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  1. Article ; Online: Carborane-Containing Polymers: Synthesis, Properties, and Applications.

    Zhang, Xinyi / Rendina, Louis M / Müllner, Markus

    ACS polymers Au

    2023  Volume 4, Issue 1, Page(s) 7–33

    Abstract: Carboranes are an important class of electron-delocalized icosahedral carbon-boron clusters with unique physical and chemical properties, which can offer various functions to polymers including enhanced heat-resistance, tuned electronic properties and ... ...

    Abstract Carboranes are an important class of electron-delocalized icosahedral carbon-boron clusters with unique physical and chemical properties, which can offer various functions to polymers including enhanced heat-resistance, tuned electronic properties and hydrophobicity, special ability of dihydrogen bond formation, and thermal neutron capture. Carborane-containing polymers have been synthesized mainly by means of step-growth polymerizations of disubstituted carborane monomers, with chain-growth polymerizations of monosubstituted carborane monomers including ATRP, RAFT, and ROMP only utilized recently. Carborane-containing polymers may find application as harsh-environment resistant materials, ceramic precursors, fluorescent materials with tuned emissive properties, novel optoelectronic devices, potential BNCT agents, and drug carriers with low cytotoxicity. This review highlights carborane-containing polymer synthesis strategies and potential applications, showcasing the versatile properties and possibilities that this unique family of boron compounds can provide to the polymeric systems.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2694-2453
    ISSN (online) 2694-2453
    DOI 10.1021/acspolymersau.3c00030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gadolinium theranostics for the diagnosis and treatment of cancer.

    Robertson, Amy G / Rendina, Louis M

    Chemical Society reviews

    2021  Volume 50, Issue 7, Page(s) 4231–4244

    Abstract: According to the World Health Organization (WHO), there were 18.1 million new cancer cases and 9.6 million cancer deaths reported worldwide in 2018. These numbers are expected to rise over the next decade, and the development of new and effective cancer ... ...

    Abstract According to the World Health Organization (WHO), there were 18.1 million new cancer cases and 9.6 million cancer deaths reported worldwide in 2018. These numbers are expected to rise over the next decade, and the development of new and effective cancer treatments and diagnostic tools is urgently required, particularly for aggressive and intractable malignant cancers such as those of the brain. An exciting field of cancer research involves combining therapeutic and diagnostic tools into a single 'theranostic' platform. The role of theranostics in the personalized management of oncology patients is increasing, as is the demand for new types of theranostic agents. Some of the most promising cancer theranostics exploit the lanthanoid metal gadolinium, an element possessing favourable therapeutic and imaging properties.
    MeSH term(s) Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Gadolinium/chemistry ; Gadolinium/therapeutic use ; Humans ; Neoplasms/diagnosis ; Neoplasms/drug therapy ; Precision Medicine ; Theranostic Nanomedicine
    Chemical Substances Antineoplastic Agents ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d0cs01075h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Carboranes in drug discovery, chemical biology and molecular imaging.

    Marfavi, Anita / Kavianpour, Poya / Rendina, Louis M

    Nature reviews. Chemistry

    2022  Volume 6, Issue 7, Page(s) 486–504

    Abstract: There exists a paucity of structural innovation and limited molecular diversity associated with molecular frameworks in drug discovery and biomolecular imaging/chemical probe design. The discovery and exploitation of new molecular entities for medical ... ...

    Abstract There exists a paucity of structural innovation and limited molecular diversity associated with molecular frameworks in drug discovery and biomolecular imaging/chemical probe design. The discovery and exploitation of new molecular entities for medical and biological applications will necessarily involve voyaging into previously unexplored regions of chemical space. Boron clusters, notably the carboranes, offer an alternative to conventional (poly)cyclic organic frameworks that may address some of the limitations associated with the use of novel molecular frameworks in chemical biology or medicine. The high thermal stability, unique 3D structure and aromaticity, kinetic inertness to metabolism and ability to engage in unusual types of intermolecular interactions, such as dihydrogen bonds, with biological receptors make carboranes exquisite frameworks in the design of probes for chemical biology, novel drug candidates and biomolecular imaging agents. This Review highlights the key developments of carborane derivatives made over the last decade as new design tools in medicinal chemistry and chemical biology, showcasing the versatility of this unique family of boron compounds.
    MeSH term(s) Boranes/chemistry ; Drug Discovery ; Boron Compounds/therapeutic use ; Molecular Imaging ; Biology
    Chemical Substances Boranes ; Boron Compounds
    Language English
    Publishing date 2022-06-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2397-3358
    ISSN (online) 2397-3358
    DOI 10.1038/s41570-022-00400-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cutting edge rare earth radiometals: prospects for cancer theranostics.

    Sadler, Alexander W E / Hogan, Leena / Fraser, Benjamin / Rendina, Louis M

    EJNMMI radiopharmacy and chemistry

    2022  Volume 7, Issue 1, Page(s) 21

    Abstract: Background: With recent advances in novel approaches to cancer therapy and imaging, the application of theranostic techniques in personalised medicine has emerged as a very promising avenue of research inquiry in recent years. Interest has been directed ...

    Abstract Background: With recent advances in novel approaches to cancer therapy and imaging, the application of theranostic techniques in personalised medicine has emerged as a very promising avenue of research inquiry in recent years. Interest has been directed towards the theranostic potential of Rare Earth radiometals due to their closely related chemical properties which allow for their facile and interchangeable incorporation into identical bifunctional chelators or targeting biomolecules for use in a diverse range of cancer imaging and therapeutic applications without additional modification, i.e. a "one-size-fits-all" approach. This review will focus on recent progress and innovations in the area of Rare Earth radionuclides for theranostic applications by providing a detailed snapshot of their current state of production by means of nuclear reactions, subsequent promising theranostic capabilities in the clinic, as well as a discussion of factors that have impacted upon their progress through the theranostic drug development pipeline.
    Main body: In light of this interest, a great deal of research has also been focussed towards certain under-utilised Rare Earth radionuclides with diverse and favourable decay characteristics which span the broad spectrum of most cancer imaging and therapeutic applications, with potential nuclides suitable for α-therapy (
    Conclusions: In order to exploit the potential of these radionuclides, reliable and economical production and purification methods that provide the desired radionuclides in high yield and purity are required. With more reactors around the world being decommissioned in future, solutions to radionuclide production issues will likely be found in a greater focus on linear accelerator and cyclotron infrastructure and production methods, as well as mass separation methods. Recent progress towards the optimisation of these and other radionuclide production and purification methods has increased the feasibility of utilising Rare Earth radiometals in both preclinical and clinical settings, thereby placing them at the forefront of radiometals research for cancer theranostics.
    Language English
    Publishing date 2022-08-26
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2365-421X
    ISSN (online) 2365-421X
    DOI 10.1186/s41181-022-00173-0
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  5. Article ; Online: Significant cell uptake of Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes: evidence for a new conformationally-dependent tumour cell targeting vector.

    Hall, Andrew J / Robertson, Amy G / Baker, Robert W / Hill, Leila R / Rendina, Louis M

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 83, Page(s) 12511–12514

    Abstract: The synthesis, characterisation, and tumour cell uptake of six novel Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes are reported. The propyl-linked Gd(III) complexes can accumulate inside human glioma cells at prodigious levels, approaching ... ...

    Abstract The synthesis, characterisation, and tumour cell uptake of six novel Gd(III)-diphenylphosphoryl-diphenylphosphonium complexes are reported. The propyl-linked Gd(III) complexes can accumulate inside human glioma cells at prodigious levels, approaching 1200%, over the parent triphenylphosphonium salts. DFT and quantum chemical topology analyses support a new type of conformationally-dependent tumour cell targeting vector.
    MeSH term(s) Humans ; Gadolinium/pharmacology ; Gadolinium/chemistry ; Neoplasms/pathology
    Chemical Substances Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc02706f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Synthesis and tumour cell uptake studies of gadolinium(III)-phosphonium complexes.

    Hall, Andrew J / Robertson, Amy G / Hill, Leila R / Rendina, Louis M

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 598

    Abstract: The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are ... ...

    Abstract The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determined to be low at therapeutically-relevant concentrations. Selected Gd(III) complexes are potential candidates for further investigation as theranostic agents.
    MeSH term(s) Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Cell Proliferation ; Gadolinium/chemistry ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Organophosphorus Compounds/chemical synthesis ; Organophosphorus Compounds/pharmacokinetics ; Organophosphorus Compounds/pharmacology ; Tissue Distribution ; Tumor Cells, Cultured
    Chemical Substances Antineoplastic Agents ; Organophosphorus Compounds ; Gadolinium (AU0V1LM3JT)
    Language English
    Publishing date 2021-01-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-79893-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Carborane clusters increase the potency of bis-substituted cyclam derivatives against

    Smith, Nicholas / Quan, Diana / Nagalingam, Gayathri / Triccas, James A / Rendina, Louis M / Rutledge, Peter J

    RSC medicinal chemistry

    2022  Volume 13, Issue 10, Page(s) 1234–1238

    Abstract: Bis-substituted cyclam derivatives have recently emerged as a promising new class of antibacterial agents, displaying excellent activity against drug- ... ...

    Abstract Bis-substituted cyclam derivatives have recently emerged as a promising new class of antibacterial agents, displaying excellent activity against drug-resistant
    Language English
    Publishing date 2022-08-02
    Publishing country England
    Document type Journal Article
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d2md00150k
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  8. Article ; Online: Histone Deacetylase 2 (HDAC2) Inhibitors Containing Boron.

    Kavianpour, Poya / Gemmell, Madeleine C M / Kahlert, Jan U / Rendina, Louis M

    Chembiochem : a European journal of chemical biology

    2020  Volume 21, Issue 19, Page(s) 2786–2791

    Abstract: Histone deacetylase enzymes (HDACs) are responsible for the global silencing of tumour-suppressor genes. Treatment with a histone deacetylase inhibitor (HDACi) can reverse this process and restore normal cell function. Herein, we report a small series of ...

    Abstract Histone deacetylase enzymes (HDACs) are responsible for the global silencing of tumour-suppressor genes. Treatment with a histone deacetylase inhibitor (HDACi) can reverse this process and restore normal cell function. Herein, we report a small series of boron-based (boronic acid, boronate ester and closo-1,2-carborane) HDAC2 inhibitors with IC
    MeSH term(s) Boron Compounds/chemical synthesis ; Boron Compounds/chemistry ; Boron Compounds/pharmacology ; Histone Deacetylase 2/antagonists & inhibitors ; Histone Deacetylase 2/metabolism ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Molecular Structure
    Chemical Substances Boron Compounds ; Histone Deacetylase Inhibitors ; HDAC2 protein, human (EC 3.5.1.98) ; Histone Deacetylase 2 (EC 3.5.1.98)
    Language English
    Publishing date 2020-06-16
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202000131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Can lithium salts herald a new era for neutron capture therapy?

    Rendina, Louis M

    Journal of medicinal chemistry

    2010  Volume 53, Issue 23, Page(s) 8224–8227

    MeSH term(s) Boron Neutron Capture Therapy ; Humans ; Lithium Compounds/chemistry ; Lithium Compounds/therapeutic use ; Neoplasms/therapy ; Salts
    Chemical Substances Lithium Compounds ; Salts
    Language English
    Publishing date 2010-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm100836m
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  10. Article: Selective delivery of remarkably high levels of gadolinium to tumour cells using an arsonium salt

    Windsor, Madeline S. A. / Busse, Madleen / Morrison, Daniel E. / Baker, Robert W. / Hill, Leila R. / Rendina, Louis M.

    Chemical communications. 2021 Sept. 1, v. 57, no. 70

    2021  

    Abstract: The use of a triphenylarsonium vector for tumour cell-targeting leads to a dramatic increase in Gd³⁺ uptake in human glioblastoma multiforme cells by up to an order of magnitude over the isosteric triarylphosphonium analogue, with significant ... ...

    Abstract The use of a triphenylarsonium vector for tumour cell-targeting leads to a dramatic increase in Gd³⁺ uptake in human glioblastoma multiforme cells by up to an order of magnitude over the isosteric triarylphosphonium analogue, with significant implications for ‘theranostic’ applications involving delivery of this important lanthanoid metal ion to tumour cells.
    Keywords gadolinium ; glioblastoma ; humans
    Language English
    Dates of publication 2021-0901
    Size p. 8806-8809.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc03082e
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