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  1. Article ; Online: Pregnancies and Gynecological Follow-Up after Solid Organ Transplantation

    Alice Bedin / Marie Carbonnel / Renaud Snanoudj / Antoine Roux / Sarah Vanlieferinghen / Claire Marchiori / Alexandre Hertig / Catherine Racowsky / Jean-Marc Ayoubi

    Journal of Clinical Medicine, Vol 11, Iss 16, p

    Experience of a Decade

    2022  Volume 4792

    Abstract: In recent years, solid organ transplantations, such as kidney or lung grafts, have been performed worldwide with an improvement of quality of life under immunosuppressive therapy and an increase in life expectancy, allowing young women to consider ... ...

    Abstract In recent years, solid organ transplantations, such as kidney or lung grafts, have been performed worldwide with an improvement of quality of life under immunosuppressive therapy and an increase in life expectancy, allowing young women to consider childbearing. In the current study, we conduct a retrospective study in two French centers for kidney and lung transplantations to evaluate the rate and outcomes of pregnancies, contraception and gynecological monitoring for women under 40 years old who underwent solid organ transplantation. Among 210 women, progestin was the most widely used contraceptive method. Of the 210 women, 24 (11.4%) conceived 33 pregnancies of which 25 (75.8%) were planned with an immunosuppressant therapy switch. Of the 33 pregnancies, 7 miscarried (21.2%) and 21 (63.7%) resulted in a live birth with a high rate of pre-eclampsia (50%). No graft rejections were observed during pregnancies. Among the deliveries, 19 were premature (90.5%, mostly due to induced delivery) and the C-section rate was high (52.4%). No particular pathology was identified among newborns. We conclude that pregnancies following solid organ transplantation are feasible, and while they are at an increased risk of pre-eclampsia and prematurity, they should still be permitted with close surveillance by a multidisciplinary care team.
    Keywords pregnancy ; organ transplantation ; immunosuppression ; kidney ; lung ; gynecology ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Uterus Transplantation with Live Donors

    Marie Carbonnel / Aurelie Revaux / Elena Menzhulina / Lea Karpel / Renaud Snanoudj / Morgan Le Guen / Dominique De Ziegler / Jean Marc Ayoubi

    Journal of Clinical Medicine, Vol 9, Iss 2001, p

    Screening Candidates in One French Center

    2020  Volume 2001

    Abstract: We report our experience regarding the profile and screening process of potential recipients (R) and their live donors (D) in our Uterus transplantation (UTx) trial from 2014 to 2020. The initial screening was performed using medical questionnaires and ... ...

    Abstract We report our experience regarding the profile and screening process of potential recipients (R) and their live donors (D) in our Uterus transplantation (UTx) trial from 2014 to 2020. The initial screening was performed using medical questionnaires and consultations. The second step of the screening consisted of two individual interviews with an independent multidisciplinary committee. Then, a complete medical, biological and imaging assessment of the directed living D, the R, and her partner was performed over a two-day hospitalization. A total of 239 women contacted our department: 165 potentials R and 74 potentials D. During the first step of screening, 141 R and 45 D were excluded. Only 12 R/D pairs were pursued. During inclusion, 10 R/D pairs were excluded. One R/D pair is still under evaluation. Finally, only 1 R/D pair was definitively included (0.6%), which led us to perform the first French UTx in March 2019 with a successful graft. The primary limiting factors of inclusion were due to very strict criteria and difficulty of having a suitable directed living D. The International Society of UTx (ISUTx) guidelines based on worldwide results of trials can help ease our inclusion criteria in the future while remaining safe for patients.
    Keywords uterine ; uterus ; transplant ; transplantation ; screening ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: COVID-19 in Patients on Maintenance Dialysis in the Paris Region

    Sarah Tortonese / Ivan Scriabine / Louis Anjou / Christopher Loens / Arthur Michon / Mohammed Benabdelhak / Sarah Ouali / Gabriel Morin / Marwa Laifi / Hélène Dobosziewicz / Matthieu Guillet / Manon Dekeyser / Liem Binh Luong Nguyen / Anne Grünenwald / Julien Dang / Geoffroy Desbuissons / Laurent Becquemont / Renaud Snanoudj / Christophe Legendre /
    Hadia Hebibi / Edouard Lefèvre / Séverine Beaudreuil / Mohamad Zaidan

    Kidney International Reports, Vol 5, Iss 9, Pp 1535-

    2020  Volume 1544

    Abstract: Introduction: Coronavirus disease 2019 (COVID-19) represents a serious threat to patients on maintenance dialysis. The clinical setting, mortality rate, and prognostic factors in these patients have not been well established. Methods: We included all ... ...

    Abstract Introduction: Coronavirus disease 2019 (COVID-19) represents a serious threat to patients on maintenance dialysis. The clinical setting, mortality rate, and prognostic factors in these patients have not been well established. Methods: We included all dialyzed patients with COVID-19 referred to our dialysis center between March 11 and April 11, 2020. Data were obtained through the review of the medical records and were censored at the time of data cutoff, on May 11, 2020. Results: Forty-four patients on maintenance dialysis with COVID-19 were referred to our dialysis unit during the COVID-19 epidemic. Median age was 61 years (interquartile range [IQR]: 51.5–72.5); 65.9% were men. Comorbidities included hypertension (97.7%), diabetes mellitus (50%), and chronic cardiac (38.6%) and respiratory (27.3%) diseases. Initial symptoms were fever (79.5%), shortness of breath (29.5%), cough (43.2%), and diarrhea (13.6%). Three profiles of severity were distinguished based on the World Health Organization (WHO) progression scale. Forty-one (93.2%) were hospitalized and only 3 were maintained on outpatient hemodialysis. Thirty-three (75%) patients required oxygen therapy, including 15 (45.5%) who were referred to the intensive care unit. Overall, 27.3% of patients died, and 58.5% were discharged from hospital, including only 2 (13.3%) of those admitted to the intensive care unit. By multivariate analysis, cough, thrombopenia <120 g/l, lactate dehydrogenase (LDH) level greater than 2 times the upper limit of normal, and blood C-reactive protein (CRP) >175 mg/l were significantly associated with death. Conclusion: A major outbreak of COVID-19 occurred in the Paris region, and spread among dialyzed patients. Our study underscores the severity of COVID-19 in these patients and identified prognostic markers.
    Keywords coronavirus ; COVID-19 ; hemodialysis ; kidney ; peritoneal dialysis ; Diseases of the genitourinary system. Urology ; RC870-923 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Home and Office Blood Pressure Monitoring in Renal Transplant Recipients

    Rebecca Sberro-Soussan / Marion Rabant / Renaud Snanoudj / Julien Zuber / Lynda Bererhi / Marie-France Mamzer / Christophe Legendre / Eric Thervet

    Journal of Transplantation, Vol

    2012  Volume 2012

    Keywords Surgery ; RD1-811 ; Medicine ; R
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  5. Article ; Online: Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab

    Taylor Pindi Sala / Jean-Marie Michot / Renaud Snanoudj / Marion Dollat / Emmanuel Estève / Bernadette Marie / Yacine Taoufik / Jean-François Delfraissy / Thierry Lazure / Olivier Lambotte

    Case Reports in Medicine, Vol

    2014  Volume 2014

    Abstract: Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. ... ...

    Abstract Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving small vessels with deposition of immunoglobulin A (IgA) complexes, usually affecting children. Compared with children, HSP in adults is more severe and frequently associated with cancer. We report the case of a 49-year-old woman with medical history of kidney transplantation for segmental glomerular hyalinosis. Eight years after the transplantation, while taking combined immunosuppressive therapy with tacrolimus and azathioprine indicated for the prevention against transplant rejection, she developed a Henoch-Schönlein purpura. Vasculitis involves skin and sciatic peroneal nerve and she received systemic corticosteroid treatment. Because of four relapses and corticosteroid dependence, the patient was treated with rituximab (two intravenous infusions of 1000 mg given two weeks apart). Successful outcome was observed along two years of follow-up. This new case of successful use of rituximab in HSP promotes more investigations of this treatment in clinical trials.
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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