LIVIVO - Search results -

Search results

Result 1 - 10 of total 43

Search options

Article ; Online: Efficacy of endoscopic porcine small intestinal submucosa graft myringoplasty: a retrospective comparative study.

Jin, Li / Pan, Xueying / Yin, Tuanfang / Ren, Jihao / Liu, Wei

2023 Volume 143, Issue 4, Page(s) 274–279

Abstract: Background: The surgical outcomes following tympanic membrane (TM) repair are affected by many factors.: Objectives: To evaluate the efficacy of endoscopic porcine small intestine submucosa graft (PSISG) myringoplasty by comparing with endoscopic ... ...

Abstract	Background: The surgical outcomes following tympanic membrane (TM) repair are affected by many factors. Objectives: To evaluate the efficacy of endoscopic porcine small intestine submucosa graft (PSISG) myringoplasty by comparing with endoscopic myringoplasty with temporal fascia (TF) and perichondrium (PC). Methods: We conducted a retrospective comparative study that a total of 98 patients with TM perforations were included. The patients underwent endoscopic myringoplasty using PSISG, TF or PC as the graft. The closure rate, hearing outcomes, operative time and complications in three groups were compared. Results: At 3 months postoperatively, the closure rate were 85.2% (23/27), 92.1% (35/38) and 87.9% (29/33) in the PSISG, TF and PC groups respectively ( Conclusion: Compare to autologous temporal fascia or perichondrium, the PSISG appears to be an effective and safe material for TM perforations closure. Endoscopic PSISG myringoplasty may be an alternative technique for repairing TM perforations, especially for revision cases.
MeSH term(s)	Swine ; Animals ; Myringoplasty/methods ; Retrospective Studies ; Treatment Outcome ; Tympanic Membrane ; Endoscopy/methods ; Tympanic Membrane Perforation/surgery
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2023.2182451
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ul II Zs 105: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article: Analysis of mRNA m

Xie, Shumin / Jin, Li / He, Jun / Fu, Jinfeng / Yin, Tuanfang / Ren, Jihao / Liu, Wei

Frontiers in genetics

2023 Volume 14, Page(s) 1188048

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1188048
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Nuclear factor E2 related factor (NRF2) inhibits mast cell- mediated allergic inflammation via SIRT4-mediated mitochondrial metabolism.

Hu, Binya / Zhao, Sijun / Huang, Min / Ren, Jihao

Annals of palliative medicine

2020 Volume 9, Issue 6, Page(s) 3839–3847

Abstract: Background: Mast cell (MC)-mediated inflammation is essential for allergic rhinitis, and nuclear factor E2 related factor (NRF2) is found to inhibit inflammation. This study investigated whether NRF2 could inhibit MC inflammation and its molecular ... ...

Abstract	Background: Mast cell (MC)-mediated inflammation is essential for allergic rhinitis, and nuclear factor E2 related factor (NRF2) is found to inhibit inflammation. This study investigated whether NRF2 could inhibit MC inflammation and its molecular mechanisms concerning SIRT4. Methods: Real-time quantitative PCR (RT-qPCR) and western blot were used to detect gene expression, and Elisa kit was used to detect the content of histamine and inflammatory cytokines in the medium of MCs, and Seahorse XF instrument was used to measure the mitochondrial metabolism of MCs. Knockdown SIRT4 and establish SIRT4 overexpression of HMC-1 cells to study the function of SIRT4. Results: As an activator of NRF2, 4-Octyl Itaconate increases not only NRF2 expression but also increases SIRT4 expression. Although 4-Octyl Itaconate could reduce the histamine release and degranulation of MCs, which was induced by compound 48/80, SIRT4 knockdown decreased the inhibition of 4-Octyl Itaconate. Similarly,4-Octyl Itaconate inhibited the secretion of inflammatory cytokines (TNF-α, IL-1β, IL6, and IL-8) by MCs, which was induced by LPS, but SIRT4 knockdown decreases the inhibition of 4-Octyl Itaconate. Also, the up-regulation of SIRT4 significantly inhibited mitochondrial metabolism in MCs and inhibited SIRT1 and P-p65 protein expression after inducing by 100 ng/mL LPS for 1 hour. Conclusions: NRF2 inhibits MC degranulation and MC-mediated inflammation by promoting SIRT4, and SIRT4 overexpression inhibits the mitochondrial metabolism of MCs.
MeSH term(s)	Humans ; Inflammation/drug therapy ; Mast Cells ; NF-E2-Related Factor 2/genetics ; Succinates
Chemical Substances	4-octyl itaconate ; NF-E2-Related Factor 2 ; Succinates
Language	English
Publishing date	2020-11-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-20-1848
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma.

Xie, Shumin / Jin, Li / Yin, Tuanfang / Ren, Jihao / Liu, Wei

Biomedical engineering online

2021 Volume 20, Issue 1, Page(s) 129

Abstract: Background: Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases. However, the role of circRNA in the etiopathogenesis of ... ...

Abstract	Background: Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases. However, the role of circRNA in the etiopathogenesis of middle ear cholesteatoma is rarely investigated so far. We aimed to investigate the differential expression profiling of circRNAs between acquired middle ear cholesteatoma and normal skin, and to identify potential circRNAs contributing to the etiopathogenesis of middle ear cholesteatoma. Microarray analysis and functional prediction were performed to investigate the circRNA expression profiling between middle ear cholesteatoma and normal skin. Validation of differentially expressed circRNAs was conducted by qRT-PCR. Prediction of m Results: Microarray analysis displayed that totally 93 up-regulated and 85 down-regulated circRNAs were identified in middle ear cholesteatoma. Through validation, expressions of hsa_circRNA_104327 and hsa_circRNA_404655 were significantly higher, while hsa_circRNA_000319 was significantly down-regulated in cholesteatoma. GO classification, KEGG pathway, and ceRNA network analyses suggested that these differentially expressed circRNAs might play important roles in the etiopathogenesis of middle ear cholesteatoma. Prediction of m Conclusions: Our study revealed that these differentially expressed circRNAs might contribute to the etiopathogenesis of middle ear cholesteatoma. Further researches should be conducted to investigate the exact mechanism of these differentially expressed circRNAs in the etiopathogenesis of middle ear cholesteatoma. Targeting on these circRNAs may provide a new strategy for middle ear cholesteatoma therapy in the future.
MeSH term(s)	Cholesteatoma, Middle Ear/genetics ; Humans ; Microarray Analysis ; RNA, Circular
Chemical Substances	RNA, Circular
Language	English
Publishing date	2021-12-18
Publishing country	England
Document type	Journal Article
ISSN	1475-925X
ISSN (online)	1475-925X
DOI	10.1186/s12938-021-00960-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Expression of PTHrP and RANKL in acquired middle ear cholesteatoma epithelium.

Xie, Shumin / Pan, Zhen / Yin, Tuanfang / Ren, Jihao / Liu, Wei

Acta oto-laryngologica

2020 Volume 140, Issue 5, Page(s) 351–355

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adolescent ; Adult ; Bone Resorption/etiology ; Bone Resorption/metabolism ; Case-Control Studies ; Child ; Cholesteatoma, Middle Ear/complications ; Cholesteatoma, Middle Ear/metabolism ; Cholesteatoma, Middle Ear/pathology ; Epithelium/metabolism ; Epithelium/pathology ; Female ; Humans ; Male ; Middle Aged ; Parathyroid Hormone-Related Protein/metabolism ; RANK Ligand/metabolism ; Young Adult
Chemical Substances	Parathyroid Hormone-Related Protein ; RANK Ligand ; TNFSF11 protein, human
Language	English
Publishing date	2020-02-28
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2020.1717609
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ul II Zs 105: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: [Intratympanic therapy in the management of tinnitus].

Xie, Shumin / Ren, Jihao

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

2014 Volume 29, Issue 8, Page(s) 699–702

Abstract: Tinnitus is a common symptom which often becomes disabling, affecting the emotional and psychosocial dimensions of life. Nowadays, therapies for tinnitus vary greatly, none of which could give a satisfactory therapeutic effect however. Intratympanic ... ...

Abstract	Tinnitus is a common symptom which often becomes disabling, affecting the emotional and psychosocial dimensions of life. Nowadays, therapies for tinnitus vary greatly, none of which could give a satisfactory therapeutic effect however. Intratympanic therapy allows the generation of high concentration of drugs within the inner ear without systemic side effects. This review aims to introduce the commonly used medications and approaches for intratympanic management of tinnitus. Although different medications have been tested for their effects on tinnitus by intratympanic application, no breakthrough has been achieved so far. Consequently, the clinical use of specific medications for tinnitus has remained limited. A more widespread adoption of intratympanic management requires the development of specific medications for tinnitus, as well as proof of their safety and efficacy.
MeSH term(s)	Ear, Inner ; Humans ; Tinnitus/drug therapy ; Tympanic Membrane
Language	Chinese
Publishing date	2014-04
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ISSN	1001-1781
ISSN	1001-1781
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Reply to the Letter to the Editor regarding "Etiopathogenesis of bone resorption in acquired middle ear cholesteatoma".

Xie, Shumin / Liu, Wei / Ren, Jihao

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2017 Volume 274, Issue 12, Page(s) 4253

Language	English
Publishing date	2017
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-017-4693-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ul II Zs.50: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma.

Xie, Shumin / Wang, Xiaoli / Ren, Jihao / Liu, Wei

2017 Volume 274, Issue 5, Page(s) 2071–2078

Abstract: Cholesteatoma is a destructive squamous epithelial lesion of the temporal bone which gradually expands and leads to serious complications by destruction of nearby bony structures. Erosion caused by bone resorption of the ossicular chain and bony ... ...

Abstract	Cholesteatoma is a destructive squamous epithelial lesion of the temporal bone which gradually expands and leads to serious complications by destruction of nearby bony structures. Erosion caused by bone resorption of the ossicular chain and bony labyrinth may result in hearing loss, vestibular dysfunction, facial paralysis, labyrinthine fistulae and intracranial complications. The exact underlying cellular and molecular mechanism of bone resorption in acquired cholesteatoma still remains unexplained. Pubmed database and China National Knowledge Infrastructure were screened for articles focusing on bone resorption in acquired cholesteatoma. Osteoclast activation, pressure necrosis, acid lysis, enzyme mediation, inflammatory mediators and several newly discovered biomolecules are outlined as main theories behind bone resorption in acquired cholesteatoma, aiming to facilitate the development of potential therapeutic targets for preventing intracranial and extracranial complications caused by bone resorption in acquired middle ear cholesteatoma.
MeSH term(s)	Bone Resorption/etiology ; Bone Resorption/prevention & control ; Cholesteatoma, Middle Ear/complications ; Cholesteatoma, Middle Ear/physiopathology ; Ear Ossicles/pathology ; Ear, Inner/pathology ; Hearing Loss/etiology ; Hearing Loss/prevention & control ; Humans ; Temporal Bone/pathology
Language	English
Publishing date	2017-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-016-4422-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ul II Zs.50: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Effectiveness of salvage intratympanic dexamethasone treatment for refractory sudden sensorineural hearing loss classified by audiogram patterns.

Hu, Bing / Chen, Mo / Chen, Xiaozhu / Zhao, Duanlong / Zheng, Qingyin / Nie, Guohui / Ren, Hongmiao / Ren, Jihao

Acta oto-laryngologica

2021 Volume 141, Issue 5, Page(s) 449–453

Abstract: Background: Intratympanic dexamethasone is commonly conducted to treat refractory sudden sensorineural hearing loss (RSSNHL). However, no consensus has been reached on its effectiveness.: Objectives: The study aimed to evaluate the effectiveness of ... ...

Abstract	Background: Intratympanic dexamethasone is commonly conducted to treat refractory sudden sensorineural hearing loss (RSSNHL). However, no consensus has been reached on its effectiveness. Objectives: The study aimed to evaluate the effectiveness of otoendoscope-assisted salvage intratympanic dexamethasone treatment (IDT) on RSSNHL with different audiogram patterns after failure of initial therapy. Material and methods: A total of 108 patients with unilateral RSSNHL were classified into 4 groups according to audiogram patterns. Hearing results were evaluated by pure-tone audiometry (PTA), which was performed at baseline and one month after otoendoscope-assisted salvage IDT. The effectiveness of otoendoscope-assisted salvage IDT was assessed in each group. Results: The efficiency in low-frequency, high-frequency, flat, and deaf group was 48%, 24.1%, 46.2%, 17.9%, respectively. The efficacy did not differ between the high-frequency and deaf group. Notably, the efficacy in the low-frequency and flat group was significantly higher than that in the deaf group. Conclusions: Otoendoscope-assisted salvage IDT is a safe and effective treatment for RSSNHL. This treatment provided better results for patients with low-frequency damaged and flat curve audiogram than patients with other audiogram patterns. Significance: Audiogram patterns should be considered in the clinical management of patients with RSSHNL prior to salvage IDT.
MeSH term(s)	Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Audiometry, Pure-Tone ; Dexamethasone/administration & dosage ; Dexamethasone/adverse effects ; Endoscopy ; Female ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/drug therapy ; Humans ; Injection, Intratympanic ; Male ; Middle Aged ; Retrospective Studies ; Salvage Therapy ; Treatment Outcome
Chemical Substances	Anti-Inflammatory Agents ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2021-02-27
Publishing country	England
Document type	Journal Article
ISSN	1651-2251
ISSN (online)	1651-2251
DOI	10.1080/00016489.2021.1889029
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ul II Zs 105: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Circle RNA hsa_circRNA_100290 serves as a ceRNA for miR-378a to regulate oral squamous cell carcinoma cells growth via Glucose transporter-1 (GLUT1) and glycolysis.

Chen, Xing / Yu, Jianjun / Tian, Hao / Shan, Zhenfeng / Liu, Wei / Pan, Zhen / Ren, Jihao

Journal of cellular physiology

2019 Volume 234, Issue 11, Page(s) 19130–19140

Abstract: Aerobic glycolysis (the Warburg effect) is a robust metabolic hallmark of most tumors, including oral squamous cell carcinoma (OSCC). Glucose transporter 1 (GLUT1), a major glucose transporter regulating the glucose uptake, is upregulated in OSCC and ... ...

Abstract	Aerobic glycolysis (the Warburg effect) is a robust metabolic hallmark of most tumors, including oral squamous cell carcinoma (OSCC). Glucose transporter 1 (GLUT1), a major glucose transporter regulating the glucose uptake, is upregulated in OSCC and participated in the cell glycolysis of OSCC. The deregulation and function of noncoding RNAs in cancers have been widely reported. Reportedly, hsa_circular RNA (circRNA)_100290 (circ_SLC30A7) is significantly upregulated (fold change = 6.91, p < 0.0000001) in OSCC. According to online tools prediction (miRWalk, miRanda, and Targetscan), miR-378a could simultaneously target circRNA_100290 and GLUT1. Herein, the expression of circRNA_100290 and GLUT1 remarkably increased in oral tumor tissue specimens and cells. In OSCC cell lines, cell proliferation and glycolysis could be remarkably downregulated by circRNA_100290 silence, which could be rescued by GLUT1 overexpression. Conversely, miR-378a expression could be remarkably inhibited in tumor tissue specimens and cells. The effect of miR-378a overexpression on OSCC cells was similar to those of circRNA_100290 silence. miR-378a directly bound to circRNA_100290 and GLUT1 3'-untranslated region, circRNA_100290 could remarkably relieve miR-378a-induced inhibition on GLUT1 via acting as a competing endogenous RNA (ceRNA). miR-378a inhibition remarkably attenuated the effect of circRNA_100290 silence on cell proliferation and glycolysis in OSCC cell lines. In summary, circRNA_100290 serves as a ceRNA to counteract miR-378a-mediated GLUT1 suppression, thus promoting glycolysis and cell proliferation in OSCC. We provide a reliable experimental basis for understanding the mechanism of cell growth and glycolysis deregulation in OSCC.
MeSH term(s)	Apoptosis ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Cell Cycle/genetics ; Cell Line, Tumor ; Cell Proliferation/genetics ; Female ; Flow Cytometry ; Gene Expression Regulation, Neoplastic ; Glucose Transporter Type 1/genetics ; Glycolysis/genetics ; Humans ; Male ; MicroRNAs/genetics ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; RNA, Circular/genetics
Chemical Substances	Glucose Transporter Type 1 ; MIRN378 microRNA, human ; MicroRNAs ; RNA, Circular ; SLC2A1 protein, human
Language	English
Publishing date	2019-06-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3116-1
ISSN	1097-4652 ; 0021-9541
ISSN (online)	1097-4652
ISSN	0021-9541
DOI	10.1002/jcp.28692
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uc I Zs.212: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito