Article ; Online: Effects of the dopamine depleting agent tetrabenazine on detailed temporal parameters of effort-related choice responding.
Journal of the experimental analysis of behavior
2022 Volume 117, Issue 3, Page(s) 331–345
Abstract: The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, rats were tested on a concurrent ... ...
| Abstract | The dopamine-depleting agent tetrabenazine alters effort-based choice, suppressing food-reinforced behaviors with high response requirements, while increasing selection of low-cost options. In the present experiments, rats were tested on a concurrent fixed ratio 5/chow feeding choice task, in which high-carbohydrate Bio-serv pellets reinforced lever pressing and lab chow was concurrently available. Detailed timing of lever pressing was monitored with an event recording system, and the temporal characteristics of operant behavior seen after 1.0 mg/kg tetrabenazine or vehicle injections were analyzed. Tetrabenazine shifted choice, decreasing lever pressing but increasing chow intake. There was a small effect on the interresponse-time distribution within ratios, but marked increases in the total duration of pauses in responding. The postreinforcement-pause (PRP) distribution was bimodal, but tetrabenazine did not increase the duration of PRPs. Tetrabenazine increased time feeding and duration and number of feeding bouts, but did not affect feeding rate or total time spent lever pressing for pellets and consuming chow. Thus, TBZ appears to predominantly affect the relative allocation of lever pressing versus chow, with little alteration in consummatory motor acts involved in chow intake. Tetrabenazine is used to model motivational symptoms in psychopathology, and these effects in rats could have implications for psychiatric research. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Animals ; Choice Behavior ; Conditioning, Operant ; Dopamine ; Feeding Behavior ; Rats ; Rats, Sprague-Dawley ; Tetrabenazine/pharmacology | |||||
| Chemical Substances | Dopamine (VTD58H1Z2X) ; Tetrabenazine (Z9O08YRN8O) | |||||
| Language | English | |||||
| Publishing date | 2022-03-28 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 219405-3 | |||||
| ISSN | 1938-3711 ; 0022-5002 | |||||
| ISSN (online) | 1938-3711 | |||||
| ISSN | 0022-5002 | |||||
| DOI | 10.1002/jeab.754 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.B 558: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.