Article ; Online: Morbillivirus Experimental Animal Models
Viruses, Vol 8, Iss 10, p
Measles Virus Pathogenesis Insights from Canine Distemper Virus
2016 Volume 274
Abstract: Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one ... ...
| Abstract | Morbilliviruses share considerable structural and functional similarities. Even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. Thus, insights gained with one morbillivirus often apply to the other members of the genus. Since the Canine distemper virus (CDV) causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate the efficacy of new prophylactic and therapeutic approaches. This review compares the cellular tropism, pathogenesis, mechanisms of persistence and immunosuppression of the Measles virus (MeV) and CDV. It then summarizes the contributions made by studies on the CDV in dogs and ferrets to our understanding of MeV pathogenesis and to vaccine and drugs development. |
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| Keywords | morbillivirus genus ; canine distemper virus ; animal models ; pathogenesis ; Microbiology ; QR1-502 ; Science ; Q |
| Subject code | 630 |
| Language | English |
| Publishing date | 2016-10-01T00:00:00Z |
| Publisher | MDPI AG |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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