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  1. Article ; Online: Suppressing label noise in medical image classification using mixup attention and self-supervised learning.

    Gao, Mengdi / Jiang, Hongyang / Hu, Yan / Ren, Qiushi / Xie, Zhaoheng / Liu, Jiang

    Physics in medicine and biology

    2024  

    Abstract: Deep neural networks (DNNs) have been widely applied in medical image classification and achieve remarkable classification performance. These achievements heavily depend on large-scale accurately annotated training data. However, label noise is ... ...

    Abstract Deep neural networks (DNNs) have been widely applied in medical image classification and achieve remarkable classification performance. These achievements heavily depend on large-scale accurately annotated training data. However, label noise is inevitably introduced in the medical image annotation, as the labeling process heavily relies on the expertise and experience of annotators. Meanwhile, DNNs suffer from overfitting noisy labels, degrading the performance of models. Therefore, in this work, we innovatively devise noise-robust training approach to mitigate the adverse effects of noisy labels in medical image classification. Specifically, we incorporate contrastive learning and intra-group attention mixup strategies into the vanilla supervised learning. The contrastive learning for feature extractor helps to enhance visual representation of DNNs. The intra-group attention mixup module constructs groups and assigns self-attention weights for group-wise samples, and subsequently interpolates massive noisy-suppressed samples through weighted mixup operation. We conduct comparative experiments on both synthetic and real-world noisy medical datasets under various noise levels. Rigorous experiments validate that our noise-robust method with contrastive learning and attention mixup can effectively handle with label noise, and is superior to state-of-the-art methods. An ablation study also shows that both components contribute to boost model performance. The proposed method demonstrates its capability of curb label noise and has certain potential toward real-world clinic applications.
    Language English
    Publishing date 2024-04-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad4083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A multi-resolution TOF-DOI detector for human brain dedicated PET scanner.

    He, Wen / Zhao, Yangyang / Huang, Wenjie / Zhao, Xin / Niu, Ming / Yang, Hang / Zhang, Lei / Ren, Qiushi / Gu, Zheng

    Physics in medicine and biology

    2024  Volume 69, Issue 2

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Positron-Emission Tomography/methods ; Brain/diagnostic imaging ; Photons ; Gamma Rays
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad1b6b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A large ascending aortic aneurysm in a 2-year-old boy with Loeys-Dietz syndrome.

    Ren, Qiushi / Hui, Chengyi / Sun, Tucheng / Zhuang, Jian / Cen, Jianzheng

    Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

    2022  Volume 71, Page(s) 69–70

    MeSH term(s) Male ; Humans ; Child, Preschool ; Loeys-Dietz Syndrome/complications ; Loeys-Dietz Syndrome/diagnosis ; Loeys-Dietz Syndrome/surgery ; Aneurysm, Ascending Aorta ; Aorta/surgery ; Blood Vessel Prosthesis Implantation
    Language English
    Publishing date 2022-12-02
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 2215027-4
    ISSN 2241-5955 ; 1109-9666
    ISSN (online) 2241-5955
    ISSN 1109-9666
    DOI 10.1016/j.hjc.2022.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Outcome of surgical repair of anomalous left coronary artery from the pulmonary artery in a single-center experience.

    Yu, Juemin / Ren, Qiushi / Chen, Tianyu / Qiu, Hailong / Wen, Shusheng / Zhuang, Jian / Liu, Xiaobing

    Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese

    2023  Volume 73, Page(s) 47–52

    Abstract: Background: This study aims to review the midterm results of surgical repair of anomalous left coronary artery from the pulmonary artery (ALCAPA) in our center and assess the postoperative cardiac function recovery and misdiagnosis.: Method: Patients ...

    Abstract Background: This study aims to review the midterm results of surgical repair of anomalous left coronary artery from the pulmonary artery (ALCAPA) in our center and assess the postoperative cardiac function recovery and misdiagnosis.
    Method: Patients who underwent repair of ALCAPA between January 2005 and January 2022 at our hospital were retrospectively reviewed.
    Results: A total of 136 patients underwent repair of ALCAPA, among which 49.3% were misdiagnosed before referral to our hospital. On multivariable logistic regression analysis, patients with low left ventricular ejection fraction (LVEF) (odds ratio = 0.975, p = 0.018) were at increased risk for misdiagnosis. The median age at surgery was 0.83 years (range, 0.08 to 56 years), and the median LVEF was 52% (range, 5% to 86%). The mortality rate was 6.6% (n = 9), and four patients underwent reintervention. The median postoperative recovery time of left ventricular function (LVF) was 10 days (1 to 692 days). Competing risk analysis revealed that a low preoperative LVEF (hazard ratio = 1.067, p < 0.001) and age younger than 1 year (hazard ratio = 0.522, p = 0.007) were risk factors for a longer postoperative recovery time of LVF. During the follow-up period, 91.9% (113/123) of the patients had no aggravation of mitral regurgitation.
    Conclusion: The perioperative and intermediate outcomes after ALCAPA repair were favorable, but preoperative misdiagnosis deserved attention, especially in patients with low LVEF. LVF normalized in most patients, but patients younger than 1 year and with low LVEF required longer recovery times.
    MeSH term(s) Humans ; Infant ; Infant, Newborn ; Child, Preschool ; Child ; Adolescent ; Young Adult ; Adult ; Middle Aged ; Bland White Garland Syndrome/diagnosis ; Bland White Garland Syndrome/surgery ; Bland White Garland Syndrome/complications ; Anomalous Left Coronary Artery/complications ; Coronary Vessel Anomalies/diagnosis ; Coronary Vessel Anomalies/surgery ; Stroke Volume ; Retrospective Studies ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/surgery ; Pulmonary Artery/abnormalities ; Ventricular Function, Left ; Mitral Valve Insufficiency/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2215027-4
    ISSN 2241-5955 ; 1109-9666
    ISSN (online) 2241-5955
    ISSN 1109-9666
    DOI 10.1016/j.hjc.2023.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Discriminative ensemble meta-learning with co-regularization for rare fundus diseases diagnosis.

    Gao, Mengdi / Jiang, Hongyang / Zhu, Lei / Jiang, Zhe / Geng, Mufeng / Ren, Qiushi / Lu, Yanye

    Medical image analysis

    2023  Volume 89, Page(s) 102884

    Abstract: Deep neural networks (DNNs) have been widely applied in the medical image community, contributing to automatic ophthalmic screening systems for some common diseases. However, the incidence of fundus diseases patterns exhibits a typical long-tailed ... ...

    Abstract Deep neural networks (DNNs) have been widely applied in the medical image community, contributing to automatic ophthalmic screening systems for some common diseases. However, the incidence of fundus diseases patterns exhibits a typical long-tailed distribution. In clinic, a small number of common fundus diseases have sufficient observed cases for large-scale analysis while most of the fundus diseases are infrequent. For these rare diseases with extremely low-data regimes, it is challenging to train DNNs to realize automatic diagnosis. In this work, we develop an automatic diagnosis system for rare fundus diseases, based on the meta-learning framework. The system incorporates a co-regularization loss and the ensemble-learning strategy into the meta-learning framework, fully leveraging the advantage of multi-scale hierarchical feature embedding. We initially conduct comparative experiments on our newly-constructed lightweight multi-disease fundus images dataset for the few-shot recognition task (namely, FundusData-FS). Moreover, we verify the cross-domain transferability from miniImageNet to FundusData-FS, and further confirm our method's good repeatability. Rigorous experiments demonstrate that our method can detect rare fundus diseases, and is superior to the state-of-the-art methods. These investigations demonstrate that the potential of our method for the real clinical practice is promising.
    MeSH term(s) Humans ; Rare Diseases/diagnostic imaging ; Fundus Oculi ; Neural Networks, Computer ; Learning
    Language English
    Publishing date 2023-06-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1356436-5
    ISSN 1361-8423 ; 1361-8431 ; 1361-8415
    ISSN (online) 1361-8423 ; 1361-8431
    ISSN 1361-8415
    DOI 10.1016/j.media.2023.102884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Human papillomavirus associated XPF deficiency increases alternative end joining and cisplatin sensitivity in head and neck squamous cell carcinoma.

    Zuo, Nan / Ma, Lin / Liu, Tianyang / Hu, Weitao / Luo, Yupeng / Meng, He / Ren, Qiushi / Deng, Yongqiang / Wei, Lanlan / Liu, Qi

    Oral oncology

    2023  Volume 140, Page(s) 106367

    Abstract: Objectives: Human papillomavirus (HPV) positive head and neck squamous cell carcinoma (HNSCC) showed a considerably better prognosis with greater cisplatin sensitivity compared to their HPV-negative counterparts. Deciphering the underlying molecular ... ...

    Abstract Objectives: Human papillomavirus (HPV) positive head and neck squamous cell carcinoma (HNSCC) showed a considerably better prognosis with greater cisplatin sensitivity compared to their HPV-negative counterparts. Deciphering the underlying molecular mechanisms for HPV-induced cisplatin sensitivity is imperative to improve the prognosis of HPV-negative HNSCC.
    Materials and methods: The Fanconi anemia (FA) pathway status in HNSCC cells was analysed by detecting the cell cycle and chromosomal aberrations. XPF expression was validated using PCR, western blot, and immunohistochemistry. Droplet digital PCR and GFP expressing reporter assay were used to analyse the changes in alternative end-joining (alt-EJ) levels. The cisplatin sensitization was verified by cell proliferation assay, clonogenic cell survival assay, and TUNEL.
    Results: HPV-positive HNSCC cells showed significant prolonged G2-M cell cycle arrest and aberrant chromosome formation under interstrand crosslinker treatment. Both mRNA and protein expression of XPF were considerably decreased in HPV-positive HNSCC, according to the analysis of cellular and clinical data. XPF inhibition upregulated the activity of the alt-EJ pathway in HPV-negative HNSCC cells by 32.02% (P < 0.001) but had little effect on HPV-positive HNSCC. Consistent with this, simultaneous suppression of XPF and alt-EJ enhanced cisplatin sensitivity of HPV-negative HNSCC in vitro and in vivo.
    Conclusion: HPV-positive HNSCC cells exhibit a profound FA pathway deficiency associated with reduced XPF expression. HNSCC cells with compromised XPF function are more reliant on the alt-EJ pathway for genomic stability. Combining FA and alt-EJ inhibition may be used to cope with the hard-to-treat HPV-negative HNSCC.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/complications ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Human Papillomavirus Viruses ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/complications ; Papillomavirus Infections/complications ; Cell Line, Tumor ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/metabolism ; Papillomaviridae/physiology
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1120465-5
    ISSN 1879-0593 ; 0964-1955 ; 1368-8375
    ISSN (online) 1879-0593
    ISSN 0964-1955 ; 1368-8375
    DOI 10.1016/j.oraloncology.2023.106367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Boron-peptide conjugates with angiopep-2 for boron neutron capture therapy.

    Xiang, Jing / Ma, Lin / Tong, Jianfei / Zuo, Nan / Hu, Weitao / Luo, Yupeng / Liu, Junqi / Liang, Tianjiao / Ren, Qiushi / Liu, Qi

    Frontiers in medicine

    2023  Volume 10, Page(s) 1199881

    Abstract: Boron neutron capture therapy (BNCT) induces intracellular nuclear reaction to destroy cancer cells during thermal neutron irradiation. To selectively eliminate cancer cells but avoid harmful effects on normal tissues, novel boron-peptide conjugates with ...

    Abstract Boron neutron capture therapy (BNCT) induces intracellular nuclear reaction to destroy cancer cells during thermal neutron irradiation. To selectively eliminate cancer cells but avoid harmful effects on normal tissues, novel boron-peptide conjugates with angiopep-2, namely ANG-B, were constructed and evaluated in preclinical settings. Boron-peptide conjugates were synthesized using solid-phase peptide synthesis, and the molecular mass was validated by mass spectrometry afterwards. Boron concentrations in 6 cancer cell lines and an intracranial glioma mouse model after treatments were analyzed by inductively coupled plasma atomic emission spectroscopy (ICP-AES). Phenylalanine (BPA) was tested in parallel for comparison.
    Language English
    Publishing date 2023-06-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1199881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Predicting ischemic stroke risk from atrial fibrillation based on multi-spectral fundus images using deep learning.

    Li, Hui / Gao, Mengdi / Song, Haiqing / Wu, Xiao / Li, Gang / Cui, Yiwei / Li, Yang / Xie, Zhaoheng / Ren, Qiushi / Zhang, Haitao

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1185890

    Abstract: Background: Ischemic stroke (IS) is one of the most common serious secondary diseases of atrial fibrillation (AF) within 1 year after its occurrence, both of which have manifestations of ischemia and hypoxia of the small vessels in the early phase of ... ...

    Abstract Background: Ischemic stroke (IS) is one of the most common serious secondary diseases of atrial fibrillation (AF) within 1 year after its occurrence, both of which have manifestations of ischemia and hypoxia of the small vessels in the early phase of the condition. The fundus is a collection of capillaries, while the retina responds differently to light of different wavelengths. Predicting the risk of IS occurring secondary to AF, based on subtle differences in fundus images of different wavelengths, is yet to be explored. This study was conducted to predict the risk of IS occurring secondary to AF based on multi-spectrum fundus images using deep learning.
    Methods: A total of 150 AF participants without suffering from IS within 1 year after discharge and 100 IS participants with persistent arrhythmia symptoms or a history of AF diagnosis in the last year (defined as patients who would develop IS within 1 year after AF, based on fundus pathological manifestations generally prior to symptoms of the brain) were recruited. Fundus images at 548, 605, and 810 nm wavelengths were collected. Three classical deep neural network (DNN) models (Inception V3, ResNet50, SE50) were trained. Sociodemographic and selected routine clinical data were obtained.
    Results: The accuracy of all DNNs with the single-spectral or multi-spectral combination images at the three wavelengths as input reached above 78%. The IS detection performance of DNNs with 605 nm spectral images as input was relatively more stable than with the other wavelengths. The multi-spectral combination models acquired a higher area under the curve (AUC) scores than the single-spectral models.
    Conclusions: The probability of IS secondary to AF could be predicted based on multi-spectrum fundus images using deep learning, and combinations of multi-spectrum images improved the performance of DNNs. Acquiring different spectral fundus images is advantageous for the early prevention of cardiovascular and cerebrovascular diseases. The method in this study is a beneficial preliminary and initiative exploration for diseases that are difficult to predict the onset time such as IS.
    Language English
    Publishing date 2023-08-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1185890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bronchus compression is a predictor for reobstruction in coarctation with hypoplastic arch repair.

    Hui, Chengyi / Ren, Qiushi / Zhuang, Jian / Chen, Jimei / Li, Xiaohua / Cui, Hujun / Cen, Jianzheng / Xu, Gang / Wen, Shusheng

    Interdisciplinary cardiovascular and thoracic surgery

    2023  Volume 37, Issue 5

    Abstract: Objectives: The surgical treatment of coarctation of aorta with hypoplastic aortic arch (CoA/HAA) was challenging to achieve long-lasting arch patency. We reviewed early and late outcomes in our centre and identified predictors for arch reobstruction.!## ...

    Abstract Objectives: The surgical treatment of coarctation of aorta with hypoplastic aortic arch (CoA/HAA) was challenging to achieve long-lasting arch patency. We reviewed early and late outcomes in our centre and identified predictors for arch reobstruction.
    Methods: A retrospective analysis of medical records was performed to identify CoA/HAA patients who underwent primary arch reconstruction via median sternotomy between 2011 and 2020. Preoperative aortic arch geometry was analysed with cardiac computed tomographic angiography. Bedside flexible fibre-optic bronchoscopy was routinely performed after surgery in intensive care unit.
    Results: There were 104 consecutive patients (median age 39.5 days) who underwent extended end-to-end anastomosis, extended end-to-side anastomosis and autograft patch augmentation. Early mortality was 3.8% and overall survival was 94.1% [95% confidence interval (CI) 89.6-98.8%] at 1, 3 and 5 years. Reobstruction-free survival was 85.1% (95% CI 78.4-92.3%) at 1 year, 80.6% (95% CI 73.1-88.9%) at 3 years and 77.4% (95% CI 69.2-86.6%) at 5 years. Preoperative aortic arch geometric parameters were not important factors for reobstruction. Nineteen patients (18.3%) were detected with left main bronchus compression (LMBC) on flexible fibre-optic bronchoscopy. Cardiopulmonary bypass time [P < 0.001, hazard ratio (95% CI): 1.02 (1.01-1.03)] and postoperative LMBC [P = 0.034, hazard ratio (95% CI): 2.99 (1.09-8.23)] were independent predictive factors on multivariable Cox regression analysis of reobstruction-free survival.
    Conclusions: Aortic arch can be satisfactorily repaired by extended end-to-end anastomosis, extended end-to-side anastomosis and autograft patch augmentation via median sternotomy in CoA/HAA. Cardiopulmonary bypass time and postoperative LMBC detected by flexible fibre-optic bronchoscopy are significant predictors for long-term arch reobstruction.
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ISSN 2753-670X
    ISSN (online) 2753-670X
    DOI 10.1093/icvts/ivad186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A CNN-based four-layer DOI encoding detector using LYSO and BGO scintillators for small animal PET imaging.

    He, Wen / Zhao, Yangyang / Zhao, Xin / Huang, Wenjie / Zhang, Lei / Prout, David L / Chatziioannou, Arion F / Ren, Qiushi / Gu, Zheng

    Physics in medicine and biology

    2023  Volume 68, Issue 9

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Animals ; Lutetium/chemistry ; Positron-Emission Tomography/methods ; Photons ; Neural Networks, Computer ; Gamma Rays
    Chemical Substances Lutetium (5H0DOZ21UJ)
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/accc07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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