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  1. Article ; Online: Neoadjuvant chemoradiation versus perioperative chemotherapy for oeosphageal adenocarcinoma.

    Reynolds, John V

    The British journal of surgery

    2023  Volume 110, Issue 12, Page(s) 1681–1682

    MeSH term(s) Humans ; Neoadjuvant Therapy ; Treatment Outcome ; Cisplatin/therapeutic use ; Adenocarcinoma/pathology ; Neoplasm Staging ; Retrospective Studies ; Chemotherapy, Adjuvant ; Chemoradiotherapy ; Esophageal Neoplasms/surgery
    Chemical Substances Cisplatin (Q20Q21Q62J)
    Language English
    Publishing date 2023-10-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znad286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.66: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction: the Neo-AEGIS trial - Authors' reply.

    Reynolds, John V / Donachie, Vicky / Marron, Jacinta / Shevlin, Anna

    The lancet. Gastroenterology & hepatology

    2024  Volume 9, Issue 2, Page(s) 104–105

    MeSH term(s) Humans ; Esophagus/pathology ; Adenocarcinoma/pathology ; Esophagogastric Junction/pathology
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Letter
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(23)00445-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Measurement and optimization of perioperative risk among patients undergoing surgery for esophageal cancer.

    Elliott, Jessie A / Guinan, Emer / Reynolds, John V

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2023  Volume 37, Issue 3

    Abstract: Esophagectomy is an exemplar of complex oncological surgery and is associated with a relatively high risk of major morbidity and mortality. In the modern era, where specific complications are targeted in prevention and treatment pathways, and where the ... ...

    Abstract Esophagectomy is an exemplar of complex oncological surgery and is associated with a relatively high risk of major morbidity and mortality. In the modern era, where specific complications are targeted in prevention and treatment pathways, and where the principles of enhanced recovery after surgery are espoused, optimum outcomes are targeted via a number of approaches. These include comprehensive clinical and physiological risk assessment, specialist perioperative care by a high-volume team, and multimodal inputs throughout the patient journey that aim to preserve or restore nutritional deficits, muscle mass and function.
    MeSH term(s) Humans ; Perioperative Care ; Esophagectomy/adverse effects ; Esophageal Neoplasms/etiology
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doad062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2378: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Visceral Obesity, Metabolic Syndrome, and Esophageal Adenocarcinoma.

    Elliott, Jessie A / Reynolds, John V

    Frontiers in oncology

    2021  Volume 11, Page(s) 627270

    Abstract: Esophageal adenocarcinoma (EAC) represents an exemplar of obesity-associated carcinogenesis, with a progressive increase in EAC risk with increased body mass index. In this context, there is increased focus on visceral adipose tissue and associated ... ...

    Abstract Esophageal adenocarcinoma (EAC) represents an exemplar of obesity-associated carcinogenesis, with a progressive increase in EAC risk with increased body mass index. In this context, there is increased focus on visceral adipose tissue and associated metabolic dysfunction, including hypertension, diabetes mellitus and hyperlipidemia, or combinations of these in the metabolic syndrome. Visceral obesity (VO) may promote EAC
    Language English
    Publishing date 2021-03-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.627270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Organ preservation in the multimodality approach to locally advanced oesophageal cancer: festina lente.

    Bolger, J C / Reynolds, J V

    The British journal of surgery

    2021  Volume 108, Issue 10, Page(s) 1142–1144

    MeSH term(s) Chemotherapy, Adjuvant ; Clinical Decision-Making ; Clinical Trials as Topic ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/therapy ; Esophagectomy ; Humans ; Neoadjuvant Therapy ; Neoplasm, Residual ; Patient Care Team ; Radiotherapy, Adjuvant
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.66: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Nature, severity, and impact of chronic oropharyngeal dysphagia following curative resection for esophageal cancer: a cross-sectional study.

    Gillman, Anna / Kenny, Ciaran / Hayes, Michelle / Walshe, Margaret / Reynolds, John V / Regan, Julie

    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    2024  

    Abstract: Chronic oropharyngeal dysphagia (COD) and aspiration after esophageal cancer surgery may have clinical significance; however, it is a rarely studied topic. In a prospective cross-sectional observational study we comprehensively evaluated the nature, ... ...

    Abstract Chronic oropharyngeal dysphagia (COD) and aspiration after esophageal cancer surgery may have clinical significance; however, it is a rarely studied topic. In a prospective cross-sectional observational study we comprehensively evaluated the nature, severity, and impact of COD, its predictors, and the impact of the surgical approach and site of anastomosis. Forty participants were recruited via purposive sampling from the (Irish) National Center between November 2021 and August 2022. Swallow evaluations included videofluoroscopy [Dynamic Imaging Grade of Swallowing Toxicity v2 (DIGESTv2), MBS Impairment Profile, Penetration-Aspiration Scale)]. Functional Oral Intake Scale (FOIS) identified oral intake status. The patient reported outcome measures of swallowing, and Quality of Life (QL) included EAT-10 and MD Anderson Dysphagia Inventory (MDADI). Fourteen (35%) participants presented with COD on DIGESTv2 and 10% had uncleared penetration/aspiration. Avoidance or modification of diet on FOIS was observed in 17 (42.5%). FOIS was associated with pharyngeal dysphagia (OR = 4.05, P = 0.046). Median (range) EAT-10 and MDADI Composite results were 3(0-30) and 77.9(60-92.6), respectively. Aspiration rates significantly differed across surgical groups (P = 0.029); only patients undergoing transhiatal surgery aspirated. Survivors of esophageal cancer surgery may have COD that is undiagnosed, potentially impacting swallow-related QL. Given the small number of aspirators, further research is required to determine whether aspiration risk is associated with surgical approach. A FOIS score below 7 may be a clinically useful prompt for the MDT to refer for evaluation of COD following curative intent surgery. These data present findings that may guide preventive and rehabilitative strategies toward optimizing survivorship.
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639470-x
    ISSN 1442-2050 ; 1120-8694
    ISSN (online) 1442-2050
    ISSN 1120-8694
    DOI 10.1093/dote/doae003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2378: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Should chemoradiotherapy be standard to maximise cure in localised gastro-oesophageal cancer?

    Reynolds, John V / Cowzer, Darren / Janjigian, Yelena Y

    The Lancet. Oncology

    2022  Volume 23, Issue 7, Page(s) 847–849

    MeSH term(s) Chemoradiotherapy/adverse effects ; Esophageal Neoplasms/drug therapy ; Esophageal Neoplasms/radiotherapy ; Humans ; Stomach Neoplasms/drug therapy ; Stomach Neoplasms/radiotherapy
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00753-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 460: Show issues

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  8. Article ; Online: Isolated oesophageal adenocarcinoma metastasis at percutaneous endoscopic gastrostomy (PEG) site.

    Butt, Waqas T / Reynolds, John V

    BMJ case reports

    2020  Volume 13, Issue 6

    MeSH term(s) Adenocarcinoma/secondary ; Adenocarcinoma/therapy ; Aged ; Endoscopy, Gastrointestinal/adverse effects ; Esophageal Neoplasms/secondary ; Esophageal Neoplasms/therapy ; Gastrostomy/adverse effects ; Humans ; Male ; Neoplasm Seeding ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/secondary
    Language English
    Publishing date 2020-06-30
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-236778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Alkaptonuria: clinical manifestations and an updated approach to treatment of a rare disease.

    Roopnarinesingh, Ryan Curtis / Donlon, Noel Edward / Reynolds, John V

    BMJ case reports

    2021  Volume 14, Issue 12

    Abstract: Alkaptonuria (AKU) is a rare autosomal recessive disorder with a global incidence of 1 in 250 000 to 1 million people worldwide. It results from a deficiency of the enzyme homogentisic acid (HGA) oxidase which when absent, leads to an accumulation of HGA. ...

    Abstract Alkaptonuria (AKU) is a rare autosomal recessive disorder with a global incidence of 1 in 250 000 to 1 million people worldwide. It results from a deficiency of the enzyme homogentisic acid (HGA) oxidase which when absent, leads to an accumulation of HGA. Without this enzymatic degradation, HGA deposits in connective tissues resulting in pigmentation (ochronosis), plaque formation and accelerated cartilage destruction. With this, many patients who suffer from AKU develop ochronotic arthropathies, tendon ruptures, fractures, and chronic joint pain. Similarly, patients can develop cardiac valvular dysfunction and interstitial renal disease. Our two cases highlight the array of pathologies seen in AKU and, in light of newly published research, give us a platform from which we can discuss the developments in management of this rare disease.
    MeSH term(s) Alkaptonuria/complications ; Alkaptonuria/diagnosis ; Cartilage, Articular ; Homogentisic Acid ; Humans ; Ochronosis/complications ; Ochronosis/diagnosis ; Rare Diseases
    Chemical Substances Homogentisic Acid (NP8UE6VF08)
    Language English
    Publishing date 2021-12-07
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-244240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 'SurgTalk': The Educational Outcomes Associated With Development of a Surgical Podcast for Undergraduate Medical Students.

    O'Neill, Susan / Deegan, Joseph / Ramjit, Sinéad / Reynolds, John V / Donohoe, Claire L

    Journal of surgical education

    2023  Volume 81, Issue 2, Page(s) 202–209

    Abstract: Objective: Educational podcast series are becoming increasingly popular as free open access medical education (FOAMed) resources, however, the educational benefit associated with their use is unclear. The aim of this study was to assess the educational ... ...

    Abstract Objective: Educational podcast series are becoming increasingly popular as free open access medical education (FOAMed) resources, however, the educational benefit associated with their use is unclear. The aim of this study was to assess the educational outcomes associated with the implementation of a surgical podcast series for undergraduate medical students.
    Methods: Two conversational case-based podcast episodes were recorded covering 2 common surgical presentations. Final-year medical students were recruited prospectively in January 2023 and underwent a baseline multiple choice question (MCQ) test covering the material within the podcast episodes. Participants were then provided with the episode files through encrypted Google Drive links. Two weeks following baseline assessment, students repeated the initial MCQ test and completed a postpodcast reaction survey. Data were analyzed using a paired t-test, multivariable regression analyses, and simple descriptive statistics.
    Results: Fifty students were enrolled in the study. All participants undertook the baseline assessment. About 98% completed the postpodcast MCQ, while 94% completed the postpodcast reaction survey. All participants who undertook the reaction survey (n = 47) found the podcast helpful in explaining surgical concepts, 92% of participants found the podcast enjoyable to listen to. The most commonly reported activity undertaken while listening was "commuting/driving" (n = 24, 48%). The mean baseline MCQ score was 44.6%. The mean postpodcast MCQ score was 65.51%. There was a mean absolute increase in test score of 20.2% from baseline which was statistically significant (95%CI 14.67-25.6, p < 0.001).
    Conclusion: Implementation of this podcast series was associated with a statistically significant improvement in mean test score from baseline, reflecting knowledge acquisition. There was a positive user reaction and students were able to listen while performing other activities. Further evaluation of the educational outcomes associated with podcast use, particularly the effects on knowledge retention and clinical competence, is required.
    MeSH term(s) Humans ; Students, Medical ; Educational Status ; Educational Measurement ; Surveys and Questionnaires ; Clinical Competence
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2023.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.230: Show issues Location:
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