LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Iris Infiltration as a Sign of Relapse in a Child with Chronic Myeloid Leukemia.

    Ploysangam, Pimpiroon / Reynolds, Andrew L

    Ophthalmology

    2021  Volume 128, Issue 5, Page(s) 780

    MeSH term(s) Child, Preschool ; Humans ; Iris/pathology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology ; Leukemic Infiltration/pathology ; Male ; Neoplasm Recurrence, Local/diagnosis
    Language English
    Publishing date 2021-04-23
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 392083-5
    ISSN 1549-4713 ; 0161-6420
    ISSN (online) 1549-4713
    ISSN 0161-6420
    DOI 10.1016/j.ophtha.2020.12.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Bilateral ocular injuries with globe perforation and retinitis sclopetaria from birdshot shotgun: A case report and review of the literature.

    Ku, Cristy A / Jeng, Franklin / Reynolds, Andrew L / Patel, Sangita P

    Trauma case reports

    2020  Volume 28, Page(s) 100329

    Language English
    Publishing date 2020-06-28
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2835433-3
    ISSN 2352-6440 ; 2352-6440
    ISSN (online) 2352-6440
    ISSN 2352-6440
    DOI 10.1016/j.tcr.2020.100329
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Corneal collagen cross-linking in pediatric keratoconus with three protocols: a systematic review and meta-analysis.

    Fard, Ali Mahdavi / Reynolds, Andrew L / Lillvis, John H / Nader, Nader D

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2020  Volume 24, Issue 6, Page(s) 331–336

    Abstract: Background: Keratoconus is a bilateral progressive noninflammatory degenerative disease of the cornea characterized by corneal thinning, irregular astigmatism, and subsequent visual impairment. It has an aggressive course in children. This systematic ... ...

    Abstract Background: Keratoconus is a bilateral progressive noninflammatory degenerative disease of the cornea characterized by corneal thinning, irregular astigmatism, and subsequent visual impairment. It has an aggressive course in children. This systematic review evaluates the efficacy of available corneal collagen cross-linking (CXL) protocols for stabilizing the cornea in pediatric patients with keratoconus.
    Methods: We searched all peer-reviewed publications from 2000 to 2019 indexed in PubMed, Google Scholars, Web of Science, and Cochrane's Database for the terms keratoconus and cross-linking. The following data were extracted from eligible studies: study design, type of intervention, number of the eyes and mean age of patients for each study, duration of follow-up period, mean pre- and postoperative uncorrected and corrected visual acuity, keratometric and aberrometric indices, were analyzed with RevMan 5.3 software. Intra-and intergroup post hoc analyses of outcome variables were performed using t tests.
    Results: A total of 28 studies, including 1,300 eyes, were reviewed. In conventional and accelerated epithelium-off techniques, there was a significant improvement in uncorrected and corrected visual acuities. Similarly, the keratometric indices improved significantly after CXL. Uncorrected visual acuity did not alter after CXL using transepithelial method.
    Conclusions: Both conventional and accelerated collagen CXL of the cornea are effective therapeutic options in management of keratoconus in children.
    MeSH term(s) Child ; Humans ; Collagen/therapeutic use ; Cornea ; Corneal Topography ; Cross-Linking Reagents/therapeutic use ; Keratoconus/drug therapy ; Photochemotherapy ; Photosensitizing Agents/therapeutic use ; Riboflavin/therapeutic use ; Ultraviolet Rays
    Chemical Substances Collagen (9007-34-5) ; Cross-Linking Reagents ; Photosensitizing Agents ; Riboflavin (TLM2976OFR)
    Language English
    Publishing date 2020-12-03
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2020.08.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Effect of EnChroma glasses on color vision screening using Ishihara and Farnsworth D-15 color vision tests.

    Varikuti, Venkata N V / Zhang, Charles / Clair, Brandon / Reynolds, Andrew L

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2020  Volume 24, Issue 3, Page(s) 157.e1–157.e5

    Abstract: Background: The prevalence of color vision deficiency (CVD) is about 0.5% in females and 8% in males. Although there is no cure for CVD, specially filtered glasses are purported to improve color contrast. One recent development is the EnChroma filter. ... ...

    Abstract Background: The prevalence of color vision deficiency (CVD) is about 0.5% in females and 8% in males. Although there is no cure for CVD, specially filtered glasses are purported to improve color contrast. One recent development is the EnChroma filter. The purpose of this study was to assess the effect of the EnChroma filter on color vision screening (CVS) using Ishihara and Farnsworth D-15 color vision tests.
    Methods: The medical records of patients with CVD were reviewed retrospectively. Responses to color vision testing with and without the EnChroma filter were evaluated using Ishihara and Farnsworth D-15 tests, and the overall scores were analyzed.
    Results: A total of 38 eyes of 19 patients were included. Mean error scores of no filter compared to EnChroma were significantly reduced in 17 eyes using the Ishihara test (0.88 ± 0.03 vs 0.85 ± 0.03, P = 0.017). The error score significantly reduced only in deutans (P = 0.022), not in protans (P = 0.44). The confusion index of no filter to the EnChroma filter was significantly reduced in 20 eyes using the Farnsworth test (3.30 ± 0.15 vs 2.98 ± 0.17; P = 0.01). The confusion index significantly reduced only in protans (P = 0.01), not in deutans (P = 0.19).
    Conclusions: In this study cohort, the EnChroma filter significantly reduced overall error scores using the Ishihara and Farnsworth tests; error scores on Ishihara testing reduced only in deutans. Conversely, the confusion index using Farnsworth reduced only in protans. The majority of patients reported subjective increase in color perception.
    MeSH term(s) Color Perception ; Color Perception Tests ; Color Vision ; Color Vision Defects ; Female ; Humans ; Male ; Retrospective Studies ; Vision Screening
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2020.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Effect of Low-dose Intravitreal Bevacizumab and Ranibizumab on Regression and Late Reactivation in Retinopathy of Prematurity in the Treatment-Naïve Eyes.

    Zhang, Charles / Reynolds, Andrew L / Beiter, Andrew / Lillvis, John H / Reynolds, James D

    Ophthalmology. Retina

    2021  Volume 6, Issue 4, Page(s) 328–330

    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Bevacizumab/therapeutic use ; Humans ; Infant, Newborn ; Intravitreal Injections ; Ranibizumab/therapeutic use ; Retinopathy of Prematurity/diagnosis ; Retinopathy of Prematurity/drug therapy
    Chemical Substances Angiogenesis Inhibitors ; Bevacizumab (2S9ZZM9Q9V) ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2021-12-27
    Publishing country United States
    Document type Journal Article
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2021.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: The effect of oral statin therapy on strabismus in patients with thyroid eye disease.

    Reynolds, Andrew L / Del Monte, Monte A / Archer, Steven M

    Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus

    2018  Volume 22, Issue 5, Page(s) 340–343

    Abstract: Background: Statins, known to possess anti-inflammatory characteristics, have recently been identified as potentially reducing the risk of developing thyroid eye disease (TED) in Graves disease patients. The current study investigates the effect of oral ...

    Abstract Background: Statins, known to possess anti-inflammatory characteristics, have recently been identified as potentially reducing the risk of developing thyroid eye disease (TED) in Graves disease patients. The current study investigates the effect of oral statin therapy on strabismus related to TED.
    Methods: This is a retrospective review of patients with a diagnosis of both TED and restrictive strabismus. Oral statin users and nonusers were analyzed for smoking status, previous radioactive iodine, thyroidectomy, number of decompressions, motility restriction, amount of strabismus, number of surgeries, surgical dose, and number of muscles involved on radiography.
    Results: Thirty patients (average age, 63.9 years; 50% male; 59% current/former smokers) were included: 12 statin users and 18 nonusers. Statin users averaged fewer decompressions (1.3 in users vs 2.4 in nonusers [P = 0.04]). Statin users on average had 15 mm of total strabismus surgery compared with 21.4 mm in the nonuser group (P = 0.09) and had fewer muscles involved radiographically (4.3 vs 5.1 [P = 0.08]) CONCLUSIONS: Compared to nonusers, statin users tended to have fewer decompressions, less restriction, fewer surgeries, and fewer muscles involved despite having more current smokers (36% vs 5%), more males, more RAI, and fewer thyroidectomies, all of which are associated with worse TED. In our cohort of patients with TED and strabismus, statin therapy significantly reduced the number of orbital decompressions. Oral statin therapy also trended toward reducing the number and amount of strabismus surgeries as well as radiographic indication of muscle involvement, although these did not meet statistical significance.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Decompression, Surgical/statistics & numerical data ; Female ; Graves Ophthalmopathy/complications ; Graves Ophthalmopathy/drug therapy ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Strabismus/prevention & control ; Strabismus/surgery
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2018-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1412476-2
    ISSN 1528-3933 ; 1091-8531
    ISSN (online) 1528-3933
    ISSN 1091-8531
    DOI 10.1016/j.jaapos.2018.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Heritable Risk and Protective Genetic Components of Glaucoma Medication Non-Adherence.

    Barr, Julie L / Feehan, Michael / Tak, Casey / Owen, Leah A / Finley, Robert C / Cromwell, Parker A / Lillvis, John H / Hicks, Patrice M / Au, Elizabeth / Farkas, Michael H / Weiner, Asher / Reynolds, Andrew L / Sieminski, Sandra F / Sherva, Richard M / Munger, Mark A / Brilliant, Murray H / DeAngelis, Margaret M

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Glaucoma is the leading cause of irreversible blindness, affecting 76 million globally. It is characterized by irreversible damage to the optic nerve. Pharmacotherapy manages intraocular pressure (IOP) and slows disease progression. However, non- ... ...

    Abstract Glaucoma is the leading cause of irreversible blindness, affecting 76 million globally. It is characterized by irreversible damage to the optic nerve. Pharmacotherapy manages intraocular pressure (IOP) and slows disease progression. However, non-adherence to glaucoma medications remains problematic, with 41-71% of patients being non-adherent to their prescribed medication. Despite substantial investment in research, clinical effort, and patient education protocols, non-adherence remains high. Therefore, we aimed to determine if there is a substantive genetic component behind patients' glaucoma medication non-adherence. We assessed glaucoma medication non-adherence with prescription refill data from the Marshfield Clinic Healthcare System's pharmacy dispensing database. Two standard measures were calculated: the medication possession ratio (MPR) and the proportion of days covered (PDC). Non-adherence on each metric was defined as less than 80% medication coverage over 12 months. Genotyping was done using the Illumina HumanCoreExome BeadChip in addition to exome sequencing on the 230 patients (1) to calculate the heritability of glaucoma medication non-adherence and (2) to identify SNPs and/or coding variants in genes associated with medication non-adherence. Ingenuity pathway analysis (IPA) was utilized to derive biological meaning from any significant genes in aggregate. Over 12 months, 59% of patients were found to be non-adherent as measured by the MPR80, and 67% were non-adherent as measured by the PDC80. Genome-wide complex trait analysis (GCTA) suggested that 57% (MPR80) and 48% (PDC80) of glaucoma medication non-adherence could be attributed to a genetic component. Missense mutations in
    MeSH term(s) Humans ; Medication Adherence ; Glaucoma/drug therapy ; Glaucoma/genetics ; Intraocular Pressure/genetics ; Disease Progression ; Sample Size ; Retrospective Studies ; Glutathione Transferase
    Chemical Substances GSTZ1 protein, human (EC 2.5.1.-) ; Glutathione Transferase (EC 2.5.1.18)
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065636
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Pseudoexfoliation and Cataract Syndrome Associated with Genetic and Epidemiological Factors in a Mayan Cohort of Guatemala.

    Hicks, Patrice M / Au, Elizabeth / Self, William / Haaland, Benjamin / Feehan, Michael / Owen, Leah A / Siedlecki, Adam / Nuttall, Elizabeth / Harrison, Deborah / Reynolds, Andrew L / Lillvis, John H / Sieminski, Sandra / Shulman, Julia P / Barnoya, Margarita / Noguera Prera, Juan Jose / Gonzalez, Orlando / Murtaugh, Maureen A / Williams, Lloyd B / Farkas, Michael H /
    Crandall, Alan S / DeAngelis, Margaret M

    International journal of environmental research and public health

    2021  Volume 18, Issue 14

    Abstract: The Mayan population of Guatemala is understudied within eye and vision research. Studying an observational homogenous, geographically isolated population of individuals seeking eye care may identify unique clinical, demographic, environmental and ... ...

    Abstract The Mayan population of Guatemala is understudied within eye and vision research. Studying an observational homogenous, geographically isolated population of individuals seeking eye care may identify unique clinical, demographic, environmental and genetic risk factors for blinding eye disease that can inform targeted and effective screening strategies to achieve better and improved health care distribution. This study served to: (a) identify the ocular health needs within this population; and (b) identify any possible modifiable risk factors contributing to disease pathophysiology within this population. We conducted a cross-sectional study with 126 participants. Each participant completed a comprehensive eye examination, provided a blood sample for genetic analysis, and received a structured core baseline interview for a standardized epidemiological questionnaire at the Salama Lions Club Eye Hospital in Salama, Guatemala. Interpreters were available for translation to the patients' native dialect, to assist participants during their visit. We performed a genome-wide association study for ocular disease association on the blood samples using Illumina's HumanOmni2.5-8 chip to examine single nucleotide polymorphism SNPs in this population. After implementing quality control measures, we performed adjusted logistic regression analysis to determine which genetic and epidemiological factors were associated with eye disease. We found that the most prevalent eye conditions were cataracts (54.8%) followed by pseudoexfoliation syndrome (PXF) (24.6%). The population with both conditions was 22.2%. In our epidemiological analysis, we found that eye disease was significantly associated with advanced age. Cataracts were significantly more common among those living in the 10 districts with the least resources. Furthermore, having cataracts was associated with a greater likelihood of PXF after adjusting for both age and sex. In our genetic analysis, the SNP most nominally significantly associated with PXF lay within the gene KSR2 (
    MeSH term(s) Cataract/ethnology ; Cataract/genetics ; Cross-Sectional Studies ; Exfoliation Syndrome/ethnology ; Exfoliation Syndrome/genetics ; Genome-Wide Association Study ; Guatemala/epidemiology ; Humans ; Indians, Central American
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18147231
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Gender Differences in Case Volume Among Ophthalmology Residents.

    Gong, Dan / Winn, Bryan J / Beal, Casey J / Blomquist, Preston H / Chen, Royce W / Culican, Susan M / Dagi Glass, Lora R / Domeracki, Gary F / Goshe, Jeffrey M / Jones, Jeremy K / Khouri, Albert S / Legault, Gary L / Martin, Timothy J / Mitchell, Kelly T / Naseri, Ayman / Oetting, Thomas A / Olson, Joshua H / Pettey, Jeff H / Reinoso, Maria A /
    Reynolds, Andrew L / Siatkowski, R Michael / SooHoo, Jeffrey R / Sun, Grace / Syed, Misha F / Tao, Jeremiah P / Taravati, Parisa / WuDunn, Darrell / Al-Aswad, Lama A

    JAMA ophthalmology

    2019  Volume 137, Issue 9, Page(s) 1015–1020

    Abstract: Importance: Although almost equal numbers of male and female medical students enter into ophthalmology residency programs, whether they have similar surgical experiences during training is unclear.: Objective: To determine differences for cataract ... ...

    Abstract Importance: Although almost equal numbers of male and female medical students enter into ophthalmology residency programs, whether they have similar surgical experiences during training is unclear.
    Objective: To determine differences for cataract surgery and total procedural volume between male and female residents during ophthalmology residency.
    Design, setting, participants: This retrospective, longitudinal analysis of resident case logs from 24 US ophthalmology residency programs spanned July 2005 to June 2017. A total of 1271 residents were included. Data were analyzed from August 12, 2017, through April 4, 2018.
    Main outcomes and measures: Variables analyzed included mean volumes of cataract surgery and total procedures, resident gender, and maternity or paternity leave status.
    Results: Among the 1271 residents included in the analysis (815 men [64.1%]), being female was associated with performing fewer cataract operations and total procedures. Male residents performed a mean (SD) of 176.7 (66.2) cataract operations, and female residents performed a mean (SD) of 161.7 (56.2) (mean difference, -15.0 [95% CI, -22.2 to -7.8]; P < .001); men performed a mean (SD) of 509.4 (208.6) total procedures and women performed a mean (SD) of 451.3 (158.8) (mean difference, -58.1 [95% CI, -80.2 to -36.0]; P < .001). Eighty-five of 815 male residents (10.4%) and 71 of 456 female residents (15.6%) took parental leave. Male residents who took paternity leave performed a mean of 27.5 (95% CI, 13.3 to 41.6; P < .001) more cataract operations compared with men who did not take leave, but female residents who took maternity leave performed similar numbers of operations as women who did not take leave (mean difference, -2.0 [95% CI, -18.0 to 14.0]; P = .81). From 2005 to 2017, each additional year was associated with a 5.5 (95% CI, 4.4 to 6.7; P < .001) increase in cataract volume and 24.4 (95% CI, 20.9 to 27.8; P < .001) increase in total procedural volume. This increase was not different between genders for cataract procedure volume (β = -1.6 [95% CI, -3.7 to 0.4]; P = .11) but was different for total procedural volume such that the increase in total procedural volume over time for men was greater than that for women (β = -8.0 [95% CI, -14.0 to -2.1]; P = .008).
    Conclusions and relevance: Female residents performed 7.8 to 22.2 fewer cataract operations and 36.0 to 80.2 fewer total procedures compared with their male counterparts from 2005 to 2017, a finding that warrants further exploration to ensure that residents have equivalent surgical training experiences during residency regardless of gender. However, this study included a limited number of programs (24 of 119 [20.2%]). Future research including all ophthalmology residency programs may minimize the selection bias issues present in this study.
    Language English
    Publishing date 2019-07-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2019.2427
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top