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Article ; Online: Expanding the reach of commercial cell therapies requires changes at medical centers.

Stroncek, David F / Zhang, Nan / Ren, Jiaqiang / Somerville, Rob / Dinh, Anh

2024 Volume 22, Issue 1, Page(s) 181

Abstract: The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactured and used at academic medical centers. ... ...

Abstract	The clinical application of cell therapies is becoming increasingly important for the treatment of cancer, congenital immune deficiencies, and hemoglobinopathies. These therapies have been primarily manufactured and used at academic medical centers. However, cell therapies are now increasingly being produced in centralized manufacturing facilities and shipped to medical centers for administration. Typically, these cell therapies are produced from a patient's own cells, which are the critical starting material. For these therapies to achieve their full potential, more medical centers must develop the infrastructure to collect, label, cryopreserve, test, and ship these cells to the centralized laboratories where these cell therapies are manufactured. Medical centers must also develop systems to receive, store, and infuse the finished cell therapy products. Since most cell therapies are cryopreserved for shipment and storage, medical centers using these therapies will require access to liquid nitrogen product storage tanks and develop procedures to thaw cell therapies. These services could be provided by the hospital pharmacy or transfusion service, but the latter is likely most appropriate. Another barrier to implementing these services is the variability among providers of these cell therapies in the processes related to handling cell therapies. The provision of these services by medical centers would be facilitated by establishing a national coordinating center and a network of apheresis centers to collect and cryopreserve the cells needed to begin the manufacturing process and cell therapy laboratories to store and issue the cells. In addition to organizing cell collections, the coordinating center could establish uniform practices for collecting, labeling, shipping, receiving, thawing, and infusing the cell therapy.
MeSH term(s)	Humans ; Academic Medical Centers ; Cell- and Tissue-Based Therapy
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-024-04966-6
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Article: Sustainable remediation of diesel-contaminated soil by low temperature thermal treatment: Improved energy efficiency and soil reusability

Ren, Jiaqiang / Song, Xin / Ding, Da

Chemosphere. 2020 Feb., v. 241

2020

Abstract: Thermal treatment can effectively remediate diesel-contaminated soil, but is considered unsustainable because of its energy-intensive nature and potential to damage soil properties. Here, we used low temperature thermal treatment (LTTT) as an energy- ... ...

Abstract	Thermal treatment can effectively remediate diesel-contaminated soil, but is considered unsustainable because of its energy-intensive nature and potential to damage soil properties. Here, we used low temperature thermal treatment (LTTT) as an energy-efficient technique to remediate diesel-contaminated soil. The impacts of LTTT on the physiochemical and ecological properties of soils were investigated to evaluate the reusability of heated soil. Heating at 250 °C for 10 min reduced the concentration of the total petroleum hydrocarbons from 6271 mg/kg to 359 mg/kg, which is lower than the Chinese risk screening level of 826 mg/kg. After LTTT, most soil physiochemical properties were nearly unchanged, and the NO₃⁻-N and NH₄⁺-N contents increased. Moreover, LTTT-remediated soil was favorable for the germination and early growth of wheat. The microbial community changed substantially, but recovered after being mixed with uncontaminated soil. Finally, exploration of the mechanisms of LTTT revealed that pyrolysis was the dominant mechanism of diesel removal. A biochar-like pyrolytic carbon was formed, which improved the soil reusability.
Keywords	ammonium nitrogen ; carbon ; energy efficiency ; germination ; heat ; heat treatment ; hydrocarbons ; microbial communities ; nitrate nitrogen ; petroleum ; polluted soils ; pyrolysis ; remediation ; risk screening ; screening ; soil properties ; temperature ; wheat
Language	English
Dates of publication	2020-02
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2019.124952
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Article ; Online: Indomethacin-induced spectral responses of naphthalimide-based dyes to serum albumin: effects of substituent and spacer.

Zhou, Langping / Huang, Rui / Yu, Zhihao / Chen, Cong / Wang, Junjun / Ren, Jiaqiang / Qian, Junhong

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

2022 Volume 38, Issue 4, Page(s) 643–650

Abstract: Four indomethacin-naphthalimide binaries with different proton receptors at 4-position of naphthalimide were designed and synthesized. N,N-Dimethylethylenediamine and N-methyl piperazine were served as proton receptors as well as solubility regulators. ... ...

Abstract	Four indomethacin-naphthalimide binaries with different proton receptors at 4-position of naphthalimide were designed and synthesized. N,N-Dimethylethylenediamine and N-methyl piperazine were served as proton receptors as well as solubility regulators. Indomethacin, an inhibitor for cyclooxygenase-2 overexpressed on cancer cells, was connected at the imine N through different spacers. The attachment of indomethacin significantly quenched the fluorescence of all compounds with obvious red-shift in the absorption maxima due to the strong photo-induced electron transfer process of the folded-state. Human serum albumin (HSA) triggered about 15-fold fluorescence enhancements of DMN-IMC-5 with 30 nm blue-shift. However, it caused much smaller fluorescence increments of other compounds, suggesting that indomethacin, the linker and proton receptor play critical roles in HSA identification. Fluorescence bioimaging results show that indomethacin enables the naphthalimide-based compounds to fluorescent imaging living cells. Molecular docking reveals that the introduction of indomethacin improved the binding affinity of the dyes to HSA.
MeSH term(s)	Fluorescent Dyes/chemistry ; Humans ; Indomethacin ; Molecular Docking Simulation ; Naphthalimides/chemistry ; Naphthalimides/metabolism ; Protons ; Serum Albumin/chemistry ; Serum Albumin/metabolism ; Serum Albumin, Human/chemistry ; Spectrometry, Fluorescence
Chemical Substances	Fluorescent Dyes ; Naphthalimides ; Protons ; Serum Albumin ; Indomethacin (XXE1CET956) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2022-03-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1483376-1
ISSN	1348-2246 ; 1348-2246
ISSN (online)	1348-2246
ISSN	1348-2246
DOI	10.1007/s44211-022-00077-8
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Article: Evaluation and management of symptomatic duodenal diverticula: a single-center retrospective analysis of 647 patients.

Ren, Jiaqiang / Ding, Jiachun / Su, Tong / Wu, Shuai / Chen, Fan / Li, Jie / Wang, Zheng / Han, Liang / Wu, Zheng

Frontiers in surgery

2023 Volume 10, Page(s) 1267436

Abstract: Aims: To explore the clinical characteristics of patients with symptomatic duodenal diverticula and to generalize how to make appropriate treatment choices for this group of patients.: Materials and methods: From January 2010 to September 2020, a ... ...

Abstract	Aims: To explore the clinical characteristics of patients with symptomatic duodenal diverticula and to generalize how to make appropriate treatment choices for this group of patients. Materials and methods: From January 2010 to September 2020, a total of 647 patients with duodenal diverticula (DD) were included in this study. 345 of them with relevant symptoms were divided into the symptomatic group and the other 302 patients were in the asymptomatic group. Results: Among all patients, most DD were located in the periampullary area, <1 cm in size, and single in number. The distribution of DD localized in the 2nd portion/periampullary ( Conclusions: Patients with DD ≥1 cm or located in the periampullary were more likely to be symptomatic. The specific size of the DD and the combination of specific biliary comorbidities may have an impact on the choice of treatment modality.
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1267436
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Article: Prognostic nomogram for primary splenic lymphoma: a SEER database-based study.

Chen, Fan / Long, Hong / Ding, Jiachun / Ren, Jiaqiang / Qu, Bolun / Cao, Peilong / Wang, Zheng / Wu, Zheng / Ma, Qingyong / Ma, Zhenhua

American journal of cancer research

2023 Volume 13, Issue 12, Page(s) 5825–5845

Abstract: This study aimed to establish a nomogram model based on the clinicopathological factors affecting the prognosis of patients with primary splenic lymphoma (PSL) to predict the overall survival (OS) and cancer-specific survival (CSS) of patients. A total ... ...

Abstract	This study aimed to establish a nomogram model based on the clinicopathological factors affecting the prognosis of patients with primary splenic lymphoma (PSL) to predict the overall survival (OS) and cancer-specific survival (CSS) of patients. A total of 4074 patients diagnosed with PSL were included in this study. Among them, 4052 cases from the SEER (Surveillance, Epidemiology, and End Results) database were randomized into a training set and an internal validation set in a 7:3 ratio. Another 22 patients from the First Affiliated Hospital of Xi'an Jiaotong University were used as an external validation set. The prognostic factors affecting the OS and CSS of patients were analyzed using univariate and multivariate Cox regression models. Survival analysis was performed using Kaplan-Meier (KM) method and compared by Log-rank test. Then, a nomogram model was established to predict OS and CSS. Finally, the model was validated both internally and externally using the concordance index (C-index), receiver operating characteristic curve (ROC), and calibration curve to evaluate its predictive value, and the decision curve analysis (DCA) was conducted to assess its clinical utility. Our results showed that the model displayed a good prediction ability. In the training set, the OS rates at 1, 3, and 5 years were 85.9%, 75.8% and 70.1%, respectively, while the CSS rates at 1, 3, and 5 years were 91.9%, 86.2% and 82.3%, respectively. Predictors in the prediction model of OS included age, sex, marital status, Ann Arbor stage, histology, surgery, chemotherapy and year at diagnosis. On the other hand, predictors in the model of CSS included age, Ann Arbor stage, histology, chemotherapy, and year at diagnosis. Internal and external validation of the nomogram model showed that the C-index for predicting OS was 0.678 (0.662, 0.694) in the training set, 0.672 (0.648, 0.696) in the internal validation set, and 0.704 (0.565, 0.843) in the external validation set; the C-index for predicting CSS was 0.685 (0.661, 0.709) in the training set, 0.683 (0.650, 0.716) in the internal validation set, and 0.676 (0.488, 0.864) in the external validation set. The calibration curves for several groups showed good consistency, and DCA suggested its clinical usability. In conclusion, the nomogram constructed in this study has a good predictive value for the survival of patients with PSL, and can be a clinically applicable and practical prediction tool, facilitating rapid and accurate individualized predictions of the patient survival.
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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Article ; Online: Sustainable remediation of diesel-contaminated soil by low temperature thermal treatment: Improved energy efficiency and soil reusability.

Ren, Jiaqiang / Song, Xin / Ding, Da

Chemosphere

2019 Volume 241, Page(s) 124952

Abstract	Thermal treatment can effectively remediate diesel-contaminated soil, but is considered unsustainable because of its energy-intensive nature and potential to damage soil properties. Here, we used low temperature thermal treatment (LTTT) as an energy-efficient technique to remediate diesel-contaminated soil. The impacts of LTTT on the physiochemical and ecological properties of soils were investigated to evaluate the reusability of heated soil. Heating at 250 °C for 10 min reduced the concentration of the total petroleum hydrocarbons from 6271 mg/kg to 359  mg/kg, which is lower than the Chinese risk screening level of 826 mg/kg. After LTTT, most soil physiochemical properties were nearly unchanged, and the NO
MeSH term(s)	Carbon ; Cold Temperature ; Environmental Pollution/prevention & control ; Environmental Restoration and Remediation/methods ; Gasoline/adverse effects ; Hot Temperature/adverse effects ; Microbiota ; Recycling ; Soil/chemistry ; Soil Pollutants/analysis ; Soil Pollutants/chemistry ; Temperature ; Triticum/growth & development
Chemical Substances	Gasoline ; Soil ; Soil Pollutants ; pyrolytic carbon ; Carbon (7440-44-0)
Language	English
Publishing date	2019-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2019.124952
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Article: The small silver nanoparticle-assisted homogeneous sensing of thiocyanate ions with an ultra-wide window based on surface-enhanced Raman-extinction spectroscopy

Bai, Xiang-Ru / Zhang, Lei / Ren, Jia-Qiang / Shen, Ai-Guo / Hu, Ji-Ming

Analytical methods. 2021 Mar. 4, v. 13, no. 8

2021

Abstract: For the first time, we present an original sensing strategy with an ultra-wide detection window from 17 nM to 20 mM to detect SCN⁻ ions. Initially, we investigated the clustering and optical properties of noble metal sol nanoparticles (NPs) due to the ... ...

Abstract	For the first time, we present an original sensing strategy with an ultra-wide detection window from 17 nM to 20 mM to detect SCN⁻ ions. Initially, we investigated the clustering and optical properties of noble metal sol nanoparticles (NPs) due to the competitive interaction of thiocyanate ions (SCN⁻) and cetyltrimethylammonium bromide (CTAB) under weak acidic conditions, and found that different dimensions and scales of nanoclusters containing the alkyne-embedded Au@Ag NPs and relatively small Ag NPs could be achieved by the mediation of CTAB through electrostatic forces and hydrophobic interaction, in which SCN⁻ could be covalently bonded with the silver surface of NPs to form a compact molecular layer (–Ag–S–CN), and CTAB could only occupy remaining sites. In this process, we found that SCN⁻ always runs counter to CTAB and tends to dissolve nanoclusters, so that they occupy the exposed surface of NPs in nanoclusters rather than the binding sites of one another. Remarkably, when the concentration of SCN⁻ initially increased, two highly recognizable SERS emissions, which were assigned to alkyne reporter molecules (2208 cm⁻¹) and CN of SCN⁻ (2110 cm⁻¹), respectively, were rapidly detected, and their ratios (I₂₁₁₀/I₂₂₀₈) increased linearly proportional to the concentration of SCN⁻ over a range of 17 nM to 172 μM, with a limit of detection (LOD) of 10 nM. With the further increase of SCN⁻, small Ag NPs started to desorb from the surface of individual Au@Ag NPs and dissociated in the solution but did not contribute to SERS signals. Instead, the surface plasmon resonance (SPR) peak of pure silver NPs at 385 nm increased gradually in the range from 0.5 to 20 mM with an LOD of 0.2 mM. Of particular significance, this simple sensor in conjunction with surface-enhanced Raman-extinction spectroscopy can be used for the rapid detection of extensive samples with an ultra-wide detection window, such as body fluids (saliva, urine, and serum) and food (milk powder and brassica vegetables), which is far superior to that of ion chromatography (IC).
Keywords	alkynes ; blood serum ; cetyltrimethylammonium bromide ; detection limit ; dried milk ; hydrophobic bonding ; ion exchange chromatography ; nanosilver ; rapid methods ; saliva ; silver ; spectroscopy ; surface plasmon resonance ; thiocyanates ; urine
Language	English
Dates of publication	2021-0304
Size	p. 1049-1057.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d0ay02221g
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Article: Sustainable Conversion of Biomass-Derived d-Xylose to Furfuryl Alcohol in a Deep Eutectic Solvent–Water System

Li, Qi / Ren, Jia-Qiang / Li, Qing / Di, Jun-Hua / Ma, Cuiluan / He, Yucai

ACS sustainable chemistry & engineering. 2021 July 21, v. 9, no. 30

2021

Abstract: In this article, the feasibility of chemoenzymatically catalyzing biomass-derived d-xylose into furfuryl alcohol was verified via tandem catalysis with HCOOH and reductase in deep eutectic solvent (DES)–water media. A high furfural yield (58.3%) was ... ...

Abstract	In this article, the feasibility of chemoenzymatically catalyzing biomass-derived d-xylose into furfuryl alcohol was verified via tandem catalysis with HCOOH and reductase in deep eutectic solvent (DES)–water media. A high furfural yield (58.3%) was achieved by catalyzing biomass-derived d-xylose (60.0 g/L) in 30 min at 180 °C with catalyst HCOOH (3.0 wt %) in the presence of DES ChCl:Gly (7.5 vol %). In addition, one newly constructed recombinant Escherichia coli CF harboring formate dehydrogenase and reductase converted d-xylose-derived furfural to furfuryl alcohol at 89.5% yield at 35 °C and pH 6.5 using HCOONa as a cosubstrate in DES ChCl:Gly–water. HCOOH was used as an acid catalyst for the dehydration of d-xylose to furfural, and its salt (HCOONa) was used as a cosubstrate for recombinant E. coli CF to catalyze the bioreduction of furfural in ChCl:Gly–water media. One effective formic acid-catalyzed conversion of biomass-derived d-xylose to furfural was successfully established for enhancing bioreduction synthesis of furfuryl alcohol using formate as a cosubstrate in DES ChCl:Gly–water under the overarching principles of sustainability. This developed chemoenzymatic catalysis strategy was green and environmentally friendly with good potential for industrial applications.
Keywords	Escherichia coli ; catalysts ; catalytic activity ; formate dehydrogenase ; formates ; furfural ; furfuryl alcohol ; green chemistry ; pH ; solvents ; xylose
Language	English
Dates of publication	2021-0721
Size	p. 10299-10308.
Publishing place	American Chemical Society
Document type	Article
ISSN	2168-0485
DOI	10.1021/acssuschemeng.1c02965
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Article: Biocatalytic Valorization of Biobased 5-Hydroxymethylfurfural to 5-Hydroxymethyl-2-furfurylamine in a Three-Constituent Deep Eutectic Solvent–Water System

Wang, Zihan / Chai, Haoyu / Ren, Jiaqiang / Tao, Yongyou / Li, Qing / Ma, Cuiluan / Ai, Yunlong / He, Yucai

ACS sustainable chemistry & engineering. 2022 June 16, v. 10, no. 26

2022

Abstract: 5-Hydroxymethyl-2-furfurylamine (HMFA), as an important 5-hydroxymethylfurfural (5-HMF) derivative, has many potential applications in the preparation of diuretics, antihypertensive drugs, preservatives, and curing agents. In this work, highly efficient ... ...

Abstract	5-Hydroxymethyl-2-furfurylamine (HMFA), as an important 5-hydroxymethylfurfural (5-HMF) derivative, has many potential applications in the preparation of diuretics, antihypertensive drugs, preservatives, and curing agents. In this work, highly efficient valorization of biomass-derived d-fructose into HMFA was attempted via a cascade reaction in a three-constituent deep eutectic solvent (3c-DES)–H₂O. Using d-fructose (63.0 g/L) as a raw material, the yield of 5-HMF reached 68.2% in 3c-DES malic acid/glycerol/betaine–H₂O (9:91, wt/wt) (pH 2.3) at 170 °C in 30 min. Whole cells of Escherichia coli CV harboring transaminase were utilized to valorize biomass-derived 5-HMF to HMFA at pH 8.0 and 30 °C using amine donor l-alanine. The valorization of 600 mM commercial 5-HMF gave a 93.2% yield of HMFA with 99.2% selectivity. In addition, CV cells transformed d-fructose-valorized 5-HMF into HMFA in 94.1% yield in 3c-DES malic acid/glycerol/betaine–H₂O. This approach provided a sustainable and eco-efficient idea for chemoenzymatically valorizing biomass-derived d-fructose to HMFA.
Keywords	Escherichia coli ; alanine ; fructose ; green chemistry ; hydroxymethylfurfural ; malic acid ; pH ; raw materials ; solvents
Language	English
Dates of publication	2022-0616
Size	p. 8452-8463.
Publishing place	American Chemical Society
Document type	Article
ISSN	2168-0485
DOI	10.1021/acssuschemeng.2c01481
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Article ; Online: Gene therapy simplified.

Ren, Jiaqiang / Stroncek, David F

Blood

2016 Volume 128, Issue 18, Page(s) 2194–2195

MeSH term(s)	Genetic Therapy ; Humans
Language	English
Publishing date	2016-11-03
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2016-09-736983
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