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  1. Article ; Online: High Effectiveness of Midazolam and Lidocaine in the Treatment of Acute Neonatal Seizures.

    Castro Conde, José Ramón / González Campo, Candelaria / González Barrios, Desiré / Reyes Millán, Beatriz / Díaz González, Candelaria Leticia / Jiménez Sosa, Alejandro

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2023  

    Abstract: Purpose: To assess the clinical effectiveness of treating acute seizures with midazolam and lidocaine infusion.: Methods: This single-center historical cohort study included 39 term neonates with electrographic seizures who underwent treatment with ... ...

    Abstract Purpose: To assess the clinical effectiveness of treating acute seizures with midazolam and lidocaine infusion.
    Methods: This single-center historical cohort study included 39 term neonates with electrographic seizures who underwent treatment with midazolam (1st line) and lidocaine (2nd line). Therapeutic response was measured using continuous video-EEG monitoring. The EEG measurements included total seizure burden (minutes), maximum ictal fraction (minutes/hour), and EEG-background (normal/slightly abnormal vs. abnormal). Treatment response was considered good (seizure control with midazolam infusion), intermediate (need to add lidocaine to the control), or no response. Using clinical assessments supplemented by BSID-III and/or ASQ-3 at 2 to 9 years old age, neurodevelopment was classified as normal, borderline, or abnormal.
    Results: A good therapeutic response was obtained in 24 neonates, an intermediate response in 15, and no response in any of the neonates. Babies with good response showed lower values in maximum ictal fraction compared with those with intermediate response (95% CI: 5.85-8.64 vs. 9.14-19.14, P = 0.002). Neurodevelopment was considered normal in 24 children, borderline in five, and abnormal in other 10 children. Abnormal neurodevelopment was significantly associated with an abnormal EEG background, maximum ictal fraction >11 minutes, and total seizure burden >25 minutes (odds ratio 95% CI: 4.74-1708.52, P = 0.003; 1.72-200, P = 0.016; 1.72-142.86, P = 0.026, respectively) but not with the therapeutic response. Serious adverse effects were not recorded.
    Conclusions: This retrospective study suggests that the midazolam/lidocaine association could potentially be efficacious in decreasing seizure burden in term neonates with acute seizures. These results would justify testing the midazolam/lidocaine combination as a first-line treatment for neonatal seizures in future clinical trials.
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000001013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1921: Show issues Location:
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  2. Article ; Online: Evaluation of Adverse Effects in Nursing Mothers and Their Infants After COVID-19 mRNA Vaccination.

    Romero Ramírez, Dolores Sabina / Suárez Hernández, María Isis / Fernández Vilar, Ana María / Rivero Falero, Mónica / Reyes Millán, Beatriz / González Carretero, Paloma / Pérez, María Magdalena Lara / Carretero Pérez, Mercedes / Martín Pulido, Saúl / Pera Villacampa, Lorena / García Bello, Miguel Ángel / Mesa Medina, Orlando Manuel / Roper, Sabine

    Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine

    2022  Volume 17, Issue 5, Page(s) 412–421

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) 2019-nCoV Vaccine mRNA-1273/adverse effects ; Adult ; BNT162 Vaccine/adverse effects ; Breast Feeding ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Female ; Humans ; Infant ; Mothers ; Prospective Studies ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2234680-6
    ISSN 1556-8342 ; 1556-8253
    ISSN (online) 1556-8342
    ISSN 1556-8253
    DOI 10.1089/bfm.2021.0256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: SARS-CoV-2 Antibodies in Breast Milk After Vaccination.

    Romero Ramírez, Dolores Sabina / Lara Pérez, María Magdalena / Carretero Pérez, Mercedes / Suárez Hernández, María Isis / Martín Pulido, Saúl / Pera Villacampa, Lorena / Fernández Vilar, Ana María / Rivero Falero, Mónica / González Carretero, Paloma / Reyes Millán, Beatriz / Roper, Sabine / García Bello, Miguel Ángel

    Pediatrics

    2021  Volume 148, Issue 5

    Abstract: Background and objectives: Passive and active immunity transfer through human milk (HM) constitutes a key element in the infant's developing immunity. Certain infectious diseases and vaccines have been described to induce changes in the immune ... ...

    Abstract Background and objectives: Passive and active immunity transfer through human milk (HM) constitutes a key element in the infant's developing immunity. Certain infectious diseases and vaccines have been described to induce changes in the immune components of HM.
    Methods: We conducted a prospective cohort single-institution study from February 2 to April 4, 2021. Women who reported to be breastfeeding at the time of their coronavirus disease 2019 (COVID-19) vaccination were invited to participate. Blood and milk samples were collected on day 14 after their second dose of the vaccine. Immunoglobulin G (IgG) antibodies against nucleocapsid protein as well as IgG, immunoglobulin M and immunoglobulin A (IgA) antibodies against the spike 1 protein receptor-binding domain against severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2 RBD-S1) were analyzed in both serum and HM samples.
    Results: Most of the participants (ie, 94%) received the BNT162b2 messenger RNA COVID-19 vaccine. The mean serum concentration of anti-SARS-CoV-2 RBD-S-IgG antibodies in vaccinated individuals was 3379.6 ± 1639.5 binding antibody units per mL. All vaccinated study participants had anti-SARS-CoV-2 RBD-S1-IgG, and 89% of them had anti-SARS-CoV-2 RBD-S-IgA in their milk. The antibody concentrations in the milk of mothers who were breastfeeding 24 months were significantly higher than in mothers with breastfeeding periods <24 months (
    Conclusions: We found a clear association between COVID-19 vaccination and specific immunoglobulin concentrations in HM. This effect was more pronounced when lactation periods exceeded 23 months. The influence of the lactation period on immunoglobulins was specific and independent of other variables.
    MeSH term(s) Adult ; Antibodies, Viral/analysis ; COVID-19 Vaccines ; Female ; Humans ; Immunoglobulin A/analysis ; Immunoglobulin G/analysis ; Immunoglobulin M/analysis ; Infant ; Infant, Newborn ; Male ; Milk, Human/chemistry ; Milk, Human/immunology ; Prospective Studies ; SARS-CoV-2/immunology ; Vaccination
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin A ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2021-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-052286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.131: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 357: Show issues

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  4. Article ; Online: Visual and Quantitative Electroencephalographic Analysis in Healthy Term Neonates Within the First Six Hours and the Third Day of Life.

    Castro Conde, José R / González Barrios, Desiré / González Campo, Candelaria / González González, Nieves L / Reyes Millán, Beatriz / Sosa, Alejandro Jiménez

    Pediatric neurology

    2017  Volume 77, Page(s) 54–60.e1

    Abstract: Background: What constitutes a "normal" background electroencephalography (EEG) rhythm immediately after birth is not well understood. We performed video-electroencephalography recordings in the first six hours (first measure) and the third day of life ( ...

    Abstract Background: What constitutes a "normal" background electroencephalography (EEG) rhythm immediately after birth is not well understood. We performed video-electroencephalography recordings in the first six hours (first measure) and the third day of life (second measure) for evidence of transient changes in brain function.
    Methods: We performed a cohort study of an incidental sample of healthy term neonates in a single-center nursery. Main outcome measures were as follows: (1) EEG visual analysis, which included sleep-wake cycles, proportions of discontinuity and bursts with delta brushes, and number per hour of alpha/theta rolandic activity, encoches frontales, and transients; and (2) the electroencephalographic spectral analysis, which included power spectrum in the following frequency bands: delta, 0.5 to 4 Hz; theta, 4 to 8 Hz; alpha, 8 to 13 Hz; and beta, 13 to 30 Hz. Theta/delta and alpha/delta ratios were also calculated.
    Results: Twenty-two babies were enrolled. Significant findings (P < 0.05) in the first six hours with respect to 48 to 72 hours of life were (1) increased discontinuity, indeterminate sleep, and bursts with delta brushes; (2) higher number of transients, and lower number of alpha/theta rolandic activity and encoches frontales. Minimal changes were found in power spectrum data. However, using receiver operating characteristic curve analysis, theta/delta ratio ≤0.484 was the best cutoff to discriminate between the two measures (positive predictive value, 100.0; 95% confidence interval 71.0 to 100).
    Conclusions: In healthy term neonates, immature electroencephalographic patterns, lack of clearly defined sleep-wake cycles, and frequent transients can be considered normal electroencephalographic findings in the first six hours of life. Normative power spectrum data are provided. These findings suggest that neonatal adaptation immediately after birth leads to transient changes in brain function.
    MeSH term(s) Brain/physiology ; Brain Mapping ; Brain Waves/physiology ; Cohort Studies ; Electroencephalography ; Female ; Fourier Analysis ; Humans ; Infant, Newborn ; Male ; Sleep/physiology ; Time Factors ; Video Recording ; Vision, Ocular/physiology
    Language English
    Publishing date 2017-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639164-3
    ISSN 1873-5150 ; 0887-8994
    ISSN (online) 1873-5150
    ISSN 0887-8994
    DOI 10.1016/j.pediatrneurol.2017.04.024
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    Zs.A 2260: Show issues Location:
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  5. Article ; Online: Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants.

    Castro Conde, José R / González Campo, Candelaria / González González, Nieves L / Reyes Millán, Beatriz / González Barrios, Desiré / Jiménez Sosa, Alejandro / Quintero Fuentes, Itziar

    Pediatric research

    2019  Volume 88, Issue 1, Page(s) 91–99

    Abstract: Background: Delayed brain function development in small-gestational-age (SGA) infants has been reported. We aimed to quantify rates of immature neonatal EEG patterns and their association with neurodevelopment in SGA full-term neonates.: Methods: ... ...

    Abstract Background: Delayed brain function development in small-gestational-age (SGA) infants has been reported. We aimed to quantify rates of immature neonatal EEG patterns and their association with neurodevelopment in SGA full-term neonates.
    Methods: Using a cohort design, 50 SGA (birthweight <10th percentile) and 44 appropriate-gestational-age (AGA) term neonates underwent continuous video-EEG recordings lasting >3 h. Seventy-three of them were assessed at 2-years-old using Bayley-III-Scales. For EEG analysis, several segments of discontinuous/alternating EEG tracings were selected.
    Main outcomes measured: (1) Visual analysis (patterns of EEG maturity); (2) Power spectrum in δ, θ, α and β frequency bands; and (3) scores in motor, cognitive and language development.
    Results: (1) SGA infants, compared to AGA, showed: (a) higher percentages of discontinuous EEG, both asynchrony and interhemispheric asymmetry, and bursts with delta-brushes, longer interburst-interval duration and more transients/hour; (b) lower relative power spectrum in δ and higher in α; and (c) lower scores on motor, language and cognitive neurodevelopment. (2) Asymmetry >5%, interburst-interval >5 s, discontinuity >11%, and bursts with delta-brushes >11% were associated with lower scores on Bayley-III.
    Conclusions: In this prospective study, SGA full-term neonates showed high rates of immature EEG patterns. Low-birthweight and immaturity EEG were both correlated with low development scores.
    MeSH term(s) Birth Weight ; Brain/physiopathology ; Child Development ; Cohort Studies ; Electroencephalography/methods ; Female ; Fetal Growth Retardation/diagnosis ; Fetal Growth Retardation/physiopathology ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age ; Male ; Prognosis ; Prospective Studies ; Vision, Ocular
    Language English
    Publishing date 2019-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-019-0693-0
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    Zs.A 564: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 373: Show issues

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  6. Article ; Online: Decreased concentrating capacity in children with febrile urinary tract infection and normal 99mTc-dimercaptosuccinic acid scan: does medullonephritis exist?

    García-Nieto, Víctor / González-Cerrato, Silvia / Luis-Yanes, María Isabel / Monge-Zamorano, Margarita / Reyes-Millán, Beatriz

    World journal of pediatrics : WJP

    2014  Volume 10, Issue 2, Page(s) 133–137

    Abstract: Background: Although 99mTc-dimercaptosuccinic acid (DMSA) scan is considered the gold standard for the diagnosis of acute pyelonephritis (AP), sometimes it produces false results in children with clinical features of AP. There are no studies on the ... ...

    Abstract Background: Although 99mTc-dimercaptosuccinic acid (DMSA) scan is considered the gold standard for the diagnosis of acute pyelonephritis (AP), sometimes it produces false results in children with clinical features of AP. There are no studies on the comparison of the sensitivity of DMSA and concentrating capacity test.
    Methods: Eighty-five infants with AP of less than one year old were studied to evaluate whether they had real AP or not. Data were compared between infants with an abnormal (group A, n=64) and those with a normal DMSA scan (group B, n=21) respectively. A DDAVP test was performed for each infant.
    Results: All the infants in both groups presented a high level of C-reactive protein and fever (≥38°C). There were no differences in clinical and analytical variables except C-reactive protein level in the two groups. Both groups exhibited a low urinary osmolality (87.5% in the group A vs. 85.7% in the group B). The patients with normal DMSA and decreased concentrating capacity have some renal parenchymal damage and not only a lower urinary infection. Of the infants with an abnormal DMSA scan, 33.9% showed renal scars after 6-12 months. No infant with a normal DMSA scan showed scars. The biochemical variables in both groups of infants were not related to vesicoureteral refl ux.
    Conclusion: Infants with AP, normal DMSA scan and low concentrating capacity may be characterized by a localized infection in the medulla (medullonephritis) or by a false negative DMSA scan.
    MeSH term(s) Acute Disease ; C-Reactive Protein/metabolism ; False Positive Reactions ; Female ; Fever ; Humans ; Infant ; Kidney Concentrating Ability/physiology ; Male ; Prospective Studies ; Pyelonephritis/diagnostic imaging ; Pyelonephritis/physiopathology ; Radionuclide Imaging ; Radiopharmaceuticals ; Retrospective Studies ; Technetium Tc 99m Dimercaptosuccinic Acid ; Urinary Tract Infections/diagnostic imaging ; Urinary Tract Infections/physiopathology
    Chemical Substances Radiopharmaceuticals ; Technetium Tc 99m Dimercaptosuccinic Acid (494JNQ8L28) ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2014-05-07
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article
    ZDB-ID 2236681-7
    ISSN 1867-0687 ; 1708-8569
    ISSN (online) 1867-0687
    ISSN 1708-8569
    DOI 10.1007/s12519-014-0482-0
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    Zs.A 6309: Show issues Location:
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