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  1. AU="Reza Ahsan"
  2. AU="Marriage, Keith"
  3. AU=Ren Ziyuan
  4. AU="Tae-Houn Kim"
  5. AU="Mias-Lucquin, Dominique"
  6. AU="Karagiannidis, Artemios G"
  7. AU="Alice H Reis"
  8. AU="Malik, Shahbaz A"
  9. AU=Mittal Rajat AU=Mittal Rajat
  10. AU="Seguin, Rebecca A"
  11. AU="Tinbergen, Jan"
  12. AU="Rodrigues-Díez, Raquel"
  13. AU="Yang, Haihao"

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  1. Artikel ; Online: Classification of imbalanced protein sequences with deep-learning approaches; application on influenza A imbalanced virus classes

    Reza Ahsan / Faezeh Ebrahimi / Mansour Ebrahimi

    Informatics in Medicine Unlocked, Vol 29, Iss , Pp 100860- (2022)

    2022  

    Abstract: Classifiers based on machine learning perform well in the classification of balanced data but struggle with imbalanced data and often merge or ignore the rarer classes, even if the rare classes are more important than other classes. A long-term learning ... ...

    Abstract Classifiers based on machine learning perform well in the classification of balanced data but struggle with imbalanced data and often merge or ignore the rarer classes, even if the rare classes are more important than other classes. A long-term learning dependency, or Long Short-Term Memory (LSTM) architecture, was developed to compare conventional models with LSTM on polynomial and time-matrix datasets to address the imbalanced classes of influenza virus A. The performances of tree induction and K-Nearest Neighborhood models were less than 90%, and they were not accurate in classifying the classes with fewer samples. The proposed LSTM model can predict all classes reached the highest possible figure of 100%. Thus, for the first time, classification of the imbalanced dataset of influenza virus A at the sequential levels is being reported, which paves the road for the analysis of the proteome-based classification of other proteins.
    Schlagwörter LSTM ; Influenza virus A ; Classification ; Imbalanced dataset ; Computer applications to medicine. Medical informatics ; R858-859.7
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Identification of Heat-Resistant Bacteria Based on Selection of Proper Representation of Protein Sequences Using Deep Learning Approach

    Reza Ahsan / Mansour Ebrahimi

    Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, Vol 14, Iss 3, Pp 54-

    2020  Band 63

    Abstract: Background and Objectives: Identification of effective mechanisms in heat-resistance in bacteria is of great importance in some industries, such as food industry, textile manufacturing, and especially in detergent production industries. For this purpose, ...

    Abstract Background and Objectives: Identification of effective mechanisms in heat-resistance in bacteria is of great importance in some industries, such as food industry, textile manufacturing, and especially in detergent production industries. For this purpose, deep learning tools were used to identify the characteristics of heat-resistant bacteria based on protein properties. Methods: Some characteristics of heat-resistant and non-heat-resistant proteins, such as the structural properties of amino acids, the number and the frequency of each amino acid, and their physicochemical properties, were calculated. Bacterial classification was performed in three steps: first, attribute weighting methods were used to select the important variables, then those variables, were selected and finally deep learning networks were employed to extract the hierarchy of the features. Results: The results of 10 weighting methods showed that out of 73 characteristics of the number and frequency of amino acids, only 40 had weights higher than zero. Of these variables, 13 variable gained weight higher than 0.5 and only 10 variables had weight above 0.09. These 10 features were selected as important variables. The frequencies of glutamine and glutamic acid obtained the highest possible weights and were considered as two important features in the classification of heat-resistant and non-heat-resistant bacteria. The highest prediction accuracy of the deep learning networks was 92.42% for the classification of heat resistant bacteria. Conclusion: The deep neural networks can be effectively used to identify heat-resistant bacteria based on their protein properties.
    Schlagwörter thermostable ; protein sequence ; classification ; deep learning networks ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 612
    Sprache Persisch
    Erscheinungsdatum 2020-06-01T00:00:00Z
    Verlag Qom University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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