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Article: Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.

Ren, Hui-Li / Zhang, Jia-Hua / Xiao, Jun-Hua

2023 Volume 9, Issue 6, Page(s) e16849

Abstract: Backgrounds: Liensinine (Lien), Neferine (Nef), Isoliensinine (Iso) and Tetrandrine (Tet), benzylisoquinoline alkaloids (BIAs), have been shown inhibitory effects on pulmonary fibrosis (PF) through anti-inflammatory, anti-oxidative activities, ... ...

Abstract	Backgrounds: Liensinine (Lien), Neferine (Nef), Isoliensinine (Iso) and Tetrandrine (Tet), benzylisoquinoline alkaloids (BIAs), have been shown inhibitory effects on pulmonary fibrosis (PF) through anti-inflammatory, anti-oxidative activities, inhibition of cytokines and NF-κB. Effects of other similar BIAs, Dauricine (Dau), Papaverine (Pap) and lotusine (Lot), on PF remain unclear. Here, we explored the effects of five bisbenzylisoquinoline (Lien, Nef, Iso, Tet and Dau) and two monobenzylisoquinoline (Pap, Lot) alkaloids on normal and PF fibroblasts. Methods: Primary normal and PF lung fibroblasts were cultured and treated with these alkaloids. Proliferation, activation, migration and apoptosis changes were detected by MTT, wound healing assay, flow cytometry. Protein level was analyzed by Western blot. Results: All BIAs inhibited proliferation of normal and PF lung fibroblasts induced by TGF-β. α-SMA protein level in normal and PF lung fibroblasts decreased after Lien, Nef, Iso, Tet and Dau treatment. Pap and Lot had no influence on α-SMA expression. Dau showed the strongest inhibitory effects on proliferation and activation among alkaloids. The migration rates of normal and PF lung fibroblasts were inhibited by Lien, Nef, Iso, and Dau. Lien, Nef, Iso and Dau significantly promoted apoptosis, while Tet had no effect on apoptosis. Pap and Lot had no influence on activation, migration and apoptosis. Dau significantly inhibited Smad3/4 and p-ERK1/2 protein overexpression induced by TGF-β1. Conclusions: Bisbenzylisoquinoline alkaloids had stronger effects on inhibiting lung fibroblasts than monobenzylisoquinoline alkaloids. Dau expressed the strongest inhibitory effects, which may be related to its inhibition of TGF-β1/Smad3/4 and p-ERK1/2 pathway proteins.
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e16849
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Article ; Online: Characterization the prognosis role and effects of snoRNAs in melanoma patients.

Wang, Lei-Yun / Song, Jia-Nan / Chen, Yi-Xuan / Zhu, Ying / Ren, Hui-Li / Li, Qiu-Qi / Zhang, Shao-Hui

Experimental dermatology

2023 Volume 33, Issue 1, Page(s) e14944

Abstract: Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable ... ...

Abstract	Melanoma is a melanocyte-derived malignant cancer and is known for its early metastasis and high mortality rates. It is a highly cutaneous tumour disease that could be related to the abnormal immune microenvironment, and the identification of reliable diagnostic and prognostic markers is crucial for improving patient outcomes. In the search for biomarkers, various types of RNAs have been discovered and recognized as reliable prognostic markers. Among these, small nucleolar RNAs (snoRNAs) have emerged as a promising avenue for studying early diagnosis and prognostic markers in tumours due to their widespread presence in tissues, tumour specificity and stability. In our study, we analysed snoRNAs data from melanoma samples in the TCGA-SKCM cohort and developed a prognostic model comprising 12 snoRNAs (SNORD9, SNORA31, SNORD14E, SNORA14A, SNORA5A, SNORD83A, SNORA75, AL096855, AC007684, SNORD14A, SNORA65 and AC004839). This model exhibited unique prognostic accuracy and demonstrated a significant correlation with the immune infiltration tumour microenvironment. Additionally, analysis of the GSE213145 dataset, which explored the sensitivity and resistance of immune checkpoint inhibitors, further supported the potential of snoRNAs as prognostic markers for immunotherapy. Overall, our study contributes reliable prognostic and immune-related biomarkers for melanoma patients. These findings can offer valuable insights for the future discovery of novel melanoma treatment strategies and hold promise for improving clinical outcomes in melanoma patients.
MeSH term(s)	Humans ; Melanoma/genetics ; RNA, Small Nucleolar/genetics ; Prognosis ; Skin Neoplasms/genetics ; Biomarkers ; Tumor Microenvironment
Chemical Substances	RNA, Small Nucleolar ; Biomarkers
Language	English
Publishing date	2023-09-29
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1130936-2
ISSN	1600-0625 ; 0906-6705
ISSN (online)	1600-0625
ISSN	0906-6705
DOI	10.1111/exd.14944
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Zs.A 3508: Show issues

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Article ; Online: The romantic history of signaling pathway discovery in cell death: an updated review.

Wang, Lei-Yun / Liu, Xing-Jian / Li, Qiu-Qi / Zhu, Ying / Ren, Hui-Li / Song, Jia-Nan / Zeng, Jun / Mei, Jie / Tian, Hui-Xiang / Rong, Ding-Chao / Zhang, Shao-Hui

Molecular and cellular biochemistry

2023

Abstract: Cell death is a fundamental physiological process in all living organisms. Processes such as embryonic development, organ formation, tissue growth, organismal immunity, and drug response are accompanied by cell death. In recent years with the development ...

Abstract	Cell death is a fundamental physiological process in all living organisms. Processes such as embryonic development, organ formation, tissue growth, organismal immunity, and drug response are accompanied by cell death. In recent years with the development of electron microscopy as well as biological techniques, especially the discovery of novel death modes such as ferroptosis, cuprotosis, alkaliptosis, oxeiptosis, and disulfidptosis, researchers have been promoted to have a deeper understanding of cell death modes. In this systematic review, we examined the current understanding of modes of cell death, including the recently discovered novel death modes. Our analysis highlights the common and unique pathways of these death modes, as well as their impact on surrounding cells and the organism as a whole. Our aim was to provide a comprehensive overview of the current state of research on cell death, with a focus on identifying gaps in our knowledge and opportunities for future investigation. We also presented a new insight for macroscopic intracellular survival patterns, namely that intracellular molecular homeostasis is central to the balance of different cell death modes, and this viewpoint can be well justified by the signaling crosstalk of different death modes. These concepts can facilitate the future research about cell death in clinical diagnosis, drug development, and therapeutic modalities.
Language	English
Publishing date	2023-10-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-023-04873-2
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Zs.A 892: Show issues

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Article ; Online: Combination of L-Arginine and L-Norvaline protects against pulmonary fibrosis progression induced by bleomycin in mice.

Gao, Lu / Zhang, Jia-Hua / Chen, Xiao-Xu / Ren, Hui-Li / Feng, Xiu-Ling / Wang, Jia-Ling / Xiao, Jun-Hua

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2019 Volume 113, Page(s) 108768

Abstract: Pulmonary fibrosis (PF) progression may be involved with arginine (Arg) metabolism and immune balance. The present study aimed to explore the effects of L-Arginine (L-Arg) and L-Norvaline (L-Nor) on bleomycin (BLM)-induced PF in mice, meanwhile, and ... ...

Abstract	Pulmonary fibrosis (PF) progression may be involved with arginine (Arg) metabolism and immune balance. The present study aimed to explore the effects of L-Arginine (L-Arg) and L-Norvaline (L-Nor) on bleomycin (BLM)-induced PF in mice, meanwhile, and observe dynamic changes of Arg metabolism, immune balance and crosstalk between them in PF progression. Followed intratracheal instillation of BLM or saline, Kunming mice were treated orally with saline, L-Arg, L-Nor and L-Arg + L-Nor three times a day. And the mice were sacrificed on Day 3, 14 and 28 after treatment. Changes of body weight, lung index, lung hydroxyproline and histopathology were analyzed to evaluate the PF degree. Peripheral blood Arg, Citrulline (Cit), Ornithine (Orn) and Proline (Pro), lung NO, NOS and arginase were analyzed to evaluate the Arg metabolism. Peripheral blood Tregs, Th17 and γδT cells were analyzed to evaluate the immune balance. Our data showed that combination of L-Arg and L-Nor dynamically reversed the weight loss, decreased lung index and hydroxyproline, and improved lung histopathological damages induced by BLM. The combination dynamically and significantly rectified Tregs, Th17, γδT and Tregs/Th17 abnormal changes. Meanwhile, these disorders of peripheral blood Arg, Cit, Orn, Pro, Orn/Cit and Pro/Orn, and lung NO, iNOS and TNOS were also improved accordingly. These results demonstrated that combination of L-Arg and L-Nor had inhibitory effects on BLM-induced PF progression, possibly due to their corrective action on immune imbalance, Arg metabolism disorder and crosstalk abnormality in the progression of PF.
MeSH term(s)	Administration, Oral ; Animals ; Arginine/administration & dosage ; Arginine/pharmacology ; Bleomycin/toxicity ; Disease Models, Animal ; Disease Progression ; Drug Therapy, Combination ; Intraepithelial Lymphocytes/immunology ; Lung/drug effects ; Lung/pathology ; Male ; Mice ; Pulmonary Fibrosis/immunology ; Pulmonary Fibrosis/pathology ; Pulmonary Fibrosis/prevention & control ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology ; Valine/administration & dosage ; Valine/analogs & derivatives ; Valine/pharmacology
Chemical Substances	Bleomycin (11056-06-7) ; Arginine (94ZLA3W45F) ; norvaline (A70UKS48FE) ; Valine (HG18B9YRS7)
Language	English
Publishing date	2019-03-17
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2019.108768
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Ud II Zs.198: Show issues

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Article ; Online: Role of canonical transient receptor potential channel-3 in acetylcholine-induced mouse airway smooth muscle cell proliferation.

Chen, Xiao-Xu / Zhang, Jia-Hua / Pan, Bin-Hua / Ren, Hui-Li / Feng, Xiu-Ling / Wang, Jia-Ling / Xiao, Jun-Hua

Life sciences

2017 Volume 187, Page(s) 64–73

Abstract: Aims: Canonical transient receptor potential channel-3 (TRPC3)-encoded Ca: Materials and methods: Primary mouse ASMCs were cultured with or without ACh treatment, then cell viability, TRPC3 expression, NSCC currents and [Ca: Key findings: TRPC3 ... ...

Abstract	Aims: Canonical transient receptor potential channel-3 (TRPC3)-encoded Ca Materials and methods: Primary mouse ASMCs were cultured with or without ACh treatment, then cell viability, TRPC3 expression, NSCC currents and [Ca Key findings: TRPC3 blocker Gd Significance: Our data suggested ACh could induce ASMC proliferation, and TRPC3 may be involved in ACh-induced ASMC proliferation that occurs with airway remodeling.
MeSH term(s)	Acetylcholine/pharmacology ; Acetylcholine/physiology ; Animals ; Calcium/metabolism ; Cell Count ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; Cell Survival/drug effects ; Cell Survival/physiology ; Gadolinium/pharmacology ; Ion Channels/antagonists & inhibitors ; Ion Channels/physiology ; Mice ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/physiology ; Primary Cell Culture ; RNA, Small Interfering/pharmacology ; Respiratory System ; TRPC Cation Channels/biosynthesis ; TRPC Cation Channels/physiology ; Up-Regulation/drug effects
Chemical Substances	Ion Channels ; RNA, Small Interfering ; TRPC Cation Channels ; TRPC3 cation channel ; nonselective cation channel protein, mouse ; Gadolinium (AU0V1LM3JT) ; Acetylcholine (N9YNS0M02X) ; gadolinium chloride (P7082WY76D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2017-10-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2017.08.009
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Uc I Zs.368: Show issues

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Article ; Online: TRPC3-mediated Ca(2+) entry contributes to mouse airway smooth muscle cell proliferation induced by lipopolysaccharide.

Chen, Xiao-Xu / Zhang, Jia-Hua / Pan, Bin-Hua / Ren, Hui-Li / Feng, Xiu-Ling / Wang, Jia-Ling / Xiao, Jun-Hua

Cell calcium

2016 Volume 60, Issue 4, Page(s) 273–281

Abstract: Airway remodeling is a histopathological hallmark of chronic respiratory diseases that includes airway smooth muscle cell (ASMC) proliferation. Canonical transient receptor potential channel-3 (TRPC3)-encoded nonselective cation channels (NSCCs) are ... ...

Abstract	Airway remodeling is a histopathological hallmark of chronic respiratory diseases that includes airway smooth muscle cell (ASMC) proliferation. Canonical transient receptor potential channel-3 (TRPC3)-encoded nonselective cation channels (NSCCs) are important native constitutively active channels that play significant roles in physiological and pathological conditions in ASMCs. Lipopolysaccharides (LPSs), known as lipoglycans and endotoxin, have been proven to be inducers of airway remodeling, though the mechanisms remain unclear. We hypothesized that TRPC3 is important in LPS-induced airway remodeling by regulating ASMC proliferation. To test this hypothesis, mouse ASMCs were cultured with or without LPS for 48h. Cell viability, TRPC3 protein expression, NSCC currents and changes in intracellular calcium concentration ([Ca(2+)]i) were then analyzed using an MTT assay, western blotting, whole-cell patch clamp and calcium imaging, respectively. The results showed that LPS treatment significantly induced ASMC proliferation, up-regulation of TRPC3 protein expression and enhancement of NSCC currents, resting [Ca(2+)]i and ACh-elicited changes in [Ca(2+)]i. TRPC3 blocker Gd(3+), TRPC3 blocking antibody or TRPC3 gene silencing by siRNA significantly inhibited LPS-induced up-regulation of TRPC3 protein, enhancement of NSCC currents, resting [Ca(2+)]i and ACh-elicited changes in [Ca(2+)]i, eventually inhibiting LPS-induced ASMCproliferation. These results demonstrated that TRPC3-mediated Ca(2+) entry contributed to LPS-induced ASMC proliferation and identified TRPC3 as a possible key target in airway remodeling intervention.
MeSH term(s)	Animals ; Calcium/metabolism ; Cell Proliferation/drug effects ; Cells, Cultured ; Female ; Lipopolysaccharides/antagonists & inhibitors ; Lipopolysaccharides/pharmacology ; Male ; Mice ; Mice, Inbred Strains ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Respiratory System/drug effects ; Respiratory System/metabolism ; TRPC Cation Channels/metabolism
Chemical Substances	Lipopolysaccharides ; TRPC Cation Channels ; TRPC3 cation channel ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	757687-0
ISSN	1532-1991 ; 0143-4160
ISSN (online)	1532-1991
ISSN	0143-4160
DOI	10.1016/j.ceca.2016.06.005
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Zs.A 1596: Show issues

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Article: [Value of 16-slice spiral CT in the diagnosis of tumor-like bronchial tuberculosis].

Zhang, Ying / Lin, Wen-yu / Fang, Wei-jun / Liu, Xian / Liu, Bo / Zhang, Hui / Song, Min / Ren, Hui-li

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2010 Volume 30, Issue 8, Page(s) 1943–1945

Abstract: Objective: To evaluate the value of 16-slice multi-detector CT (MDCT) in the diagnosis of tumor-like bronchial tuberculosis.: Methods: Twenty-five patients with tumor-like bronchial tuberculosis underwent 16-slice CT scanning and the CT data were ... ...

Abstract	Objective: To evaluate the value of 16-slice multi-detector CT (MDCT) in the diagnosis of tumor-like bronchial tuberculosis. Methods: Twenty-five patients with tumor-like bronchial tuberculosis underwent 16-slice CT scanning and the CT data were analyzed. Results: Tumor-like bronchial tuberculosis were classified into 4 types according to the imaging features, namely intra-lumen nodule, intra-lumen mass, compression from outside of the bronchial lumens, and lung hilum mass. Tumor-like bronchial tuberculosis was featured by irregular bronchial wall thickening which led to decreased internal diameter of the bronchi with the external diameter remaining unchanged, ring-shaped enhancement, and absence of clear boundaries between the lesion and normal bronchi. Conclusion: 16-slice MDCT can be advantageous in displaying tumor-like bronchial tuberculosis, and axial scan with 16-slice spiral CT combined with image reconstruction allows detection of the lesions inside the trachea and bronchus.
MeSH term(s)	Bronchial Diseases/diagnostic imaging ; Bronchial Neoplasms/diagnostic imaging ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Tomography, Spiral Computed/methods ; Tuberculosis/diagnostic imaging
Language	Chinese
Publishing date	2010-08
Publishing country	China
Document type	Journal Article
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
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