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  1. Article ; Online: Assessment of radio-frequency heating of a parallel transmit coil in a phantom using multi-echo proton resonance frequency shift thermometry.

    Jeong, Hongbae / Restivo, Matthew C / Jezzard, Peter / Hess, Aaron T

    Magnetic resonance imaging

    2020  Volume 77, Page(s) 57–68

    Abstract: We propose a workflow for validating parallel transmission (pTx) radio-frequency (RF) magnetic field heating patterns using Proton-Resonance Frequency shift (PRF)-based MR thermometry. Electromagnetic (EM) and thermal simulations of a 7 T 8-channel ... ...

    Abstract We propose a workflow for validating parallel transmission (pTx) radio-frequency (RF) magnetic field heating patterns using Proton-Resonance Frequency shift (PRF)-based MR thermometry. Electromagnetic (EM) and thermal simulations of a 7 T 8-channel dipole coil were done using commercially available software (Sim4Life) to assess RF heating. The fabrication method for a phantom with electrical properties matched to human tissue is also described, along with methods for its electrical and thermal characterisation. Energy was deposited to specific transmit channels, whilst acquiring 3D PRF data using a pair of interleaved RF shim transmit modes. A multi-echo readout and pre-scan stabilisation protocol were used for increased sensitivity and to correct for measurement-to-measurement instabilities. The electrical properties of the phantom were found to be within 10% of the intended values. Adoption of a 14-min stabilisation scan gave sufficient suppression of any evolving background spatial variation in the B
    MeSH term(s) Hot Temperature ; Humans ; Magnetic Resonance Imaging ; Phantoms, Imaging ; Protons ; Radio Waves ; Thermometry/instrumentation
    Chemical Substances Protons
    Language English
    Publishing date 2020-12-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604885-7
    ISSN 1873-5894 ; 0730-725X
    ISSN (online) 1873-5894
    ISSN 0730-725X
    DOI 10.1016/j.mri.2020.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1817: Show issues Location:
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  2. Article ; Online: Efficient spiral in-out and EPI balanced steady-state free precession cine imaging using a high-performance 0.55T MRI.

    Restivo, Matthew C / Ramasawmy, Rajiv / Bandettini, W Patricia / Herzka, Daniel A / Campbell-Washburn, Adrienne E

    Magnetic resonance in medicine

    2020  Volume 84, Issue 5, Page(s) 2364–2375

    Abstract: Purpose: Low-field MRI offers favorable physical properties for SNR-efficient long readout acquisitions such as spiral and EPI. We used a 0.55 tesla (T) MRI system equipped with high-performance hardware to increase the sampling duty cycle and extend ... ...

    Abstract Purpose: Low-field MRI offers favorable physical properties for SNR-efficient long readout acquisitions such as spiral and EPI. We used a 0.55 tesla (T) MRI system equipped with high-performance hardware to increase the sampling duty cycle and extend the TR of balanced steady-state free precession (bSSFP) cardiac cine acquisitions, which typically are limited by banding artifacts.
    Methods: We developed a high-efficiency spiral in-out bSSFP acquisition, with zeroth- and first-gradient moment nulling, and an EPI bSSFP acquisition for cardiac cine imaging using a contemporary MRI system modified to operate at 0.55T. Spiral in-out and EPI bSSFP cine protocols, with TR = 8 ms, were designed to maintain both spatiotemporal resolution and breath-hold length. Simulations, phantom imaging, and healthy volunteer imaging studies (n = 12) were performed to assess SNR and image quality using these high sampling duty-cycle bSSFP sequences.
    Results: Spiral in-out bSSFP performed favorably at 0.55T and generated good image quality, whereas EPI bSSFP suffered motion and flow artifacts. There was no difference in ejection fraction comparing spiral in-out with standard Cartesian imaging. Moreover, human images demonstrated a 79% ± 21% increase in myocardial SNR using spiral in-out bSSFP and 50% ± 14% increase in SNR using EPI bSSFP as compared with the reference Cartesian acquisition. Spiral in-out acquisitions at 0.55T recovered 69% ± 14% of the myocardial SNR at 1.5T.
    Conclusion: Efficient bSSFP spiral in-out provided high-quality cardiac cine imaging and SNR recovery on a high-performance 0.55T MRI system.
    MeSH term(s) Artifacts ; Breath Holding ; Heart/diagnostic imaging ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging ; Magnetic Resonance Imaging, Cine
    Language English
    Publishing date 2020-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.28278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1959: Show issues Location:
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  3. Article ; Online: Subarachnoid Hemorrhage and Cerebral Perfusion Are Associated with Brain Volume Decrease in a Cohort of Predominantly Mild Traumatic Brain Injury Patients.

    van der Kleij, Lisa A / De Vis, Jill B / Restivo, Matthew C / Turtzo, L Christine / Hendrikse, Jeroen / Latour, Lawrence L

    Journal of neurotrauma

    2019  Volume 37, Issue 4, Page(s) 600–607

    Abstract: Biomarkers are needed to identify traumatic brain injury (TBI) patients at risk for accelerated brain volume loss and its associated functional impairment. Subarachnoid hemorrhage (SAH) has been shown to affect cerebral volume and perfusion, possibly by ... ...

    Abstract Biomarkers are needed to identify traumatic brain injury (TBI) patients at risk for accelerated brain volume loss and its associated functional impairment. Subarachnoid hemorrhage (SAH) has been shown to affect cerebral volume and perfusion, possibly by induction of inflammation and vasospasm. The purpose of this study was to assess the impact of SAH due to trauma on cerebral perfusion and brain volume. For this, magnetic resonance imaging (MRI) was performed <48 h and at 90 days after TBI. The <48-h scan was used to assess SAH presence and perfusion. Brain volume changes were assessed quantitatively over time. Differences in brain volume change and perfusion were compared between SAH and non-SAH patients. A linear regression analysis with clinical and imaging variables was used to identify predictors of brain volume change. All patients had a relatively good status on admission, and 83% presented with the maximum Glasgow Coma Scale (GCS) score. Brain volume decrease was greater in the 11 SAH patients (-3.2%, interquartile range [IQR] -4.8 to -1.3%) compared with the 46 non-SAH patients (-0.4%, IQR -1.8 to 0.9%;
    MeSH term(s) Adult ; Aged ; Brain/diagnostic imaging ; Brain/pathology ; Brain Concussion/diagnostic imaging ; Brain Concussion/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Organ Size/physiology ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/pathology
    Language English
    Publishing date 2019-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2019.6514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2016: Show issues Location:
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  4. Article ; Online: A framework for constraining image SNR loss due to MR raw data compression.

    Restivo, Matthew C / Campbell-Washburn, Adrienne E / Kellman, Peter / Xue, Hui / Ramasawmy, Rajiv / Hansen, Michael S

    Magma (New York, N.Y.)

    2018  Volume 32, Issue 2, Page(s) 213–225

    Abstract: Introduction: Computationally intensive image reconstruction algorithms can be used online during MRI exams by streaming data to remote high-performance computers. However, data acquisition rates often exceed the bandwidth of the available network ... ...

    Abstract Introduction: Computationally intensive image reconstruction algorithms can be used online during MRI exams by streaming data to remote high-performance computers. However, data acquisition rates often exceed the bandwidth of the available network resources creating a bottleneck. Data compression is, therefore, desired to ensure fast data transmission.
    Methods: The added noise variance due to compression was determined through statistical analysis for two compression libraries (one custom and one generic) that were implemented in this framework. Limiting the compression error variance relative to the measured thermal noise allowed for image signal-to-noise ratio loss to be explicitly constrained.
    Results: Achievable compression ratios are dependent on image SNR, user-defined SNR loss tolerance, and acquisition type. However, a 1% reduction in SNR yields approximately four to ninefold compression ratios across MRI acquisition strategies. For free-breathing cine data reconstructed in the cloud, the streaming bandwidth was reduced from 37 to 6.1 MB/s, alleviating the network transmission bottleneck.
    Conclusion: Our framework enabled data compression for online reconstructions and allowed SNR loss to be constrained based on a user-defined SNR tolerance. This practical tool will enable real-time data streaming and greater than fourfold faster cloud upload times.
    MeSH term(s) Algorithms ; Computer Simulation ; Data Compression/methods ; Data Compression/statistics & numerical data ; Humans ; Image Enhancement/methods ; Image Interpretation, Computer-Assisted/methods ; Image Interpretation, Computer-Assisted/statistics & numerical data ; Image Processing, Computer-Assisted/methods ; Image Processing, Computer-Assisted/statistics & numerical data ; Magnetic Resonance Imaging/methods ; Magnetic Resonance Imaging/statistics & numerical data ; Magnetic Resonance Imaging, Cine/methods ; Magnetic Resonance Imaging, Cine/statistics & numerical data ; Phantoms, Imaging ; Signal-To-Noise Ratio ; Software
    Language English
    Publishing date 2018-10-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1160826-2
    ISSN 1352-8661 ; 0968-5243
    ISSN (online) 1352-8661
    ISSN 0968-5243
    DOI 10.1007/s10334-018-0709-5
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    Zs.A 3788: Show issues Location:
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  5. Article ; Online: Local specific absorption rate in brain tumors at 7 tesla.

    Restivo, Matthew C / van den Berg, Cornelis A T / van Lier, Astrid L H M W / Polders, Daniël L / Raaijmakers, Alexander J E / Luijten, Peter R / Hoogduin, Hans

    Magnetic resonance in medicine

    2016  Volume 75, Issue 1, Page(s) 381–389

    Abstract: Purpose: MR safety at 7 Tesla relies on accurate numerical simulations of transmit electromagnetic fields to fully assess local specific absorption rate (SAR) safety. Numerical simulations for SAR safety are currently performed using models of healthy ... ...

    Abstract Purpose: MR safety at 7 Tesla relies on accurate numerical simulations of transmit electromagnetic fields to fully assess local specific absorption rate (SAR) safety. Numerical simulations for SAR safety are currently performed using models of healthy patients. These simulations might not be useful for estimating SAR in patients who have large lesions with potentially abnormal dielectric properties, e.g., brain tumors.
    Theory and methods: In this study, brain tumor patient models are constructed based on scans of four patients with high grade brain tumors. Dielectric properties for the modeled tumors are assigned based on electrical properties tomography data for the same patients. Simulations were performed to determine SAR.
    Results: Local SAR increases in the tumors by as much as 30%. However, the location of the maximum 10-gram averaged SAR typically occurs outside of the tumor, and thus does not increase. In the worst case, if the tumor model is moved to the location of maximum electric field intensity, then we do observe an increase in the estimated peak 10-gram SAR directly related to the tumor.
    Conclusion: Peak local SAR estimation made on the results of a healthy patient model simulation may underestimate the true peak local SAR in a brain tumor patient.
    MeSH term(s) Absorption, Radiation ; Brain/pathology ; Brain/physiopathology ; Brain Neoplasms/pathology ; Brain Neoplasms/physiopathology ; Computer Simulation ; Electric Impedance ; Humans ; Models, Biological ; Patient-Specific Modeling ; Radio Waves ; Radiometry/methods ; Reproducibility of Results ; Sensitivity and Specificity
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605774-3
    ISSN 1522-2594 ; 0740-3194
    ISSN (online) 1522-2594
    ISSN 0740-3194
    DOI 10.1002/mrm.25653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1959: Show issues Location:
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  6. Article ; Online: Opportunities in Interventional and Diagnostic Imaging by Using High-Performance Low-Field-Strength MRI.

    Campbell-Washburn, Adrienne E / Ramasawmy, Rajiv / Restivo, Matthew C / Bhattacharya, Ipshita / Basar, Burcu / Herzka, Daniel A / Hansen, Michael S / Rogers, Toby / Bandettini, W Patricia / McGuirt, Delaney R / Mancini, Christine / Grodzki, David / Schneider, Rainer / Majeed, Waqas / Bhat, Himanshu / Xue, Hui / Moss, Joel / Malayeri, Ashkan A / Jones, Elizabeth C /
    Koretsky, Alan P / Kellman, Peter / Chen, Marcus Y / Lederman, Robert J / Balaban, Robert S

    Radiology

    2019  Volume 293, Issue 2, Page(s) 384–393

    Abstract: Background Commercial low-field-strength MRI systems are generally not equipped with state-of-the-art MRI hardware, and are not suitable for demanding imaging techniques. An MRI system was developed that combines low field strength (0.55 T) with high- ... ...

    Abstract Background Commercial low-field-strength MRI systems are generally not equipped with state-of-the-art MRI hardware, and are not suitable for demanding imaging techniques. An MRI system was developed that combines low field strength (0.55 T) with high-performance imaging technology. Purpose To evaluate applications of a high-performance low-field-strength MRI system, specifically MRI-guided cardiovascular catheterizations with metallic devices, diagnostic imaging in high-susceptibility regions, and efficient image acquisition strategies. Materials and Methods A commercial 1.5-T MRI system was modified to operate at 0.55 T while maintaining high-performance hardware, shielded gradients (45 mT/m; 200 T/m/sec), and advanced imaging methods. MRI was performed between January 2018 and April 2019. T1, T2, and T2* were measured at 0.55 T; relaxivity of exogenous contrast agents was measured; and clinical applications advantageous at low field were evaluated. Results There were 83 0.55-T MRI examinations performed in study participants (45 women; mean age, 34 years ± 13). On average, T1 was 32% shorter, T2 was 26% longer, and T2* was 40% longer at 0.55 T compared with 1.5 T. Nine metallic interventional devices were found to be intrinsically safe at 0.55 T (<1°C heating) and MRI-guided right heart catheterization was performed in seven study participants with commercial metallic guidewires. Compared with 1.5 T, reduced image distortion was shown in lungs, upper airway, cranial sinuses, and intestines because of improved field homogeneity. Oxygen inhalation generated lung signal enhancement of 19% ± 11 (standard deviation) at 0.55 T compared with 7.6% ± 6.3 at 1.5 T (
    MeSH term(s) Adult ; Artifacts ; Cardiac Catheterization/instrumentation ; Catheterization ; Contrast Media ; Equipment Design ; Female ; Humans ; Image Enhancement/instrumentation ; Magnetic Resonance Imaging/instrumentation ; Magnetic Resonance Imaging, Interventional/instrumentation ; Metals ; Signal-To-Noise Ratio
    Chemical Substances Contrast Media ; Metals
    Language English
    Publishing date 2019-10-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2019190452
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