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Article ; Online: Autoinflammation and Immunomodulation in Inflammatory Fibromyalgia Syndrome- A Review.

Metyas, Samy / Rezk, Tamer / Arkfeld, Daniel / Leptich, Thomas

Current rheumatology reviews

2017 Volume 13, Issue 2, Page(s) 98–102

Abstract: Generalized pain with tender points in specific areas accompanied by systemic symptoms such as fatigue and stiffness is characteristic of fibromyalgia (FM) syndrome. The genesis of FM is still being investigated with conflicting data on factors including ...

Abstract	Generalized pain with tender points in specific areas accompanied by systemic symptoms such as fatigue and stiffness is characteristic of fibromyalgia (FM) syndrome. The genesis of FM is still being investigated with conflicting data on factors including autonomic dysfunction, neurotransmitters, and hormones often in combination with external stressful events. However, recent research is starting to suggest that there is a previously underappreciated subtype of fibromyalgia called inflammatory Fibromyalgia (iFM). Recent studies have described cytokines, inflammatory markers, sleep disorders, hyperalgesia, cognitive dysfunction, serum leptin levels and other inflammatory indicators as potential markers for iFM. This article will; 1) review the inflammatory markers and abnormal levels of other laboratory indicators that can help to identify the subgroup of patients that fall into the new category of Inflammatory Fibromyalgia [1-5] and 2) review all completed trials that were focused on treating this new category of disease. Through this review it is hoped that and further understanding of the complexity of the etiology of fibromyalgia can be explored.
Language	English
Publishing date	2017
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6360
ISSN (online)	1875-6360
DOI	10.2174/1573397112666160919120530
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Article ; Online: Comparison of

Somers, Henry / Tanzim, Ubaid / Porcari, Aldostefano / Razvi, Yousuf / Rezk, Tamer / Patel, Rishi / Chacko, Liza / Rowczenio, Dorota / Gilbertson, Janet A / Hutt, David F / Hawkins, Philip N / Fontana, Marianna / Gillmore, Julian D

JACC. Cardiovascular imaging

2022 Volume 15, Issue 7, Page(s) 1353–1355

MeSH term(s)	Amyloid Neuropathies, Familial/diagnostic imaging ; Amyloid Neuropathies, Familial/genetics ; Cardiomyopathies/etiology ; Cardiomyopathies/genetics ; Echocardiography ; Humans ; Prealbumin/genetics ; Predictive Value of Tests ; Radionuclide Imaging ; Radiopharmaceuticals
Chemical Substances	Prealbumin ; Radiopharmaceuticals
Language	English
Publishing date	2022-05-11
Publishing country	United States
Document type	Letter
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2022.02.016
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Article ; Online: Renal transplant outcomes in amyloidosis.

Law, Steven / Cohen, Oliver / Lachmann, Helen J / Rezk, Tamer / Gilbertson, Janet A / Rowczenio, Dorota / Wechalekar, Ashutosh D / Hawkins, Philip N / Motallebzadeh, Reza / Gillmore, Julian D

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2021 Volume 36, Issue 2, Page(s) 355–365

Abstract: Background: Outcomes after renal transplantation have traditionally been poor in systemic amyloid A (AA) amyloidosis and systemic light chain (AL) amyloidosis, with high mortality and frequent recurrent disease. We sought to compare outcomes with ... ...

Abstract	Background: Outcomes after renal transplantation have traditionally been poor in systemic amyloid A (AA) amyloidosis and systemic light chain (AL) amyloidosis, with high mortality and frequent recurrent disease. We sought to compare outcomes with matched transplant recipients with autosomal dominant polycystic kidney disease (ADPKD) and diabetic nephropathy (DN), and identify factors predictive of outcomes. Methods: We performed a retrospective cohort study of 51 systemic AL and 48 systemic AA amyloidosis patients undergoing renal transplantation. Matched groups were generated by propensity score matching. Patient and death-censored allograft survival were compared via Kaplan-Meier survival analyses, and assessment of clinicopathological features predicting outcomes via Cox proportional hazard analyses. Results: One-, 5- and 10-year death-censored unadjusted graft survival was, respectively, 94, 91 and 78% for AA amyloidosis, and 98, 93 and 93% for AL amyloidosis; median patient survival was 13.1 and 7.9 years, respectively. Patient survival in AL and AA amyloidosis was comparable to DN, but poorer than ADPKD [hazard ratio (HR) = 3.12 and 3.09, respectively; P < 0.001]. Death-censored allograft survival was comparable between all groups. In AL amyloidosis, mortality was predicted by interventricular septum at end diastole (IVSd) thickness >12 mm (HR = 26.58; P = 0.03), while survival was predicted by haematologic response (very good partial or complete response; HR = 0.07; P = 0.018). In AA amyloidosis, recurrent amyloid was associated with elevated serum amyloid A concentration but not with outcomes. Conclusions: Renal transplantation outcomes for selected patients with AA and AL amyloidosis are comparable to those with DN. In AL amyloidosis, IVSd thickness and achievement of deep haematologic response pre-transplant profoundly impact patient survival.
MeSH term(s)	Aged ; Amyloidosis/complications ; Amyloidosis/surgery ; Female ; Humans ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/pathology ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Survival Rate ; Time Factors ; Transplantation, Homologous
Language	English
Publishing date	2021-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfaa293
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Article ; Online: An acute case of herpes zoster ophthalmicus with ophthalmoplegia.

Hakim, Wasim / Sherman, Rosalie / Rezk, Tamer / Pannu, Kanwar

Case reports in ophthalmological medicine

2012 Volume 2012, Page(s) 953910

Abstract: Herpes zoster ophthalmicus (HZO) with oculomotor nerve involvement is rare, even rarer as an acute presentation rather than sequelae of HZO. In this paper we present a case of cutaneous HZO in which our patient's initial presentation was one of complete ... ...

Abstract	Herpes zoster ophthalmicus (HZO) with oculomotor nerve involvement is rare, even rarer as an acute presentation rather than sequelae of HZO. In this paper we present a case of cutaneous HZO in which our patient's initial presentation was one of complete ophthalmoplegia.
Language	English
Publishing date	2012-05-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2659091-8
ISSN	2090-6730 ; 2090-6722
ISSN (online)	2090-6730
ISSN	2090-6722
DOI	10.1155/2012/953910
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Article: Scleroderma renal crisis.

Rezk, Tamer / Henderson, Scott R / Lynch, Bernadette / Burns, Aline

British journal of hospital medicine (London, England : 2005)

2013 Volume 74, Issue 9, Page(s) C130–3

MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/etiology ; Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/etiology ; Scleroderma, Systemic/complications
Language	English
Publishing date	2013-09
Publishing country	England
Document type	Journal Article ; Review
ISSN	1750-8460
ISSN	1750-8460
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Article: Scleroderma renal crisis.

Rezk, Tamer / R Henderson, Scott / Lynch, Bernadette / Burns, Aine

British journal of hospital medicine (London, England : 2005)

2013 Volume 74 Suppl 9, Page(s) C130–3

Abstract: Systemic sclerosis is an autoimmune connective tissue disorder characterized by endothelial cell injury, vascular hyper-reactivity, obliterative microvasculopathy and excess collagen deposition, particularly within the dermis of the skin. Table 1 ... ...

Abstract	Systemic sclerosis is an autoimmune connective tissue disorder characterized by endothelial cell injury, vascular hyper-reactivity, obliterative microvasculopathy and excess collagen deposition, particularly within the dermis of the skin. Table 1 outlines the various terms that are used to describe the extent and location of sclerosis. Limited cutaneous and diffuse cutaneous are the two main forms that exist.
MeSH term(s)	Autoimmune Diseases ; Connective Tissue Diseases ; Humans ; Scleroderma, Systemic ; Skin
Language	English
Publishing date	2013-09
Publishing country	England
Document type	Journal Article
ISSN	1750-8460
ISSN	1750-8460
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Article: Cardiac transplantation in transthyretin amyloid cardiomyopathy: Outcomes from three decades of tertiary center experience.

Razvi, Yousuf / Porcari, Aldostefano / Di Nora, Concetta / Patel, Rishi K / Ioannou, Adam / Rauf, Muhammad U / Masi, Ambra / Law, Steven / Chacko, Liza / Rezk, Tamer / Ravichandran, Sriram / Gilbertson, Janet / Rowczenio, Dorota / Blakeney, Iona J / Kaza, Nandita / Hutt, David F / Lachmann, Helen / Wechalekar, Ashutosh / Moody, William /

Lim, Sern / Chue, Colin / Whelan, Carol / Venneri, Lucia / Martinez-Naharro, Ana / Merlo, Marco / Sinagra, Gianfranco / Livi, Ugolino / Hawkins, Philip / Fontana, Marianna / Gillmore, Julian D

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1075806

Abstract: Aims: Transthyretin cardiac amyloidosis (ATTR-CM) is a progressive and fatal cardiomyopathy. Treatment options in patients with advanced ATTR-CM are limited to cardiac transplantation (CT). Despite case series demonstrating comparable outcomes with CT ... ...

Abstract	Aims: Transthyretin cardiac amyloidosis (ATTR-CM) is a progressive and fatal cardiomyopathy. Treatment options in patients with advanced ATTR-CM are limited to cardiac transplantation (CT). Despite case series demonstrating comparable outcomes with CT between patients with ATTR-CM and non-amyloid cardiomyopathies, ATTR-CM is considered to be a contraindication to CT in some centers, partly due to a perceived risk of amyloid recurrence in the allograft. We report long-term outcomes of CT in ATTR-CM at two tertiary centers. Materials and methods and results: We retrospectively evaluated ATTR-CM patients across two tertiary centers who underwent transplantation between 1990 and 2020. Pre-transplantation characteristics were determined and outcomes were compared with a cohort of non-transplanted ATTR-CM patients. Fourteen (12 male, 2 female) patients with ATTR-CM underwent CT including 11 with wild-type ATTR-CM and 3 with variant ATTR-CM (ATTRv). Median age at CT was 62 years and median follow up post-CT was 66 months. One, three, and five-year survival was 100, 92, and 90%, respectively and the longest surviving patient was Censored > 19 years post CT. No patients had recurrence of amyloid in the cardiac allograft. Four patients died, including one with ATTRv-CM from complications of leptomeningeal amyloidosis. Survival among the cohort of patients who underwent CT was significantly prolonged compared to UK patients with ATTR-CM generally ( Conclusion: CT is well-tolerated, restores functional capacity and improves prognosis in ATTR-CM. The risk of amyloid recurrence in the cardiac allograft appears to be low.
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1075806
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Article ; Online: Proteomic Analysis for the Diagnosis of Fibrinogen Aα-chain Amyloidosis.

Taylor, Graham W / Gilbertson, Janet A / Sayed, Rabya / Blanco, Angel / Rendell, Nigel B / Rowczenio, Dorota / Rezk, Tamer / Mangione, P Patrizia / Canetti, Diana / Bass, Paul / Hawkins, Philip N / Gillmore, Julian D

Kidney international reports

2019 Volume 4, Issue 7, Page(s) 977–986

Abstract: Introduction: Hereditary fibrinogen Aα-chain (AFib) amyloidosis is a relatively uncommon renal disease associated with a small number of pathogenic fibrinogen Aα (FibA) variants; wild-type FibA normally does not result in amyloid deposition. Proteomics ... ...

Abstract	Introduction: Hereditary fibrinogen Aα-chain (AFib) amyloidosis is a relatively uncommon renal disease associated with a small number of pathogenic fibrinogen Aα (FibA) variants; wild-type FibA normally does not result in amyloid deposition. Proteomics is now routinely used to identify the amyloid type in clinical samples, and we report here our algorithm for identification of FibA in amyloid. Methods: Proteomics data from 1001 Congo red-positive patient samples were examined using the Mascot search engine to interrogate the Swiss-Prot database and generate protein identity scores. An algorithm was applied to identify FibA as the amyloid protein based on Mascot scores. FibA variants were identified by appending the known amyloidogenic variant sequences to the Swiss-Prot database. Results: AFib amyloid was identified by proteomics in 64 renal samples based on the Mascot scores relative to other amyloid proteins, the presence of a pathogenic variant, and coverage of the p.449-621 sequence. Contamination by blood could be excluded from a comparison of the FibA score with that of the fibrinogen β and γ chains. The proteomics results were consistent with the clinical diagnosis. Four additional renal samples did not fulfill all the criteria using the algorithm but were adjudged as AFib amyloid based on a full assessment of the clinical and biochemical results. Conclusion: AFib amyloid can be identified reliably in glomerular amyloid by proteomics using a score-based algorithm. Proteomics data should be used as a guide to AFib diagnosis, with the results considered together with all available clinical and laboratory information.
Language	English
Publishing date	2019-04-15
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2019.04.007
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Article ; Online: British kindred with dominant FMF associated with high incidence of AA amyloidosis caused by novel MEFV variant, and a review of the literature.

Rowczenio, Dorota M / Youngstein, Taryn / Trojer, Hadija / Omoyinmi, Ebun / Baginska, Anna / Brogan, Paul / Papadopoulou, Charalampia / Rezk, Tamer / Hawkins, Philip N / Lachmann, Helen J

Rheumatology (Oxford, England)

2019 Volume 59, Issue 3, Page(s) 554–558

Abstract: Objectives: Hereditary systemic autoinflammatory diseases are rare genetic disorders, which if untreated, can be complicated by AA amyloidosis leading to renal failure and premature death. Our objective was to find a genetic cause in a British family ... ...

Abstract	Objectives: Hereditary systemic autoinflammatory diseases are rare genetic disorders, which if untreated, can be complicated by AA amyloidosis leading to renal failure and premature death. Our objective was to find a genetic cause in a British family with a dominantly inherited autoinflammatory disease complicated by AA amyloidosis. Methods: The index patient and his sister underwent comprehensive clinical and laboratory assessment including the next-generation sequencing panel targeting autoinflammatory genes. Subsequently, other relatives underwent clinical evaluation and genetic testing. Screening of the SAA1 gene was performed in all symptomatic cases. Results: The index case and his sister presented with proteinuria due to AA amyloidosis. They have been suffering from episodes of fever accompanied by severe abdominal and chest pain, arthritis and erythema since childhood. Their father died aged 52 years from complications following a cadaveric renal transplantation. The post-mortem examination demonstrated AA amyloidosis. The index case's grandmother, two paternal cousins and two of their children described similar symptoms. All symptomatic individuals had excellent responses to colchicine. Next-generation sequencing analysis identified a single MEFV p.P373L variant in the index case, his sister and subsequently, in symptomatic family members. Sequencing of the SAA1 gene revealed all cases were heterozygous for the SAA1.1 allele. Conclusion: Typically FMF is an autosomal recessive disorder; nonetheless rare cases of dominantly inherited disease have previously been described. Here we report a novel MEFV variant p.P373L, causing dominant FMF complicated by AA amyloidosis in four generations of a British family.
MeSH term(s)	Adult ; Amyloidosis/drug therapy ; Amyloidosis/genetics ; Colchicine/therapeutic use ; Familial Mediterranean Fever/drug therapy ; Familial Mediterranean Fever/genetics ; Female ; Humans ; Male ; Middle Aged ; Pedigree ; Pyrin/genetics ; Treatment Outcome ; Tubulin Modulators/therapeutic use
Chemical Substances	Pyrin ; Tubulin Modulators ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2019-08-05
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kez334
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Zs.B 240: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 497: Show issues

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Article ; Online: The complementary role of histology and proteomics for diagnosis and typing of systemic amyloidosis.

Rezk, Tamer / Gilbertson, Janet A / Mangione, P Patrizia / Rowczenio, Dorota / Rendell, Nigel B / Canetti, Diana / Lachmann, Helen J / Wechalekar, Ashutosh D / Bass, Paul / Hawkins, Philip N / Bellotti, Vittorio / Taylor, Graham W / Gillmore, Julian D

The journal of pathology. Clinical research

2019 Volume 5, Issue 3, Page(s) 145–153

Abstract: The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific antibodies. ... ...

Abstract	The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific antibodies. However, amyloid IHC is qualitative, non-standardised, requires operator expertise, and not infrequently fails to produce definitive results. More recently, laser dissection mass spectrometry (LDMS) has been developed as an alternative method to characterise amyloid in tissue sections. We sought to compare these techniques in a real world setting. During 2017, we performed LDMS on 640 formalin-fixed biopsies containing amyloid (CR+ve) comprising all 320 cases that could not be typed by IHC (IHC-ve) and 320 randomly selected CR+ve samples that had been typed (IHC+ve). In addition, we studied 60 biopsies from patients in whom there was a strong suspicion of amyloidosis, but in whom histology was non-diagnostic (CR-ve). Comprehensive clinical assessments were conducted in 532 (76%) of cases. Among the 640 CR+ve samples, 602 (94%) contained ≥2 of 3 amyloid signature proteins (ASPs) on LDMS (ASP+ve) supporting the presence of amyloid. A total of 49 of the 60 CR-ve samples were ASP-ve; 7 of 11 that were ASP+ve were glomerular. The amyloid fibril protein was identified by LDMS in 255 of 320 (80%) of the IHC-ve samples and in a total of 545 of 640 (85%) cases overall. The LDMS and IHC techniques yielded discordant results in only 7 of 320 (2%) cases. CR histology and LDMS are corroborative for diagnosis of amyloid, but LDMS is superior to IHC for confirming amyloid type.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Amyloidosis/classification ; Amyloidosis/diagnosis ; Female ; Humans ; Immunohistochemistry/methods ; Laser Capture Microdissection/methods ; Male ; Middle Aged ; Pregnancy ; Proteomics/methods ; Staining and Labeling/methods ; Tandem Mass Spectrometry/methods
Language	English
Publishing date	2019-04-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814357-7
ISSN	2056-4538 ; 2056-4538
ISSN (online)	2056-4538
ISSN	2056-4538
DOI	10.1002/cjp2.126
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