Artikel ; Online: Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset of Alzheimer's disease-related neuropathology.
2024 Band 235, Seite(n) 102591
Abstract: Objective: Hyperexcitability is intimately linked to Alzheimer's disease (AD) pathology, but the precise timing and contributions of neuronal hyperexcitability to disease progression is unclear. Seizure induction in rodent AD models can uncover new ... ...
| Abstract | Objective: Hyperexcitability is intimately linked to Alzheimer's disease (AD) pathology, but the precise timing and contributions of neuronal hyperexcitability to disease progression is unclear. Seizure induction in rodent AD models can uncover new therapeutic targets. Further, investigator-evoked seizures can directly establish how hyperexcitability and AD-associated risk factors influence neuropathological hallmarks and disease course at presymptomatic stages. Methods: Corneal kindling is a well-characterized preclinical epilepsy model that allows for precise control of seizure history to pair to subsequent behavioral assessments. 2-3-month-old APP/PS1, PSEN2-N141I, and transgenic control male and female mice were thus sham or corneal kindled for 2 weeks. Seizure-induced changes in glia, serotonin pathway proteins, and amyloid β levels in hippocampus and prefrontal cortex were quantified. Results: APP/PS1 females were more susceptible to corneal kindling. However, regardless of sex, APP/PS1 mice experienced extensive seizure-induced mortality versus kindled Tg- controls. PSEN2-N141I mice were not negatively affected by corneal kindling. Mortality correlated with a marked downregulation of hippocampal tryptophan hydroxylase 2 and monoamine oxidase A protein expression versus controls; these changes were not detected in PSEN2-N141I mice. Kindled APP/PS1 mice also exhibited soluble amyloid β upregulation and glial reactivity without plaque deposition. Significance: Evoked convulsive seizures and neuronal hyperexcitability in pre-symptomatic APP/PS1 mice promoted premature mortality without pathological Aβ plaque deposition, whereas PSEN2-N141I mice were unaffected. Disruptions in serotonin pathway metabolism in APP/PS1 mice was associated with increased glial reactivity without Aβ plaque deposition, demonstrating that neuronal hyperexcitability in early AD causes pathological Aβ overexpression and worsens long-term outcomes through a serotonin-related mechanism. |
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| Mesh-Begriff(e) | Mice ; Male ; Female ; Animals ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; Serotonin ; Mice, Transgenic ; Plaque, Amyloid/complications ; Seizures/complications ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics |
| Chemische Substanzen | Amyloid beta-Peptides ; Serotonin (333DO1RDJY) ; Amyloid beta-Protein Precursor |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-03-13 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 185535-9 |
| ISSN | 1873-5118 ; 0301-0082 |
| ISSN (online) | 1873-5118 |
| ISSN | 0301-0082 |
| DOI | 10.1016/j.pneurobio.2024.102591 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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