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Article: Industrial Investment Funds, Government R&D Subsidies, and Technological Innovation: Evidence From Chinese Companies.

Ren, Yuan-Ming

2022 Volume 13, Page(s) 890208

Abstract: Industrial investment funds are a new financing innovation mode that can build an effective financing channel for enterprises.Based on the panel data of Chinese Listed Companies in 2008-2017, this manuscript constructed a static panel model between ... ...

Abstract	Industrial investment funds are a new financing innovation mode that can build an effective financing channel for enterprises.Based on the panel data of Chinese Listed Companies in 2008-2017, this manuscript constructed a static panel model between industrial investment funds, government R&D subsidies, and technological innovation to empirically analyze the effects of industrial investment fund involvement and government R&D subsidies on companies' technological innovation. The research shows that industrial investment fund involvement can increase the company's R&D investment by providing financial funds for the company, which can effectively solve the company's lack of funds in the process of technological innovation and guarantee the smooth running of the company's innovation activities. Secondly, government R&D subsidies can alleviate the pressure of R&D investment to a certain extent, which is conducive to promote a higher level of technological innovation in the company. Thirdly, for companies with industrial investment fund involvement, government R&D subsidies are conducive to promote technological innovation. In contrast, for companies without industrial investment fund involvement, government R&D subsidies have no significant impact on technological innovation to a certain extent or even have a "crowding out effect."
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.890208
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Article ; Online: Spacecraft Attitude Measurement and Control Using VSMSCSG and Fractional-Order Zeroing Neural Network Adaptive Steering Law.

Li, Lei / Ren, Yuan / Wang, Weijie / Pang, Weikun

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 3

Abstract: In order to improve the accuracy and convergence speed of the steering law under the conditions of high dynamics, high bandwidth, and a small deflection angle, and in an effort to improve attitude measurement and control accuracy of the spacecraft, a ... ...

Abstract	In order to improve the accuracy and convergence speed of the steering law under the conditions of high dynamics, high bandwidth, and a small deflection angle, and in an effort to improve attitude measurement and control accuracy of the spacecraft, a spacecraft attitude measurement and control method based on variable speed magnetically suspended control sensitive gyroscopes (VSMSCSGs) and the fractional-order zeroing neural network (FO-ZNN) steering law is proposed. First, a VSMSCSG configuration is designed to realize attitude measurement and control integration in which the VSMSCSGs are employed as both actuators and attitude-rate sensors. Second, a novel adaptive steering law using FO-ZNN is designed. The matrix pseudoinverses are replaced by FO-ZNN outputs, which solves the problem of accuracy degradation in the traditional pseudoinverse steering laws due to the complexity of matrix pseudoinverse operations under high dynamics conditions. In addition, the convergence and robustness of the FO-ZNN are proven. The results show that the proposed FO-ZNN converges faster than the traditional zeroing neural network under external disturbances. Finally, a new weighting function containing rotor deflection angles is added to the steering law to ensure that the saturation of the rotor deflection angles can be avoided. Semi-physical simulation results demonstrate the correctness and superiority of the proposed method.
Language	English
Publishing date	2024-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24030766
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Article ; Online: Transcriptomic and biochemical analysis of metabolic remodeling in Bacillus subtilis MSC4 under Benzo[a]pyrene stress.

Chen, Rui / Liu, Na / Ren, Yuan / Cui, Tangbing

Chemosphere

2024 Volume 353, Page(s) 141637

Abstract: Polyaromatic benzo[a]pyrene (B[a]P) is a toxic carcinogenic environmental pollutant, and the use of microorganisms to remediate B[a]P contamination is considered to be one of the most effective strategies. However, there is still a gap in studying the ... ...

Abstract	Polyaromatic benzo[a]pyrene (B[a]P) is a toxic carcinogenic environmental pollutant, and the use of microorganisms to remediate B[a]P contamination is considered to be one of the most effective strategies. However, there is still a gap in studying the metabolic remodeling of microorganisms under B[a]P stress. In this study, our systematically investigated the effects of B[a]P on the metabolism of Bacillus subtilis MSC4 based on transcriptomic, molecular and biochemical analyses. The results showed that in response to B[a]P stress, MSC4 formed more biofilm matrix and endospores, the structure of the endospores also was changed, which led to a reduction in their resistance and made them more difficult to germinate. In addition to an increase in glycolysis activity, the activities of tricarboxylic acid cycle, pentose phosphate pathway and the electron transport chain were decreased. B[a]P stress forced MSC4 to strengthen arginine synthesis, urea cycle, and urea decomposition, meanwhile, synthesize more ribonucleotides. The activity of DNA replication, transcription activities and the expression of multiple ribosomal protein genes were reduced. Moreover, all of the reported enzymes involved in B[a]P degradation showed decreased transcript abundance, and the degradation of B[a]P caused significant up-regulation of the gene expression of the acid inducible enzyme OxdC and the synthesis of acetoin. In addition, the cytotoxicity of B[a]P to bacteria was directly displayed in four aspects: increased intracellular level of reactive oxygen species (ROS), elevated cell membrane permeability, up-regulation of the cell envelope stress-sensing two-component system LiaRS, and downregulation of siderophores biosynthesis. Finally, B[a]P also caused morphological changes in the cells, with some cells exhibiting significant deformation and concavity. These findings provide effective research directions for targeted improvement the cellular activity of B[a]P-degrading strains, and is beneficial for further application of microorganisms to remediate B[a]P -contaminated soils.
MeSH term(s)	Benzo(a)pyrene/toxicity ; Benzo(a)pyrene/metabolism ; Bacillus subtilis/genetics ; Bacillus subtilis/metabolism ; Glycolysis ; Gene Expression Profiling ; Urea/metabolism
Chemical Substances	Benzo(a)pyrene (3417WMA06D) ; Urea (8W8T17847W)
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2024.141637
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Zs.A 2540: Show issues

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Article ; Online: Trace Analysis of Five Androgens in Environmental Waters by Optimization of Enzymolysis and Solid-Phase Extraction Ultra-Performance Liquid Chromatography-Mass Spectrometry and its Risk Assessment.

Xie, Yufei / Gao, Zhihan / Ren, Yuan

Environmental toxicology and chemistry

2024 Volume 43, Issue 4, Page(s) 915–925

Abstract: Steroid hormones (SHs) have received widespread attention in recent years. However, current studies of SHs have primarily focused on estrogenic substances, with androgen-related studies being quite limited. We optimized the solid-phase extraction (SPE) ... ...

Abstract	Steroid hormones (SHs) have received widespread attention in recent years. However, current studies of SHs have primarily focused on estrogenic substances, with androgen-related studies being quite limited. We optimized the solid-phase extraction (SPE) pretreatment method, as well as the enzymolysis conditions of five androgens (androstenedione, boldenone, methandienone, nandrolone, and testosterone), to simultaneously determine their concentrations in the effluent from wastewater treatment plants and surface water samples. Then we evaluated the ecological risks of the five androgens in the effluent and Pearl River basin of Guangzhou (PR China) using the risk quotient method. The recovery rates of the targets were 90% to 99% in water samples when digested with β-glucosidase for 90 min before solid-phase extraction, extracted with a Poly-Sery HLB column, and washed with 15% methanol aqueous solution and 2% ammonia. The established instrument's limit of detection was between 0.02 and 0.39 μg/L, and the limit of quantification was between 0.05 and 1.29 μg/L. Androstenedione, boldenone, methandienone, nandrolone, and testosterone were detected in all samples from the 2018 and 2022 wastewater influent and the 2018 surface water, with concentrations of 3.06 × 10
MeSH term(s)	Androgens ; Wastewater ; Liquid Chromatography-Mass Spectrometry ; Tandem Mass Spectrometry/methods ; Androstenedione/analysis ; Methandrostenolone/analysis ; Steroids ; Testosterone ; Water/chemistry ; Nandrolone/analysis ; Solid Phase Extraction ; Risk Assessment ; Chromatography, High Pressure Liquid/methods ; Water Pollutants, Chemical/analysis
Chemical Substances	Androgens ; Wastewater ; Androstenedione (409J2J96VR) ; Methandrostenolone (COZ1R7EOCC) ; Steroids ; Testosterone (3XMK78S47O) ; Water (059QF0KO0R) ; Nandrolone (6PG9VR430D) ; Water Pollutants, Chemical
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	46234-2
ISSN	1552-8618 ; 0730-7268
ISSN (online)	1552-8618
ISSN	0730-7268
DOI	10.1002/etc.5805
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Zs.A 2312: Show issues

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Article ; Online: Real-time multilingual speech recognition and speaker diarization system based on Whisper segmentation.

Lyu, Ke-Ming / Lyu, Ren-Yuan / Chang, Hsien-Tsung

PeerJ. Computer science

2024 Volume 10, Page(s) e1973

Abstract: This research presents the development of a cutting-edge real-time multilingual speech recognition and speaker diarization system that leverages OpenAI's Whisper model. The system specifically addresses the challenges of automatic speech recognition (ASR) ...

Abstract	This research presents the development of a cutting-edge real-time multilingual speech recognition and speaker diarization system that leverages OpenAI's Whisper model. The system specifically addresses the challenges of automatic speech recognition (ASR) and speaker diarization (SD) in dynamic, multispeaker environments, with a focus on accurately processing Mandarin speech with Taiwanese accents and managing frequent speaker switches. Traditional speech recognition systems often fall short in such complex multilingual and multispeaker contexts, particularly in SD. This study, therefore, integrates advanced speech recognition with speaker diarization techniques optimized for real-time applications. These optimizations include handling model outputs efficiently and incorporating speaker embedding technology. The system was evaluated using data from Taiwanese talk shows and political commentary programs, featuring 46 diverse speakers. The results showed a promising word diarization error rate (WDER) of 2.68% in two-speaker scenarios and 11.65% in three-speaker scenarios, with an overall WDER of 6.96%. This performance is comparable to that of non-real-time baseline models, highlighting the system's ability to adapt to various complex conversational dynamics, a significant advancement in the field of real-time multilingual speech processing.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Journal Article
ISSN	2376-5992
ISSN (online)	2376-5992
DOI	10.7717/peerj-cs.1973
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Article ; Online: Isolated THATCH domain of End4 is unable to bind F-actin independently in the fission yeast

Ren, Yuan / Berro, Julien

microPublication biology

2022 Volume 2022

Abstract: Clathrin mediated endocytosis (CME) in the fission ... ...

Abstract	Clathrin mediated endocytosis (CME) in the fission yeast
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2578-9430
ISSN (online)	2578-9430
DOI	10.17912/micropub.biology.000508
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Article ; Online: Treatment of diabetic retinopathy with herbs for tonifying kidney and activating blood circulation: A review of pharmacological studies.

Liang, Huan / Ren, Yuan / Huang, Yuxia / Xie, Xuejun / Zhang, Mei

Journal of ethnopharmacology

2024 Volume 328, Page(s) 118078

Abstract: Ethnopharmacological relevance: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes. Chinese medicine believes that kidney deficiency and blood stasis are significant pathogenesis of DR. A characteristic therapeutic approach ... ...

Abstract	Ethnopharmacological relevance: Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes. Chinese medicine believes that kidney deficiency and blood stasis are significant pathogenesis of DR. A characteristic therapeutic approach for this pathogenesis is the kidney-tonifying and blood-activating method. By literature retrieval from several databases, we methodically summarized the commonly used kidney-tonifying and blood-activating herbs for treating DR, including Lycii Fructus, Rehmanniane Radix Praeparata, and Corni Fructus with the function of nourishing kidney; Salvia Miltiorrhizae Radix et Rhizoma with the function of enhancing blood circulation; Rehmanniae Radix with the function of nourishing kidney yin; and Astragali Radix with the function of tonifying qi. It has been demonstrated that these Chinese herbs described above, by tonifying the kidney and activating blood circulation, significantly improve the course of DR. Aim of the study: Through literature research, to gain a thorough comprehension of the pathogenesis of DR. Simultaneously, through the traditional application analysis, modern pharmacology research and network pharmacology analysis of kidney-tonifying and blood-activating herbs, to review the effectiveness and advantages of kidney-tonifying and blood-activating herbs in treating DR comprehensively. Materials and methods: PubMed, the China National Knowledge Infrastructure (CNKI), and Wanfang Data were used to filter the most popular herbs for tonifying kidney and activating blood in the treatment of DR. The search terms were "diabetic retinopathy" and "tonifying kidney and activating blood". Mostly from 2000 to 2023. Network pharmacology was applied to examine the key active components and forecast the mechanisms of kidney-tonifying and blood-activating herbs in the treatment of DR. Results: Kidney deficiency and blood stasis are the pathogenesis of DR, and the pathogenesis is linked to oxidative stress, inflammation, hypoxia, and hyperglycemia. Scientific data and network pharmacology analysis have demonstrated the benefit of tonifying kidney and activating blood herbs in treating DR through several channels, multiple components, and multiple targets. Conclusions: This review first presents useful information for subsequent research into the material foundation and pharmacodynamics of herbs for tonifying kidney and activating blood, and offers fresh insights into the treatment of DR.
MeSH term(s)	Humans ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Diabetic Retinopathy/drug therapy ; Medicine, Chinese Traditional ; Plant Roots ; Kidney ; Diabetes Mellitus/drug therapy
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-20
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118078
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Zs.A 1494: Show issues

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Article ; Online: Management of duodenal foreign bodies using the novel combined laparoscopic and endoscopic approaches in two unique cases.

Wang, Fang-Tao / Gao, Ren-Yuan / Wu, Tian-Qi / Chen, Chun-Qiu

Asian journal of surgery

2024 Volume 47, Issue 5, Page(s) 2302–2303

MeSH term(s)	Humans ; Laparoscopy/methods ; Foreign Bodies/surgery ; Foreign Bodies/diagnostic imaging ; Duodenum/surgery ; Male ; Female ; Adult ; Treatment Outcome
Language	English
Publishing date	2024-02-09
Publishing country	Netherlands
Document type	Letter ; Case Reports
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.01.162
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Article ; Online: Simultaneous inversion method of thermal barrier coating parameters based on electromagnetic/capacitive dual-module sensor.

Wang, Wei / Ren, Yuan / Hu, Jiafei / Chen, Dixiang

The Review of scientific instruments

2023 Volume 94, Issue 1, Page(s) 15002

Abstract: Thermal barrier coating (TBC) of turbine blades can prevent aeroengine damage resulting from high temperature. TBC exhibits a multilayer complex structure of ceramic and bonding layers. The ceramic layer is dielectric, whereas the bonding layer is ... ...

Abstract	Thermal barrier coating (TBC) of turbine blades can prevent aeroengine damage resulting from high temperature. TBC exhibits a multilayer complex structure of ceramic and bonding layers. The ceramic layer is dielectric, whereas the bonding layer is conductive. Disabling either layer can endanger aircraft safety. Changes in TBC parameters are indicative of failure. This study proposed a neural-network-based method to inverse the three key parameters of TBC simultaneously based on electromagnetic/capacitive dual-module sensor. Thus, this method can be used for monitoring the status of aeroengines. The experimental results revealed that the inversion error of thickness and permittivity of the ceramic layer and the conductivity of the bonding layer is less than 2%. Therefore, the proposed method can satisfy application requirements.
Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0132563
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Article ; Online: Exploration of the mechanism of 2-CP degradation by Acinetobacter sp. stimulated by Lactobacillus plantarum fermentation waste: A bio-waste reuse.

Lin, Han / Chen, Guotao / Zhang, Zhen / Ren, Yuan

Environmental research

2023 Volume 231, Issue Pt 1, Page(s) 116119

Abstract: Green and economical pollution management methods which reusing bio-waste as biostimulant to effectively improve the removal of target pollutants are receiving more and more attention. In this study, Lactobacillus plantarum fermentation waste solution ( ... ...

Abstract	Green and economical pollution management methods which reusing bio-waste as biostimulant to effectively improve the removal of target pollutants are receiving more and more attention. In this study, Lactobacillus plantarum fermentation waste solution (LPS) was used to investigate its facilitative effect and the stimulation mechanisms on the degradation of 2-chlorophenol (2-CP) by strain Acinetobacter sp. strain ZY1 in terms of both cell physiology and transcriptomics. The degradation efficiency of 2-CP was improved from 60% to > 80% under LPS treatment. The biostimulant maintained the morphology of strain, reduced the level of reactive oxygen species, and recovered the cell membrane permeability from 39% to 22%. It also significantly increased the level of electron transfer activity and extracellular polymeric substances secretion and improved the metabolic activity of the strain. The transcriptome results revealed the stimulation of LPS to promote biological processes such as bacterial proliferation, metabolism, membrane structure composition, and energy conversion. This study provided new insights and references for the reuse of fermentation waste streams in biostimulation methods.
MeSH term(s)	Fermentation ; Lactobacillus plantarum/metabolism ; Acinetobacter/metabolism ; Lipopolysaccharides/metabolism ; Reactive Oxygen Species/metabolism
Chemical Substances	Lipopolysaccharides ; Reactive Oxygen Species
Language	English
Publishing date	2023-05-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116119
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