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  1. Article: "Recurrence" in rhinology.

    Reitsma, S

    Rhinology

    2023  Volume 61, Issue 6, Page(s) 481

    MeSH term(s) Humans ; Otolaryngology ; Recurrence
    Language English
    Publishing date 2023-11-13
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin23.906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: "Co(o)horts" in rhinology.

    Reitsma, S

    Rhinology

    2023  Volume 61, Issue 2, Page(s) 97

    MeSH term(s) Humans ; Otolaryngology
    Language English
    Publishing date 2023-02-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin23.902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: "Who is it?" in rhinology.

    Reitsma, S

    Rhinology

    2022  Volume 60, Issue 4, Page(s) 241

    MeSH term(s) Humans ; Otolaryngology
    Language English
    Publishing date 2022-08-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin22.911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: 'Whodunnit' in rhinology.

    Reitsma, S

    Rhinology

    2021  Volume 59, Issue 6, Page(s) 489

    MeSH term(s) Humans ; Otolaryngology
    Language English
    Publishing date 2021-11-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin21.806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Microbiome analyses in chronic rhinosinusitis.

    Smulders, T / Reitsma, S / van Drunen, C M

    Rhinology

    2024  Volume 62, Issue 2, Page(s) 129

    Abstract: In this edition of Rhinology we feature the work of Connell and colleagues from Australia on chronic rhinosinusitis that describes an interesting new pipeline to characterize the bacterial composition of microbiota. We are constantly exposed to a ... ...

    Abstract In this edition of Rhinology we feature the work of Connell and colleagues from Australia on chronic rhinosinusitis that describes an interesting new pipeline to characterize the bacterial composition of microbiota. We are constantly exposed to a multitude of micro-organisms in the environment and our immune system has the important task discerning and fighting off potential threats. In most people the immune system is doing its job properly and prevents anything untoward from happening. On occasion, a microbe slips by the first (innate) level of defense and we might suffer from an infection. This then activates the second layer of (the adaptive) defense tasked to clear this infection. Sometimes the immune system gets its wrong and starts a full-out defense against something harmless, and an allergy is born. The task of the immune system of doing what is right is even more difficult than it might seem at first sight. In addition to these incidental potential threats, our mucosal surfaces are lined with commensal bacteria which contributes to the complexity of our environment. This collection of bacteria or microbiome has become a major focus of research, as the composition of this microbiome seems related to the health state of the individual. Originally the relationship between the gut microbiome and the development of asthma and allergy was the main focus. In recent years, the focus has been broadened to include the microbiome of the upper and lower airways. In addition to allergy, our field has also been given more and more attention to studying the microbiome in chronic rhinosinusitis.
    MeSH term(s) Humans ; Rhinosinusitis ; Microbiota ; Sinusitis/microbiology ; Gastrointestinal Microbiome ; Bacteria ; Asthma
    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin24.902
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Aetiology of cerebrospinal fluid rhinorrhoea in a Dutch retrospective cohort from two tertiary referral centres.

    de Jong, W B / Hoogmoed, J / Adriaensen, G F J P M / Nagtegaal, A P / Reitsma, S

    Rhinology

    2024  Volume 62, Issue 2, Page(s) 208–215

    Abstract: Background: Cerebrospinal fluid (CSF) rhinorrhoea has different aetiologies, with spontaneous leaks related to female gender and obesity. Limited data is available on patient characteristics and surgical outcomes across different aetiologies of CSF ... ...

    Abstract Background: Cerebrospinal fluid (CSF) rhinorrhoea has different aetiologies, with spontaneous leaks related to female gender and obesity. Limited data is available on patient characteristics and surgical outcomes across different aetiologies of CSF leaks in relatively non-obese populations.
    Methods: Retrospective cohort study from two tertiary referral centres including adult patients that underwent surgical closure of a CSF leak, divided into four aetiologies: traumatic, iatrogenic, secondary to structural intracranial pathology (SIP), and spontaneous. Data included patient characteristics, presenting symptoms, preoperative radiologic findings, intracranial pressure (ICP) and surgical outcomes.
    Results: 72 patients were included: 9 traumatic, 15 iatrogenic, 4 SIP and 44 spontaneous leaks. Primary surgical success was 79%, rising to 93% with reinterventions. Spontaneous leak cases displayed highest female proportion and BMI. A meningo(-encephalo)cele was present in 33 patients and was associated with surgical failure and previous meningitis. No significant differences were observed between different aetiologies regarding patient characteristics, presenting symptoms, or surgical success rates.
    Conclusions: Even in a relatively non-obese population, the majority of CSF leaks is spontaneous and associated with female gender and obesity. Otherwise, no differences exist across aetiologies regarding patient characteristics, presenting symptoms or surgical success.
    MeSH term(s) Adult ; Humans ; Female ; Cerebrospinal Fluid Rhinorrhea/etiology ; Cerebrospinal Fluid Rhinorrhea/surgery ; Cerebrospinal Fluid Rhinorrhea/diagnosis ; Retrospective Studies ; Tertiary Care Centers ; Cerebrospinal Fluid Leak/etiology ; Cerebrospinal Fluid Leak/surgery ; Obesity ; Iatrogenic Disease ; Treatment Outcome
    Language English
    Publishing date 2024-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin23.158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Unified Airway Disease: A Contemporary Review and Introduction.

    Fokkens, Wytske / Reitsma, Sietze

    Otolaryngologic clinics of North America

    2022  Volume 56, Issue 1, Page(s) 1–10

    Abstract: Upper and lower airways diseases are very common, with population prevalence of 10% to 40%. The conditions are usually interlinked and referred to as "unified airway disease" or "the united airways." Especially in phenotypes with more severe disease, ... ...

    Abstract Upper and lower airways diseases are very common, with population prevalence of 10% to 40%. The conditions are usually interlinked and referred to as "unified airway disease" or "the united airways." Especially in phenotypes with more severe disease, type 2 immunologic endotype is often noted. Comorbid upper and lower airway diseases are usually caused by similar underlying immunologic response. Any patient with rhinitis or rhinosinusitis should have their lower respiratory tract evaluated. A multidisciplinary approach in the diagnosis and treatment of airway disease is advised, especially, for more severe phenotypes.
    MeSH term(s) Humans ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy ; Rhinitis/diagnosis ; Rhinitis/epidemiology ; Rhinitis/therapy ; Sinusitis/diagnosis ; Sinusitis/epidemiology ; Sinusitis/therapy ; Respiratory System ; Comorbidity
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 417489-6
    ISSN 1557-8259 ; 0030-6665
    ISSN (online) 1557-8259
    ISSN 0030-6665
    DOI 10.1016/j.otc.2022.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Towards a new epidemiological definition of chronic rhinitis: prevalence of nasal complaints in the general population.

    Avdeeva, K S / Fokkens, W J / Reitsma, S

    Rhinology

    2021  Volume 59, Issue 3, Page(s) 258–266

    Abstract: Background: Chronic rhinitis (CR) is currently defined as the presence of at least two nasal symptoms for at least 1 hour per day for more than 12 weeks per year. Such definition lacks evidence-based foundation. CR patients are often divided into " ... ...

    Abstract Background: Chronic rhinitis (CR) is currently defined as the presence of at least two nasal symptoms for at least 1 hour per day for more than 12 weeks per year. Such definition lacks evidence-based foundation. CR patients are often divided into "runners" and "blockers", although the evidence supporting such subdivision is limited. The aim of the study was to define CR, to estimate its prevalence and the proportion of "runners" and "blockers".
    Methods: Cross-sectional, questionnaire-based study in a random sample of participants representing the general population of the Netherlands.
    Results: The questionnaire was sent to 5000 residents of the Netherlands; the response rate was 27%. CR was defined as at least 1 nasal complaint present for more than 3 weeks per year. The prevalence of CR in the general population was 40%. Participants who would have been excluded by the former CR definition were shown to have a significantly higher VAS compared to the controls. The larger part of CR group was represented by non-allergic rhinitis (NAR): 70% vs 30%. There were 25% "Blockers" and 22% "Runners" in the CR group, whereas more than a half of the CR group could be classified in neither of these subgroups.
    Conclusion: Based on our data, we suggest that the current definition of CR should be revised and propose a new definition: at least one nasal complaint present for at least 3 weeks per year; although future studies are needed to further validate the proposed definition.
    MeSH term(s) Cross-Sectional Studies ; Humans ; Netherlands/epidemiology ; Nose ; Prevalence ; Rhinitis/epidemiology
    Language English
    Publishing date 2021-06-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin20.637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Direct and indirect costs of adult patients with chronic rhinosinusitis with nasal polyps.

    Lourijsen, E S / Fokkens, W J / Reitsma, S

    Rhinology

    2020  Volume 58, Issue 3, Page(s) 213–217

    Abstract: Background: European direct and indirect cost data is missing for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study was aimed to establish the economic burden of CRSwNP based on a Dutch cohort of patients.: Methods: A cross- ... ...

    Abstract Background: European direct and indirect cost data is missing for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This study was aimed to establish the economic burden of CRSwNP based on a Dutch cohort of patients.
    Methods: A cross-sectional study was performed in adult patients with CRSwNP (N=115) to calculate mean annual direct medical costs and indirect costs per patient with CRSwNP. Outpatient visits, general practitioner visits, first aid visits, hospitalisation and patient travel expenses were measured with the iMTA medical consumption questionnaire. Missed workdays (absenteeism) and decreased productivity during paid work (presenteeism) or during daily life were measured with the and the iMTA productivity cost questionnaire.
    Results: Total direct costs were €1501 per patient/year, primarily due to outpatient department visits and hospitalisation. Indirect costs were €5659 per patient/year, with productivity losses as major cost expense.
    Conclusion: Adult patients with CRSwNP have higher indirect costs than direct costs and this forms a substantial burden to society. Total annual costs of patients with CRSwNP are estimated to be 1,9 billion/year in the Netherlands.
    MeSH term(s) Absenteeism ; Adult ; Cost of Illness ; Cross-Sectional Studies ; Humans ; Nasal Polyps/complications ; Nasal Polyps/economics ; Netherlands ; Sinusitis/complications ; Sinusitis/economics ; Sinusitis/therapy
    Language English
    Publishing date 2020-05-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin19.468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Endoscopic grading systems for nasal polyps: are we comparing apples to oranges?

    Djupesland, P G / Reitsma, S / Hopkins, C / Sedaghat, A R / Peters, A / Fokkens, W J

    Rhinology

    2022  Volume 60, Issue 3, Page(s) 169–176

    Abstract: Endoscopic grading of nasal polyps (NP) is typically a coprimary endpoint in clinical trials evaluating treatments for chronic rhinosinusitis with nasal polyps (CRSwNP). However, a consensus on the most effective way to grade nasal polyps has not been ... ...

    Abstract Endoscopic grading of nasal polyps (NP) is typically a coprimary endpoint in clinical trials evaluating treatments for chronic rhinosinusitis with nasal polyps (CRSwNP). However, a consensus on the most effective way to grade nasal polyps has not been reached. Different scales have been used, hampering the interpretation of data across trials. This review compares the characteristics of NP grading systems used in registration trials for approved NP treatments. These fundamental differences in grading systems make quantitative comparison of outcomes between trials inaccurate and potentially misleading. In lieu of a universal grading system, reporting the baseline distribution of polyp grades (unilateral and/or summed/total grades), as well as changes from baseline over time by baseline grade may help improve interpretability of outcomes and reduce inaccuracy when attempting cross-trial comparisons and making therapeutic decisions.
    MeSH term(s) Humans ; Nasal Polyps/drug therapy ; Rhinitis/drug therapy ; Administration, Intranasal ; Endoscopy ; Sinusitis/drug therapy ; Chronic Disease
    Language English
    Publishing date 2022-03-28
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 80336-4
    ISSN 0300-0729
    ISSN 0300-0729
    DOI 10.4193/Rhin21.401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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