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  1. Article ; Online: Porcine Intestinal Organoids: Overview of the State of the Art.

    Ma, Panpan / Fang, Puxian / Ren, Tianze / Fang, Liurong / Xiao, Shaobo

    Viruses

    2022  Volume 14, Issue 5

    Abstract: The intestinal tract is a crucial part of the body for growth and development, and its dysregulation can cause several diseases. The lack of appropriate in vitro models hampers the development of effective preventions and treatments against these ... ...

    Abstract The intestinal tract is a crucial part of the body for growth and development, and its dysregulation can cause several diseases. The lack of appropriate in vitro models hampers the development of effective preventions and treatments against these intestinal tract diseases. Intestinal organoids are three-dimensional (3D) polarized structures composed of different types of cells capable of self-organization and self-renewal, resembling their organ of origin in architecture and function. Porcine intestinal organoids (PIOs) have been cultured and are used widely in agricultural, veterinary, and biomedical research. Based on the similarity of the genomic sequence, anatomic morphology, and drug metabolism with humans and the difficulty in obtaining healthy human tissue, PIOs are also considered ideal models relative to rodents. In this review, we summarize the current knowledge on PIOs, emphasizing their culturing, establishment and development, and applications in the study of host-microbe interactions, nutritional development, drug discovery, and gene editing potential.
    MeSH term(s) Animals ; Drug Discovery ; Intestines ; Organoids ; Swine
    Language English
    Publishing date 2022-05-21
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14051110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Experimental and numerical investigations of solar charging performances of 3D porous skeleton based latent heat storage devices

    Yao, Haichen / Liu, Xianglei / Luo, Qingyang / Xu, Qiao / Tian, Yang / Ren, Tianze / Zheng, Hangbin / Gao, Ke / Dang, Chunzhuo / Xuan, Yimin / Liu, Zhan / Yang, Xiaohu / Ding, Yulong

    Elsevier Ltd Applied energy. 2022 Aug. 15, v. 320

    2022  

    Abstract: Volumetric-absorption-based solar charging via phase change processes is an emerging technology to harvest solar energy, however, how pore-scale radiation transport interacts with latent heat thermal energy storage processes is still vague. In this paper, ...

    Abstract Volumetric-absorption-based solar charging via phase change processes is an emerging technology to harvest solar energy, however, how pore-scale radiation transport interacts with latent heat thermal energy storage processes is still vague. In this paper, volumetric-absorption-based solar charging processes at pore scale are investigated by experiments and numerical simulations based on Monte Carlo ray tracing coupled with the Finite Volume Method. The solar radiation transport, temperature distribution, liquid fraction, and solar thermal energy storage efficiency are systematically evaluated under different radiation intensities and skeleton thermal conductivities. Compared to the traditional surface-absorption-based mode, solar thermal energy storage efficiency of the volumetric-absorption mode is enhanced by 94% due to presence of multi-region heat sources. The solar thermal energy storage efficiency reaches a peak value of 54.09% at a radiation intensity of 10 kW·m⁻². That is because low radiation intensities increase the melting time while too high intensities lead to large temperature nonuniformity, leading to high heat losses for both scenarios. Increasing the skeleton thermal conductivity can continuously improve the efficiency by reducing temperature nonuniformity, but further enhancement becomes marginal for thermal conductivity over 90 W·m⁻¹·K⁻¹. This work paves the way for the design and deployment of efficient integrated solar thermal conversion and latent heat storage systems.
    Keywords heat ; latent heat ; liquids ; radiative transfer ; skeleton ; solar radiation ; solar thermal energy ; temperature ; thermal conductivity ; thermal energy
    Language English
    Dates of publication 2022-0815
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2000772-3
    ISSN 0306-2619
    ISSN 0306-2619
    DOI 10.1016/j.apenergy.2022.119297
    Database NAL-Catalogue (AGRICOLA)

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