geneva, Switzerland, from November 10 to 12, 1996]

    (International psychogeriatrics ; 9, Suppl. 1)

    1997  

    Author's details guest ed.: Barry Reisberg
    Series title International psychogeriatrics ; 9, Suppl. 1
    Collection
    Language English
    Size 327 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT008279483
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2621 -9,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  2. Book ; Conference proceedings: Outcome methodologies for pharmacologic trials in mild, moderate, and severe Alzheimer's disease

    Reisberg, Barry

    [Meeting Entitled Outcome Methodologies for Pharmacologic Trials in Mild, Moderate, and Severe Alzheimer's Disease, was held ... on July 26, 1994 in New York City]

    (International psychogeriatrics ; 8,2 : Special issue)

    1996  

    Institution International Psychogeriatric Association
    Event/congress Meeting Entitled Outcome Methodologies for Pharmacological Trials in Mild, Moderate, and Severe Alzheimer's Disease (1994, NewYorkNY)
    Author's details [special meeting of the International Psychogeriatric Association (IPA)]. Guest eds.: Barry Reisberg
    Series title International psychogeriatrics ; 8,2 : Special issue
    Collection
    Keywords Alzheimer Disease / congresses ; Clinical Trials / congresses ; Outcome Assessment (Health Care) / congresses
    Language English
    Size S. 155 - 344 : graph. Darst.
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT007464504
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Conference proceedings: Alzheimer's disease - clinical course

    Reisberg, Barry

    methodologic implications for pharmacologic trials ; [special symposium of the IPA fifth international congress in Rome, Italy, August 18 - 23, 1991]

    (International psychogeriatrics ; 4, Suppl. 1)

    1992  

    Author's details guest ed.: Barry Reisberg
    Series title International psychogeriatrics ; 4, Suppl. 1
    Collection
    Keywords Alzheimer Disease / congresses
    Size 135 S. : graph. Darst.
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT004329819
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Zs A 2621 -4,Suppl.1- verfügbar in Königswinter Königswinter

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  4. Article ; Online: Global cognitive trajectory patterns in Alzheimer's disease.

    Cohen, Carl I / Reisberg, Barry / Yaffee, Robert

    International psychogeriatrics

    2022  Volume 36, Issue 3, Page(s) 200–209

    Abstract: Objectives: The literature on Alzheimer's disease (AD) provides little data about long-term cognitive course trajectories. We identify global cognitive outcome trajectories and associated predictor variables that may inform clinical research and care.!## ...

    Abstract Objectives: The literature on Alzheimer's disease (AD) provides little data about long-term cognitive course trajectories. We identify global cognitive outcome trajectories and associated predictor variables that may inform clinical research and care.
    Design: Data derived from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set were used to examine the cognitive course of persons with possible or probable AD, a Mini-Mental State Examination (MMSE) of ≥10, and complete annual assessments for 5 years.
    Setting: Thirty-six Alzheimer's Disease Research Centers.
    Participants: Four hundred and fourteen persons.
    Measurements: We used a hybrid approach comprising qualitative analysis of MMSE trajectory graphs that were operationalized empirically and binary logistic regression analyses to assess 19 variables' associations with each trajectory. MMSE scores of ±3 points or greater were considered clinically meaningful.
    Results: Five distinct cognitive trajectories were identified: fast decliners (32.6%), slow decliners (30.7%), zigzag stable (15.9%), stable (15.9%), and improvers (4.8%). The decliner groups had three subtypes: curvilinear, zigzag, and late decline. The fast decliners were associated with female gender, lower baseline MMSE scores, a shorter illness duration, or receiving a cognitive enhancer. An early MMSE decline of ≥3 points predicted a worse outcome. A higher rate of traumatic brain injury, the absence of an ApoE ϵ4 allele, and male gender were the strongest predictors of favorable outcomes.
    Conclusions: Our hybrid approach revealed five distinct cognitive trajectories and a variegated pattern within the decliners and stable/improvers that was more consistent with real-world clinical experience than prior statistically modeled studies. Future investigations need to determine the consistency of the distribution of these categories across settings.
    MeSH term(s) Humans ; Male ; Female ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Mental Status and Dementia Tests ; Cognition ; Cognitive Dysfunction/psychology ; Disease Progression
    Language English
    Publishing date 2022-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610222000047
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    Zs.MO 513: Show issues

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  5. Article ; Online: Global cognitive trajectory patterns in Alzheimer's disease - CORRIGENDUM.

    Cohen, Carl I / Reisberg, Barry / Yaffee, Robert

    International psychogeriatrics

    2022  Volume 35, Issue 10, Page(s) 588

    MeSH term(s) Humans ; Alzheimer Disease/psychology ; Cognitive Dysfunction ; Cognition Disorders ; Cognition ; Disease Progression
    Language English
    Publishing date 2022-08-05
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610222000485
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  6. Book: ALZHEIMER'S DISEASE

    Reisberg, Barry

    1983  

    Author's details BARRY REISBERG, EDITOR
    Keywords DEMENTIA ; Alzheimerkrankheit
    Subject Alzheimer-Krankheit ; Alzheimersche Krankheit ; Alzheimer-Demenz ; Morbus Alzheimer ; Greisenblödsinn ; Alzheimer's Disease
    Size XIX, 475 S. : ILL.
    Publisher FREE PRESS ; COLLIER MACMILLAN
    Publishing place NEW YORK ; LONDON
    Document type Book
    HBZ-ID HT002573177
    ISBN 0-02-926230-5 ; 978-0-02-926230-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1985 A 1443 order for loan Magazin

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  7. Book: Hirnleistungsstörungen: Alzheimersche Krankheit und Demenz

    Reisberg, Barry

    (Edition Psychiatrie)

    1986  

    Title translation A guide to Alzheimer's disease
    Author's details Barry Reisberg
    Series title Edition Psychiatrie
    Keywords Alzheimer Disease ; Dementia ; Alzheimerkrankheit ; Demenz
    Subject Anoia ; Dementia ; Chronische Verwirrtheit ; Alzheimer-Krankheit ; Alzheimersche Krankheit ; Alzheimer-Demenz ; Morbus Alzheimer ; Greisenblödsinn ; Alzheimer's Disease
    Language German
    Size 236 S. : graph. Darst.
    Publisher Psychologie-Verl.-Union Beltz
    Publishing place Weinheim u.a.
    Publishing country Germany
    Document type Book
    Note Aus d. Engl. übers.
    HBZ-ID HT002808810
    ISBN 3-621-86106-8 ; 978-3-621-86106-9
    Database Catalogue ZB MED Medicine, Health

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    1986 B 827 order for loan Magazin

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  8. Article ; Online: Cortical myelin profile variations in healthy aging brain: A T1w/T2w ratio study.

    Sui, Yu Veronica / Masurkar, Arjun V / Rusinek, Henry / Reisberg, Barry / Lazar, Mariana

    NeuroImage

    2022  Volume 264, Page(s) 119743

    Abstract: Demyelination is observed in both healthy aging and age-related neurodegenerative disorders. While the significance of myelin within the cortex is well acknowledged, studies focused on intracortical demyelination and depth-specific structural alterations ...

    Abstract Demyelination is observed in both healthy aging and age-related neurodegenerative disorders. While the significance of myelin within the cortex is well acknowledged, studies focused on intracortical demyelination and depth-specific structural alterations in normal aging are lacking. Using the recently available Human Connectome Project Aging dataset, we investigated intracortical myelin in a normal aging population using the T1w/T2w ratio. To capture the fine changes across cortical depths, we employed a surface-based approach by constructing cortical profiles traveling perpendicularly through the cortical ribbon and sampling T1w/T2w values. The curvatures of T1w/T2w cortical profiles may be influenced by differences in local myeloarchitecture and other tissue properties, which are known to vary across cortical regions. To quantify the shape of these profiles, we parametrized the level of curvature using a nonlinearity index (NLI) that measures the deviation of the profile from a straight line. We showed that NLI exhibited a steep decline in aging that was independent of local cortical thinning. Further examination of the profiles revealed that lower T1w/T2w near the gray-white matter boundary and superficial cortical depths were major contributors to the apparent NLI variations with age. These findings suggest that demyelination and changes in other T1w/T2w related tissue properties in normal aging may be depth-specific and highlight the potential of NLI as a unique marker of microstructural alterations within the cerebral cortex.
    MeSH term(s) Humans ; Aged ; Myelin Sheath ; Magnetic Resonance Imaging ; Gray Matter ; Cerebral Cortex/diagnostic imaging ; Brain
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2022.119743
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    Zs.MO 7: Show issues

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  9. Article ; Online: Translation and psychometric evaluation of a Persian version of the functional assessment staging scale (I-FAST) in older patients with mild cognitive impairment and Alzheimer's disease in Iran.

    Noroozian, Maryam / Reisberg, Barry / Farhadi, Akram / Sharifi, Farshad / Sadeghi Zangeneh, Arghavan / Mohammadi, Maryam

    Acta neurologica Belgica

    2021  Volume 122, Issue 4, Page(s) 987–996

    Abstract: The Functional Assessment Staging procedure is a clinical instrument which has been designed for staging Alzheimer's disease (AD) from the stage of no deficits to the pre-clinical stage of subjective deficits, to Mild Cognitive Impairment (MCI), to the ... ...

    Abstract The Functional Assessment Staging procedure is a clinical instrument which has been designed for staging Alzheimer's disease (AD) from the stage of no deficits to the pre-clinical stage of subjective deficits, to Mild Cognitive Impairment (MCI), to the stages of AD. This study examined the psychometric properties and the validity of the Persian version of the FAST (I-FAST) in an elderly outpatient population in Iran. We conducted a validation study of the FAST scale at the two referral centers for dementia and cognitive disorders in Tehran, Iran. The participants consisted of subjects with normal cognition, MCI and AD. The scores of the Persian version of the Mini-Mental State Examination (MMSE) and the Persian version of the I-FAST were examined. Demographic variables were also collected. The diagnosis of MCI was made based on Petersen criteria and AD based on the McKhann et al. criteria by a neurologist with expertise in dementia. Data was collected from 219 participants. A total of 54.7% of the sample was female and their mean age was 72.54 ± 8.88 years. The area under the ROC curve was calculated 0.952 and 0.982. The I-FAST had a sensitivity of 92.2% and specificity of 98.0% for the differentiation of normal cognition from MCI. The sensitivity of the I-FAST for discrimination of subjects with AD from MCI was 99.0% and the specificity was 93.7%. The I-FAST showed good psychometric characteristics in the discrimination of MCI from both normal elderly and patients with Alzheimer's. The I-FAST is also a sensitive and accurate instrument for staging persons at risk for MCI and Alzheimer's, relatively free of the confounding effects of education, culture and language in comparison with the MMSE.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Female ; Humans ; Iran ; Language ; Male ; Middle Aged ; Neuropsychological Tests ; Psychometrics ; Sensitivity and Specificity
    Language English
    Publishing date 2021-06-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-021-01686-2
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  10. Article: Global measures: utility in defining and measuring treatment response in dementia.

    Reisberg, Barry

    International psychogeriatrics

    2007  Volume 19, Issue 3, Page(s) 421–456

    Abstract: Global measures used in treatment trials in dementia encompass two distinct categories: (1) clinician's interview-based global severity scales, and (2) clinician's interview-based global change scales. The global severity scales that have been used ... ...

    Abstract Global measures used in treatment trials in dementia encompass two distinct categories: (1) clinician's interview-based global severity scales, and (2) clinician's interview-based global change scales. The global severity scales that have been used include: the Clinical Dementia Rating (CDR) and the related CDR-sum of boxes (CDR-SB), the Global Deterioration Scale (GDS), and the Functional Assessment Staging (FAST) procedure. The global severity scales are clearly useful in subject categorization in treatment trials, in part because they are relatively free of many of the sociocultural biases inherent in mental status and psychometric descriptors. Global severity scales can also be used to demonstrate therapeutic efficacy in terms of the general progression of the dementia process. These measures have also proven to be useful in sensitively assessing pharmacotherapeutic effects in Alzheimer's disease (AD) treatment trials. For example, in pivotal trials: (1) in Mild to Moderate AD, the GDS has shown significant change in response to medication, whereas the results on the Mini-mental State Examination (MMSE) were not significant, and (2) in Moderate to Severe AD, the FAST has shown significant pharmacotherapeutic efficacy, whereas the results using the MMSE were not significant. The global change scales employed in dementia trials differ widely in assessment methodology. Clinical Global Impressions of Change (CGIC) scales do not have defined methodologies, whereas Clinician's Interview-Based Impression of Change Plus Caregiver Input (CIBIC-Plus) scales are much more elaborate. The CIBIC-Plus procedures require an independent clinician assessment and can provide independent, comprehensive evidence of therapeutic efficacy. The CIBIC-Plus procedure may also be useful in sensitively assessing efficacy in future prevention trials, for example in subjects with Subjective Cognitive Impairment. For Mild Cognitive Impairment (MCI), global severity scales already appear to be one modality for the sensitive assessment of change. The CIBIC-Plus procedures might also productively be applied in future MCI therapeutic trials.
    MeSH term(s) Aged ; Alzheimer Disease/diagnosis ; Alzheimer Disease/drug therapy ; Alzheimer Disease/psychology ; Cholinesterase Inhibitors/therapeutic use ; Clinical Trials as Topic ; Cognition Disorders/diagnosis ; Cognition Disorders/drug therapy ; Cognition Disorders/psychology ; Follow-Up Studies ; Geriatric Assessment ; Humans ; Interview, Psychological ; Mental Status Schedule ; Neuropsychological Tests ; Nootropic Agents/therapeutic use ; Outcome Assessment (Health Care)
    Chemical Substances Cholinesterase Inhibitors ; Nootropic Agents
    Language English
    Publishing date 2007-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S1041610207005261
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