Article ; Online: Gut microbiota density influences host physiology and is shaped by host and microbial factors.
2019 Volume 8
Abstract: To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions. Physiologic ... ...
| Abstract | To identify factors that regulate gut microbiota density and the impact of varied microbiota density on health, we assayed this fundamental ecosystem property in fecal samples across mammals, human disease, and therapeutic interventions. Physiologic features of the host (carrying capacity) and the fitness of the gut microbiota shape microbiota density. Therapeutic manipulation of microbiota density in mice altered host metabolic and immune homeostasis. In humans, gut microbiota density was reduced in Crohn's disease, ulcerative colitis, and ileal pouch-anal anastomosis. The gut microbiota in recurrent Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter). |
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| MeSH term(s) | Adiposity ; Adult ; Aged ; Aged, 80 and over ; Animals ; Clostridioides difficile ; Clostridium Infections/microbiology ; Crohn Disease/microbiology ; Fecal Microbiota Transplantation ; Female ; Gastrointestinal Microbiome ; Homeostasis ; Humans ; Ileum/microbiology ; Immune System ; Inflammatory Bowel Diseases ; Male ; Mice ; Mice, Inbred C57BL ; Microbiota ; Middle Aged ; Mucous Membrane/microbiology ; Phenotype ; RNA, Ribosomal, 16S/metabolism ; Species Specificity ; Young Adult |
| Chemical Substances | RNA, Ribosomal, 16S |
| Language | English |
| Publishing date | 2019-01-22 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2687154-3 |
| ISSN | 2050-084X ; 2050-084X |
| ISSN (online) | 2050-084X |
| ISSN | 2050-084X |
| DOI | 10.7554/eLife.40553 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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