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  1. AU="Renfu, Chen"
  2. AU="Pisani, Antonio Rosario"
  3. AU=Zhang Yue-Miao AU=Zhang Yue-Miao
  4. AU="Chen, Z P"
  5. AU="Pinzón-Navarro, Beatriz Adriana"
  6. AU="Dong, Chuan-Ding"
  7. AU="Gomes, Rafael"
  8. AU="Goncin, Una"
  9. AU="Chen, Yan-Nan"
  10. AU="Revuelta, Belen"
  11. AU="Parmar, Dharati"
  12. AU="Herrera-Mateo, Sergio"
  13. AU="Fejes, I"
  14. AU="Zhang, Zhuhua"
  15. AU="Taillé, C"
  16. AU="San Martín, Juan Víctor"
  17. AU=Sun Yi AU=Sun Yi
  18. AU="Wu, Changping"
  19. AU="Polette, Myriam"
  20. AU="Ian D. Hickson"
  21. AU="Raasch, Siegfried"
  22. AU="Liu, Miao-Miao"
  23. AU="Beschastnov, V V"
  24. AU="Mehdi Benamar"
  25. AU="Manzoor, Jaida"

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  1. Artikel: A sandwich technique for the removal of stone embedded intrauterine devices in the urinary bladder.

    Raj, Ashok / Xiaolei, Sun / Wenjing, Xie / Renfu, Chen / Yunpeng, Peng

    Urology case reports

    2021  Band 38, Seite(n) 101599

    Abstract: A urinary bladder stone in young adults is uncommon. Dislocation of an IUD to adjection organs is a rare condition. We present a case of a 28-year female with a chief complaint of right side pelvis discomfort, off and on with the urinary system. In this ... ...

    Abstract A urinary bladder stone in young adults is uncommon. Dislocation of an IUD to adjection organs is a rare condition. We present a case of a 28-year female with a chief complaint of right side pelvis discomfort, off and on with the urinary system. In this case, we performed cystoscopy assisted laser lithotripsy, hysteroscopy to localize and remove IUD, transurethral resectoscope for removing IUD residual, and resection sinus tract. This article's objective states that the multidisciplinary approach to removing dislocated IUD is safe and effective and raises awareness of forgotten contraceptive devices and their potential complications.
    Sprache Englisch
    Erscheinungsdatum 2021-03-10
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2745459-9
    ISSN 2214-4420
    ISSN 2214-4420
    DOI 10.1016/j.eucr.2021.101599
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Knockdown of Cripto-1 inhibits the proliferation, migration, invasion, and angiogenesis in prostate carcinoma cells

    Wu, Ding / Hao Xu / Renfu Chen / Song Xue / Xiaoqing Sun / Zhan Shi

    Journal of biosciences. 2017 Sept., v. 42, no. 3

    2017  

    Abstract: Cripto-1 (CR-1) is a member of the epidermal growth factor-Cripto-1/FRL1/Cryptic gene family that plays a key role in the various malignant cancers. However, the role of CR-1 in prostate carcinoma (PCa) remains limited. The expression of CR-1 was down- ... ...

    Abstract Cripto-1 (CR-1) is a member of the epidermal growth factor-Cripto-1/FRL1/Cryptic gene family that plays a key role in the various malignant cancers. However, the role of CR-1 in prostate carcinoma (PCa) remains limited. The expression of CR-1 was down-regulated by small interfering RNA (siRNA). Western blot measured the expression levels of CR-1 and some related proteins. We performed Cell Counting Kit-8, 5-ethynyl-2-deoxyuridine (EdU) incorporation assay and flow cytometry to detect the cellular proliferation and cycle. The transwell assay was used to observe cellular migration and invasion. The ability of angiogenesis was evaluated by tube formation assay. Our results showed that CR-1 knockdown markedly inhibited cell proliferation and induced cycle arrest in G1 phase, as p21 and p27 were up-regulated, whereas cyclin D1 and cyclin E1 were diminished. Moreover, silencing of CR-1 dramatically inhibited cell migration and invasion, repressed matrix metalloproteinases, and disturbed epithelial-mesenchymal transition. CR-1 siRNA suppressed the secreted level of vascular endothelial growth factor, and reduced protein level of Vascular endothelial growth factor receptor 2. We further found that decreased CR-1 expression inhibited FAK/Src/PI3K and Wnt/β-catenin signalling in PCa cells. These results suggested CR-1 might be served as an effective therapeutic target in PCa.
    Schlagwörter angiogenesis ; cell movement ; cell proliferation ; cyclins ; flow cytometry ; genes ; interphase ; metalloproteinases ; neoplasm cells ; prostatic neoplasms ; small interfering RNA ; vascular endothelial growth factor receptor-2 ; vascular endothelial growth factors ; Western blotting
    Sprache Englisch
    Erscheinungsverlauf 2017-09
    Umfang p. 405-416.
    Erscheinungsort Springer India
    Dokumenttyp Artikel
    ZDB-ID 756157-x
    ISSN 0973-7138 ; 0250-5991
    ISSN (online) 0973-7138
    ISSN 0250-5991
    DOI 10.1007/s12038-017-9700-y
    Datenquelle NAL Katalog (AGRICOLA)

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  3. Artikel ; Online: Sodium Tanshinone IIA Sulfonate Ameliorates Bladder Fibrosis in a Rat Model of Partial Bladder Outlet Obstruction by Inhibiting the TGF-β/Smad Pathway Activation.

    Xiaoxiao Jiang / Yaping Chen / Haitao Zhu / Bo Wang / Ping Qu / Renfu Chen / Xiaoqing Sun

    PLoS ONE, Vol 10, Iss 6, p e

    2015  Band 0129655

    Abstract: Transforming growth factor (TGF)-β1 is known to play a pivotal role in a diverse range of biological systems including modulation of fibrosis in several organs. The precise role of TGF-β/Smad signaling in the progression of bladder fibrosis secondary to ... ...

    Abstract Transforming growth factor (TGF)-β1 is known to play a pivotal role in a diverse range of biological systems including modulation of fibrosis in several organs. The precise role of TGF-β/Smad signaling in the progression of bladder fibrosis secondary to partial bladder outlet obstruction (PBOO) is yet to be conclusively. Using a rat PBOO model, we investigated TGF-β1 expression and exaimined whether sodium tanshinone IIA sulfonate (STS) could inhibit TGF-β/Smad signaling pathway activation and ameliorate bladder fibrosis. Forty-eight female Sprague-Dawley rats were randomly divided into three groups: sham operation group (n = 16), PBOO operation without STS treatment group (n = 16) and PBOO operation with STS treatment group (n = 16). Thirty-two rats underwent the operative procedure to create PBOO and subsequently received intraperitoneal injections of STS (10 mg/kg/d; n = 16) or vehicle (n = 16) two days after the surgery. Sham surgery was conducted on 16 rats, which received intraperitoneal vehicle injection two days later. In each of the three groups, an equal number of rats were sacrificed at weeks 4 and 8 after the PBOO or sham operation. The TGF-β/Smad signaling pathway was analyzed using western blotting, immunohistochemical staining and reverse transcriptase polymerase chain reaction (RT-PCR). One-way analysis of variance was conducted to draw statistical inferences. At 4 and 8 weeks, the expression of TGF-β1 and phosphorylated Smad2 and Smad3 in STS-treated PBOO rats was significantly lower than in the PBOO rats not treated with STS. Alpha smooth muscle actin (α-SMA), collagen I and collagen III expression at 4 and 8 weeks post PBOO was lower in STS-treated PBOO rats when compared to that in PBOO rats not treated with STS. Our findings indicate that STS ameliorates bladder fibrosis by inhibiting TGF-β/Smad signaling pathway activation, and may prove to be a potential therapeutic measure for preventing bladder fibrosis secondary to PBOO operation.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2015-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells

    Shi, Zhan / Ding Wu / Run Tang / Xiang Li / Renfu Chen / Song Xue / Chengjing Zhang / Xiaoqing Sun

    Journal of biosciences. 2016 June, v. 41, no. 2

    2016  

    Abstract: The high mobility group protein A2 (HMGA2) has been demonstrated as an architectural transcription factor that is associated with pathogenesis of many malignant cancers; however, its role in prostate cancer cells remains largely unknown. To explore ... ...

    Abstract The high mobility group protein A2 (HMGA2) has been demonstrated as an architectural transcription factor that is associated with pathogenesis of many malignant cancers; however, its role in prostate cancer cells remains largely unknown. To explore whether HMGA2 participates in the development and progression of prostate cancer, small interfering RNA (siRNA) targeted on human HMGA2 was transfected to suppress the HMGA2 expression in prostate cancer PC3 and DU145 cells, and then the cellular biology changes after decreased the expression of HMGA2 was examined. Our results showed that knockdown of HMGA2 markedly inhibited cell proliferation; this reduced cell proliferation was due to the promotion of cell apoptosis as the Bcl-xl was decreased, whereas Bax was up-regulated. In addition, we found that HMGA2 knockdown resulted in reduction of cell migration and invasion, as well as repressed the expression of matrix metalloproteinases (MMPs) and affected the occurrence of epithelial-mesenchymal transition (EMT) in both cell types. We further found that decreased HMGA2 expression inhibited the transforming growth factor-β (TGF-β)/Smad signalling pathway in cancer cells. In conclusion, our data indicated that HMGA2 was associated with apoptosis, migration and invasion of prostate cancer, which might be a promising therapeutic target for prostate cancer.
    Schlagwörter apoptosis ; cell movement ; cell proliferation ; humans ; metalloproteinases ; neoplasm cells ; pathogenesis ; prostatic neoplasms ; signal transduction ; small interfering RNA ; transcription factors ; transforming growth factor beta
    Sprache Englisch
    Erscheinungsverlauf 2016-06
    Umfang p. 229-236.
    Erscheinungsort Springer India
    Dokumenttyp Artikel
    ZDB-ID 756157-x
    ISSN 0973-7138 ; 0250-5991
    ISSN (online) 0973-7138
    ISSN 0250-5991
    DOI 10.1007/s12038-016-9603-3
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel: Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells

    Shi, Zhan / Ding Wu / Run Tang / Xiang Li / Renfu Chen / Song Xue / Chengjing Zhang / Xiaoqing Sun

    Journal of biosciences

    Band v. 41,, Heft no. 2

    Abstract: The high mobility group protein A2 (HMGA2) has been demonstrated as an architectural transcription factor that is associated with pathogenesis of many malignant cancers; however, its role in prostate cancer cells remains largely unknown. To explore ... ...

    Abstract The high mobility group protein A2 (HMGA2) has been demonstrated as an architectural transcription factor that is associated with pathogenesis of many malignant cancers; however, its role in prostate cancer cells remains largely unknown. To explore whether HMGA2 participates in the development and progression of prostate cancer, small interfering RNA (siRNA) targeted on human HMGA2 was transfected to suppress the HMGA2 expression in prostate cancer PC3 and DU145 cells, and then the cellular biology changes after decreased the expression of HMGA2 was examined. Our results showed that knockdown of HMGA2 markedly inhibited cell proliferation; this reduced cell proliferation was due to the promotion of cell apoptosis as the Bcl-xl was decreased, whereas Bax was up-regulated. In addition, we found that HMGA2 knockdown resulted in reduction of cell migration and invasion, as well as repressed the expression of matrix metalloproteinases (MMPs) and affected the occurrence of epithelial-mesenchymal transition (EMT) in both cell types. We further found that decreased HMGA2 expression inhibited the transforming growth factor-β (TGF-β)/Smad signalling pathway in cancer cells. In conclusion, our data indicated that HMGA2 was associated with apoptosis, migration and invasion of prostate cancer, which might be a promising therapeutic target for prostate cancer.
    Sprache Englisch
    Dokumenttyp Artikel
    ISSN 0250-5991
    Datenquelle AGRIS - International Information System for the Agricultural Sciences and Technology

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