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Article: Exceptional response to immunotherapy monotherapy in a patient with an unfavorable subset of cancer of unknown primary.

Huang, Xiangzhong / Ren, Dongqing / Sun, Qiulian / Xu, Xinjian / Ding, Yiwen

Quantitative imaging in medicine and surgery

2023 Volume 13, Issue 12, Page(s) 8832–8838

Language	English
Publishing date	2023-10-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-284
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Article: Spontaneous renal artery dissection complicated by renal infarction: description of two cases.

Gao, Fulei / Chen, Zejun / Gao, Feng / Ren, Dongqing / Huang, Xiangzhong

Quantitative imaging in medicine and surgery

2022 Volume 12, Issue 10, Page(s) 4972–4978

Language	English
Publishing date	2022-09-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-22-342
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Article ; Online: Results Obtained with the Protege EverFlex Self-expanding Bare Stent in Interventional Treatment of Spontaneous Isolated Visceral Artery Dissection.

Gao, Fulei / Huang, Xiangzhong / Ren, Dongqing / Wang, Yong / Guo, Jinhe / Deng, Gang

Annals of vascular surgery

2021 Volume 77, Page(s) 86–93

Abstract: Objective: We evaluated the early and midterm results of the endovascular approach with a certain type of bare stent to treat spontaneous isolated visceral artery dissection (SIVAD).: Methods: 28 patients with symptomatic SIVAD were selected from two ...

Abstract	Objective: We evaluated the early and midterm results of the endovascular approach with a certain type of bare stent to treat spontaneous isolated visceral artery dissection (SIVAD). Methods: 28 patients with symptomatic SIVAD were selected from two hospitals from July 2014 to September 2020. All patients had symptoms of acute persistent abdominal pain accompanied by varying degrees of nausea and vomiting. The diagnosis of SIVAD was made according to the multidetector CT angiography (CTA) findings. We retrospectively analyzed the patients' medical records. According to our previous clinical experience, the Protege EverFlex self-expanding bare stent was used in these patients, and we subsequently followed up the patients to record and analyze their outcomes after surgery. The imaging results before and after the operations were compared. Results: All 28 patients were successfully implanted with Protege EverFlex stents. The true lumen blood flow of the SIVAD recovered during the operation. The residual stenosis rate was less than 30%, and the technical success rate was 100%. There were no complications, such as bleeding, intestinal necrosis, digestive tract perforation, liver failure or spleen infarction. The abdominal pain was relieved or eliminated in all patients. Conclusion: The Protege EverFlex self-expanding bare stent and the endovascular approach could be a minimally invasive, safe and effective treatment method for SIVAD with a high success rate and a relatively low price.
MeSH term(s)	Adult ; Aged ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/surgery ; Arteries/diagnostic imaging ; Arteries/surgery ; China ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Female ; Humans ; Male ; Middle Aged ; Prosthesis Design ; Retrospective Studies ; Stents ; Time Factors ; Treatment Outcome ; Viscera/blood supply
Language	English
Publishing date	2021-08-17
Publishing country	Netherlands
Document type	Journal Article ; Multicenter Study
ZDB-ID	1027366-9
ISSN	1615-5947 ; 0890-5096
ISSN (online)	1615-5947
ISSN	0890-5096
DOI	10.1016/j.avsg.2021.05.017
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Zs.A 2882: Show issues

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Article: Neuroprotective and Anti-Inflammatory Effect of Pterostilbene Against Cerebral Ischemia/Reperfusion Injury

Yan, Wenjun / Ren, Dongqing / Feng, Xiaoxue / Huang, Jinwen / Wang, Dabin / Li, Ting / Zhang, Dong

Frontiers in pharmacology

2021 Volume 12, Page(s) 770329

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.770329
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Article ; Online: An updated meta-analysis of partial splenic embolization versus splenectomy in the treatment of hypersplenism due to cirrhosis.

Huang, Yiyang / Ren, Dongqing / Gao, Feng / Ding, Yiwen / Cheng, Hong / Huang, Xiangzhong / Xu, Xinjian

Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy

2021 Volume 31, Issue 5, Page(s) 664–675

Abstract: Objective: To evaluate the efficacy and safety of partial splenic embolization (PSE) versus splenectomy (SP) for hypersplenism.: Material and methods: Pubmed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, and ... ...

Abstract	Objective: To evaluate the efficacy and safety of partial splenic embolization (PSE) versus splenectomy (SP) for hypersplenism. Material and methods: Pubmed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, and Chinese Science and Technology Periodical Database (VIP) databases were systematically searched to identify all relevant studies. Stratified meta-analysis was also conducted to control the influence of confounding factors on the research results. Results: Twenty-three studies comparing PSE with SP involving a total of 1849 hypersplenism patients were selected. Postoperative increased level of platelet (PLT) [mean difference (MD) = -65.51; 95% confidence interval (CI), -81.33 to - Conclusion: PSE had similar efficacy with SP in improving postoperative PLT, WBC, and HB levels. Moreover, PSE had the advantages of less trauma and fewer complications as well as faster recovery when compared with SP. Therefore, we tended to be cautious about SP and considered that patients with hypersplenism might benefit more from PSE.
MeSH term(s)	Embolization, Therapeutic/methods ; Humans ; Hypersplenism/etiology ; Hypersplenism/surgery ; Liver Cirrhosis/complications ; Liver Cirrhosis/surgery ; Splenectomy ; Treatment Outcome
Language	English
Publishing date	2021-06-09
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	1317160-4
ISSN	1365-2931 ; 1364-5706
ISSN (online)	1365-2931
ISSN	1364-5706
DOI	10.1080/13645706.2021.1933535
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Zs.A 3467: Show issues

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Article ; Online: A new predictor of coronary artery disease in acute ischemic stroke or transient ischemic attack patients: pericarotid fat density.

Lan, Yu / Shang, Jin / Ma, Yue / Zhen, Yanhua / Dang, Yuxue / Ren, Dongqing / Liu, Ting / Ju, Ronghui / Guo, Ning / Wang, Ximing / Hou, Yang

European radiology

2023 Volume 34, Issue 3, Page(s) 1667–1676

Abstract: Objectives: The study aims to evaluate the incremental predictive value of pericarotid fat density (PFD) on head and neck computed tomography angiography (CTA) for the obstructive coronary artery disease (CAD) (≥ 50% stenosis) relative to a clinical ... ...

Abstract	Objectives: The study aims to evaluate the incremental predictive value of pericarotid fat density (PFD) on head and neck computed tomography angiography (CTA) for the obstructive coronary artery disease (CAD) (≥ 50% stenosis) relative to a clinical risk model (Framingham risk score (FRS)) and the degree of carotid artery stenosis and plaque type in acute ischemic stroke (AIS) or transient ischemic attack (TIA) patients without a known history of CAD. Methods: In a cohort of 134 consecutive stable patients diagnosed with AIS or TIA undergoing head and neck CTA between January 2010 and December 2021, pericarotid adipose tissue density (PFD) was quantified using a dedicated software. We collected demographic and clinical data, assessed the risk of CAD using the FRS, and analyzed coronary and carotid artery CTA images. Univariate and multivariate logistic regression analyses were performed to assess associations between FRS, PFD, CTA variables, and obstructive CAD risk. Four prediction models were established to evaluate the incremental predictive value of PFD relative to FRS, stenosis degree, and plaque types. Receiver operating characteristic (ROC) curves were generated, and the areas under the curves (AUC) were compared. Results: Increasing FRS, stenosis degree, and PFD values were positively correlated with obstructive CAD (all p < 0.05). In the predictive models for obstructive CAD, the model incorporating carotid stenosis exhibited superior predictive performance compared to FRS alone (p < 0.05). Moreover, the predictive model integrating PFD demonstrated enhanced performance and yielded the highest AUC of the receiver operator characteristic curve (AUC = 0.783), with sensitivity and specificity values of 86.89% and 65.75%, respectively. Conclusion: CTA-derived PFD measurements offer supplementary predictive value for obstructive CAD beyond FRS and stenosis, thereby facilitating improved risk stratification of TIA or stroke patients without a history of CAD history. Clinical relevance statement: CTA-derived PFD provides incremental predictive value for obstructive coronary artery disease in acute ischemic stroke or transient ischemic attack patients without CAD history, beyond Framingham risk score and carotid artery stenosis degree, improving risk stratification. Key points: • Pericarotid fat density is associated with obstructive coronary artery disease in acute ischemic stroke or transient ischemic attack patients. • Higher pericarotid fat density corresponds to an increased risk of obstructive coronary artery disease. • Estimation of pericarotid fat density using computed tomography angiography imparts additional predictive value for obstructive CAD in risk stratification of acute ischemic stroke or transient ischemic attack patients.
MeSH term(s)	Humans ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Ischemic Attack, Transient/complications ; Ischemic Attack, Transient/diagnostic imaging ; Ischemic Stroke ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Constriction, Pathologic ; Coronary Angiography/methods ; Predictive Value of Tests ; Plaque, Atherosclerotic ; Computed Tomography Angiography/methods ; Risk Factors ; Adipose Tissue/diagnostic imaging ; Coronary Stenosis
Language	English
Publishing date	2023-09-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-10046-y
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Zs.A 3300: Show issues

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Article: Insertion of I-125 seed-loaded stent for inoperable hilar cholangiocarcinoma.

Gao, Fu-Lei / Wang, Yong / Lu, Jian / Zhu, Guang-Yu / Huang, Xiang-Zhong / Ren, Dong-Qing / Guo, Jin-He

Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques

2021 Volume 16, Issue 4, Page(s) 678–685

Abstract: Introduction: Stent insertion is the most frequently used option to treat malignant biliary obstruction (MBO) patients. Hilar cholangiocarcinoma (HCCA) is the most common disease that causes hilar MBO.: Aim: To assess the clinical efficacy and long- ... ...

Abstract	Introduction: Stent insertion is the most frequently used option to treat malignant biliary obstruction (MBO) patients. Hilar cholangiocarcinoma (HCCA) is the most common disease that causes hilar MBO. Aim: To assess the clinical efficacy and long-term outcomes of I-125 seed-loaded stent (ISS) insertion for HCCA patients. Material and methods: Consecutive patients with HCCA underwent either normal stent (NS) or ISS insertion between January 2017 and December 2019. The baseline and treatment data of these two groups were compared. Results: During the period, a total of 93 patients with inoperable HCCA were divided into either NS (n = 48) or ISS (n = 45) insertion groups at our centre. Technical success rates of the NS and ISS insertion were 91.7% and 95.6%, respectively (p = 0.733). Clinical success rates were 93.2% and 100% in the NS and ISS groups, respectively (p = 0.24). Stent dysfunction was observed in 11 and 8 patients in the NS and ISS groups, respectively (p = 0.47). The median stent patency was 143 days and 208 days in the NS and ISS groups, respectively (p < 0.001). All patients died in the follow-up period, with median survival duration of 178 days and 220 days in the NS and ISS groups, respectively (p < 0.001). ISS insertion was the only predictor of longer patency (p = 0.002) and survival (p = 0.01). Conclusions: ISS insertion might achieve longer patency and overall survival in patients with inoperable HCCA as compared with NS insertion.
Language	English
Publishing date	2021-04-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596147-0
ISSN	2299-0054 ; 1895-4588
ISSN (online)	2299-0054
ISSN	1895-4588
DOI	10.5114/wiitm.2021.105530
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Article ; Online: AMPKα1 overexpression improves postoperative cognitive dysfunction in aged rats through AMPK-Sirt1 and autophagy signaling.

Yan, Wen-Jun / Wang, Da-Bin / Ren, Dong-Qing / Wang, Ling-Kai / Hu, Zhong-Yuan / Ma, Ya-Bing / Huang, Jin-Wen / Ding, Shao-Li

Journal of cellular biochemistry

2019 Volume 120, Issue 7, Page(s) 11633–11641

Abstract: Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients who undergo surgery involving anesthesia. Its underlying mechanisms remain unclear. Autophagy plays an important role in the damage and repair of the nervous system ... ...

Abstract	Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients who undergo surgery involving anesthesia. Its underlying mechanisms remain unclear. Autophagy plays an important role in the damage and repair of the nervous system and is associated with the development of POCD. Using a rat model, adenosine monophosphate-activated protein kinase α1 (AMPKα1), an important autophagy regulator, was found to be significantly downregulated in rats with POCD that was induced by sevoflurane anesthesia or by appendectomy. Overexpression of AMPKα1-ameliorated POCD, as indicated by decreased escape latencies and increased target quadrant swimming times, swimming distances, and platform crossing times during Morris water maze tests. AMPKα1 overexpression activated autophagy signals by increasing the expression of light chain 3 II (LC3-II) and Beclin1 and decreasing the expression of p62 in the hippocampus of rats with POCD. Moreover, blocking autophagy by 3-methyladenine partly attenuated AMPKα1-mediated POCD improvement. Furthermore, overexpression of AMPKα1 could upregulate the expression of p-AMPK and Sirt1 in the hippocampus of rats with POCD. Intriguingly, inhibiting AMPK signals via Compound C effectively attenuated AMPKα1-mediated POCD improvement, concomitant with the downregulation of p-AMPK, Sirt1, LC3-II, and Beclin1 and the upregulation of p62. We thus concluded that overexpression of AMPKα1 can improve POCD via the AMPK-Sirt1 and autophagy signaling pathway.
Language	English
Publishing date	2019-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.28443
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Article ; Online: Rutin ameliorates diabetic neuropathy by lowering plasma glucose and decreasing oxidative stress via Nrf2 signaling pathway in rats.

Tian, Ruifeng / Yang, Wenqing / Xue, Qiang / Gao, Liang / Huo, Junli / Ren, Dongqing / Chen, Xiaoyan

European journal of pharmacology

2016 Volume 771, Page(s) 84–92

Abstract: Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After ... ...

Abstract	Rutin exhibits antidiabetic, antioxidant and anti-inflammatory properties, which makes rutin an attractive candidate for diabetic complications. The present study was designed to investigate the potential effect of rutin on diabetic neuropathy. After induction of diabetic neuropathy, rutin (5mg/kg, 25mg/kg and 50mg/kg) were daily given to the diabetic rats for 2 weeks. At the end of rutin administration, rutin produced a significant inhibition of mechanical hyperalgesia, thermal hyperalgesia and cold allodynia, as well as partial restoration of nerve conduction velocities in diabetic rats. Furthermore, rutin significantly increased Na(+), K(+)-ATPase activities in sciatic nerves and decreased caspase-3 expression in dorsal root ganglions (DRG). In addition, rutin significantly decreased plasma glucose, attenuated oxidative stress and neuroinflammation. Further studies showed that rutin significantly increased hydrogen sulfide (H2S) level, up-regulated the expression of nuclear factor-E2-related factor-2 (Nrf2) and heme oxygenase-1 (HO-1) in DRG. The evidences suggest the beneficial effect of rutin on diabetic neuropathy. Additionally, insulin (2 IU) and BG-12 (15mg/kg) were used to investigate the mechanisms underlying the beneficial effect of rutin on diabetic neuropathy. Insulin achieved lower plasma glucose and BG-12 achieved comparable Nrf2 expression than/to rutin (50mg/kg), respectively. In contrast, the beneficial effect of insulin and BG-12 was inferior to that of rutin (50mg/kg), suggesting that both lowered plasma glucose and Nrf2 signaling contribute to the beneficial effect of rutin on diabetic neuropathy. In conclusion, rutin produces significant protection in diabetic neuropathy, which makes it an attractive candidate for the treatment of diabetic neuropathy.
MeSH term(s)	Animals ; Blood Glucose/metabolism ; Caspase 3/biosynthesis ; Caspase 3/genetics ; Diabetic Neuropathies/blood ; Diabetic Neuropathies/drug therapy ; Heme Oxygenase-1/metabolism ; Hydrogen Sulfide/metabolism ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Hypoglycemic Agents/therapeutic use ; Insulin/therapeutic use ; Male ; NF-E2-Related Factor 2/drug effects ; Neural Conduction/drug effects ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Rutin/therapeutic use ; Signal Transduction/drug effects ; Sodium-Potassium-Exchanging ATPase/metabolism
Chemical Substances	Blood Glucose ; Hypoglycemic Agents ; Insulin ; NF-E2-Related Factor 2 ; Rutin (5G06TVY3R7) ; Heme Oxygenase-1 (EC 1.14.14.18) ; Casp3 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-) ; Sodium-Potassium-Exchanging ATPase (EC 3.6.3.9) ; Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2016-01-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2015.12.021
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Article: Effects of Electromagnetic Pulse on Serum Element Levels in Rat

Li, Kangchu / Ma, Shirong / Ren, Dongqing / Li, Yurong / Ding, Guirong / Liu, Junye / Guo, Yao / Guo, Guozhen

Biological trace element research. 2014 Apr., v. 158, no. 1

2014

Abstract: Electromagnetic pulse (EMP) was a potentially harmful factor to the human body, and a biological dosimetry to evaluate effects of EMP is necessary. Little is known about effects of EMP on concentration of macro and trace elements in serum so far. In this ...

Abstract	Electromagnetic pulse (EMP) was a potentially harmful factor to the human body, and a biological dosimetry to evaluate effects of EMP is necessary. Little is known about effects of EMP on concentration of macro and trace elements in serum so far. In this study, Sprague-Dawley rats were randomly divided into 50-kV/m EMP-exposed group (n = 10), 100-kV/m EMP-exposed group (n = 10), 200-kV/m EMP-exposed group (n = 40), and the sham-exposed group (n = 20). The macro and trace element concentrations in serum were examined at 6, 12, 24, and 48� h after EMP exposure at different electric field intensities. Compared with the sham-exposed groups, the concentration of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), selenium (Se), and manganese (Mn) in rat serum was not changed significantly within 48� h after 200 pulses of EMP exposure at electric field intensity of 50, 100, and 200� kV/m although the K level was decreased and the Ca level was increased with the electric field intensity of EMP increasing. In addition, there was a tendency that the Zn level was decreased with the time going on within 48� h after EMP exposure. Under our experimental conditions, EMP exposure cannot affect the concentration of macro and trace elements in rat serum. There was no time–effect or dose–effect relationship between EMP exposure and serum element levels. The macro and trace elements in serum are not suitable endpoints of biological dosimetry of EMP.
Keywords	blood serum ; calcium ; copper ; electric field ; humans ; iron ; magnesium ; manganese ; potassium ; rats ; selenium ; sodium ; zinc
Language	English
Dates of publication	2014-04
Size	p. 81-86.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-014-9903-0
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