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  1. Article ; Online: Prehospital and emergency department airway management of severe penetrating trauma in Sweden during the past decade.

    Renberg, Mattias / Dahlberg, Martin / Gellerfors, Mikael / Rostami, Elham / Günther, Mattias

    Scandinavian journal of trauma, resuscitation and emergency medicine

    2023  Volume 31, Issue 1, Page(s) 85

    Abstract: Background: Prehospital tracheal intubation (TI) is associated with increased mortality in patients with penetrating trauma, and the utility of prehospital advanced airway management is debated. The increased incidence of deadly violence in Sweden ... ...

    Abstract Background: Prehospital tracheal intubation (TI) is associated with increased mortality in patients with penetrating trauma, and the utility of prehospital advanced airway management is debated. The increased incidence of deadly violence in Sweden warrants a comprehensive evaluation of current airway management for patients with penetrating trauma in the Swedish prehospital environment and on arrival in the emergency department (ED).
    Methods: This was an observational, multicenter study of all patients with penetrating trauma and injury severity scores (ISSs) ≥ 15 included in the Swedish national trauma register (SweTrau) between 2011 and 2019. We investigated the frequency and characteristics of prehospital and ED TI, including 30-day mortality and patient characteristics associated with TI.
    Result: Of 816 included patients, 118 (14.5%) were intubated prehospitally, and 248 (30.4%) were intubated in the ED. Patients who were intubated prehospitally had a higher ISS, 33 (interquartile range [IQR] 25, 75), than those intubated in the ED, 25 (IQR 18, 34). Prehospital TI was associated with a higher associated mortality, OR 4.26 (CI 2.57, 7.27, p < 0.001) than TI in the ED, even when adjusted for ISS (OR 2.88 [CI 1.64, 5.14, p < 0.001]). Hemodynamic collapse (≤ 40 mmHg) and low GCS score (≤ 8) were the characteristics most associated with prehospital TI. Traumatic cardiac arrests (TCAs) occurred in 154 (18.9%) patients, of whom 77 (50%) were intubated prehospitally and 56 (36.4%) were intubated in the ED. A subgroup analysis excluding TCA showed that patients with prehospital TI did not have a higher mortality rate than those with ED TI, OR 2.07 (CI 0.93, 4.51, p = 0.068), with OR 1.39 (0.56, 3.26, p = 0.5) when adjusted for ISS.
    Conclusion: Prehospital TI was associated with a higher mortality rate than those with ED TI, which was specifically related to TCA; intubation did not affect mortality in patients without cardiac arrest. Mortality was high when airway management was needed, regardless of cardiac arrest, thereby emphasizing the challenges posed when anesthesia is needed. Several interventions, including whole blood transfusions, the implementation of second-tier EMS units and measures to shorten scene times, have been initiated in Sweden to counteract these challenges.
    MeSH term(s) Humans ; Sweden/epidemiology ; Emergency Medical Services ; Retrospective Studies ; Emergency Service, Hospital ; Airway Management ; Wounds, Penetrating/epidemiology ; Wounds, Penetrating/therapy ; Intubation, Intratracheal ; Heart Arrest
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Observational Study ; Multicenter Study ; Journal Article
    ZDB-ID 2455990-8
    ISSN 1757-7241 ; 1757-7241
    ISSN (online) 1757-7241
    ISSN 1757-7241
    DOI 10.1186/s13049-023-01151-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prehospital transportation of severe penetrating trauma victims in Sweden during the past decade: a police business?

    Renberg, Mattias / Dahlberg, Martin / Gellerfors, Mikael / Rostami, Amir / Günther, Mattias / Rostami, Elham

    Scandinavian journal of trauma, resuscitation and emergency medicine

    2023  Volume 31, Issue 1, Page(s) 45

    Abstract: Introduction: Sweden is facing a surge of gun violence that mandates optimized prehospital transport approaches, and a survey of current practice is fundamental for such optimization. Management of severe, penetrating trauma is time sensitive, and there ...

    Abstract Introduction: Sweden is facing a surge of gun violence that mandates optimized prehospital transport approaches, and a survey of current practice is fundamental for such optimization. Management of severe, penetrating trauma is time sensitive, and there may be a survival benefit in limiting prehospital interventions. An important aspect is unregulated transportation by police or private vehicles to the hospital, which may decrease time but may also be associated with adverse outcomes. It is not known whether transport of patients with penetrating trauma occurs outside the emergency medical services (EMS) in Sweden and whether it affects outcome.
    Method: This was a retrospective, descriptive nationwide study of all patients with penetrating trauma and injury severity scores (ISSs) ≥ 15 registered in the Swedish national trauma registry (SweTrau) between June 13, 2011, and December 31, 2019. We hypothesized that transport by police and private vehicles occurred and that it affected mortality.
    Result: A total of 657 patients were included. EMS transported 612 patients (93.2%), police 10 patients (1.5%), and private vehicles 27 patients (4.1%). Gunshot wounds (GSWs) were more common in police transport, 80% (n = 8), compared with private vehicles, 59% (n = 16), and EMS, 32% (n = 198). The Glasgow coma scale score (GCS) in the emergency department (ED) was lower for patients transported by police, 11.5 (interquartile range [IQR] 3, 15), in relation to EMS, 15 (IQR 14, 15) and private vehicles 15 (IQR 12.5, 15). The 30-day mortality for EMS was 30% (n = 184), 50% (n = 5) for police transport, and 22% (n = 6) for private vehicles. Transport by private vehicle, odds ratio (OR) 0.65, (confidence interval [CI] 0.24, 1.55, p = 0.4) and police OR 2.28 (CI 0.63, 8.3, p = 0.2) were not associated with increased mortality in relation to EMS.
    Conclusion: Non-EMS transports did occur, however with a low incidence and did not affect mortality. GSWs were more common in police transport, and victims had lower GCS scorescores when arriving at the ED, which warrants further investigations of the operational management of shooting victims in Sweden.
    MeSH term(s) Humans ; Wounds, Gunshot/epidemiology ; Wounds, Gunshot/therapy ; Sweden/epidemiology ; Police ; Retrospective Studies ; Wounds, Penetrating ; Emergency Medical Services
    Language English
    Publishing date 2023-09-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2455990-8
    ISSN 1757-7241 ; 1757-7241
    ISSN (online) 1757-7241
    ISSN 1757-7241
    DOI 10.1186/s13049-023-01112-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pediatric Prehospital Advanced Airway Management by Anesthesiologist and Nurse Anesthetist Staffed Critical Care Teams.

    Renberg, Mattias / Hertzberg, Daniel / Kornhall, Daniel / Günther, Mattias / Gellerfors, Mikael

    Prehospital and disaster medicine

    2021  Volume 36, Issue 5, Page(s) 547–552

    Abstract: Introduction: Prehospital pediatric tracheal intubation (TI) is a possible life-saving intervention that requires adequate experience to mitigate associated complications. The pediatric airway and respiratory physiology present challenges in addition to ...

    Abstract Introduction: Prehospital pediatric tracheal intubation (TI) is a possible life-saving intervention that requires adequate experience to mitigate associated complications. The pediatric airway and respiratory physiology present challenges in addition to a relatively rare incidence of prehospital pediatric TI.
    Study objective: The aim of this study was to describe characteristics and outcomes of prehospital TI in pediatric patients treated by critical care teams.
    Methods: This is a sub-group analysis of all pediatric (<16 years old) patients from a prospective, observational, multi-center study on prehospital advanced airway management in the Nordic countries from May 2015 through November 2016. The TIs were performed by anesthesiologists and nurse anesthetists staffing six helicopter and six Rapid Response Car (RRC) prehospital critical care teams.
    Results: In the study, 74 children were tracheal intubated, which corresponds to 3.7% (74/2,027) of the total number of patients. The pediatric patients were intubated by very experienced providers, of which 80% had performed ≥2,500 TIs. The overall TI success rate, first pass success rate, and airway complication rate were in all children (<16 years) 98%, 82%, and 12%. The corresponding rates among infants (<2 years) were 94%, 67%, and 11%. The median time on scene was 30 minutes.
    Conclusion: This study observed a high overall prehospital TI success rate in children with relatively few associated complications and short time on scene, despite the challenges presented by the pediatric prehospital TI.
    MeSH term(s) Adolescent ; Airway Management ; Anesthesiologists ; Child ; Critical Care ; Emergency Medical Services ; Humans ; Infant ; Intubation, Intratracheal ; Nurse Anesthetists ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2021-07-13
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1025975-2
    ISSN 1945-1938 ; 1049-023X
    ISSN (online) 1945-1938
    ISSN 1049-023X
    DOI 10.1017/S1049023X21000637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients – A prospective multicenter observational study (iSOFA study)

    Reintam Blaser, Annika / Padar, Martin / Mändul, Merli / Elke, Gunnar / Engel, Christoph / Fischer, Krista / Giabicani, Mikhael / Gold, Thomas / Hess, Benjamin / Hiesmayr, Michael / Jakob, Stephan M. / Loudet, Cecilia I. / Meesters, Dennis M. / Mongkolpun, Wasineenart / Paugam-Burtz, Catherine / Poeze, Martijn / Preiser, Jean-Charles / Renberg, Mattias / Rooijackers, Olav /
    Tamme, Kadri / Wernerman, Jan / Starkopf, Joel

    Clinical nutrition. 2021 Aug., v. 40, no. 8

    2021  

    Abstract: To develop a five grade score (0–4 points) for the assessment of gastrointestinal (GI) dysfunction in adult critically ill patients.This prospective multicenter observational study enrolled consecutive adult patients admitted to 11 intensive care units ... ...

    Abstract To develop a five grade score (0–4 points) for the assessment of gastrointestinal (GI) dysfunction in adult critically ill patients.This prospective multicenter observational study enrolled consecutive adult patients admitted to 11 intensive care units in nine countries. At all sites, daily clinical data with emphasis on GI clinical symptoms were collected and intra-abdominal pressure measured. In five out of 11 sites, the biomarkers citrulline and intestinal fatty acid-binding protein (I-FABP) were measured additionally. Cox models with time-dependent scores were used to analyze associations with 28- and 90-day mortality. The models were estimated with stratification for study center.We included 540 patients (224 with biomarker measurements) with median age of 65 years (range 18–94), the Simplified Acute Physiology Score II score of 38 (interquartile range 26–53) points, and Sequential Organ Failure Assessment (SOFA) score of 6 (interquartile range 3–9) points at admission. Median ICU length of stay was 3 (interquartile range 1–6) days and 90-day mortality 18.9%.A new five grade Gastrointestinal Dysfunction Score (GIDS) was developed based on the rationale of the previously developed Acute GI Injury (AGI) grading. Citrulline and I-FABP did not prove their potential for scoring of GI dysfunction in critically ill. GIDS was independently associated with 28- and 90-day mortality when added to SOFA total score (HR 1.40; 95%CI 1.07–1.84 and HR 1.40; 95%CI 1.02–1.79, respectively) or to a model containing all SOFA subscores (HR 1.48; 95%CI 1.13–1.92 and HR 1.47; 95%CI 1.15–1.87, respectively), improving predictive power of SOFA score in all analyses.The newly developed GIDS is additive to SOFA score in prediction of 28- and 90-day mortality. The clinical usefulness of this score should be validated prospectively.NCT02613000, retrospectively registered 24 November 2015.
    Keywords adults ; biomarkers ; citrulline ; clinical nutrition ; fatty acid-binding proteins ; health status ; intestines ; models ; mortality ; observational studies ; prediction
    Language English
    Dates of publication 2021-08
    Size p. 4932-4940.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2021.07.015
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients - A prospective multicenter observational study (iSOFA study).

    Reintam Blaser, Annika / Padar, Martin / Mändul, Merli / Elke, Gunnar / Engel, Christoph / Fischer, Krista / Giabicani, Mikhael / Gold, Thomas / Hess, Benjamin / Hiesmayr, Michael / Jakob, Stephan M / Loudet, Cecilia I / Meesters, Dennis M / Mongkolpun, Wasineenart / Paugam-Burtz, Catherine / Poeze, Martijn / Preiser, Jean-Charles / Renberg, Mattias / Rooijackers, Olav /
    Tamme, Kadri / Wernerman, Jan / Starkopf, Joel

    Clinical nutrition (Edinburgh, Scotland)

    2021  Volume 40, Issue 8, Page(s) 4932–4940

    Abstract: Background & aims: To develop a five grade score (0-4 points) for the assessment of gastrointestinal (GI) dysfunction in adult critically ill patients.: Methods: This prospective multicenter observational study enrolled consecutive adult patients ... ...

    Abstract Background & aims: To develop a five grade score (0-4 points) for the assessment of gastrointestinal (GI) dysfunction in adult critically ill patients.
    Methods: This prospective multicenter observational study enrolled consecutive adult patients admitted to 11 intensive care units in nine countries. At all sites, daily clinical data with emphasis on GI clinical symptoms were collected and intra-abdominal pressure measured. In five out of 11 sites, the biomarkers citrulline and intestinal fatty acid-binding protein (I-FABP) were measured additionally. Cox models with time-dependent scores were used to analyze associations with 28- and 90-day mortality. The models were estimated with stratification for study center.
    Results: We included 540 patients (224 with biomarker measurements) with median age of 65 years (range 18-94), the Simplified Acute Physiology Score II score of 38 (interquartile range 26-53) points, and Sequential Organ Failure Assessment (SOFA) score of 6 (interquartile range 3-9) points at admission. Median ICU length of stay was 3 (interquartile range 1-6) days and 90-day mortality 18.9%. A new five grade Gastrointestinal Dysfunction Score (GIDS) was developed based on the rationale of the previously developed Acute GI Injury (AGI) grading. Citrulline and I-FABP did not prove their potential for scoring of GI dysfunction in critically ill. GIDS was independently associated with 28- and 90-day mortality when added to SOFA total score (HR 1.40; 95%CI 1.07-1.84 and HR 1.40; 95%CI 1.02-1.79, respectively) or to a model containing all SOFA subscores (HR 1.48; 95%CI 1.13-1.92 and HR 1.47; 95%CI 1.15-1.87, respectively), improving predictive power of SOFA score in all analyses.
    Conclusions: The newly developed GIDS is additive to SOFA score in prediction of 28- and 90-day mortality. The clinical usefulness of this score should be validated prospectively.
    Trial registration: NCT02613000, retrospectively registered 24 November 2015.
    MeSH term(s) Abdomen/physiopathology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Citrulline/blood ; Critical Illness/mortality ; Fatty Acid-Binding Proteins/blood ; Female ; Gastrointestinal Diseases/diagnosis ; Gastrointestinal Tract/physiopathology ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Organ Dysfunction Scores ; Predictive Value of Tests ; Pressure ; Proportional Hazards Models ; Prospective Studies ; Simplified Acute Physiology Score ; Time Factors ; Young Adult
    Chemical Substances Biomarkers ; Fatty Acid-Binding Proteins ; Citrulline (29VT07BGDA)
    Language English
    Publishing date 2021-07-18
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2021.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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