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  1. Article ; Online: Therapeutics + diagnostics = theranostics.

    Haslerud, Torjan / Revheim, Mona-Elisabeth R

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2023  Volume 143, Issue 1

    Title translation Terapi + diagnostikk = teranostikk.
    MeSH term(s) Humans ; Precision Medicine
    Language Norwegian
    Publishing date 2023-01-09
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.22.0776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 422: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 546: Show issues

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  2. Article ; Online: Re: Aducanumab-Related ARIA: Paean or Lament?

    Høilund-Carlsen, Poul F / Alavi, Abass / Revheim, Mona-Elisabeth

    Clinical nuclear medicine

    2023  Volume 48, Issue 6, Page(s) 505–506

    MeSH term(s) Humans ; Antibodies, Monoclonal, Humanized/adverse effects ; Alzheimer Disease ; Amyloid beta-Peptides
    Chemical Substances aducanumab (105J35OE21) ; Antibodies, Monoclonal, Humanized ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-02-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000004509
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1276: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: PET-based Novel Imaging Techniques with Recently Introduced Radiotracers. Preface.

    Revheim, Mona-Elisabeth / Alavi, Abass

    PET clinics

    2021  Volume 16, Issue 2, Page(s) xv–xvi

    MeSH term(s) Humans ; Positron-Emission Tomography ; Radiopharmaceuticals
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2021.01.001
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    Einzelsignatur: Show issues

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  4. Article ; Online: The value of FDG-PET/CT imaging in the assessment, monitoring, and management of COVID-19.

    Griffin, Matthew T / Werner, Thomas J / Alavi, Abass / Revheim, Mona-Elisabeth

    European physical journal plus

    2023  Volume 138, Issue 3, Page(s) 283

    Abstract: The pathogenesis of Coronavirus Disease 2019 (COVID-19) involves cytokine-driven recruitment and accumulation of inflammatory cells at sites of infection. These activated neutrophils, monocytes, and effector T cells are highly glycolytic and thus appear ... ...

    Abstract The pathogenesis of Coronavirus Disease 2019 (COVID-19) involves cytokine-driven recruitment and accumulation of inflammatory cells at sites of infection. These activated neutrophils, monocytes, and effector T cells are highly glycolytic and thus appear as [18]F-labeled fluorodeoxyglucose (FDG) avid sites on positron emission tomography (PET) imaging. FDG-PET-computed tomography (FDG-PET/CT) is a highly sensitive modality for the detection, monitoring, and assessing response related to COVID-19 disease activity that holds significant clinical relevance. To date, concerns over cost, access, and undue radiation exposure have limited the use of FDG-PET/CT in COVID-19 to a small number of individuals where PET-based interventions were already indicated. In this review, we summarize the existing literature on the use of FDG-PET in the detection and monitoring of COVID-19 with particular focus on several areas of clinical relevance that warrant future research: (1) incidental early detection of subclinical COVID-19 in patients who have undergone FDG-PET for other underlying diseases, (2) standardized quantitative assessment of COVID-19 disease burden at specific points in time, and (3) analysis of FDG-PET/CT data leading to better characterization of COVID-19 pathogenesis. Employing FDG-PET/CT for these purposes may allow for the earliest detection of COVID-19-associated venous thromboembolism (VTE), standardized monitoring of disease progression and response to treatment, and better characterization of the acute and chronic complications of this disease.
    Language English
    Publishing date 2023-03-27
    Publishing country Germany
    Document type Journal Article ; Review
    ISSN 2190-5444
    ISSN (online) 2190-5444
    DOI 10.1140/epjp/s13360-023-03797-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Quantitative SPECT/CT imaging of lead-212: a phantom study.

    Kvassheim, Monika / Revheim, Mona-Elisabeth R / Stokke, Caroline

    EJNMMI physics

    2022  Volume 9, Issue 1, Page(s) 52

    Abstract: Background: Lead-212 (: Results: Both acquisition parameters (combining two different energy windows and two different collimators) and iterative reconstruction parameters (varying the iterations x subsets between 10 × 1, 15 × 1, 30 × 1, 30 × 2, 30 ×  ...

    Abstract Background: Lead-212 (
    Results: Both acquisition parameters (combining two different energy windows and two different collimators) and iterative reconstruction parameters (varying the iterations x subsets between 10 × 1, 15 × 1, 30 × 1, 30 × 2, 30 × 3, 30 × 4, and 30 × 30) were investigated to evaluate visual quality and quantitative uncertainties based on phantom images. Calibration factors were determined using a homogeneous phantom and were stable when the total activity imaged exceeded 1 MBq for all the imaging protocols studied, but they increased sharply as the activity decayed below 1 MBq. Both a 20% window centred on 239 keV and a 40% window on 79 keV, with dual scatter windows of 5% and 20%, respectively, could be used. Visual quality at the lowest activity concentrations was improved with the High Energy collimator and the 79 keV energy window. Fractional uncertainty in the activity quantitation, including uncertainties from calibration factors and small volume effects, in spheres of 2.6 ml in the NEMA phantom was 16-21% for all protocols with the 30 × 4 filtered reconstruction except the High Energy collimator with the 239 keV energy window. Quantitative analysis was possible both with and without filters, but the visual quality of the images improved with a filter.
    Conclusions: Only minor differences were observed between the imaging protocols which were all determined suitable for quantitative imaging of
    Language English
    Publishing date 2022-08-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2768912-8
    ISSN 2197-7364
    ISSN 2197-7364
    DOI 10.1186/s40658-022-00481-z
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  6. Article: Correction to: Quantitative SPECT/CT imaging of lead-212: a phantom study.

    Kvassheim, Monika / Revheim, Mona-Elisabeth R / Stokke, Caroline

    EJNMMI physics

    2022  Volume 9, Issue 1, Page(s) 71

    Language English
    Publishing date 2022-10-10
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2768912-8
    ISSN 2197-7364
    ISSN 2197-7364
    DOI 10.1186/s40658-022-00499-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Alzheimer's Disease at a Crossroad: Time to Part from Amyloid to More Promising Aspects-Atherosclerosis for a Start.

    Høilund-Carlsen, Poul F / Revheim, Mona-Elisabeth / Alavi, Abass

    Journal of Alzheimer's disease : JAD

    2022  Volume 88, Issue 2, Page(s) 455–458

    Abstract: Three decades with the amyloid hypothesis, nearly two with amyloid-PET imaging, and one with testing of anti-amyloid therapy have not yielded benefits to patients with Alzheimer's disease (AD). It is time to focus on more promising options, e.g., ... ...

    Abstract Three decades with the amyloid hypothesis, nearly two with amyloid-PET imaging, and one with testing of anti-amyloid therapy have not yielded benefits to patients with Alzheimer's disease (AD). It is time to focus on more promising options, e.g., infection, low dose radiation, and atherosclerosis. The relevance of the latter in managing AD has fluctuated from being significant to insignificant. Current methodologies for detecting cerebral atherosclerosis reflect advanced changes in only major arteries. In contrast, 18F-sodium fluoride PET imaging assessing early-stage cerebral atherosclerosis regionally or in the entire vascular bed may provide new insight in this age-related process in dementia.
    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Amyloid ; Amyloid beta-Peptides ; Amyloidogenic Proteins ; Amyloidosis ; Atherosclerosis/diagnostic imaging ; Humans ; Intracranial Arteriosclerosis ; Positron-Emission Tomography/methods
    Chemical Substances Amyloid ; Amyloid beta-Peptides ; Amyloidogenic Proteins
    Language English
    Publishing date 2022-05-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?

    Høilund-Carlsen, Poul F / Alavi, Abass / Castellani, Rudolph J / Neve, Rachael L / Perry, George / Revheim, Mona-Elisabeth / Barrio, Jorge R

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: The amyloid cascade hypothesis for Alzheimer's disease is still alive, although heavily challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that the protein amyloid-beta is the cause of the disease. Two antibodies, ... ...

    Abstract The amyloid cascade hypothesis for Alzheimer's disease is still alive, although heavily challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that the protein amyloid-beta is the cause of the disease. Two antibodies, aducanumab and lecanemab, have been approved by the U.S. Food and Drug Administration, while a third, donanemab, is under review. The main argument for the FDA approvals is a presumed therapy-induced removal of cerebral amyloid deposits. Lecanemab and donanemab are also thought to cause some statistical delay in the determination of cognitive decline. However, clinical efficacy that is less than with conventional treatment, selection of amyloid-positive trial patients with non-specific amyloid-PET imaging, and uncertain therapy-induced removal of cerebral amyloids in clinical trials cast doubt on this anti-Alzheimer's antibody therapy and hence on the amyloid hypothesis, calling for a more thorough investigation of the negative impact of this type of therapy on the brain.
    MeSH term(s) United States ; Humans ; Alzheimer Disease/therapy ; Ice Cover ; Amyloidogenic Proteins ; Radioimmunotherapy ; Antibodies, Monoclonal, Humanized
    Chemical Substances donanemab ; Amyloidogenic Proteins ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073892
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  9. Article: Optimization of Q.Clear reconstruction for dynamic

    Lysvik, Elisabeth Kirkeby / Mikalsen, Lars Tore Gyland / Rootwelt-Revheim, Mona-Elisabeth / Emblem, Kyrre Eeg / Hjørnevik, Trine

    EJNMMI physics

    2023  Volume 10, Issue 1, Page(s) 65

    Abstract: Background: Q.Clear, a Bayesian penalized likelihood reconstruction algorithm, has shown high potential in improving quantitation accuracy in PET systems. The Q.Clear algorithm controls noise during the iterative reconstruction through a β penalization ... ...

    Abstract Background: Q.Clear, a Bayesian penalized likelihood reconstruction algorithm, has shown high potential in improving quantitation accuracy in PET systems. The Q.Clear algorithm controls noise during the iterative reconstruction through a β penalization factor. This study aimed to determine the optimal β-factor for accurate quantitation of dynamic PET scans.
    Methods: A Flangeless Esser PET Phantom with eight hollow spheres (4-25 mm) was scanned on a GE Discovery MI PET/CT system. Data were reconstructed into five sets of variable acquisition times using Q.Clear with 18 different β-factors ranging from 100 to 3500. The recovery coefficient (RC), coefficient of variation (CV
    Results: In general, RC and CV
    Conclusion: In a complex dynamic dataset with variable acquisition times, the optimal β-factor provides a balance between accuracy and precision. Based on our results, we suggest a β-factor of 300-500 for quantitation of small structures with dynamic PET imaging, while large structures may benefit from higher β-factors.
    Trial registration: Clinicaltrials.gov, NCT03951142. Registered 5 October 2019, https://clinicaltrials.gov/ct2/show/NCT03951142 . EudraCT no 2018-003229-27. Registered 26 February 2019, https://www.clinicaltrialsregister.eu/ctr-search/trial/2018-003229-27/NO .
    Language English
    Publishing date 2023-10-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2768912-8
    ISSN 2197-7364
    ISSN 2197-7364
    DOI 10.1186/s40658-023-00584-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: 18

    Reddy, Natasha / Raynor, William Y / Werner, Thomas J / Baker, Joshua F / Alavi, Abass / Revheim, Mona-Elisabeth

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 13

    Abstract: Rheumatoid arthritis (RA) involves chronic inflammation of synovial joints, causing pain, stiffness, and limited mobility. ...

    Abstract Rheumatoid arthritis (RA) involves chronic inflammation of synovial joints, causing pain, stiffness, and limited mobility.
    Language English
    Publishing date 2023-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13132149
    Database MEDical Literature Analysis and Retrieval System OnLINE

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