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  1. Article ; Online: Analysis of the detection of transfusion-related infectious diseases in blood recipients before transfusion.

    Ren, Xiaoliang / Zhuang, Hui / Guo, Nan / Wang, Bingshuang

    Minerva medica

    2024  

    Language English
    Publishing date 2024-02-15
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123586-2
    ISSN 1827-1669 ; 0026-4806
    ISSN (online) 1827-1669
    ISSN 0026-4806
    DOI 10.23736/S0026-4806.24.09176-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.132: Show issues Location:
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  2. Article ; Online: Nano Strategies for Artemisinin Derivatives to Enhance Reverse Efficiency of Multidrug Resistance in Breast Cancer.

    Zhang, Xueyan / Li, Na / Zhang, Guoqin / Li, Jiayang / Liu, Yi / Wang, Meng / Ren, Xiaoliang

    Current pharmaceutical design

    2024  Volume 29, Issue 43, Page(s) 3458–3466

    Abstract: Artemisinin (ART) has been found to exert anti-tumor activity by regulating the cell cycle, inducing apoptosis, inhibiting angiogenesis and tumor invasion and metastasis. Its derivatives (ARTs) can regulate the expression of drug-resistant proteins and ... ...

    Abstract Artemisinin (ART) has been found to exert anti-tumor activity by regulating the cell cycle, inducing apoptosis, inhibiting angiogenesis and tumor invasion and metastasis. Its derivatives (ARTs) can regulate the expression of drug-resistant proteins and reverse the multidrug resistance (MDR) of tumor cells by inhibiting intracellular drug efflux, inducing apoptosis and autophagy of tumor cells, thus enhancing the sensitivity of tumor cells to chemotherapy and radiotherapy. Recent studies have shown that nanodrugs play an important role in the diagnosis and treatment of cancer, which can effectively solve the shortcomings of poor hydrophilicity and low bioavailability of ARTs in the human body, prolong the in vivo circulation time, improve the targeting of drugs (including tumor tissues or specific organelles), and control the release of drugs in target tissues, thereby reducing the side effect. This review systematically summarized the latest research progress of nano-strategies of ARTs to enhance the efficiency of MDR reversal in breast cancer (BC) from the following two aspects: (1) Chemicals encapsulated in nanomaterials based on innovative anti-proliferation mechanism: non-ABC transporter receptor candidate related to ferroptosis (dihydroartemisinin/DHA analogs). (2) Combination therapy strategy of nanomedicine (drug-drug combination therapy, drug-gene combination, and chemical-physical therapy). Self-assembled nano-delivery systems enhance therapeutic efficacy through increased drug loading, rapid reactive release, optimized delivery sequence, and realization of cascade-increasing effects. New nanotechnology methods must be designed for specific delivery routines to achieve targeting administration and overcome MDR without affecting normal cells. The significance of this review is to expect that ART and ARTs can be widely used in clinical practice. In the future, nanotechnology can help people to treat multidrug resistance of breast cancer more accurately and efficiently.
    MeSH term(s) Female ; Humans ; Artemisinins/pharmacology ; Artemisinins/therapeutic use ; Breast Neoplasms/drug therapy ; Drug Resistance, Multiple ; Drug Therapy, Combination
    Chemical Substances artemisinin (9RMU91N5K2) ; Artemisinins
    Language English
    Publishing date 2024-01-17
    Publishing country United Arab Emirates
    Document type Journal Article ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128282248231205105408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
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  3. Article ; Online: A rapid-floating natural polysaccharide gel-raft with double-effect for the treatment of gastroesophageal reflux disease.

    Li, Na / Zhang, Guoqin / Zhang, Xueyan / Liu, Yi / Kong, Yan / Wang, Meng / Ren, Xiaoliang

    International journal of biological macromolecules

    2024  Volume 261, Issue Pt 1, Page(s) 129667

    Abstract: Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal condition characterized by regurgitating stomach contents into the esophagus, causing mucosal damage or erosion. Clinical physical protection treatment mainly relies on the use of ... ...

    Abstract Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal condition characterized by regurgitating stomach contents into the esophagus, causing mucosal damage or erosion. Clinical physical protection treatment mainly relies on the use of floating rafts. Bletilla striata (BS) is widely regarded as the first-choice drug for treating digestive tract injuries in Chinese Medicine. The rapid-floating gel-raft (B-R) was prepared via a one-step swelling method using natural BS polysaccharide and glyceryl monooleate. Panax notoginseng saponins (PNS) were loaded to further prepare P/B-R according to clinical experience. Possessing hydrophobic dense, stratified porous structure and stable rheological properties, an outperforming floating performance of P/B-R was proven compared with Gaviscon® (alginate-antacid formulation) in vitro. In vivo imaging results showed that P/B-R can retain and adhere to the gastric mucosa of rats for up to 90 min, protecting and repairing the mucosa. Besides physical protection in situ, the systemic effects of antioxidant and anti-inflammatory actions for treating GERD were achieved through the intestinal release of PNS. Acid-labile PNS was protected by P/B-R against gastric acid, attaining the desired release and permeability. A significantly effective mucosa injury protective effect of P/B-R was found in ethanol-induced gastric damage model on rats. Moreover, P/B-R exhibits excellent biosafety at the cellular level.
    MeSH term(s) Rats ; Animals ; Gastroesophageal Reflux/drug therapy ; Antacids ; Anti-Ulcer Agents
    Chemical Substances Antacids ; Anti-Ulcer Agents
    Language English
    Publishing date 2024-01-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2374: Show issues Location:
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  4. Article ; Online: Insight on Structural Modification, Cytotoxic or Anti-Proliferative Activity, Structure-Activity Relationship of Berberine Derivatives.

    Yin, Mengxuan / Mou, Jiajia / Sun, Lili / Deng, Yanru / Ren, Xiaoliang

    Medicinal chemistry (Shariqah (United Arab Emirates))

    2023  Volume 19, Issue 9, Page(s) 823–837

    Abstract: Berberine (BBR) is a quaternary ammonium alkaloid isolated from the Traditional Chinese ... ...

    Abstract Berberine (BBR) is a quaternary ammonium alkaloid isolated from the Traditional Chinese Medicine
    MeSH term(s) Berberine/pharmacology ; Berberine/chemistry ; Structure-Activity Relationship ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry
    Chemical Substances Berberine (0I8Y3P32UF) ; Antineoplastic Agents
    Language English
    Publishing date 2023-04-04
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-6638
    ISSN (online) 1875-6638
    DOI 10.2174/1573406419666230403120956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Structural modifications of berberine and their binding effects towards polymorphic deoxyribonucleic acid structures: A review.

    Fu, Lanlan / Mou, Jiajia / Deng, Yanru / Ren, Xiaoliang

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 940282

    Abstract: Berberine (BBR) is a plant derived quaternary benzylisoquinoline alkaloid, which has been widely used in traditional medicines for a long term. It possesses broad pharmacological effects and is widely applied in clinical. In recent years, the anti-tumor ... ...

    Abstract Berberine (BBR) is a plant derived quaternary benzylisoquinoline alkaloid, which has been widely used in traditional medicines for a long term. It possesses broad pharmacological effects and is widely applied in clinical. In recent years, the anti-tumor effects of BBR have attracted more and more attention of the researchers. The canonical right-handed double-stranded helical deoxyribonucleic acid (B-DNA) and its polymorphs occur under various environmental conditions and are involved in a plethora of genetic instability-related diseases especially tumor. BBR showed differential binding effects towards various polymorphic DNA structures. But its poor lipophilicity and fast metabolism limited its clinical utility. Structural modification of BBR is an effective approach to improve its DNA binding activity and bioavailability
    Language English
    Publishing date 2022-08-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.940282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characterization and classification of non-herbal honey and herb honey with the chemometric approach

    Feng, Tao / Liu, Meiqi / Liu, Guoqiang / Chen, Meiling / Sun, Lili / Wang, Meng / Ren, Xiaoliang

    Eur Food Res Technol. 2023 Mar., v. 249, no. 3 p.777-785

    2023  

    Abstract: Herbal honey, mainly from herbal plants, has certain clinical benefits. Because of its higher economic benefits, non-herbal honey is often used in the market as herbal honey. There is an urgent need to differentiate between different types and varieties ... ...

    Abstract Herbal honey, mainly from herbal plants, has certain clinical benefits. Because of its higher economic benefits, non-herbal honey is often used in the market as herbal honey. There is an urgent need to differentiate between different types and varieties of herbal honey and non-herbal honey. For this purpose, 31 honey samples of ten varieties were collected and synthesized for three characteristics (color, antioxidant capacity, and 16 kinds of phenolic content). From the principal component analysis, it was clear that the classification of non-herb honey by different plant origins (acacia honey, chaste honey, jujube honey, and linden tree honey). Self-organizing maps and pooled bagged trees were used to assess the effect of the ten honey varieties on all investigated characteristics. The results showed that polyphenols were the primary marker to distinguish them. Non-herbal honey was identified according to its botanical origins with the majority of scrub jungles, such as jujube honey, chaste honey, and linden tree honey. Herbal and acacia honey were divided into a group due to their similarity. The established method distinguishes between herbal and non-herbal honey for effective quality control of herbal honey. Moreover, the technique enriches the research related to honey and provides a reference for developing its quality standards.
    Keywords Acacia ; Ziziphus ; antioxidant activity ; chemometrics ; color ; honey ; markets ; polyphenols ; principal component analysis ; quality control ; shrublands ; trees
    Language English
    Dates of publication 2023-03
    Size p. 777-785.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1359456-4
    ISSN 1431-4630 ; 1438-2377
    ISSN 1431-4630 ; 1438-2377
    DOI 10.1007/s00217-022-04175-9
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 792: Show issues

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  7. Article ; Online: The Current Status and Trends of Chinese Medicine Polysaccharides: A Bibliometric Review [1998–2021]

    Feng, Tao / Ma, Zicheng / Li, Jingya / Sun, Lili / Wang, Meng / Chen, Meiling / Ren, Xiaoliang

    Starch ‐ Stärke. 2023 May, v. 75, no. 5-6 p.e2200221-

    2023  

    Abstract: Chinese medicine polysaccharides refer to a class of active polysaccharides extracted from traditional Chinese medicines. They are widely used natural macromolecules with various pharmacological activities such as antiviral, antibacterial, anti‐ ... ...

    Abstract Chinese medicine polysaccharides refer to a class of active polysaccharides extracted from traditional Chinese medicines. They are widely used natural macromolecules with various pharmacological activities such as antiviral, antibacterial, anti‐inflammatory, anti‐cancer, anti‐hypertensive, and antioxidant effects, as well as affecting the immunomodulation and regulation of intestinal flora. In recent years, the research on Chinese medicine polysaccharides in pharmacological disciplines has grown rapidly. To understand the research trends of Chinese medicine polysaccharides, this study adopts a bibliometric approach based on the Web of Science core database (WoSCC) by analyzing the publication year, authors, countries/regions, organizations, journals, and critical characteristics of relevant literature to explore the current and future research trends related to Chinese medicine polysaccharides. In addition, the traditional and modern extraction methods of Chinese medicine polysaccharides are reviewed. This paper lays a framework for the development of Chinese medicine polysaccharides. The information helps researchers explore new directions and perspectives for future research.
    Keywords Oriental traditional medicine ; antioxidants ; databases ; immunomodulation ; intestinal microorganisms ; starch
    Language English
    Dates of publication 2023-05
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 241168-4
    ISSN 0038-9056
    ISSN 0038-9056
    DOI 10.1002/star.202200221
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 1923: Show issues

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  8. Article: Design, Synthesis, and Activity Assays of Cyclin-Dependent Kinase 1 Inhibitors With Flavone Scaffolds.

    Fu, Lanlan / Mou, Jiajia / Deng, Yanru / Ren, Xiaoliang / Qiu, Shuang

    Frontiers in chemistry

    2022  Volume 10, Page(s) 940427

    Abstract: Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of ... ...

    Abstract Cyclin-dependent kinase 1 (CDK1) plays an indispensable role in the whole cell cycle. It has become a new target for cancer therapy. According to the binding mode of a pan-CDK inhibitor, flavopiridol with CDK1, and our previous work, a new series of flavone derivatives were discovered. Among them, compound
    Language English
    Publishing date 2022-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.940427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Structural characterization, antioxidant activity, and the effects of Codonopsis pilosula polysaccharides on the solubility and stability of flavonoids.

    Liu, Meiqi / Zhang, Guoqin / Zhou, Kexin / Wen, Jinli / Zheng, Fuxiang / Sun, Lili / Ren, Xiaoliang

    Journal of pharmaceutical and biomedical analysis

    2023  Volume 229, Page(s) 115368

    Abstract: Codonopsis pilosula (CP) possesses properties related to nourishing the spleen and stomach, and tonifying Qi of the stomach and mind in traditional Chinese medicine (TCM). Codonopsis pilosula polysaccharides (CPPS), which are the primary active ... ...

    Abstract Codonopsis pilosula (CP) possesses properties related to nourishing the spleen and stomach, and tonifying Qi of the stomach and mind in traditional Chinese medicine (TCM). Codonopsis pilosula polysaccharides (CPPS), which are the primary active components of CP, are thought to be in charge of their extensive use. Rutin, quercetin, luteoloside, and luteolin, are common and pharmacologically significant flavonoids with many pharmacological activities, but their oral bioavailability is limited by poor solubility and stability. In this study, high-performance gel permeation chromatography (HPGPC) estimated the molecular weight of CPPS to be 9.7 × 10
    MeSH term(s) Antioxidants/pharmacology ; Codonopsis/chemistry ; Solubility ; Flavonoids ; Polysaccharides/chemistry
    Chemical Substances Antioxidants ; Flavonoids ; Polysaccharides
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2023.115368
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1850: Show issues Location:
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  10. Article ; Online: Least Absolute Shrinkage and Selection Operator-Based Prediction of the Binding Constant of

    Yin, Yu / Yang, Zhen / Li, Na / Yu, Xuan / Chen, Mei-Ling / Wang, Meng / Ren, Xiao-Liang

    Journal of chemical information and modeling

    2024  Volume 64, Issue 2, Page(s) 359–377

    Abstract: ... ...

    Abstract p
    MeSH term(s) Medicine, Chinese Traditional ; Alkaloids/chemistry
    Chemical Substances Alkaloids
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.3c01272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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