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  1. Article: The Dangerous Liaisons in the Oxidative Stress Response to

    Reverte, Marta / Snäkä, Tiia / Fasel, Nicolas

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 4

    Abstract: ... ...

    Abstract Leishmania
    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11040409
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  2. Article ; Online: Leishmania

    Reverte, Marta / Fasel, Nicolas

    Bio-protocol

    2019  Volume 9, Issue 22, Page(s) e3431

    Abstract: Leishmaniasis remains a major public health problem worldwide with a prevalence of 12 million, an incidence of 1 million persons, and 350 million people being at risk. Murine models have been largely used for studying the host-pathogen relationship and ... ...

    Abstract Leishmaniasis remains a major public health problem worldwide with a prevalence of 12 million, an incidence of 1 million persons, and 350 million people being at risk. Murine models have been largely used for studying the host-pathogen relationship and developing effective chemotherapies against
    Language English
    Publishing date 2019-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3431
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  3. Book ; Online: Measuring arousal and stress physiology on Esports, a League of Legends case study

    Berga, David / Pereda, Alexandre / De Filippi, Eleonora / Nandi, Arijit / Febrer, Eulalia / Reverte, Marta / Russo, Lautaro

    2023  

    Abstract: Esports gaming is an area in which videogame players need to cooperate and compete with each other, influencing their cognitive load, processing, stress, and social skills. Here it is unknown to which extent competitive videogame play using a desktop ... ...

    Abstract Esports gaming is an area in which videogame players need to cooperate and compete with each other, influencing their cognitive load, processing, stress, and social skills. Here it is unknown to which extent competitive videogame play using a desktop setting can affect the physiological responses of players' autonomic nervous system. For such, we propose a study where we have measured distinct electrodermal and cardiac activity metrics over competitive players during several League of Legends gameplay sessions in a Esports stadium. We mainly found that game performance (whether winning or losing the game) significantly affects both electrodermal and cardiac activity, where players who lost the game showed higher stress-related physiological responses, as compared to winning players. We also found that important specific in-game events such as "Killing", "Dying" or "Destroying Turret" significantly increased both electrodermal and cardiac activity over players more than other less-relevant events such as "Placing Wards" or "Destroying Turret Plates". Finally, by analyzing activity over player roles we found different trends of activity on these measurements, this could foster the exploration on human physiology with a higher set of participants in future Esports studies.

    Comment: 10 pages, 6 tables
    Keywords Computer Science - Human-Computer Interaction
    Subject code 796
    Publishing date 2023-02-27
    Publishing country us
    Document type Book ; Online
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  4. Article ; Online: Dissection of the macrophage response towards infection by the

    Bekkar, Amel / Isorce, Nathalie / Snäkä, Tiia / Claudinot, Stéphanie / Desponds, Chantal / Kopelyanskiy, Dmitry / Prével, Florence / Reverte, Marta / Xenarios, Ioannis / Fasel, Nicolas / Teixeira, Filipa

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 941888

    Abstract: ... ...

    Abstract Leishmania
    MeSH term(s) Animals ; Humans ; Interferon Type I/immunology ; Leishmania/virology ; Leishmaniasis/immunology ; Leishmaniasis/parasitology ; Leishmaniasis/virology ; Leishmaniavirus ; Macrophages/immunology ; Macrophages/parasitology ; Mice
    Chemical Substances Interferon Type I
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.941888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Trained Immunity Confers Prolonged Protection From Listeriosis.

    Théroude, Charlotte / Reverte, Marta / Heinonen, Tytti / Ciarlo, Eleonora / Schrijver, Irene T / Antonakos, Nikolaos / Maillard, Nicolas / Pralong, Florian / Le Roy, Didier / Roger, Thierry

    Frontiers in immunology

    2021  Volume 12, Page(s) 723393

    Abstract: Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection ...

    Abstract Trained immunity refers to the ability of the innate immune system exposed to a first challenge to provide an enhanced response to a secondary homologous or heterologous challenge. We reported that training induced with β-glucan one week before infection confers protection against a broad-spectrum of lethal bacterial infections. Whether this protection persists over time is unknown. To tackle this question, we analyzed the immune status and the response to
    MeSH term(s) Animals ; Bone Marrow ; Cytokines/metabolism ; Female ; Immunity, Innate ; Inflammation/immunology ; Listeria monocytogenes/immunology ; Listeriosis/immunology ; Listeriosis/microbiology ; Mice ; Mice, Inbred C57BL ; Monocytes/metabolism ; Neutrophils/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-09-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.723393
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  6. Article ; Online: In and out:

    Jha, Baijayanti / Reverte, Marta / Ronet, Catherine / Prevel, Florence / Morgenthaler, Florence D / Desponds, Chantal / Lye, Lon-Fye / Owens, Katherine L / Scarpellino, Leonardo / Dubey, Lalit Kumar / Sabine, Amélie / Petrova, Tatiana V / Luther, Sanjiv A / Beverley, Stephen M / Fasel, Nicolas

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 941860

    Abstract: The lymphatic system plays a crucial role in mounting immune response against intracellular pathogens, and recent studies have documented its role in facilitating tumor dissemination linked largely with cancer cells. However, in mucocutaneous ... ...

    Abstract The lymphatic system plays a crucial role in mounting immune response against intracellular pathogens, and recent studies have documented its role in facilitating tumor dissemination linked largely with cancer cells. However, in mucocutaneous leishmaniasis (MCL) caused by
    MeSH term(s) Humans ; Leishmania ; Leishmania braziliensis ; Leishmaniasis, Mucocutaneous ; Lymphatic System ; Neoplasms
    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.941860
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  7. Article ; Online: The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism.

    Reverte, Marta / Eren, Remzi Onur / Jha, Baijayanti / Desponds, Chantal / Snäkä, Tiia / Prevel, Florence / Isorce, Nathalie / Lye, Lon-Fye / Owens, Katherine L / Gazos Lopes, Ulisses / Beverley, Stephen M / Fasel, Nicolas

    PLoS pathogens

    2021  Volume 17, Issue 3, Page(s) e1009422

    Abstract: The oxidative burst generated by the host immune system can restrict intracellular parasite entry and growth. While this burst leads to the induction of antioxidative enzymes, the molecular mechanisms and the consequences of this counter-response on the ... ...

    Abstract The oxidative burst generated by the host immune system can restrict intracellular parasite entry and growth. While this burst leads to the induction of antioxidative enzymes, the molecular mechanisms and the consequences of this counter-response on the life of intracellular human parasites are largely unknown. The transcription factor NF-E2-related factor (NRF2) could be a key mediator of antioxidant signaling during infection due to the entry of parasites. Here, we showed that NRF2 was strongly upregulated in infection with the human Leishmania protozoan parasites, its activation was dependent on a NADPH oxidase 2 (NOX2) and SRC family of protein tyrosine kinases (SFKs) signaling pathway and it reprogrammed host cell metabolism. In inflammatory leishmaniasis caused by a viral endosymbiont inducing TNF-α in chronic leishmaniasis, NRF2 activation promoted parasite persistence but limited TNF-α production and tissue destruction. These data provided evidence of the dual role of NRF2 in protecting both the invading pathogen from reactive oxygen species and the host from an excess of the TNF-α destructive pro-inflammatory cytokine.
    MeSH term(s) Animals ; Host-Parasite Interactions/physiology ; Inflammation/immunology ; Inflammation/metabolism ; Leishmania/immunology ; Leishmania/metabolism ; Leishmaniasis/immunology ; Leishmaniasis/metabolism ; Mice ; NF-E2-Related Factor 2/immunology ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/physiology ; Signal Transduction/immunology
    Chemical Substances NF-E2-Related Factor 2
    Language English
    Publishing date 2021-03-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1009422
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  8. Article ; Online: Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.

    Eren, Remzi Onur / Reverte, Marta / Rossi, Matteo / Hartley, Mary-Anne / Castiglioni, Patrik / Prevel, Florence / Martin, Ricardo / Desponds, Chantal / Lye, Lon-Fye / Drexler, Stefan K / Reith, Walter / Beverley, Stephen M / Ronet, Catherine / Fasel, Nicolas

    Cell host & microbe

    2016  Volume 20, Issue 3, Page(s) 318–328

    Abstract: Some strains of the protozoan parasite Leishmania guyanensis (L.g) harbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1). LRV1 recognition by TLR-3 increases parasite burden and lesion swelling in vivo. However, the mechanisms by which anti- ... ...

    Abstract Some strains of the protozoan parasite Leishmania guyanensis (L.g) harbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1). LRV1 recognition by TLR-3 increases parasite burden and lesion swelling in vivo. However, the mechanisms by which anti-viral innate immune responses affect parasitic infection are largely unknown. Upon investigating the mammalian host's response to LRV1, we found that miR-155 was singularly and strongly upregulated in macrophages infected with LRV1+ L.g when compared to LRV1- L.g. LRV1-driven miR-155 expression was dependent on TLR-3/TRIF signaling. Furthermore, LRV1-induced TLR-3 activation promoted parasite persistence by enhancing macrophage survival through Akt activation in a manner partially dependent on miR-155. Pharmacological inhibition of Akt resulted in a decrease in LRV1-mediated macrophage survival and consequently decreased parasite persistence. Consistent with these data, miR-155-deficient mice showed a drastic decrease in LRV1-induced disease severity, and lesional macrophages from these mice displayed reduced levels of Akt phosphorylation.
    MeSH term(s) Animals ; Cell Survival ; Disease Models, Animal ; Immunity, Innate ; Leishmania guyanensis/pathogenicity ; Leishmania guyanensis/physiology ; Leishmania guyanensis/virology ; Leishmaniasis, Mucocutaneous/parasitology ; Leishmaniasis, Mucocutaneous/pathology ; Leishmaniavirus/immunology ; Macrophages/immunology ; Macrophages/parasitology ; Mice ; Mice, Knockout ; MicroRNAs/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Toll-Like Receptor 3/metabolism
    Chemical Substances MicroRNAs ; Mirn155 microRNA, mouse ; TLR3 protein, mouse ; Toll-Like Receptor 3 ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2016-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2016.08.001
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: Individualised, perioperative open-lung ventilation strategy during one-lung ventilation (iPROVE-OLV): a multicentre, randomised, controlled clinical trial.

    Ferrando, Carlos / Carramiñana, Albert / Piñeiro, Patricia / Mirabella, Lucia / Spadaro, Savino / Librero, Julián / Ramasco, Fernando / Scaramuzzo, Gaetano / Cervantes, Oriol / Garutti, Ignacio / Parera, Ana / Argilaga, Marta / Herranz, Gracia / Unzueta, Carmen / Vives, Marc / Regi, Kevin / Costa-Reverte, Marta / Sonsoles Leal, María / Nieves-Alonso, Jesús /
    García, Esther / Rodríguez-Pérez, Aurelio / Fariña, Roberto / Cabrera, Sergio / Guerra, Elisabeth / Gallego-Ligorit, Lucia / Herrero-Izquierdo, Alba / Vallés-Torres, J / Ramos, Silvia / López-Herrera, Daniel / De La Matta, Manuel / Gokhan, Sertcakacilar / Kucur, Evrim / Mugarra, Ana / Soro, Marina / García, Laura / Sastre, José Alfonso / Aguirre, Pilar / Salazar, Claudia Jimena / Ramos, María Carolina / Morocho, Diego Rolando / Trespalacios, Ramón / Ezequiel-Fernández, Félix / Lamanna, Angella / Pia Cantatore, Leonarda / Laforgia, Donato / Bellas, Soledad / López, Carlos / Navarro-Ripoll, Ricard / Martínez, Samira / Vallverdú, Jordi / Jacas, Adriana / Yepes-Temiño, María José / Belda, Francisco Javier / Tusman, Gerardo / Suárez-Sipmann, Fernando / Villar, Jesús

    The Lancet. Respiratory medicine

    2023  Volume 12, Issue 3, Page(s) 195–206

    Abstract: Background: It is uncertain whether individualisation of the perioperative open-lung approach (OLA) to ventilation reduces postoperative pulmonary complications in patients undergoing lung resection. We compared a perioperative individualised OLA (iOLA) ...

    Abstract Background: It is uncertain whether individualisation of the perioperative open-lung approach (OLA) to ventilation reduces postoperative pulmonary complications in patients undergoing lung resection. We compared a perioperative individualised OLA (iOLA) ventilation strategy with standard lung-protective ventilation in patients undergoing thoracic surgery with one-lung ventilation.
    Methods: This multicentre, randomised controlled trial enrolled patients scheduled for open or video-assisted thoracic surgery using one-lung ventilation in 25 participating hospitals in Spain, Italy, Turkey, Egypt, and Ecuador. Eligible adult patients (age ≥18 years) were randomly assigned to receive iOLA or standard lung-protective ventilation. Eligible patients (stratified by centre) were randomly assigned online by local principal investigators, with an allocation ratio of 1:1. Treatment with iOLA included an alveolar recruitment manoeuvre to 40 cm H
    Findings: Between Sept 11, 2018, and June 14, 2022, we enrolled 1380 patients, of whom 1308 eligible patients (670 [434 male, 233 female, and three with missing data] assigned to iOLA and 638 [395 male, 237 female, and six with missing data] to standard lung-protective ventilation) were included in the final analysis. The proportion of patients with the composite outcome of severe postoperative pulmonary complications within the first 7 postoperative days was lower in the iOLA group compared with the standard lung-protective ventilation group (40 [6%] vs 97 [15%], relative risk 0·39 [95% CI 0·28 to 0·56]), with an absolute risk difference of -9·23 (95% CI -12·55 to -5·92). Recruitment manoeuvre-related adverse events were reported in five patients.
    Interpretation: Among patients subjected to lung resection under one-lung ventilation, iOLA was associated with a reduced risk of severe postoperative pulmonary complications when compared with conventional lung-protective ventilation.
    Funding: Instituto de Salud Carlos III and the European Regional Development Funds.
    MeSH term(s) Adult ; Humans ; Female ; Male ; Adolescent ; One-Lung Ventilation ; Respiration ; Continuous Positive Airway Pressure ; Lung/surgery ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00346-6
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    In stock of ZB MED Cologne/Königswinter

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