LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Zurück zur letzten Suche Suchhistorie
Erweiterte Suche

Ihre letzten Suchen

  1. AU="Rezende, Carlos Eduardo Borges"
  2. AU="Brunvand, E."
  3. AU="Gateno, Jaime"

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: Cholesteatoma gene expression of matrix metalloproteinases and their inhibitors by RT-PCR.

    Rezende, Carlos Eduardo Borges / Souto, Ricardo Peres do / Rapoport, Priscila Bogar / Campos, Laís de / Generato, Marcela Bovo

    Brazilian journal of otorhinolaryngology

    2012  Band 78, Heft 3, Seite(n) 116–121

    Abstract: Unlabelled: Acquired middle ear cholesteatoma is a benign keratinizing hyperproliferative squamous epithelial lesion that may result in the destruction of the bone structures surrounding the temporal bone. Recent studies show that variations in cellular ...

    Abstract Unlabelled: Acquired middle ear cholesteatoma is a benign keratinizing hyperproliferative squamous epithelial lesion that may result in the destruction of the bone structures surrounding the temporal bone. Recent studies show that variations in cellular production of matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs) contribute to the pathophysiology of cholesteatoma.
    Objective: This study aims to analyze the use of RNA amplification tests to evaluate the expression of MMP and TIMP isoforms in cholesteatomas and their correlation with disease severity.
    Materials and methods: This is a prospective study. Nineteen cholesteatoma cases at different stages were selected. RNA collected from biopsy specimens was submitted to reverse transcription polymerase chain reaction (RT-PCR) for semiquantitative amplification of MMP2, MMP3, MMP9, MMP13 and TIMP1.
    Results: Six cholesteatomas were positive for at least one of the studied genes. Four samples amplified a single gene (MMP2 or MMP13) and two samples amplified three genes (MMP2, TIMP1 and MMP3 or MMP13). No sample amplified MMP9.
    Conclusion: RT-PCR can be used to assess MMP and TIMP gene expression in cholesteatomas despite technical difficulties. Gene expression profiles could not be related to disease severity.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Audiometry ; Biomarkers/analysis ; Child ; Child, Preschool ; Cholesteatoma, Middle Ear/complications ; Cholesteatoma, Middle Ear/enzymology ; Cholesteatoma, Middle Ear/genetics ; Gene Expression/genetics ; Hearing Loss/diagnosis ; Hearing Loss/etiology ; Humans ; Matrix Metalloproteinases/genetics ; Matrix Metalloproteinases/metabolism ; Middle Aged ; Prospective Studies ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Severity of Illness Index ; Tissue Inhibitor of Metalloproteinase-1/genetics ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tomography, X-Ray Computed ; Young Adult
    Chemische Substanzen Biomarkers ; RNA, Messenger ; Tissue Inhibitor of Metalloproteinase-1 ; Matrix Metalloproteinases (EC 3.4.24.-)
    Sprache Portugiesisch
    Erscheinungsdatum 2012-04-03
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8686 ; 1808-8694
    ISSN (online) 1808-8686
    ISSN 1808-8694
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6641: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel: Tympanoplasty: surgical results and a comparison of the factors that may interfere in their success.

    Fukuchi, Ilana / Cerchiari, Dafne Patrícia / Garcia, Eduardo / Rezende, Carlos Eduardo Borges / Rapoport, Priscila Bogar

    Brazilian journal of otorhinolaryngology

    2006  Band 72, Heft 2, Seite(n) 267–271

    Abstract: Unlabelled: Chronic otitis media has a high prevalence on the population and their treatment continuous to be a challenge for the otorhinolaryngologists.: Aim: To demonstrate the factors that could interfere in the tympanoplasty success and the ... ...

    Abstract Unlabelled: Chronic otitis media has a high prevalence on the population and their treatment continuous to be a challenge for the otorhinolaryngologists.
    Aim: To demonstrate the factors that could interfere in the tympanoplasty success and the surgical results during 2002.
    Study design: Clinical prospective.
    Material and method: were included 37 patients with chronic otitis media non cholesteatoma (COMNC) undergo to tympanoplasty (in lay or underlay, with homologous graft). All the patients were submitted to a survey pre and postoperative include clinical, physical examinations, flexible nasal endoscope and audiometry.
    Results: The age, the dimension and localization of the tympanic membrane perforation; the condition of middle ear mucosa; number of otorrhea/year; smoking; parents history of otorrhea and hearing loss; personals history of otological surgery; monthly family income; the graft, technique and access used were not significantly to repair tympanic membrane perforations. The closure rate was 65% and the gain in air-bone gap was 100%.
    Conclusion: The timpanoplasty must be considerate in the treatment of the COMNC.
    Mesh-Begriff(e) Adolescent ; Adult ; Audiometry ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Otitis Media/complications ; Otitis Media/surgery ; Prospective Studies ; Risk Factors ; Treatment Outcome ; Tympanic Membrane Perforation/etiology ; Tympanic Membrane Perforation/surgery ; Tympanoplasty/adverse effects ; Tympanoplasty/methods
    Sprache Englisch
    Erscheinungsdatum 2006-08-30
    Erscheinungsland Brazil
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 2428110-4
    ISSN 1808-8694
    ISSN 1808-8694
    DOI 10.1016/s1808-8694(15)30067-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6641: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang