LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Back to previous search Search history
Advanced search

Your last searches

  1. AU="Retamal, Catalina"
  2. AU="Lee-Wing, Matthew"
  3. AU="Dostálová, I"
  4. AU=McCloskey Kayleigh A
  5. AU="Dharmarajan, Arun"
  6. AU="Stebel, Luigi"
  7. AU=Amico Patrizia
  8. AU="Kojev, Aslan"
  9. AU="Zhiyu Wang"
  10. AU="Shannon C Peyton"
  11. AU="Shiltsev, V."
  12. AU="Edward S. Debnam"
  13. AU="Freeston, Sarah L"
  14. AU="Bertolucci, S."
  15. AU="de Barros, Rosires M B"
  16. AU="Carr, Crystal C"
  17. AU="Davies, Mark Lloyd"
  18. AU=St Gelais Corine
  19. AU=Engstrom Malitta
  20. AU="Hongo, Akane"
  21. AU="Krykorková, I"
  22. AU=Yan Bing
  23. AU="Nakos, Konstantinos"
  24. AU="Schreiner, Ryan"
  25. AU=Pltz T
  26. AU="Akhmanova, Anna" AU="Akhmanova, Anna"
  27. AU="Goretsky, Anton"
  28. AU="Cordoza, Makayla L"
  29. AU=Midoux Patrick AU=Midoux Patrick
  30. AU="Mundt, H M"
  31. AU=Tsivitse Susan

Search results

Result 1 - 2 of total 2

Search options

  1. Article ; Online: Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin.

    Rodrigo, Ramón / Retamal, Catalina / Schupper, Denisse / Vergara-Hernández, Diego / Saha, Sarmistha / Profumo, Elisabetta / Buttari, Brigitta / Saso, Luciano

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 8

    Abstract: Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to 50% of the final infarct size, ... ...

    Abstract Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to 50% of the final infarct size, there has been no available pharmacological treatment until now. Oxidative stress contributes to the underlying production mechanism, exerting the most marked injury during the early onset of reperfusion. So far, antioxidants have been shown to protect the AMI patients undergoing PCI to mitigate these detrimental effects; however, no clinical trials to date have shown any significant infarct size reduction. Therefore, it is worthwhile to consider multitarget antioxidant therapies targeting multifactorial AMI. Indeed, this clinical setting involves injurious effects derived from oxygen deprivation, intracellular pH changes and increased concentration of cytosolic Ca
    MeSH term(s) Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Humans ; Myocardial Infarction/drug therapy ; Myocardial Infarction/pathology ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/prevention & control ; Percutaneous Coronary Intervention/adverse effects ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Reperfusion Injury/drug therapy ; Resveratrol/pharmacology ; Resveratrol/therapeutic use
    Chemical Substances Antioxidants ; Quercetin (9IKM0I5T1E) ; Resveratrol (Q369O8926L)
    Language English
    Publishing date 2022-04-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27082564
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Tic-Tac: A Translational Approach in Mechanisms Associated with Irregular Heartbeat and Sinus Rhythm Restoration in Atrial Fibrillation Patients.

    Parra-Lucares, Alfredo / Villa, Eduardo / Romero-Hernández, Esteban / Méndez-Valdés, Gabriel / Retamal, Catalina / Vizcarra, Geovana / Henríquez, Ignacio / Maldonado-Morales, Esteban A J / Grant-Palza, Juan H / Ruíz-Tagle, Sofía / Estrada-Bobadilla, Victoria / Toro, Luis

    International journal of molecular sciences

    2023  Volume 24, Issue 16

    Abstract: Atrial fibrillation (AF) is a prevalent cardiac condition predominantly affecting older adults, characterized by irregular heartbeat rhythm. The condition often leads to significant disability and increased mortality rates. Traditionally, two therapeutic ...

    Abstract Atrial fibrillation (AF) is a prevalent cardiac condition predominantly affecting older adults, characterized by irregular heartbeat rhythm. The condition often leads to significant disability and increased mortality rates. Traditionally, two therapeutic strategies have been employed for its treatment: heart rate control and rhythm control. Recent clinical studies have emphasized the critical role of early restoration of sinus rhythm in improving patient outcomes. The persistence of the irregular rhythm allows for the progression and structural remodeling of the atria, eventually leading to irreversible stages, as observed clinically when AF becomes permanent. Cardioversion to sinus rhythm alters this progression pattern through mechanisms that are still being studied. In this review, we provide an in-depth analysis of the pathophysiological mechanisms responsible for maintaining AF and how they are modified during sinus rhythm restoration using existing therapeutic strategies at different stages of clinical investigation. Moreover, we explore potential future therapeutic approaches, including the promising prospect of gene therapy.
    MeSH term(s) Humans ; Aged ; Atrial Fibrillation/therapy ; Heart Rate ; Tics ; Heart Diseases ; Heart Atria
    Language English
    Publishing date 2023-08-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241612859
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top