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  1. Book ; Online ; E-Book: Perioperative inflammation as triggering origin of metastasis development

    Retsky, Michael W. / Demicheli, Romano

    2017  

    Author's details Michael W. Retsky, Romano Demicheli editors
    Keywords Medicine ; Cancer research
    Subject code 614.5999
    Language English
    Size 1 Online-Ressource (XXIII, 236 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019414764
    ISBN 978-3-319-57943-6 ; 9783319579429 ; 3-319-57943-6 ; 3319579428
    DOI 10.1007/978-3-319-57943-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Article ; Online: It May Be Possible to Prevent both Early and Late Relapses in Breast Cancer; Perhaps This Is an Opportunity for Sensors or Biosensors to Help.

    Retsky, Michael

    Sensors (Basel, Switzerland)

    2020  Volume 20, Issue 24

    Abstract: Data presented in 1993 showed an unexpected bimodal relapse pattern in surgically treated breast cancer [ ... ]. ...

    Abstract Data presented in 1993 showed an unexpected bimodal relapse pattern in surgically treated breast cancer [...].
    MeSH term(s) Biosensing Techniques ; Breast Neoplasms/diagnosis ; Humans ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/prevention & control ; Pharmaceutical Preparations ; Prospective Studies ; Retrospective Studies
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2020-12-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s20247261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: An argument for discovery-driven research: from physicist to cancer researcher.

    Retsky, Michael

    Ecancermedicalscience

    2014  Volume 8, Page(s) ed38

    Language English
    Publishing date 2014-07-03
    Publishing country England
    Document type Journal Article
    ISSN 1754-6605
    ISSN 1754-6605
    DOI 10.3332/ecancer.2014.ed38
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comments on John D. Keen and James E. Keen, What is the point

    Retsky Michael

    BMC Medical Informatics and Decision Making, Vol 9, Iss 1, p

    will screening mammography save my life? BMC Medical Informatics and Decision Making , 2009

    2009  Volume 20

    Abstract: Abstract This paper by John D. Keen and James E. Keen addresses a thorny subject. The numerical findings and commentaries in their paper will be disturbing to some readers and seem to defy logic and well established viewpoints. It may well generate angry ...

    Abstract Abstract This paper by John D. Keen and James E. Keen addresses a thorny subject. The numerical findings and commentaries in their paper will be disturbing to some readers and seem to defy logic and well established viewpoints. It may well generate angry letters to the editor. However such numerical analysis and reporting including civil discussion should be welcomed and are the basis for informed decision making – something that is highly needed in this field.
    Keywords Computer applications to medicine. Medical informatics ; R858-859.7
    Language English
    Publishing date 2009-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Breast Cancer Relapse, Post-Surgical Confusion, and Dementia in the Elderly: An Unexpected Connection but with the Same Proposed Solution.

    Retsky, Michael W / Forget, Patrice

    Medicina (Kaunas, Lithuania)

    2018  Volume 54, Issue 6

    Abstract: A simple solution may exist for both the problem of sudden dementia and confusion after surgery in the elderly and the bimodal relapse pattern among breast cancer patients who were treated with a mastectomy. Systemic inflammation by a variety of ... ...

    Abstract A simple solution may exist for both the problem of sudden dementia and confusion after surgery in the elderly and the bimodal relapse pattern among breast cancer patients who were treated with a mastectomy. Systemic inflammation by a variety of mechanisms can induce tumor outgrowth from dormant states, such as single dormant cells and avascular micrometastases. This may also explain sudden confusion and dementia for the elderly after surgery. We propose that surgery-induced inflammation may be addressed by "protective anesthesia". We suggest ketorolac for 4 days starting at the time of surgery to prevent early relapse in breast and probably other cancers; perhaps that or something similar could be used before surgery in elderly patients to prevent post-operative cognitive dysfunction.
    MeSH term(s) Aged ; Aged, 80 and over ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Confusion/ethnology ; Dementia/epidemiology ; Female ; Humans ; Inflammation/drug therapy ; Interleukin-6/blood ; Ketorolac/therapeutic use ; Mastectomy/adverse effects ; Mice ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Interleukin-6 ; Ketorolac (YZI5105V0L)
    Language English
    Publishing date 2018-12-03
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina54060101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Interpreting Breast Cancer Survival Data by the Hazard Function: Remarkable Findings from Event Dynamics.

    Demicheli, Romano / Hrushesky, William / Retsky, Michael / Biganzoli, Elia

    Medicina (Kaunas, Lithuania)

    2020  Volume 56, Issue 9

    Abstract: The report addresses the role of the hazard function in the analysis of disease-free survival data in breast cancer. An investigation on local recurrences after mastectomy provided evidence that uninterrupted growth is inconsistent with clinical findings ...

    Abstract The report addresses the role of the hazard function in the analysis of disease-free survival data in breast cancer. An investigation on local recurrences after mastectomy provided evidence that uninterrupted growth is inconsistent with clinical findings and that tumor dormancy could be assumed as working hypothesis to understand the clinical course of the disease. Additionally, it was deemed that the lag-time between primary tumor removal and tumor recurrence is dynamically dependent on the subclinical metastasis development within the host-tumor system and, therefore, may be informative about the biology of the disease. Accordingly, the hazard function, which estimates the event risk pattern through the time, was adopted to analyze survival data. The multipeak pattern of the hazard function suggested that the process metastasis development has discontinuous features. A new paradigm of breast cancer metastatic development was proposed, involving the notions of tumor homeostasis, tumor quiescence in specific metastatic microscopic phases and surgery-related acceleration of the metastatic process. All analyses by prognostic factors (e.g., by menopausal status) or treatment modalities (e.g., by adjuvant chemotherapy) or other parameters (e.g., site of metastasis), provided coherent data in agreement with the model. The hazard rate function allowed addressing several clinical questions including meaning of ipsilateral breast tumor recurrence (IBTR), oncologic effect of delayed breast reconstruction, surgery related metastasis acceleration, possible role of anti-inflammatory drugs and body mass index (BMI) to modulate the recurrence risk. We conclude that the hazard function is a powerful tool to investigate the post-surgical course of early breast cancer and other operable tumors and to make inferences on their biology.
    MeSH term(s) Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Humans ; Mastectomy ; Neoplasm Recurrence, Local
    Language English
    Publishing date 2020-09-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina56090468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: New concepts in breast cancer emerge from analyzing clinical data using numerical algorithms.

    Retsky, Michael

    International journal of environmental research and public health

    2009  Volume 6, Issue 1, Page(s) 329–348

    Abstract: A small international group has recently challenged fundamental concepts in breast cancer. As a guiding principle in therapy, it has long been assumed that breast cancer growth is continuous. However, this group suggests tumor growth commonly includes ... ...

    Abstract A small international group has recently challenged fundamental concepts in breast cancer. As a guiding principle in therapy, it has long been assumed that breast cancer growth is continuous. However, this group suggests tumor growth commonly includes extended periods of quasi-stable dormancy. Furthermore, surgery to remove the primary tumor often awakens distant dormant micrometastases. Accordingly, over half of all relapses in breast cancer are accelerated in this manner. This paper describes how a numerical algorithm was used to come to these conclusions. Based on these findings, a dormancy preservation therapy is proposed.
    MeSH term(s) Algorithms ; Biomedical Research ; Breast/pathology ; Breast Neoplasms/etiology ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Female ; Humans ; Mastectomy/adverse effects ; Models, Biological ; Neoplasm Metastasis ; Recurrence
    Language English
    Publishing date 2009-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph6010347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comments on John D. Keen and James E. Keen, What is the point: will screening mammography save my life? BMC Medical Informatics and Decision Making, 2009.

    Retsky, Michael

    BMC medical informatics and decision making

    2009  Volume 9, Page(s) 20

    Abstract: This paper by John D. Keen and James E. Keen addresses a thorny subject. The numerical findings and commentaries in their paper will be disturbing to some readers and seem to defy logic and well established viewpoints. It may well generate angry letters ... ...

    Abstract This paper by John D. Keen and James E. Keen addresses a thorny subject. The numerical findings and commentaries in their paper will be disturbing to some readers and seem to defy logic and well established viewpoints. It may well generate angry letters to the editor. However such numerical analysis and reporting including civil discussion should be welcomed and are the basis for informed decision making - something that is highly needed in this field.
    MeSH term(s) Adult ; Age Factors ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/prevention & control ; Humans ; Mammography/adverse effects ; Mass Screening/adverse effects ; Middle Aged
    Language English
    Publishing date 2009-04-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2046490-3
    ISSN 1472-6947 ; 1472-6947
    ISSN (online) 1472-6947
    ISSN 1472-6947
    DOI 10.1186/1472-6947-9-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Guest Editor's Concluding Remarks-Advances in Usage of ANN, Discussion of an Unsolved Problem, and Some Differences between Papers Written by Engineers and by Physicians.

    Retsky, Michael W

    Sensors (Basel, Switzerland)

    2009  Volume 9, Issue 10, Page(s) 8126–8129

    Language English
    Publishing date 2009-10-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s91008126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Multimodal hazard rate for relapse in breast cancer: quality of data and calibration of computer simulation.

    Retsky, Michael / Demicheli, Romano

    Cancers

    2014  Volume 6, Issue 4, Page(s) 2343–2355

    Abstract: Much has occurred since our 2010 report in Cancers. In the past few years we published several extensive reviews of our research so a brief review is all that will be provided here. We proposed in the earlier reports that most relapses in breast cancer ... ...

    Abstract Much has occurred since our 2010 report in Cancers. In the past few years we published several extensive reviews of our research so a brief review is all that will be provided here. We proposed in the earlier reports that most relapses in breast cancer occur within 5 years of surgery and seem to be associated with some unspecified manner of surgery-induced metastatic initiation. These events can be identified in relapse data and are correlated with clinical data. In the last few years an unexpected mechanism has become apparent. Retrospective analysis of relapse events by a Brussels anesthesiology group reported that a perioperative NSAID analgesic seems to reduce early relapses five-fold. We then proposed that primary surgery produces a transient period of systemic inflammation. This has now been identified by inflammatory markers in serum post mastectomy. That could explain the early relapses. It is possible that an inexpensive and non-toxic NSAID can reduce breast cancer relapses significantly. We want to take this opportunity to discuss database quality issues and our relapse hazard data in some detail. We also present a demonstration that the computer simulation can be calibrated with Adjuvant-on-line, an often used clinical tool for prognosis in breast cancer.
    Language English
    Publishing date 2014-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers6042343
    Database MEDical Literature Analysis and Retrieval System OnLINE

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