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  1. Article: Convergence Science to Transform Biomedicine: A Narrative Review.

    Bahadori, Moslem / Rezayat Sorkhabadi, Seyed Mahdi / Fazli Tabaei, Soheila / Farhud, Dariush D

    Iranian journal of public health

    2020  Volume 49, Issue 2, Page(s) 221–229

    Abstract: Recently convergence science was proposed and promoted in a large report from US National Science Foundation and Department of Commerce (NSF/DOC). The report was entitled "converging technologies for improving human performance. " ...

    Abstract Recently convergence science was proposed and promoted in a large report from US National Science Foundation and Department of Commerce (NSF/DOC). The report was entitled "converging technologies for improving human performance. "
    Language English
    Publishing date 2020-05-20
    Publishing country Iran
    Document type Journal Article ; Review
    ISSN 2251-6085
    ISSN 2251-6085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Synthesis, characterization and hepatoprotective effect of silymarin phytosome nanoparticles on ethanol-induced hepatotoxicity in rats.

    Gohari Mahmoudabad, Arezoo / Gheybi, Fatemeh / Mehrabi, Mohsen / Masoudi, Alireza / Mobasher, Zeinab / Vahedi, Hamid / Gharravi, Anneh Mohammad / Bitaraf, Fatemeh Sadat / Rezayat Sorkhabadi, Seyed Mahdi

    BioImpacts : BI

    2023  Volume 13, Issue 4, Page(s) 301–311

    Language English
    Publishing date 2023-05-30
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2604624-6
    ISSN 2228-5660 ; 2228-5652
    ISSN (online) 2228-5660
    ISSN 2228-5652
    DOI 10.34172/bi.2023.24128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Erratum to "Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles,

    Ghaffari, Solmaz / Alihosseini, Faezeh / Rezayat Sorkhabadi, Seyed Mahdi / Arbabi Bidgoli, Sepideh / Mousavi, Seyyedeh Elaheh / Haghighat, Setareh / Afshar Nasab, Ahoo / Kianvash, Nooshin

    Advanced pharmaceutical bulletin

    2020  Volume 11, Issue 1, Page(s) 204

    Abstract: This corrects the article DOI: 10.15171/apb.2018.046.]. ...

    Abstract [This corrects the article DOI: 10.15171/apb.2018.046.].
    Language English
    Publishing date 2020-11-07
    Publishing country Iran
    Document type Published Erratum
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.34172/apb.2021.088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Organelles and chromatin fragmentation of human umbilical vein endothelial cell influence by the effects of zeta potential and size of silver nanoparticles in different manners.

    Tavakol, Shima / Hoveizi, Elham / Kharrazi, Sharmin / Tavakol, Behnaz / Karimi, Shabnam / Rezayat Sorkhabadi, Seyed Mahdi

    Artificial cells, nanomedicine, and biotechnology

    2017  Volume 45, Issue 4, Page(s) 817–823

    Abstract: Recently, it has been disclosed that silver nanoparticles (AgNPs) have the potential to inhibit infection and cancerous cells and eventually penetrate through injected site into the capillary due to their small size. This study focuses on the effect of ... ...

    Abstract Recently, it has been disclosed that silver nanoparticles (AgNPs) have the potential to inhibit infection and cancerous cells and eventually penetrate through injected site into the capillary due to their small size. This study focuses on the effect of size and zeta potential of bare and citrate-coated AgNPs on human umbilical vein endothelial cells (HUVECs) as main capillary cells. AgNPs with high and low concentrations and no citrate coating were synthesized by using simple wet chemical method and named as AgNP/HC, AgNP/LC, and AgNP, respectively. Citrate coated particles showed larger zeta potential of -22 mV and AgNp/HC showed the smallest size of 13.2 nm. UV-Visible spectroscopy and dynamic light scattering (DLS) were performed to evaluate particle size and hydrodynamic diameter of NPs in water and cell culture media. Results indicated that higher concentrations of citrate decreased hydrodynamic diameter and NP agglomeration. reactive oxygen species (ROS) production of all AgNPs was similar at 28 ppm although it was significantly higher than control group. Their effects on cell membrane and chromosomal structure were studied using LDH measurement and 4',6-diamidino-2-phenylindole (DAPI) staining, as well. Results demonstrated that AgNP/LC was less toxic to cells owing to higher value of IC
    MeSH term(s) Cell Survival/drug effects ; Chromatin/drug effects ; Chromatin/metabolism ; Citrates/chemistry ; Free Radical Scavengers/chemistry ; Free Radical Scavengers/pharmacology ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/secretion ; Humans ; L-Lactate Dehydrogenase/secretion ; Metal Nanoparticles ; Organelles/drug effects ; Organelles/metabolism ; Particle Size ; Silver/chemistry ; Silver/pharmacology
    Chemical Substances Chromatin ; Citrates ; Free Radical Scavengers ; Silver (3M4G523W1G) ; L-Lactate Dehydrogenase (EC 1.1.1.27)
    Language English
    Publishing date 2017-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723095-8
    ISSN 2169-141X ; 2169-1401
    ISSN (online) 2169-141X
    ISSN 2169-1401
    DOI 10.1080/21691401.2016.1178132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1164: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article: Synergic Antibacterial Effect of Curcumin with Ampicillin; Free Drug Solutions in Comparison with SLN Dispersions.

    Alihosseini, Faezeh / Azarmi, Shirzad / Ghaffari, Solmaz / Haghighat, Setareh / Rezayat Sorkhabadi, Seyed Mahdi

    Advanced pharmaceutical bulletin

    2016  Volume 6, Issue 3, Page(s) 461–465

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2016-09-25
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.15171/apb.2016.060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Nanotechnology in Wound Healing; Semisolid Dosage Forms Containing Curcumin-Ampicillin Solid Lipid Nanoparticles,

    Ghaffari, Solmaz / Alihosseini, Faezeh / Rezayat Sorkhabadi, Seyed Mahdi / Arbabi Bidgoli, Sepideh / Mousavi, Seyyedeh Elaheh / Haghighat, Setareh / Afshar Nasab, Ahoo / Kianvash, Nooshin

    Advanced pharmaceutical bulletin

    2018  Volume 8, Issue 3, Page(s) 395–400

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2018-08-29
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 3018440-X
    ISSN 2251-7308 ; 2228-5881
    ISSN (online) 2251-7308
    ISSN 2228-5881
    DOI 10.15171/apb.2018.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development and physicochemical, toxicity and immunogenicity assessments of recombinant hepatitis B surface antigen (rHBsAg) entrapped in chitosan and mannosylated chitosan nanoparticles: as a novel vaccine delivery system and adjuvant.

    Mehrabi, Mohsen / Dounighi, Naser Mohammadpour / Rezayat Sorkhabadi, Seyed Mahdi / Doroud, Delaram / Amani, Amir / Khoobi, Mehdi / Ajdary, Soheila / Pilehvar-Soltanahmadi, Younes

    Artificial cells, nanomedicine, and biotechnology

    2017  Volume 46, Issue sup1, Page(s) 230–240

    Abstract: In this study chitosan nanoparticles (CS NPs) and mannosylated chitosan nanoparticles (MCH NPs) loaded with recombinant hepatitis B surface antigen (rHBsAg) was synthesized as a vaccine delivery system and assessed toxically and immunologically. The ... ...

    Abstract In this study chitosan nanoparticles (CS NPs) and mannosylated chitosan nanoparticles (MCH NPs) loaded with recombinant hepatitis B surface antigen (rHBsAg) was synthesized as a vaccine delivery system and assessed toxically and immunologically. The physicochemical properties of the nanoparticles (NPs) were determined by methods including scanning electron microscope (SEM) and dynamic light scattering (DLS). The morphology of the NPs was semi spherical and the average diameter of the loaded CS and MCH NPs was found to be 189 and 239 nm, respectively. The release studies showed that after the initial burst, both of the loaded NPs provided a continuous and slow release of the antigens. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed concentration and time dependent toxicity profile for both formulations, but rHBsAg loaded CS nanoparticle showed higher toxicity due to smaller particle size and larger zeta potential. Abnormal toxicity test (ATT) results showed no signs of toxicity in mice and guinea-pigs treated with loaded MCHNPs. Stability test for six months showed acceptable changes in size, surface charge, and antigenicity for loaded MCH nanoparticles. Finally, in vivo immunogenicity study revealed greater adjuvant capability of MCH nanoparticles than others formulations. Our results showed MCH NPs can be used as a controlled and targeted vaccine delivery system.
    MeSH term(s) Adjuvants, Immunologic/chemistry ; Adjuvants, Immunologic/pharmacology ; Animals ; Chemical Phenomena ; Chitosan/chemistry ; Drug Carriers/chemistry ; Drug Liberation ; Drug Stability ; Guinea Pigs ; HEK293 Cells ; Hepatitis B Surface Antigens/chemistry ; Hepatitis B Surface Antigens/immunology ; Humans ; Mannose/chemistry ; Mice ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Temperature
    Chemical Substances Adjuvants, Immunologic ; Drug Carriers ; Hepatitis B Surface Antigens ; Chitosan (9012-76-4) ; Mannose (PHA4727WTP)
    Language English
    Publishing date 2017-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2723095-8
    ISSN 2169-141X ; 2169-1401
    ISSN (online) 2169-141X
    ISSN 2169-1401
    DOI 10.1080/21691401.2017.1417868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1164: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Synthesis of a phenylalanine imprinted polymer for attenuation of phenylalanine absorption via the gut in a murine hyperphenylalaninemia model.

    Najafizadeh, Parvaneh / Ebrahimi, Soltan Ahmad / Panjeshahin, Mohammad Reza / Hesari, Kambiz Kamyab / Rezayat Sorkhabadi, Seyed Mahdi

    Journal of materials chemistry. B

    2014  Volume 2, Issue 15, Page(s) 2144–2152

    Abstract: Polymer technology plays an influential role in biomedical sciences. Molecular imprinting is a technique for preparation of polymers with structure-selective adsorptive properties. High selectivities of these materials have nowadays advanced to the point ...

    Abstract Polymer technology plays an influential role in biomedical sciences. Molecular imprinting is a technique for preparation of polymers with structure-selective adsorptive properties. High selectivities of these materials have nowadays advanced to the point that they are being utilized for several biomedical applications such as drug delivery. Phenylketonuria is a genetic disease characterized by accumulation of phenylalanine (Phe) in blood with toxic consequences. The aim of the present study is to synthesize a phenylalanine imprinted polymer for attenuation of phenylalanine absorption in the gut in a murine hyperphenylalaninemia model. A molecularly imprinted polymer (MIP) against Phe and a non-imprinted polymer (NIP) were synthesized and their Phe binding properties were studied in Simulated Intestinal Fluid (SIF). Two classes of binding sites were then found in the MIP: high affinity (K
    Language English
    Publishing date 2014-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/c3tb21826k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Preparation of a selective L-phenylalanine imprinted polymer implicated in patients with phenylketonuria.

    Najafizadeh, Parvaneh / Ebrahimi, Soltan Ahmad / Panjehshahin, Mohammad Reza / Rezayat Sorkhabadi, Seyed Mahdi

    Iranian journal of medical sciences

    2014  Volume 39, Issue 6, Page(s) 552–558

    Abstract: Background: Molecular imprinting is a method for synthesizing polymers with structure-selective adsorption properties with applications such as, selectivity binding, drug delivery systems and anti-bodies. The present study aims at optimizing the ... ...

    Abstract Background: Molecular imprinting is a method for synthesizing polymers with structure-selective adsorption properties with applications such as, selectivity binding, drug delivery systems and anti-bodies. The present study aims at optimizing the preparation of molecularly imprinted polymer (MIP) against l-phenylalanine, in order to increase phenylalanine-binding in Enzymatic Intestinal Simulated Fluid (ESIF).
    Methods: The MIP for l-phenylalanine, as a water-soluble template, was successfully synthesized without derivatization. Synthesization was done by a UV polymerization method in which methacrylic acid (MAA), as a functional monomer, and ethylene glycol dimethacrylate (EGDMA), as a cross-linker, were used in the presence of five different porogenic solvents including; acetonitrile, tetrahydrofuran (THF), chloroform, toluene and dimethyl sulfoxide (DMSO). The selectivity of the MIP was examined using 19 different amino acids in human serum and was evaluated by HPLC. In addition, morphological studies were conducted using SEM.
    Results: The results showed that the obtained MIP with acetonitrile had the highest capacity and selectivity compared with other solvents. The data indicated that Phe-binding to MIP was significantly more than the former binding to NIP in EISF (P≤0.05). Moreover, in comparison with NIP and control group, MIP showed a better selectivity and binding for Phe. This could be used for the reduction of Phe in human serum samples of Phenylketonuria.
    Conclusion: Our findings suggest that the MIP against Phe prepared with acetonitrile, showed a good selectivity and binding, which caused a reduction of blood Phe concentration in enzymatic simulated intestinal fluid and human serum sample of Phenylketonuria.
    Language English
    Publishing date 2014-11-26
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 603872-4
    ISSN 1735-3688 ; 0253-0716
    ISSN (online) 1735-3688
    ISSN 0253-0716
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1634: Show issues Location:
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  10. Article: Synthesis of a phenylalanine imprinted polymer for attenuation of phenylalanine absorption via the gut in a murine hyperphenylalaninemia model

    Najafizadeh, Parvaneh / Ebrahimi, Soltan Ahmad / Hesari, Kambiz Kamyab / Panjeshahin, Mohammad Reza / Rezayat Sorkhabadi, Seyed Mahdi

    Journal of materials chemistry B. 2014 Mar. 19, v. 2, no. 15

    2014  

    Abstract: Polymer technology plays an influential role in biomedical sciences. Molecular imprinting is a technique for preparation of polymers with structure-selective adsorptive properties. High selectivities of these materials have nowadays advanced to the point ...

    Abstract Polymer technology plays an influential role in biomedical sciences. Molecular imprinting is a technique for preparation of polymers with structure-selective adsorptive properties. High selectivities of these materials have nowadays advanced to the point that they are being utilized for several biomedical applications such as drug delivery. Phenylketonuria is a genetic disease characterized by accumulation of phenylalanine (Phe) in blood with toxic consequences. The aim of the present study is to synthesize a phenylalanine imprinted polymer for attenuation of phenylalanine absorption in the gut in a murine hyperphenylalaninemia model. A molecularly imprinted polymer (MIP) against Phe and a non-imprinted polymer (NIP) were synthesized and their Phe binding properties were studied in Simulated Intestinal Fluid (SIF). Two classes of binding sites were then found in the MIP: high affinity (KD = 62.5 μM) and low affinity (KD = 1 mM). Histological toxicity and LD50 of the MIP, after oral administration to murine hyperphenylalaninemia, were examined prior to investigation of the effects of the imprinted polymer on blood Phe concentrations in animal models. Our findings suggest that the MIP against Phe can decrease the blood Phe concentration in an animal model of hyperphenylalaninemia.
    Keywords absorption ; animal models ; binding properties ; binding sites ; biomedical research ; blood ; drugs ; histology ; intestinal absorption ; intestines ; lethal dose 50 ; mice ; molecular imprinting ; oral administration ; phenylalanine ; phenylketonuria ; polymers
    Language English
    Dates of publication 2014-0319
    Size p. 2144-2152.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/c3tb21826k
    Database NAL-Catalogue (AGRICOLA)

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