Article: Dysbiotic Proteobacteria expansion: a microbial signature of epithelial dysfunction
Current opinion in microbiology. 2017 Oct., v. 39
2017
Abstract: A balanced gut microbiota is important for health, but the mechanisms maintaining homeostasis are incompletely understood. Anaerobiosis of the healthy colon drives the composition of the gut microbiota towards a dominance of obligate anaerobes, while ... ...
Abstract | A balanced gut microbiota is important for health, but the mechanisms maintaining homeostasis are incompletely understood. Anaerobiosis of the healthy colon drives the composition of the gut microbiota towards a dominance of obligate anaerobes, while dysbiosis is often associated with a sustained increase in the abundance of facultative anaerobic Proteobacteria, indicative of a disruption in anaerobiosis. The colonic epithelium is hypoxic, but intestinal inflammation or antibiotic treatment increases epithelial oxygenation in the colon, thereby disrupting anaerobiosis to drive a dysbiotic expansion of facultative anaerobic Proteobacteria through aerobic respiration. These observations suggest a dysbiotic expansion of Proteobacteria is a potential diagnostic microbial signature of epithelial dysfunction, a hypothesis that could spawn novel preventative or therapeutic strategies for a broad spectrum of human diseases. |
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Keywords | aerobiosis ; anaerobes ; anaerobiosis ; antibiotics ; colon ; epithelium ; homeostasis ; human diseases ; inflammation ; intestinal microorganisms ; Proteobacteria ; spawning |
Language | English |
Dates of publication | 2017-10 |
Size | p. 1-6. |
Publishing place | Elsevier Ltd |
Document type | Article |
ZDB-ID | 1418474-6 |
ISSN | 1879-0364 ; 1369-5274 |
ISSN (online) | 1879-0364 |
ISSN | 1369-5274 |
DOI | 10.1016/j.mib.2017.07.003 |
Database | NAL-Catalogue (AGRICOLA) |
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