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  1. Article: Céphalées chroniques sur hypotension de liquide céphalorachidien idiopathique traitées par bloc sphénopalatin.

    Nicolet, G / Reuter, G / Tran, G

    Revue medicale de Liege

    2022  Volume 77, Issue 7-8, Page(s) 477–480

    Abstract: Sphenopalatine ganglion block (SPGB) is a well-known technique of anesthesia used for the treatment of many types of facial pain syndromes. Its utility in the treatment of headaches due to cerebrospinal fluid hypotension, caused by dural breach or not, ... ...

    Title translation Chronic headaches due to idiopathic cerebrospinal fluid hypotension treated with sphenopalatine ganglion block.
    Abstract Sphenopalatine ganglion block (SPGB) is a well-known technique of anesthesia used for the treatment of many types of facial pain syndromes. Its utility in the treatment of headaches due to cerebrospinal fluid hypotension, caused by dural breach or not, seems established but the lack of strong studies proving its efficacy or its superiority compared to epidural blood patch doesn't allow it, for now, to be a part of the official treatment algorithm. We report the case of a patient presenting idiopathic cerebrospinal hypotension (Schaltenbrand syndrome) treated effectively with a sphenopalatine ganglion block using the intranasal approach.
    MeSH term(s) Headache/etiology ; Headache/therapy ; Headache Disorders ; Humans ; Hypotension ; Sphenopalatine Ganglion Block/methods
    Language French
    Publishing date 2022-08-05
    Publishing country Belgium
    Document type Case Reports
    ZDB-ID 414001-1
    ISSN 0370-629X ; 0035-3663
    ISSN 0370-629X ; 0035-3663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: High seroprevalence of hepatitis E virus (HEV) in South Transdanubia, Hungary (2010-2022).

    Balázs, Benigna / Boros, Ákos / Pankovics, Péter / Reuter, Gábor

    Acta microbiologica et immunologica Hungarica

    2023  Volume 70, Issue 2, Page(s) 119–125

    Abstract: Hepatitis E virus (HEV) is an increasingly recognized etiological agent of acute, chronic and extrahepatic human infections with primarily zoonotic origin in Europe. Limited numbers of comprehensive population-based studies are available related to HEV ... ...

    Abstract Hepatitis E virus (HEV) is an increasingly recognized etiological agent of acute, chronic and extrahepatic human infections with primarily zoonotic origin in Europe. Limited numbers of comprehensive population-based studies are available related to HEV seroepidemiology, especially from Central Europe.The aim of this study was to investigate the seroprevalence and trends of total and IgM antibodies against HEV in different age groups in the population of South Transdanubia, Hungary, within a thirteen years long period between the years 2010 and 2022.We retrospectively analysed the serological test results of HEV total and HEV IgM antibodies carried out by ELISA technique using Dia.Pro (Diagnostic Bioprobes, Italy) kit from serum samples collected from patients with or without hepatitis between January 1, 2010 and December 31, 2022.The number of tested samples (∑6,996 for total antibody and ∑6,582 for IgM) increased during the study period. The average HEV total and the IgM antibody seropositivities were 33% (2,307/6,996 samples) and 9.6% (642/6,582 samples), respectively, in the study population. The HEV total antibody seropositivity varied in different age groups between 3.9% (age group 1-5 years) and 58.6% (86-90 years) and showed an increasing positivity by age. At the age groups >50 years, nearly half (43%) of the population had antibodies against HEV. The HEV IgM positivity had an increasing trend of up to 13.9% in the age group 81-85 years.High HEV total and IgM antibody seroprevalence were detected in South Transdanubia, Hungary, confirming that this region is highly endemic for HEV infections in Europe.
    MeSH term(s) Humans ; Adolescent ; Child, Preschool ; Hepatitis E virus ; Seroepidemiologic Studies ; Hungary/epidemiology ; Retrospective Studies ; Immunoglobulin G ; Hepatitis Antibodies ; Immunoglobulin M
    Chemical Substances Immunoglobulin G ; Hepatitis Antibodies ; Immunoglobulin M
    Language English
    Publishing date 2023-05-09
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 918256-1
    ISSN 1588-2640 ; 1217-8950
    ISSN (online) 1588-2640
    ISSN 1217-8950
    DOI 10.1556/030.2023.02010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Molecular epidemiology and characterization of endemic, epidemic and imported hepatitis A virus (HAV) strains in Hungary (2003-2022).

    Reuter, Gábor / Boros, Ákos / Pankovics, Péter

    Acta microbiologica et immunologica Hungarica

    2023  Volume 70, Issue 3, Page(s) 246–251

    Abstract: Hepatitis A virus (HAV) is one of the most important etiological agents of acute viral hepatitis but comprehensive molecular epidemiological study with chrono-phylogeographical data are not available from Hungary.Between 2003 and 2022, a total of 8,307 ... ...

    Abstract Hepatitis A virus (HAV) is one of the most important etiological agents of acute viral hepatitis but comprehensive molecular epidemiological study with chrono-phylogeographical data are not available from Hungary.Between 2003 and 2022, a total of 8,307 HAV infections were registered officially in Hungary of which 400 (4.8%) HAV IgM antibody-positive serum samples were collected countrywide. HAV genomic RNA was successfully detected in 216/400 (54%) sera by RT-PCR subsequently confirmed by sequencing. The complete nucleotide sequences of VP1 region were determined in 32 representative HAV strains. Based on the sequence analysis, 150 (69.4%) strains were characterized as HAV sub-genotype IA and 66 (30.6%) as sub-genotype IB, respectively. Based on the combined epidemiological and molecular data, epidemic, endemic, and imported HAV strains were also characterized. The first two registered countrywide outbreaks started among men-sex-with men (MSM) in 2011 (sub-genotype IA) and 2021 (sub-genotype IB), the continuously circulating endemic/domestic HAV strain (sub-genotype IA) in East Hungary and the travel-related sub-genotype IB strains from Egypt should be highlighted. All HAV strains are deposited in the HAVNET database (https://www.rivm.nl/en/havnet).In this 20-year-long comprehensive molecular epidemiological study, we report the genetic characterization and geographic distribution of endemic, epidemic and imported HAV strains for the first time in Hungary with continuous co-circulation of sub-genotypes IA and IB HAV strains since 2003. These data provide basic information about the HAV situation in the country in an international context and can promote more effective national public health intervention strategies for the prevention of HAV transmissions and infections.
    MeSH term(s) Male ; Humans ; Hepatitis A virus/genetics ; Molecular Epidemiology ; Hungary/epidemiology ; Homosexuality, Male ; Travel ; Phylogeny ; Sexual and Gender Minorities ; Travel-Related Illness ; Genotype ; RNA, Viral/genetics
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2023-07-25
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 918256-1
    ISSN 1588-2640 ; 1217-8950
    ISSN (online) 1588-2640
    ISSN 1217-8950
    DOI 10.1556/030.2023.02099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Human orf virus (family Poxviridae) infection following a lamb bite in Hungary.

    Németh, Csongor / Boros, Ákos / Mészáros, Endre / Gyömörei, Csaba / Albert, Ervin / Pankovics, Péter / Reuter, Gábor

    Archives of virology

    2024  Volume 169, Issue 3, Page(s) 59

    Abstract: Human orf disease (called ecthyma contagiosum or contagious/infectious pustular dermatitis in animals) was confirmed on the fingers of both hands of a 24-year-old female, after feeding diseased lambs with a nursing bottle in April 2023. In addition to ... ...

    Abstract Human orf disease (called ecthyma contagiosum or contagious/infectious pustular dermatitis in animals) was confirmed on the fingers of both hands of a 24-year-old female, after feeding diseased lambs with a nursing bottle in April 2023. In addition to skin symptoms, she had low-grade fever (37.6°C) and swollen lymph nodes in both axilla. The presence of orf virus (genus Parapoxvirus, family Poxviridae) was confirmed, and this strain, Baja/2023/HUN (OR372161-OR372163), was found to have > 98% nucleotide sequence identity to sheep-origin orf viruses in four tested genome regions (ORF011/B2L, ORF019, ORF020/VIR, and ORF056). This is the first report of a human case of infection with the neglected zoonotic orf virus in Hungary.
    MeSH term(s) Female ; Humans ; Animals ; Sheep ; Young Adult ; Adult ; Orf virus/genetics ; Hungary ; Ecthyma, Contagious/epidemiology ; Poxviridae/genetics ; DNA, Viral/genetics
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2024-03-02
    Publishing country Austria
    Document type Case Reports ; Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-024-06002-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Detection and complete genome characterization of a genogroup X (GX) sapovirus (family Caliciviridae) from a golden jackal (Canis aureus) in Hungary.

    Balázs, Benigna / Boros, Ákos / Pankovics, Péter / Nagy, Gábor / Szekeres, Sándor / Urbán, Péter / Reuter, Gábor

    Archives of virology

    2024  Volume 169, Issue 5, Page(s) 100

    Abstract: In this study, a novel genotype of genogroup X (GX) sapovirus (family Caliciviridae) was detected in the small intestinal contents of a golden jackal (Canis aureus) in Hungary and characterised by viral metagenomics and next-generation sequencing ... ...

    Abstract In this study, a novel genotype of genogroup X (GX) sapovirus (family Caliciviridae) was detected in the small intestinal contents of a golden jackal (Canis aureus) in Hungary and characterised by viral metagenomics and next-generation sequencing techniques. The complete genome of the detected strain, GX/Dömsöd/DOCA-11/2020/HUN (PP105600), is 7,128 nt in length. The ORF1- and ORF2-encoded viral proteins (NSP, VP1, and VP2) have 98%, 95%, and 88% amino acid sequence identity to the corresponding proteins of genogroup GX sapoviruses from domestic pigs, but the nucleic acid sequence identity values for their genes are significantly lower (83%, 77%, and 68%). During an RT-PCR-based epidemiological investigation of additional jackal and swine samples, no other GX strains were detected, but a GXI sapovirus strain, GXI/Tótfalu/WBTF-10/2012/HUN (PP105601), was identified in a faecal sample from a wild boar (Sus scrofa). We report the detection of members of two likely underdiagnosed groups of sapoviruses (GX and GXI) in a golden jackal and, serendipitously, in a wild boar in Europe.
    MeSH term(s) Animals ; Swine ; Sapovirus/genetics ; Jackals ; Hungary/epidemiology ; Genotype ; Caliciviridae ; Canidae ; Sus scrofa
    Language English
    Publishing date 2024-04-17
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-024-06034-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Closure strategy for endoscopic pituitary surgery: Experience from 3015 patients.

    Baussart, Bertrand / Venier, Alice / Jouinot, Anne / Reuter, Gilles / Gaillard, Stephan

    Frontiers in oncology

    2023  Volume 12, Page(s) 1067312

    Abstract: Introduction: Effective strategies are required to ensure optimal management of the crucial closure step in endoscopic pituitary surgery. Many surgical techniques have been reported but no significant consensus has been defined.: Methods: Between ... ...

    Abstract Introduction: Effective strategies are required to ensure optimal management of the crucial closure step in endoscopic pituitary surgery. Many surgical techniques have been reported but no significant consensus has been defined.
    Methods: Between January 2006 and March 2022, 3015 adult patients with pituitary adenomas were operated on by a single expert neurosurgical team, using a mononostril endoscopic endonasal approach. Based of preoperative risk factors of and operative findings, a detailed closure strategy was used. Body mass index >40, sellar floor lysis, number of surgeries>2, large skull base destruction, prior radiotherapy were considered as preoperative risk factors for closure failure. All patients treated with an expanded endonasal approach were excluded.
    Results: Patients were mostly women (F/M ratio: 1.4) with a median age of 50 (range: 18 -89). Intraoperative CSF leak requiring specific surgical management was observed in 319/3015 (10.6%) of patients. If intraoperative leak occurred, patients with predictive risk factors were managed using a Foley balloon catheter in case of sellar floor lysis or BMI>40 and a multilayer repair strategy with a vascularized nasoseptal flap in other cases. Postoperative CSF leak occurred in 29/3015 (1%) of patients, while meningitis occurred in 24/3015 (0.8%) of patients. In patients with intraoperative leak, closure management failed in 11/319 (3.4%) of cases.
    Conclusion: Based on our significant 16-year experience, our surgical management is reliable and easy to follow. With a planned and stepwise strategy, the closure step can be optimized and tailored to each patient with a very low failure rate.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1067312
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  7. Article ; Online: A novel mammarenavirus (family Arenaviridae) in hedgehogs (Erinaceus roumanicus) in Europe.

    Reuter, Gábor / Boros, Ákos / Takáts, Károly / Mátics, Róbert / Pankovics, Péter

    Archives of virology

    2023  Volume 168, Issue 7, Page(s) 174

    Abstract: In this study, a novel mammarenavirus (family Arenaviridae) was identified in a hedgehog (family Erinaceidae) in Hungary and genetically characterized. Mecsek Mountains virus (MEMV, OP191655, OP191656) was detected in nine (45%) out of 20 faecal ... ...

    Abstract In this study, a novel mammarenavirus (family Arenaviridae) was identified in a hedgehog (family Erinaceidae) in Hungary and genetically characterized. Mecsek Mountains virus (MEMV, OP191655, OP191656) was detected in nine (45%) out of 20 faecal specimens collected from a Northern white-breasted hedgehog (Erinaceus roumanicus). The L-segment proteins (RdRp and Z) and S-segment proteins (NP and GPC) of MEMV had 67.5%/70% and 74.6%/65.6% amino acid sequence identity, respectively, to the corresponding proteins of Alxa virus (species Mammarenavirus alashanense) identified recently in an anal swab from a three-toed jerboa (Dipus sagitta) in China. MEMV is the second known arenavirus endemic in Europe.
    MeSH term(s) Animals ; Hedgehogs ; Arenaviridae/genetics ; Europe ; Hungary/epidemiology ; China
    Language English
    Publishing date 2023-06-08
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05804-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A novel vesivirus (family Caliciviridae) in European badgers (Meles meles) in Hungary, 2020/2021.

    Reuter, Gábor / Pankovics, Péter / Nagy, Gábor / Szekeres, Sándor / Boros, Ákos

    Archives of virology

    2023  Volume 168, Issue 4, Page(s) 108

    Abstract: In this study, a novel vesivirus (family Caliciviridae) was detected and characterized in faecal and tissue (blood and spleen) specimens collected from three (23.1%) out of 13 European badgers (Meles meles) in Hungary that were tested using RT-PCR and ... ...

    Abstract In this study, a novel vesivirus (family Caliciviridae) was detected and characterized in faecal and tissue (blood and spleen) specimens collected from three (23.1%) out of 13 European badgers (Meles meles) in Hungary that were tested using RT-PCR and sequencing methods. The complete genome of the vesivirus strain European badger/B40/2021/HUN (OQ161773) is 8,375 nucleotides in length. The ORF1, ORF2, and ORF3 proteins have 81.1%, 70.5%, and 64.2% amino acid sequence identity, respectively, to the corresponding proteins of Asian badger vesivirus, which was first reported in badgers in China in 2022. These results indicate that more than one lineage/species of vesiviruses circulates in mustelid badgers in geographically different regions.
    MeSH term(s) Animals ; Vesivirus ; Hungary ; Mustelidae/genetics ; China
    Language English
    Publishing date 2023-03-11
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 7491-3
    ISSN 1432-8798 ; 0304-8608
    ISSN (online) 1432-8798
    ISSN 0304-8608
    DOI 10.1007/s00705-023-05733-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Seroprevalence and genotype distribution of hepatitis A virus in the pre-vaccine era in South Transdanubia, Hungary (2010-2020).

    Reuter, Gábor / Boros, Ákos / Pankovics, Péter

    Acta microbiologica et immunologica Hungarica

    2022  Volume 69, Issue 3, Page(s) 228–232

    Abstract: In this study, the age-related seroprevalence of hepatitis A virus (HAV) infection was investigated in the population in South-Transdanubia, Southwest Hungary (Central Europe) between years 2010 and 2020. Up to the age of 40, the HAV seropositivity was ... ...

    Abstract In this study, the age-related seroprevalence of hepatitis A virus (HAV) infection was investigated in the population in South-Transdanubia, Southwest Hungary (Central Europe) between years 2010 and 2020. Up to the age of 40, the HAV seropositivity was less than 18% in all age groups indicating a low level of HAV endemicity in this part of the country in the covered study period. The HAV seropositivity started to increase at the age group 41-45 years, reaching the ∼50% at age group 56-60, and 75-80% at age group 66-70, respectively. A total of 43 (0.2%) of the 21,106 tested sera were HAV IgM-positive (the annual percentage range of HAV IgM-positivity was 0.046-0.6%). Total of 24 (55.8%) of the 43 HAV IgM-positive samples tested RT-PCR-positive confirmed as HAV sub-genotypes IA (N = 17; 70.8%) and IB (N = 7; 29.2%), respectively. Imported HAV infections (three cases from Romania, and one-one case from Austria and Italy), two small outbreaks and 11 cases of a genetically identical sub-genotype IA strain (GenBank number of the prototype strain: KM657825) from 2012 to 2014 were identified later connected directly to the enormous HAV outbreak initiated among men who have sex with men (MSM) at the end of 2011 in the capital Budapest.In summary, low endemicity but high and increased susceptibility for HAV infection was found in the population in Southwest Hungary, where repeated introduction of sub-genotypes IA and IB HAV strains were identified between 2010 and 2020.
    MeSH term(s) Male ; Humans ; Hepatitis A virus/genetics ; Homosexuality, Male ; Hungary/epidemiology ; Seroepidemiologic Studies ; Phylogeny ; Sexual and Gender Minorities ; Hepatitis A/epidemiology ; Hepatitis A Antibodies ; Genotype ; Disease Outbreaks ; Immunoglobulin M
    Chemical Substances Hepatitis A Antibodies ; Immunoglobulin M
    Language English
    Publishing date 2022-08-16
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 918256-1
    ISSN 1588-2640 ; 1217-8950
    ISSN (online) 1588-2640
    ISSN 1217-8950
    DOI 10.1556/030.2022.01814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Du respect que l'on doit au patient, même anesthésié.

    Reuter, G / Nollet, A

    Neuro-Chirurgie

    2015  Volume 61, Issue 4, Page(s) 298–299

    Title translation Even anesthetized, the patient deserves our respect.
    MeSH term(s) Anesthesia ; Humans ; Patient Satisfaction ; Physician's Role
    Language French
    Publishing date 2015-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 207146-0
    ISSN 1773-0619 ; 0028-3770 ; 0150-9586
    ISSN (online) 1773-0619
    ISSN 0028-3770 ; 0150-9586
    DOI 10.1016/j.neuchi.2015.03.004
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