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Article ; Online: An acute care surgeons's dilemma: Operative vs. non-operative management of emergency general surgery conditions in patients with recent colorectal cancer treatment.

Reynolds, Ian S

2023 Volume 227, Page(s) 13–14

MeSH term(s)	Humans ; Acute Care Surgery ; Critical Care ; Surgeons ; Colorectal Neoplasms/surgery ; Retrospective Studies
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Editorial
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2023.10.006
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Article ; Online: Immunotherapy in surgical oncology.

Reynolds, Ian S / Fennelly, David

The British journal of surgery

2022

Language	English
Publishing date	2022-11-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znac385
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Article ; Online: Academic surgery at home and abroad: A guide for students and residents.

Reynolds, Ian S / Brown, Lawrence B

American journal of surgery

2022 Volume 225, Issue 2, Page(s) 442–445

MeSH term(s)	Humans ; Students ; Motivation ; Students, Medical
Language	English
Publishing date	2022-09-17
Publishing country	United States
Document type	Editorial
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2022.09.017
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Article ; Online: Obesity and outcomes in trauma - a systematic review and meta-analysis.

Cromwell, Paul M / Reynolds, Ian S / Heneghan, Helen M / Glasgow, Simon M

Injury

2022 Volume 54, Issue 2, Page(s) 469–480

Abstract: Background: The physiological abnormalities relating to obesity and metabolic syndrome can contribute to worse outcomes following trauma especially in class 2 and 3 obesity. The aim of this systematic review was to determine whether patients with a ... ...

Abstract	Background: The physiological abnormalities relating to obesity and metabolic syndrome can contribute to worse outcomes following trauma especially in class 2 and 3 obesity. The aim of this systematic review was to determine whether patients with a higher class of obesity who suffer traumatic injury have a higher risk of worse outcomes including in-hospital mortality than normal-weight patients. Methods: A systematic search of MEDLINE, EMBASE, CENTRAL, Web of Science and CINAHL was performed for studies that reported a comparison of in-hospital obesity-related outcomes against normal-weight individuals aged 15 years and older following trauma. Single or multiple injuries from either blunt and/or penetrating trauma were included. Burn-related injuries, isolated head injury and studies focusing on orthopaedic related perioperative complications were excluded. Results: The search yielded 7405 articles; 26 were included in this systematic review. 945,511 patients had a BMI>30. A random-effects meta-analysis was performed for analysis of all four outcomes. Patients with class 3 obesity (BMI>40) have significantly higher odds of in-hospital mortality than normal-BMI individuals following blunt and penetrating trauma (OR, 1.75; 95% CI, 1.39-2.19, p=<0.00001), significantly longer hospital LOS (SMD, 0.23; 95% CI, 0.21-0.25; p<0.00001) and significantly longer ICU LOS (SMD, 0.19; 95% CI, 0.12-0.26; p<0.0001). In contrast, studies that examined blunt and penetrating trauma and classified obesity with a threshold of BMI>30 found no significant difference in the odds of in-hospital mortality (OR, 0.94; 95% CI, 0.86-1.02, p=0.13). Conclusions: There is a higher risk of in-hospital mortality in patients living with class 3 obesity following trauma when compared with individuals with normal BMI. The management of patients with obesity is complex and trauma systems should develop specific weight related pathways to manage and anticipate the complications that arise in these patients. Systematic review registration number PROSPERO registration: CRD42021234482 Level of Evidence: Level 3.
MeSH term(s)	Humans ; Obesity/complications ; Wounds, Penetrating ; Body Mass Index
Language	English
Publishing date	2022-10-26
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	218778-4
ISSN	1879-0267 ; 0020-1383
ISSN (online)	1879-0267
ISSN	0020-1383
DOI	10.1016/j.injury.2022.10.026
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Zs.A 778: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Clinicopathological characteristics and survival outcomes for patients with mucinous colorectal cancer liver metastases undergoing hepatic resection: A systematic review and meta-analysis.

Reynolds, Ian S / Cromwell, Paul M / Hoti, Emir

American journal of surgery

2021 Volume 222, Issue 3, Page(s) 529–535

Abstract: Background: Mucinous adenocarcinoma represents a distinct histological subtype of colorectal cancer. To date there has been limited data available for patients with colorectal cancer liver metastases (CRCLM) derived from mucinous adenocarcinoma. This ... ...

Abstract	Background: Mucinous adenocarcinoma represents a distinct histological subtype of colorectal cancer. To date there has been limited data available for patients with colorectal cancer liver metastases (CRCLM) derived from mucinous adenocarcinoma. This systematic review and meta-analysis aims to provide data on the clinicopathological and survival outcomes of this cohort. Methods: Databases were searched for studies comparing clinicopathological and survival outcomes between patients with mucinous CRCLM and CRCLM from adenocarcinoma not otherwise specified who underwent liver resection. A random-effects model was used for analysis. Results: Eight studies describing 9157 patients were included. Mucinous CRCLM were positively associated with colon tumors (OR 1⋅64, P = 0⋅01), T3/T4 tumors (OR 1⋅58, P = 0⋅02), node positive tumors (OR 1⋅55, P = 0⋅005). The review also identified a trend towards worse overall survival in patients with mucinous CRCLM. Conclusions: Despite the distinct clinicopathological characteristics and impaired long term outcomes of mucinous CRCLM, resection should remain the gold standard where possible.
MeSH term(s)	Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/secondary ; Adenocarcinoma/surgery ; Adenocarcinoma, Mucinous/mortality ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/secondary ; Adenocarcinoma, Mucinous/surgery ; Age Factors ; Colonic Neoplasms/mortality ; Colonic Neoplasms/pathology ; Colonic Neoplasms/secondary ; Colonic Neoplasms/surgery ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Databases, Factual ; Female ; Hepatectomy ; Humans ; Kaplan-Meier Estimate ; Liver Neoplasms/mortality ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Male ; Rectal Neoplasms/mortality ; Rectal Neoplasms/pathology ; Rectal Neoplasms/secondary ; Rectal Neoplasms/surgery ; Sex Factors
Language	English
Publishing date	2021-03-03
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2021.02.031
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Article ; Online: Tips for early career academic surgeons.

Keating, Muireann / Ferrada, Paula / O'Halloran, Philip J / Perry, William / Potter, Shirley / Reddy, Sanjay S / Wilder, Fatima G / Reynolds, Ian S

American journal of surgery

2024

Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Editorial
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2024.01.029
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Article ; Online: Rapid urease testing in isolation is inadequate during invasive testing for H. pylori.

Penny, Zakya / Reynolds, Ian S / Buckley, Máire / Martin, Sean T

Irish journal of medical science

2021 Volume 191, Issue 2, Page(s) 963–964

MeSH term(s)	Biopsy ; Helicobacter Infections/diagnosis ; Helicobacter pylori ; Humans ; Sensitivity and Specificity ; Urease
Chemical Substances	Urease (EC 3.5.1.5)
Language	English
Publishing date	2021-05-29
Publishing country	Ireland
Document type	Letter
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-021-02670-8
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Article ; Online: Acute colonic pseudo-obstruction post-cesarean section is not a benign entity: A case series and review of the literature.

Reynolds, Ian S / McDermott, Edward / Liddy, Richard / Aird, John J / Flood, Karen / McCormack, Orla / Geoghegan, Tony / Brannigan, Ann E

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

2023 Volume 165, Issue 1, Page(s) 59–66

Abstract: Acute colonic pseudo-obstruction (ACPO) is an infrequent occurrence after cesarean section. Anecdotal evidence suggests that the clinical course of ACPO in the obstetric setting is different to that seen in non-pregnant adult patients with ACPO secondary ...

Abstract	Acute colonic pseudo-obstruction (ACPO) is an infrequent occurrence after cesarean section. Anecdotal evidence suggests that the clinical course of ACPO in the obstetric setting is different to that seen in non-pregnant adult patients with ACPO secondary to alternative causes, such as systemic illnesses, the use of certain medications, and after non-abdominal surgery. The risk of progression to ischemia and perforation, as well as the need for emergency surgery, appears to be higher after cesarean section. Here we describe the clinical course of ACPO in four patients after cesarean section from our institution, followed by a review of the literature and a discussion of the important issues surrounding this condition in the postpartum time period. The findings from our cohort of patients and the reports from the medical literature support a hands-on combined approach from a group of specialists including obstetricians, surgeons, radiologists, and enterostomal therapists. Immediate imaging followed by regular observation is mandatory for any patient being managed conservatively. Early use of endoscopic decompression should be considered for patients who are not resolving with a conservative approach. Clinical signs of peritonism or radiological signs of ischemia or perforation in patients with ACPO mandate immediate surgical intervention. Appropriate postoperative care is necessary to deal with the complex physiological and psychological consequences of emergency surgery and potential stoma formation so soon after cesarean section.
MeSH term(s)	Adult ; Humans ; Pregnancy ; Female ; Colonic Pseudo-Obstruction/diagnosis ; Colonic Pseudo-Obstruction/etiology ; Colonic Pseudo-Obstruction/therapy ; Cesarean Section/adverse effects ; Decompression, Surgical/adverse effects ; Lumbar Vertebrae/surgery ; Ischemia/complications ; Ischemia/surgery ; Disease Progression
Language	English
Publishing date	2023-09-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80149-5
ISSN	1879-3479 ; 0020-7292
ISSN (online)	1879-3479
ISSN	0020-7292
DOI	10.1002/ijgo.15086
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Zs.A 355: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The Impact of Bariatric Surgery on the Incidence of Colorectal Cancer in Patients with Obesity-a Systematic Review and Meta-analysis of Registry Data.

Davey, Matthew G / Ryan, Odhrán K / Ryan, Éanna J / Donlon, Noel E / Reynolds, Ian S / Fearon, Naomi M / Martin, Sean T / Heneghan, Helen M

Obesity surgery

2023 Volume 33, Issue 8, Page(s) 2293–2302

Abstract: Purpose: Cancer and obesity represent two of the most significant global health concerns. The risk of malignancy, including colorectal cancer (CRC), increases with obesity. The aim of this study was to perform a systematic review and meta-analysis to ... ...

Abstract	Purpose: Cancer and obesity represent two of the most significant global health concerns. The risk of malignancy, including colorectal cancer (CRC), increases with obesity. The aim of this study was to perform a systematic review and meta-analysis to determine the value of bariatric surgery in reducing CRC risk in patients with obesity using registry data. Materials and methods: A systematic review and meta-analysis were performed as per PRISMA guidelines. The risk of CRC was expressed as a dichotomous variable and reported as odds ratios (OR) with 95% confidence intervals (CIs) using the Mantel-Haenszel method. A multi-treatment comparison was performed, examining the risk reduction associated with existing bariatric surgery techniques. Analysis was performed using RevMan, R packages, and Shiny. Results: Data from 11 registries including 6,214,682 patients with obesity were analyzed. Of these, 14.0% underwent bariatric surgery (872,499/6,214,682), and 86.0% did not undergo surgery (5,432,183/6,214,682). The mean age was 49.8 years, and mean follow-up was 5.1 years. In total, 0.6% of patients who underwent bariatric surgery developed CRC (4,843/872,499), as did 1.0% of unoperated patients with obesity (54,721/5,432,183). Patients with obesity who underwent bariatric surgery were less likely to develop CRC (OR: 0.53, 95% CI: 0.36-0.77, P < 0.001, I Conclusion: At a population level, bariatric surgery is associated with reduced CRC risk in patients with obesity. GB and SG are associated with the most significant reduction in CRC risk. Prospero registration: CRD42022313280.
MeSH term(s)	Humans ; Middle Aged ; Obesity, Morbid/surgery ; Incidence ; Routinely Collected Health Data ; Obesity/complications ; Obesity/epidemiology ; Obesity/surgery ; Bariatric Surgery/adverse effects ; Gastrectomy/methods ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/surgery ; Gastric Bypass/methods
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-023-06674-4
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Article ; Online: Hepatic resection for breast cancer related liver metastases: A single institution experience.

Reynolds, Ian S / Cromwell, Paul M / Walshe, Janice M / Crown, John / Maguire, Donal / Geoghegan, Justin / Swan, Niall / Hoti, Emir

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society

2022 Volume 111, Issue 1, Page(s) 14574969221088685

Abstract: Background & objective: Liver resection for breast cancer liver metastases is becoming a more widely accepted therapeutic option for selected groups of patients. The aim of this study was to describe the outcomes of patients undergoing liver resection ... ...

Abstract	Background & objective: Liver resection for breast cancer liver metastases is becoming a more widely accepted therapeutic option for selected groups of patients. The aim of this study was to describe the outcomes of patients undergoing liver resection for breast cancer-related liver metastases and identify any variables associated with recurrence or survival. Methods: A retrospective review of a prospectively maintained database was undertaken for the 12 year period between 2009 and 2021. Clinicopathological, treatment, intraoperative, recurrence, survival and follow-up data were collected on all patients. Kaplan-Meier methods, the log-rank test and Cox proportional hazards regression analysis were used to identify variables that were associated with recurrence and survival. Results: A total of 20 patients underwent 21 liver resections over the 12-year period. There were no deaths within 30 days of surgery and an operative morbidity occurred in 23.8% of cases. The median local recurrence free survival and disease free survival times were both 50 months, while the 5 year overall survival rate was 65%. The presence of extrahepatic metastases were associated with a decreased time to local recurrence (p < 0.01) and worse overall survival (p = 0.02). Conclusions: This study has demonstrated that liver resection for breast cancer-related liver metastases is feasible, safe and associated with prolonged disease free and overall survival in selected patients. It is likely that this option will be offered to more patients going forward, however, the difficulty lies in selecting out those who will benefit from liver resection particularly given the increasing number of systemic treatments and local ablative methods available that offer good long-term results.
MeSH term(s)	Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Disease-Free Survival ; Female ; Hepatectomy/methods ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery
Language	English
Publishing date	2022-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2077691-3
ISSN	1799-7267 ; 1457-4969
ISSN (online)	1799-7267
ISSN	1457-4969
DOI	10.1177/14574969221088685
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