Article ; Online: Prognostic impact of the post-treatment T cell composition and spatial organization in soft tissue sarcoma patients treated with neoadjuvant hyperthermic radio(chemo)therapy.
2023 Volume 14, Page(s) 1185197
Abstract: Soft tissue sarcomas (STS) form a heterogeneous group of tumors sharing a mesenchymal origin. Despite good local control of the disease, the occurrence of distant metastases often limits survival of STS patients with localized, high-risk tumors of the ... ...
| Abstract | Soft tissue sarcomas (STS) form a heterogeneous group of tumors sharing a mesenchymal origin. Despite good local control of the disease, the occurrence of distant metastases often limits survival of STS patients with localized, high-risk tumors of the extremities. Accumulating evidence suggests a central role for the tumor immune microenvironment in determining the clinical outcome and response to therapy. Thus, it has been reported that STS patients with a high immune signature and especially presence of B cells and tertiary lymphoid structures display improved overall survival and response to checkpoint inhibitor treatment. Here, we explored the effect of curative multimodal therapy on the T cell landscape of STS using multiplex immunohistochemistry. We analyzed the phenotype, frequency, and spatial distribution of STS-infiltrating CD8 |
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| MeSH term(s) | Humans ; Neoadjuvant Therapy ; CD8-Positive T-Lymphocytes ; Programmed Cell Death 1 Receptor ; Ki-67 Antigen ; Hyperthermia, Induced ; Sarcoma/pathology ; Soft Tissue Neoplasms/pathology ; Tumor Microenvironment |
| Chemical Substances | Programmed Cell Death 1 Receptor ; Ki-67 Antigen |
| Language | English |
| Publishing date | 2023-05-16 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2023.1185197 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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