Article ; Online: Glycerol as a precursor for hepatic de novo glutathione synthesis in human liver.
2023 Volume 63, Page(s) 102749
Abstract: Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components ... ...
Abstract | Background: Glycerol is a substrate for gluconeogenesis and fatty acid esterification in the liver, processes which are upregulated in obesity and may contribute to excess fat accumulation. Glycine and glutamate, in addition to cysteine, are components of glutathione, the major antioxidant in the liver. In principle, glycerol could be incorporated into glutathione via the TCA cycle or 3-phosphoglycerate, but it is unknown whether glycerol contributes to hepatic de novo glutathione biosynthesis. Methods: Glycerol metabolism to hepatic metabolic products including glutathione was examined in the liver from adolescents undergoing bariatric surgery. Participants received oral [U- Results: Data were collected from 8 participants (2 male, 6 female; age 17.1 years [range 14-19]; BMI 47.4 kg/m Conclusions: This is the first report of glycerol incorporation into glutathione through glycine or glutamate metabolism in human liver. This could represent a compensatory mechanism to increase glutathione in the setting of excess glycerol delivery to the liver. |
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MeSH term(s) | Humans ; Liver/metabolism ; Glutathione/metabolism ; Glycerol/metabolism ; Male ; Female ; Adolescent ; Young Adult ; Magnetic Resonance Spectroscopy |
Chemical Substances | Glutathione (GAN16C9B8O) ; Glycerol (PDC6A3C0OX) |
Language | English |
Publishing date | 2023-05-16 |
Publishing country | Netherlands |
Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
ZDB-ID | 2701011-9 |
ISSN | 2213-2317 ; 2213-2317 |
ISSN (online) | 2213-2317 |
ISSN | 2213-2317 |
DOI | 10.1016/j.redox.2023.102749 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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