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Article: New Challenges for Anatomists in the Era of Omics.

Stabile, Anna Maria / Pistilli, Alessandra / Mariangela, Ruggirello / Rende, Mario / Bartolini, Desirée / Di Sante, Gabriele

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 18

Abstract: Anatomic studies have traditionally relied on macroscopic, microscopic, and histological techniques to investigate the structure of tissues and organs. Anatomic studies are essential in many fields, including medicine, biology, and veterinary science. ... ...

Abstract	Anatomic studies have traditionally relied on macroscopic, microscopic, and histological techniques to investigate the structure of tissues and organs. Anatomic studies are essential in many fields, including medicine, biology, and veterinary science. Advances in technology, such as imaging techniques and molecular biology, continue to provide new insights into the anatomy of living organisms. Therefore, anatomy remains an active and important area in the scientific field. The consolidation in recent years of some omics technologies such as genomics, transcriptomics, proteomics, and metabolomics allows for a more complete and detailed understanding of the structure and function of cells, tissues, and organs. These have been joined more recently by "omics" such as radiomics, pathomics, and connectomics, supported by computer-assisted technologies such as neural networks, 3D bioprinting, and artificial intelligence. All these new tools, although some are still in the early stages of development, have the potential to strongly contribute to the macroscopic and microscopic characterization in medicine. For anatomists, it is time to hitch a ride and get on board omics technologies to sail to new frontiers and to explore novel scenarios in anatomy.
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13182963
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Article ; Online: The unknown and misunderstood life of Ruggero Oddi, the pioneer of biliary system physiology.

Maovaz, Marco / Di Sante, Gabriele / Bartolini, Desirée / Pistilli, Alessandra / Stabile, Anna Maria / Rende, Mario

Journal of medical biography

2023 , Page(s) 9677720231188721

Abstract: Ruggero Oddi was a talented scientist who initiated the modern era of biliary system physiology, not only with the anatomical discovery of the hepatopancreatic sphincter, but also with the detailed description of its spinal center and nerve regulation. ... ...

Abstract	Ruggero Oddi was a talented scientist who initiated the modern era of biliary system physiology, not only with the anatomical discovery of the hepatopancreatic sphincter, but also with the detailed description of its spinal center and nerve regulation. However, his personal and scientific life were determined by an incredible series of unfortunate circumstances. Until now most of these events have been unknown, while the few known have produced biographies distorted by fake interpretations. The purpose of this article is to document Oddi's biography and scientific production in detail, comprehensively framing the scientific environment in which his discoveries occurred. It clears many misinterpretations about events in Oddi's life and academic career, bringing to a new light his figure as scientist in gastroenterological field.
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1159267-9
ISSN	1758-1087 ; 0967-7720
ISSN (online)	1758-1087
ISSN	0967-7720
DOI	10.1177/09677720231188721
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Article ; Online: The S100B Protein: A Multifaceted Pathogenic Factor More Than a Biomarker.

Michetti, Fabrizio / Clementi, Maria Elisabetta / Di Liddo, Rosa / Valeriani, Federica / Ria, Francesco / Rende, Mario / Di Sante, Gabriele / Romano Spica, Vincenzo

International journal of molecular sciences

2023 Volume 24, Issue 11

Abstract: S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system. Its levels in biological fluids are recognized as a reliable biomarker of active neural distress, and more recently, mounting evidence points to S100B as a Damage- ...

Abstract	S100B is a calcium-binding protein mainly concentrated in astrocytes in the nervous system. Its levels in biological fluids are recognized as a reliable biomarker of active neural distress, and more recently, mounting evidence points to S100B as a Damage-Associated Molecular Pattern molecule, which, at high concentration, triggers tissue reactions to damage. S100B levels and/or distribution in the nervous tissue of patients and/or experimental models of different neural disorders, for which the protein is used as a biomarker, are directly related to the progress of the disease. In addition, in experimental models of diseases such as Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, multiple sclerosis, traumatic and vascular acute neural injury, epilepsy, and inflammatory bowel disease, alteration of S100B levels correlates with the occurrence of clinical and/or toxic parameters. In general, overexpression/administration of S100B worsens the clinical presentation, whereas deletion/inactivation of the protein contributes to the amelioration of the symptoms. Thus, the S100B protein may be proposed as a common pathogenic factor in different disorders, sharing different symptoms and etiologies but appearing to share some common pathogenic processes reasonably attributable to neuroinflammation.
MeSH term(s)	Humans ; Biomarkers/metabolism ; Nervous System Diseases ; Parkinson Disease/metabolism ; S100 Calcium Binding Protein beta Subunit
Chemical Substances	Biomarkers ; S100 Calcium Binding Protein beta Subunit ; S100B protein, human
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24119605
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Article ; Online: Melatonin as a Repairing Agent in Cadmium- and Free Fatty Acid-Induced Lipotoxicity.

Migni, Anna / Mancuso, Francesca / Baroni, Tiziano / Di Sante, Gabriele / Rende, Mario / Galli, Francesco / Bartolini, Desirée

Biomolecules

2023 Volume 13, Issue 12

Abstract: 1) Background: Cadmium (Cd) is a potentially toxic element with a long half-life in the human body (20-40 years). Cytotoxicity mechanisms of Cd include increased levels of oxidative stress and apoptotic signaling, and recent studies have suggested that ... ...

Abstract	(1) Background: Cadmium (Cd) is a potentially toxic element with a long half-life in the human body (20-40 years). Cytotoxicity mechanisms of Cd include increased levels of oxidative stress and apoptotic signaling, and recent studies have suggested that these aspects of Cd toxicity contribute a role in the pathobiology of non-alcoholic fatty liver disease (NAFLD), a highly prevalent ailment associated with hepatic lipotoxicity and an increased generation of reactive oxygen species (ROS). In this study, Cd toxicity and its interplay with fatty acid (FA)-induced lipotoxicity have been studied in intestinal epithelium and liver cells; the cytoprotective function of melatonin (MLT) has been also evaluated. (2) Methods: human liver cells (HepaRG), primary murine hepatocytes and Caco-2 intestinal epithelial cells were exposed to CdCl
MeSH term(s)	Mice ; Humans ; Animals ; Fatty Acids, Nonesterified ; Cadmium/pharmacology ; Melatonin/pharmacology ; Reactive Oxygen Species ; Caco-2 Cells ; Hepatocytes ; Non-alcoholic Fatty Liver Disease/prevention & control ; Fatty Acids/pharmacology ; Palmitic Acid/pharmacology ; Oleic Acid/pharmacology
Chemical Substances	Fatty Acids, Nonesterified ; Cadmium (00BH33GNGH) ; Melatonin (JL5DK93RCL) ; Reactive Oxygen Species ; Fatty Acids ; Palmitic Acid (2V16EO95H1) ; Oleic Acid (2UMI9U37CP)
Language	English
Publishing date	2023-12-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13121758
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Article ; Online: In Vitro and Ex Vivo Methodologies for T-Cell Trafficking Through Blood-Brain Barrier After TLR Activation.

Moliterni, Camilla / Tredicine, Maria / Pistilli, Alessandra / Falcicchia, Renato / Bartolini, Desirée / Stabile, Anna Maria / Rende, Mario / Ria, Francesco / Di Sante, Gabriele

Methods in molecular biology (Clifton, N.J.)

2023 Volume 2700, Page(s) 199–219

Abstract: This chapter describes ex vivo isolation of human T cells and of naïve splenocytes respectively collected from multiple sclerosis patients and healthy controls and experimental autoimmune encephalomyelitis-affected mice. After the magnetic sorting of ... ...

Abstract	This chapter describes ex vivo isolation of human T cells and of naïve splenocytes respectively collected from multiple sclerosis patients and healthy controls and experimental autoimmune encephalomyelitis-affected mice. After the magnetic sorting of naïve and activated T helper lymphocytes, we provide details about the cell cultures to measure the interaction with extracellular matrix proteins using standard cell invasion or hand-made in vitro assays, upon different stimuli, through Toll-like receptor(s) ligands, T-cell activators, and cell adhesion molecules modulators. Finally, we describe the methods to harvest and recover T cells to evaluate the properties associated with their trafficking ability.
MeSH term(s)	Humans ; Animals ; Mice ; Blood-Brain Barrier ; T-Lymphocytes ; Protein Transport ; Cell Culture Techniques ; Cell Movement
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-3366-3_12
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Article ; Online: The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

Michetti, Fabrizio / Di Sante, Gabriele / Clementi, Maria Elisabetta / Valeriani, Federica / Mandarano, Martina / Ria, Francesco / Di Liddo, Rosa / Rende, Mario / Romano Spica, Vincenzo

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations ... ...

Abstract	The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.
MeSH term(s)	Humans ; Diabetes Mellitus ; Obesity ; Adiposity ; Adipose Tissue ; Astrocytes ; S100 Calcium Binding Protein beta Subunit
Chemical Substances	S100B protein, human ; S100 Calcium Binding Protein beta Subunit
Language	English
Publishing date	2024-01-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25020776
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Article ; Online: Subcellular distribution and Nrf2/Keap1-interacting properties of Glutathione S-transferase P in hepatocellular carcinoma.

Bartolini, Desirée / Stabile, Anna Maria / Migni, Anna / Gurrado, Fabio / Lioci, Gessica / De Franco, Francesca / Mandarano, Martina / Svegliati-Baroni, Gianluca / Di Cristina, Manlio / Bellezza, Guido / Rende, Mario / Galli, Francesco

Archives of biochemistry and biophysics

2024 , Page(s) 110043

Abstract: The oncogene and phase 2 detoxification enzyme glutathione S-transferase P (GSTP) is a GSH-dependent chaperone of signal transduction and transcriptional proteins with key role in liver carcinogenesis. In this study, we explored this role of GSTP in ... ...

Abstract	The oncogene and phase 2 detoxification enzyme glutathione S-transferase P (GSTP) is a GSH-dependent chaperone of signal transduction and transcriptional proteins with key role in liver carcinogenesis. In this study, we explored this role of GSTP in hepatocellular carcinoma (HCC) investigating the possible interaction of this protein with one of its transcription factor and metronome of cancer cell redox, namely the nuclear factor erythroid 2-related factor 2 (Nrf2). Expression, cellular distribution, and function as glutathionylation factor of GSTP1-1 isoform were investigated in the mouse model of N-nitrosodiethylamine (DEN)-induced HCC and in vitro in human HCC cell lines. The GSTP-Nrf2/Keap1 physical and functional interaction was investigated by immunoprecipitation and gene manipulation experiments. GSTP protein increased its liver expression, enzymatic activity and nuclear levels during DEN-induced tumor development in mice; protein glutathionylation (PSSG) was increased in the tumor masses. Higher levels and a preferential nuclear localization of GSTP protein were also observed in HepG2 and Huh-7 hepatocarcinoma cells compared to HepaRG non-cancerous cells, along with increased basal and Ebselen-stimulated levels of free GSH and PSSG. GSTP activity inhibition with the GSH analogue EZT induced apoptotic cell death in HCC cells. Hepatic Nrf2 and c-Jun, two transcription factors involved in GSTP expression and GSH biosynthesis, were induced in DEN-HCC compared to control animals; the Nrf2 inhibitory proteins Keap1 and β-TrCP also increased and GSTP co-immunoprecipitated with both Nrf2 and Keap1. Nrf2 nuclear translocation and β-TrCP expression also increased in HCC cells, whereas the GSTP transfection in HepaRG cells induced Nrf2 transcriptional activation. In conclusion, GSTP expression and subcellular distribution can contribute to the GSH-dependent redox reprogramming of HCC cells directly influencing the Nrf2/Keap1 system.
Language	English
Publishing date	2024-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2024.110043
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Article ; Online: Short-Term Effects of Side-Stream Smoke on Nerve Growth Factor and Its Receptors TrKA and p75

Stabile, Anna Maria / Pistilli, Alessandra / Bartolini, Desirée / Angelucci, Eleonora / Dell'Omo, Marco / Di Sante, Gabriele / Rende, Mario

International journal of environmental research and public health

2022 Volume 19, Issue 16

Abstract: Environmental tobacco smoke remains a major risk factor, for both smokers and non-smokers, able to trigger the initiation and/or the progression of several human diseases. Although in recent times governments have acted with the aim of banning or ... ...

Abstract	Environmental tobacco smoke remains a major risk factor, for both smokers and non-smokers, able to trigger the initiation and/or the progression of several human diseases. Although in recent times governments have acted with the aim of banning or strongly reducing its impact within public places and common spaces, environmental tobacco smoke remains a major pollutant in private places, such as the home environment or cars. Several inflammatory and long-term biomarkers have been analysed and well-described, but the list of mediators modulated during the early phases of inhalation of environmental tobacco smoke needs to be expanded. The aim of this study was to measure the short-term effects after exposure to side-stream smoke on Nerve Growth Factor and its receptors Tropomyosin-related kinase A and neurotrophin p75, molecules already described in health conditions and respiratory diseases. Twenty-one non-smokers were exposed to a home-standardized level of SS as well as to control smoke-free air. Nerve Growth Factor and inflammatory cytokines levels, as well the expression of Tropomyosin-related kinase A and neurotrophin receptor p75, were analysed in white blood cells. The present study demonstrates that during early phases, side-stream smoke exposure induced increases in the percentage of neurotrophin receptor p75-positive white blood cells, in their mean fluorescent intensity, and in gene expression. In addition, we found a positive correlation between the urine cotinine level and the percentage of neurotrophin receptor-positive white blood cells. For the first time, the evidence that short-term exposure to side-stream smoke is able to increase neurotrophin receptor p75 expression confirms the very early involvement of this receptor, not only among active smokers but also among non-smokers exposed to SS. Furthermore, the correlation between cotinine levels in urine and the increase in neurotrophin receptor p75-positive white blood cells could represent a potential novel molecule to be investigated for the detection of SS exposure at early time points.
MeSH term(s)	Cotinine ; Humans ; Non-Smokers ; Receptor, Nerve Growth Factor ; Receptor, trkA/genetics ; Receptor, trkA/metabolism ; Receptors, Nerve Growth Factor/genetics ; Receptors, Nerve Growth Factor/metabolism ; Rivers ; Tobacco Smoke Pollution/adverse effects ; Tropomyosin
Chemical Substances	Receptor, Nerve Growth Factor ; Receptors, Nerve Growth Factor ; Tobacco Smoke Pollution ; Tropomyosin ; Receptor, trkA (EC 2.7.10.1) ; Cotinine (K5161X06LL)
Language	English
Publishing date	2022-08-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191610317
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Article ; Online: Wheat germ oil vitamin E cytoprotective effect and its nutrigenomics signature in human hepatocyte lipotoxicity

Bartolini, Desirée / Marinelli, Rita / Stabile, Anna Maria / Frammartino, Tiziana / Guerrini, Angela / Garetto, Stefano / Lucci, Jacopo / Migni, Anna / Zatini, Linda / Marcantonini, Giada / Rende, Mario / Galli, Francesco

Heliyon. 2022 Sept., v. 8, no. 9 p.e10748-

2022

Abstract: Wheat germ oil (WGO) is rich in α-tocopherol (vitamin E, VE), a vitamin that has long been suggested to exert hepatoprotective effects. In this study, this function of WGO-VE and its transcriptomics fingerprint were investigated in comparison with RRR−α- ... ...

Abstract	Wheat germ oil (WGO) is rich in α-tocopherol (vitamin E, VE), a vitamin that has long been suggested to exert hepatoprotective effects. In this study, this function of WGO-VE and its transcriptomics fingerprint were investigated in comparison with RRR−α-tocopherol and all-rac-α-tocopherol (nVE and sVE, respectively), in human liver cells treated with oleic acid (OA) to develop steatosis and lipotoxicity. Used in chemoprevention mode, all the VE formulations afforded significant reduction of the OA-induced steatosis and its consequent impact on lipotoxicity indicators, including ROS production and efflux (as H₂O₂), and apoptotic and necrotic cell death. A trend toward a better control of lipotoxicity was observed for WGO-VE and nVE compared to sVE. Gene microarray data demonstrated that these effects of VE formulations were associated with significantly different responses of the cellular transcriptome to compensate for the modifications of OA treatment, including the downregulation of cellular homeostasis genes and the induction of genes associated with defects of liver cell metabolism, fibrosis and inflammation, liver disease and cancer. Ingenuity Pathway Analysis data showed that WGO-VE modulated genes associated with liver carcinogenesis and steatosis, whereas nVE modulated genes involved in liver cell metabolism and viability biofunctions; sVE did not significantly modulate any gene dataset relevant to such biofunctions. In conclusion, WGO-VE prevents lipotoxicity in human liver cells modulating genes that differ from those affected by the natural or synthetic forms of pure VE. These differences can be captured by precision nutrition tools, reflecting the molecular complexity of this VE-rich extract and its potential in preventing specific cues of hepatocellular lipotoxicity.
Keywords	alpha-tocopherol ; apoptosis ; carcinogenesis ; chemoprevention ; data collection ; fibrosis ; genes ; hepatocytes ; homeostasis ; humans ; inflammation ; lipotoxicity ; liver ; liver diseases ; metabolism ; microarray technology ; necroptosis ; nutrigenomics ; oleic acid ; transcriptome ; transcriptomics ; viability ; wheat germ oil ; Vitamin E ; NAFLD ; NASH ; Human hepatocytes ; Reactive oxygen species ; Precision nutrition
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10748
Database	NAL-Catalogue (AGRICOLA)

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Article: A Possible Role for Nerve Growth Factor and Its Receptors in Human Sperm Pathology.

Stabile, Anna Maria / Pistilli, Alessandra / Moretti, Elena / Bartolini, Desirée / Ruggirello, Mariangela / Rende, Mario / Castellini, Cesare / Mattioli, Simona / Ponchia, Rosetta / Tripodi, Sergio Antonio / Collodel, Giulia

Biomedicines

2023 Volume 11, Issue 12

Abstract: Nerve growth factor (NGF) signalling affects spermatogenesis and mature sperm traits. In this paper, we aimed to evaluate the distribution and the role of NGF and its receptors ( ... ...

Abstract	Nerve growth factor (NGF) signalling affects spermatogenesis and mature sperm traits. In this paper, we aimed to evaluate the distribution and the role of NGF and its receptors (p75
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11123345
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