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  1. Book: Sexual differentiation of vertebrate reproductive organs

    Renfree, Marilyn B.

    (Sexual development ; 8,5)

    2014  

    Author's details ed. Marilyn B. Renfree
    Series title Sexual development ; 8,5
    Collection
    Language English
    Size S. 198 - 337 : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018397122
    ISBN 978-3-318-02727-3 ; 9783318027280 ; 3-318-02727-8 ; 3318027286
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6595 -8,5- verfügbar in Königswinter Königswinter

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  2. Article ; Online: The alternate pathway of androgen metabolism and window of sensitivity.

    Renfree, Marilyn B / Shaw, Geoff

    The Journal of endocrinology

    2023  Volume 258, Issue 3

    Abstract: Since the discovery in 1968 that dihydrotestosterone (DHT) is a major mediator of androgen action, a convincing body of evidence has accumulated to indicate that the major pathway of DHT formation is the 5α-reduction of circulating testosterone in ... ...

    Abstract Since the discovery in 1968 that dihydrotestosterone (DHT) is a major mediator of androgen action, a convincing body of evidence has accumulated to indicate that the major pathway of DHT formation is the 5α-reduction of circulating testosterone in androgen target tissues. However, we now know that DHT can also be formed in peripheral tissues by the oxidation of 5α-androstane-3α,17β-diol (adiol). This pathway is responsible for the formation of the male phenotype. We discuss the serendipitous discovery in the tammar wallaby of an alternate pathway by which adiol is formed in the testes, secreted into plasma and converted in peripheral tissues to DHT. This alternate pathway is responsible for virilisation of the urogenital system in this species and is present in the testes at the onset of male puberty of all mammals studied so far. This is the first clear-cut function for steroid 5α-reductase 1 in males. Unexpectedly, the discovery of this pathway in this Australian marsupial has had a major impact in understanding the pathophysiology of aberrant virilisation in female newborns. Overactivity of the alternate pathway appears to explain virilisation in congenital adrenal hyperplasia CAH, in X-linked 46,XY disorders of sex development. It also appears to be important in polycystic ovarian syndrome (PCOS) since PCOS ovaries have enhanced the expression of genes and proteins of the alternate pathway. It is now clear that normal male development in marsupials, rodents and humans requires the action of both the classic and the alternate (backdoor) pathways.
    MeSH term(s) Infant, Newborn ; Humans ; Animals ; Male ; Female ; Androgens/metabolism ; Australia ; Testosterone/metabolism ; Dihydrotestosterone ; Macropodidae/metabolism ; Virilism
    Chemical Substances Androgens ; Testosterone (3XMK78S47O) ; Dihydrotestosterone (08J2K08A3Y)
    Language English
    Publishing date 2023-08-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 3028-4
    ISSN 1479-6805 ; 0022-0795
    ISSN (online) 1479-6805
    ISSN 0022-0795
    DOI 10.1530/JOE-22-0296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.133: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Embryos and embryonic stem cells from the white rhinoceros

    Hildebrandt, Thomas Bernd / Hermes, Robert / Holtze, Susanne / Renfree, Marilyn / Goeritz, Frank / GALLI, CESARE

    Nature Communications, 9:2589

    2018  

    Abstract: The northern white rhinoceros (NWR, Ceratotherium simum cottoni) is the most endangered mammal in the world with only two females surviving. Here we adapt existing assisted reproduction techniques (ART) to fertilize Southern White Rhinoceros (SWR) ... ...

    Institution Leibniz-Institut für Zoo- und Wildtierforschung (Berlin)
    Abstract The northern white rhinoceros (NWR, Ceratotherium simum cottoni) is the most endangered mammal in the world with only two females surviving. Here we adapt existing assisted reproduction techniques (ART) to fertilize Southern White Rhinoceros (SWR) oocytes with NWR spermatozoa. We show that rhinoceros oocytes can be repeatedly recovered from live SWR females by transrectal ovum pick-up, matured, fertilized by intracytoplasmic sperm injection and developed to the blastocyst stage in vitro. Next, we generate hybrid rhinoceros embryos in vitro using gametes of NWR and SWR. We also establish embryonic stem cell lines from the SWR blastocysts. Blastocysts are cryopreserved for later embryo transfer. Our results indicate that ART could be a viable strategy to rescue genes from the iconic, almost extinct, northern white rhinoceros and may also have broader impact if applied with similar success to other endangered large mammalian species.
    Language English
    Document type Article
    Database Repository for Life Sciences

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  4. Article ; Online: WOMEN IN REPRODUCTIVE SCIENCE: Reproduction down under.

    Renfree, Marilyn B

    Reproduction (Cambridge, England)

    2019  Volume 158, Issue 6, Page(s) F127–F137

    Abstract: Australia is home to a unique assembly of mammals - the marsupials and monotremes. Despite this uniqueness, they have been largely ignored by the biomedical scientific community, and yet study of marsupials has contributed to modern research on ... ...

    Abstract Australia is home to a unique assembly of mammals - the marsupials and monotremes. Despite this uniqueness, they have been largely ignored by the biomedical scientific community, and yet study of marsupials has contributed to modern research on reproduction, development, evolution, conservation, molecular and comparative genomics. My lifetime passion for these long-neglected Australian fauna has led to unexpected discoveries and insights that challenged assumptions and opened up new areas of international research. I used a range of disciplinary expertise to pursue the study of these unique mammals. My main experimental species has been the tammar wallaby that I have used as a model species to investigate and understand not only biomedical problems but also to provide knowledge that is critical for the continued conservation and management of Australia's dwindling native mammals. This model provided more than a few surprises for me and my wonderful team of students, post-docs and collaborators about how hormones, genes and signalling molecules control reproductive biology and development in a wider context as well as how the interactions of the environment with mother and conceptus, with mother and fetus and mother and young ultimately control most aspects of successful reproduction in mammals.
    MeSH term(s) Animals ; Biomedical Research/history ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Female ; Genomics ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Meiosis ; Mice ; Ovarian Follicle/cytology ; Ovarian Follicle/metabolism ; Reproduction ; United States
    Language English
    Publishing date 2019-11-15
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Review
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
    DOI 10.1530/REP-19-0230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.362: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Women in reproductive science.

    Renfree, Marilyn B

    Reproduction (Cambridge, England)

    2019  Volume 158, Issue 6, Page(s) E5–E7

    MeSH term(s) Biomedical Research/statistics & numerical data ; Female ; Humans ; Reproduction ; Science/standards ; Women, Working/statistics & numerical data
    Language English
    Publishing date 2019-10-25
    Publishing country England
    Document type Editorial
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
    DOI 10.1530/REP-19-0482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.362: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Placentation in Marsupials.

    Renfree, Marilyn B / Shaw, Geoff

    Advances in anatomy, embryology, and cell biology

    2021  Volume 234, Page(s) 41–60

    Abstract: It is sometimes implied that marsupials are "aplacental," on the presumption that the only mammals that have a placenta are the eponymous "placental" mammals. This misconception has persisted despite the interest in and descriptions of the marsupial ... ...

    Abstract It is sometimes implied that marsupials are "aplacental," on the presumption that the only mammals that have a placenta are the eponymous "placental" mammals. This misconception has persisted despite the interest in and descriptions of the marsupial placenta, even in Amoroso's definitive chapter. It was also said that marsupials had no maternal recognition of pregnancy and no placental hormone production. In addition, it was thought that genomic imprinting could not exist in marsupials because pregnancy was so short. We now know that none of these ideas have held true with extensive studies over the last four decades definitively showing that they are indeed mammals with a fully functional placenta, and with their own specializations.
    MeSH term(s) Animals ; Female ; Genomic Imprinting ; Mammals ; Marsupialia/genetics ; Placenta ; Placentation/genetics ; Pregnancy
    Language English
    Publishing date 2021-09-06
    Publishing country Germany
    Document type Journal Article
    ISSN 0301-5556
    ISSN 0301-5556
    DOI 10.1007/978-3-030-77360-1_4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hormonal and Molecular Regulation of Phallus Differentiation in a Marsupial Tammar Wallaby.

    Chen, Yu / Renfree, Marilyn B

    Genes

    2020  Volume 11, Issue 1

    Abstract: Congenital anomalies in phalluses caused by endocrine disruptors have gained a great deal of attention due to its annual increasing rate in males. However, the endocrine-driven molecular regulatory mechanism of abnormal phallus development is complex and ...

    Abstract Congenital anomalies in phalluses caused by endocrine disruptors have gained a great deal of attention due to its annual increasing rate in males. However, the endocrine-driven molecular regulatory mechanism of abnormal phallus development is complex and remains largely unknown. Here, we review the direct effect of androgen and oestrogen on molecular regulation in phalluses using the marsupial tammar wallaby, whose phallus differentiation occurs after birth. We summarize and discuss the molecular mechanisms underlying phallus differentiation mediated by sonic hedgehog (
    MeSH term(s) Androgens/metabolism ; Animals ; Cell Differentiation/drug effects ; Endocrine Disruptors ; Estrogens/metabolism ; Estrogens/pharmacology ; Female ; Genitalia, Female ; Genitalia, Male/growth & development ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Insulin-Like Growth Factor Binding Protein 3/genetics ; Insulin-Like Growth Factor Binding Protein 3/metabolism ; Insulin-Like Growth Factor I/genetics ; Insulin-Like Growth Factor I/metabolism ; Macropodidae/growth & development ; Macropodidae/metabolism ; Male ; Penis/growth & development ; Penis/metabolism ; Receptors, Androgen/metabolism ; Sex Differentiation/drug effects
    Chemical Substances Androgens ; Endocrine Disruptors ; Estrogens ; Hedgehog Proteins ; Insulin-Like Growth Factor Binding Protein 3 ; Receptors, Androgen ; Insulin-Like Growth Factor I (67763-96-6)
    Language English
    Publishing date 2020-01-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11010106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Hormonal and Molecular Regulation of Phallus Differentiation in a Marsupial Tammar Wallaby

    Chen, Yu / Renfree, Marilyn B

    Genes. 2020 Jan. 16, v. 11, no. 1

    2020  

    Abstract: Congenital anomalies in phalluses caused by endocrine disruptors have gained a great deal of attention due to its annual increasing rate in males. However, the endocrine-driven molecular regulatory mechanism of abnormal phallus development is complex and ...

    Abstract Congenital anomalies in phalluses caused by endocrine disruptors have gained a great deal of attention due to its annual increasing rate in males. However, the endocrine-driven molecular regulatory mechanism of abnormal phallus development is complex and remains largely unknown. Here, we review the direct effect of androgen and oestrogen on molecular regulation in phalluses using the marsupial tammar wallaby, whose phallus differentiation occurs after birth. We summarize and discuss the molecular mechanisms underlying phallus differentiation mediated by sonic hedgehog (SHH) at day 50 pp and phallus elongation mediated by insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3), as well as multiple phallus-regulating genes expressed after day 50 pp. We also identify hormone-responsive long non-coding RNAs (lncRNAs) that are co-expressed with their neighboring coding genes. We show that the activation of SHH and IGF1, mediated by balanced androgen receptor (AR) and estrogen receptor 1 (ESR1) signalling, initiates a complex regulatory network in males to constrain the timing of phallus differentiation and to activate the downstream genes that maintain urethral closure and phallus elongation at later stages.
    Keywords Macropus eugenii ; androgen receptors ; androgens ; binding proteins ; congenital abnormalities ; endocrine-disrupting chemicals ; estrogen receptors ; estrogens ; genes ; insulin-like growth factor I ; male genitalia ; male reproductive system ; males ; non-coding RNA
    Language English
    Dates of publication 2020-0116
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes11010106
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Presence of H3K4me3 on Paternally Expressed Genes of the Paternal Genome From Sperm to Implantation.

    Ishihara, Teruhito / Griffith, Oliver W / Suzuki, Shunsuke / Renfree, Marilyn B

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 838684

    Abstract: Genomic imprinting, parent-of-origin-specific gene expression, is controlled by differential epigenetic status of the parental chromosomes. While DNA methylation and suppressive histone modifications established during gametogenesis suppress imprinted ... ...

    Abstract Genomic imprinting, parent-of-origin-specific gene expression, is controlled by differential epigenetic status of the parental chromosomes. While DNA methylation and suppressive histone modifications established during gametogenesis suppress imprinted genes on the inactive allele, how and when the expressed allele gains its active status is not clear. In this study, we asked whether the active histone-3 lysine-4 trimethylation (H3K4me3) marks remain at paternally expressed genes (PEGs) in sperm and embryos before and after fertilization using published data. Here we show that mouse sperm had the active H3K4me3 at more than half of known PEGs, and these genes were present even after fertilization. Using reciprocal cross data, we identified 13 new transient PEGs during zygotic genome activation. Next, we confirmed that the 12 out of the 13 new transient PEGs were associated with the paternal H3K4me3 in sperm. Nine out of the 12 genes were associated with the paternal H3K4me3 in zygotes. Our results show that paternal H3K4me3 marks escape inactivation during the histone-to-protamine transition that occurs during sperm maturation and are present in embryos from early zygotic stages up to implantation.
    Language English
    Publishing date 2022-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.838684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals.

    Ishihara, Teruhito / Griffith, Oliver W / Suzuki, Shunsuke / Renfree, Marilyn B

    Epigenetics & chromatin

    2022  Volume 15, Issue 1, Page(s) 32

    Abstract: Background: The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice. Airn silences two neighbouring genes, Solute carrier family 22 member 2 ( ... ...

    Abstract Background: The eutherian IGF2R imprinted domain is regulated by an antisense long non-coding RNA, Airn, which is expressed from a differentially methylated region (DMR) in mice. Airn silences two neighbouring genes, Solute carrier family 22 member 2 (Slc22a2) and Slc22a3, to establish the Igf2r imprinted domain in the mouse placenta. Marsupials also have an antisense non-coding RNA, ALID, expressed from a DMR, although the exact function of ALID is currently unknown. The eutherian IGF2R DMR is located in intron 2, while the marsupial IGF2R DMR is located in intron 12, but it is not yet known whether the adjacent genes SLC22A2 and/or SLC22A3 are also imprinted in the marsupial lineage. In this study, the imprinting status of marsupial SLC22A2 and SLC22A3 in the IGF2R imprinted domain in the chorio-vitelline placenta was examined in a marsupial, the tammar wallaby.
    Results: In the tammar placenta, SLC22A3 but not SLC22A2 was imprinted. Tammar SLC22A3 imprinting was evident in placental tissues but not in the other tissues examined in this study. A putative promoter of SLC22A3 lacked DNA methylation, suggesting that this gene is not directly silenced by a DMR on its promoter as seen in the mouse. Based on immunofluorescence, we confirmed that the tammar SLC22A3 is localised in the endodermal cell layer of the tammar placenta where nutrient trafficking occurs.
    Conclusions: Since SLC22A3 is imprinted in the tammar placenta, we conclude that this placental imprinting of SLC22A3 has been positively selected after the marsupial and eutherian split because of the differences in the DMR location. Since SLC22A3 is known to act as a transporter molecule for nutrient transfer in the eutherian placenta, we suggest it was strongly selected to control the balance between supply and demand of nutrients in marsupial as it does in eutherian placentas.
    MeSH term(s) Animals ; DNA Methylation ; Female ; Genomic Imprinting ; Macropodidae ; Mammals ; Mice ; Placenta ; Pregnancy
    Language English
    Publishing date 2022-08-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2462129-8
    ISSN 1756-8935 ; 1756-8935
    ISSN (online) 1756-8935
    ISSN 1756-8935
    DOI 10.1186/s13072-022-00465-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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