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  1. Article ; Online: Trends in the activity of mold-active azole agents against

    Pfaller, M A / Carvalhaes, C G / Rhomberg, P R / Desphande, L M / Castanheira, M

    Journal of clinical microbiology

    2024  Volume 62, Issue 2, Page(s) e0114123

    Abstract: Azole resistance ... ...

    Abstract Azole resistance in
    MeSH term(s) Humans ; Aspergillus fumigatus ; Azoles/pharmacology ; Antifungal Agents/pharmacology ; Fungi ; Europe/epidemiology ; Invasive Fungal Infections ; Drug Resistance, Fungal/genetics ; Microbial Sensitivity Tests ; Fungal Proteins/genetics ; Nitriles ; Pyridines ; Triazoles
    Chemical Substances isavuconazole (60UTO373KE) ; Azoles ; Antifungal Agents ; Fungal Proteins ; Nitriles ; Pyridines ; Triazoles
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/jcm.01141-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Brain Tissue Damage Induced by Multimodal Neuromonitoring In Situ during MRI after Severe Traumatic Brain Injury: Incidence and Clinical Relevance.

    Pinggera, Daniel / Rhomberg, Paul / Beer, Ronny / Thomé, Claudius / Petr, Ondra

    Journal of clinical medicine

    2022  Volume 11, Issue 11

    Abstract: Both neuromonitoring and early magnetic resonance imaging (MRI) provide crucial information for treatment management and prognosis in patients with severe traumatic brain injury (sTBI). So far, neuromonitoring in situ impedes the routine implementation ... ...

    Abstract Both neuromonitoring and early magnetic resonance imaging (MRI) provide crucial information for treatment management and prognosis in patients with severe traumatic brain injury (sTBI). So far, neuromonitoring in situ impedes the routine implementation of MRI due to safety concerns. We aimed to evaluate the brain tissue damage induced by inserted neuromonitoring devices and its clinical relevance. Nineteen patients with sTBI and being exposed to at least one MRI with neuromonitoring in situ and one follow-up MRI after neuromonitoring removal were analyzed. All MRIs were reviewed for specific tissue damage. Three females and sixteen males (aged 20-74 years, mean 42.8 years) with an initial median GCS of 5 (range 3-8) were analyzed. No lesion was observed in six patients (31.6%), whereas another six patients (31.6%) demonstrated a detectable probe trajectory. Probe-related tissue damage was visible in seven patients (36.8%) with the size of the lesion prone to further enlarge with increasing cumulative duration of MRI examinations. Upon interdisciplinary evaluation, the lesions were not considered clinically relevant. Neuromonitoring probes in situ during MRI examinations may cause local brain tissue damage, yet without any clinical implications if placed correctly. Therefore, indications must be strictly based on joint decision from all involved disciplines.
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11113169
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  3. Article ; Online: Activities of Manogepix and Comparators against 1,435 Recent Fungal Isolates Collected during an International Surveillance Program (2020).

    Pfaller, M A / Huband, M D / Rhomberg, P R / Bien, P A / Castanheira, M

    Antimicrobial agents and chemotherapy

    2022  Volume 66, Issue 11, Page(s) e0102822

    Abstract: We evaluated ... ...

    Abstract We evaluated the
    MeSH term(s) Anidulafungin/pharmacology ; Micafungin/pharmacology ; Fluconazole/pharmacology ; Voriconazole/pharmacology ; Itraconazole/pharmacology ; Microbial Sensitivity Tests ; Antifungal Agents/pharmacology ; Candida ; Aspergillus ; Cryptococcus neoformans ; Drug Resistance, Fungal
    Chemical Substances Anidulafungin (9HLM53094I) ; Micafungin (R10H71BSWG) ; Fluconazole (8VZV102JFY) ; APX001A ; Voriconazole (JFU09I87TR) ; Itraconazole (304NUG5GF4) ; Antifungal Agents
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/aac.01028-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Antifungal susceptibilities of opportunistic filamentous fungal pathogens from the Asia and Western Pacific Region: data from the SENTRY Antifungal Surveillance Program (2011-2019).

    Pfaller, Michael A / Carvalhaes, Cecilia G / Rhomberg, Paul / Messer, Shawn A / Castanheira, Mariana

    The Journal of antibiotics

    2021  Volume 75, Issue 2, Page(s) 123

    Language English
    Publishing date 2021-08-18
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-021-00460-z
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    Zs.A 207: Show issues Location:
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  5. Article ; Online: Antifungal susceptibilities of opportunistic filamentous fungal pathogens from the Asia and Western Pacific Region: data from the SENTRY Antifungal Surveillance Program (2011-2019).

    Pfaller, Michael A / Carvalhaes, Cecilia G / Rhomberg, Paul / Messer, Shawn A / Castanheira, Mariana

    The Journal of antibiotics

    2021  Volume 74, Issue 8, Page(s) 519–527

    Abstract: Antifungal surveillance is an important tool to monitor the prevalence of uncommon fungal species and increasing antifungal resistance throughout the world, but data comparing results across several different Asian countries are scarce. In this study, ... ...

    Abstract Antifungal surveillance is an important tool to monitor the prevalence of uncommon fungal species and increasing antifungal resistance throughout the world, but data comparing results across several different Asian countries are scarce. In this study, 372 invasive molds collected in the Asia-Western Pacific region in 2011-2019 were susceptibility tested for mold-active triazoles (isavuconazole, posaconazole, voriconazole, and itraconazole). The collection includes 318 Aspergillus spp. isolates and 53 non-Aspergillus molds. The MIC values using CLSI methods for isavuconazole versus Aspergillus fumigatus ranged from 0.25 to 2 mg l
    MeSH term(s) Antifungal Agents/pharmacology ; Asia ; Aspergillus/drug effects ; Aspergillus fumigatus/drug effects ; Drug Resistance, Fungal ; Fungi/drug effects ; Humans ; Microbial Sensitivity Tests ; Mycoses/microbiology ; Opportunistic Infections/microbiology ; Pacific Islands ; Public Health Surveillance ; Triazoles/pharmacology
    Chemical Substances Antifungal Agents ; Triazoles
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-021-00431-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 207: Show issues Location:
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  6. Article ; Online: The Loss of Temporal Muscle Volume is Associated with Poor Outcome in Patients with Subarachnoid Hemorrhage: An Observational Cohort Study.

    Kofler, Mario / Reitmeir, Philipp / Glodny, Bernhard / Rass, Verena / Lindner, Anna / Ianosi, Bogdan A / Gaasch, Max / Schiefecker, Alois J / Putnina, Lauma / Beer, Ronny / Rhomberg, Paul / Schmutzhard, Erich / Pfausler, Bettina / Helbok, Raimund

    Neurocritical care

    2023  Volume 39, Issue 1, Page(s) 198–206

    Abstract: Background: Intensive care unit (ICU) acquired weakness is a major contributor to poor functional outcome of ICU patients. Quantification of temporal muscle volume assessed on routine computed tomography (CT) scans may serve as a biomarker for muscle ... ...

    Abstract Background: Intensive care unit (ICU) acquired weakness is a major contributor to poor functional outcome of ICU patients. Quantification of temporal muscle volume assessed on routine computed tomography (CT) scans may serve as a biomarker for muscle wasting in patients suffering from acute brain injury.
    Methods: This is a retrospective analysis of prospectively collected data. Temporal muscle volume was assessed on head CT scans of consecutive patients with spontaneous subarachnoid hemorrhage within prespecified time frames (on admission, then weekly ± 2 days). Whenever possible, temporal muscle volume was assessed bilaterally and averaged for the analysis. Poor functional outcome was defined as a 3-month modified Rankin Scale Score ≥ 3. Statistical analysis was performed using generalized estimating equations to handle repeated measurements within individuals.
    Results: The analysis comprised 110 patients with a median Hunt & Hess score of 4 (interquartile range 3-5). Median age was 61 (50-70) years, 73 patients (66%) were women. Baseline temporal muscle volume was 18.5 ± 0.78 cm
    Conclusions: Temporal muscle volume, which is easily assessable on routine head CT scans, progressively decreases during the ICU stay after spontaneous subarachnoid hemorrhage. Because of its association with disease severity and functional outcome, it may serve as a biomarker for muscle wasting and outcome prognostication.
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; Subarachnoid Hemorrhage/complications ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/therapy ; Retrospective Studies ; Temporal Muscle ; Cohort Studies ; Hydrocephalus/complications ; Treatment Outcome
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-023-01751-z
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    Zs.A 6538: Show issues Location:
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  7. Article ; Online: In Vitro

    Flamm, R K / Rhomberg, P R / Sader, H S

    Antimicrobial agents and chemotherapy

    2017  Volume 61, Issue 12

    Abstract: Nafithromycin (WCK 4873), a novel antimicrobial agent of the lactone ketolide class, is currently in phase 2 development for treatment of community-acquired bacterial pneumonia (CABP). A total of 4,739 nonduplicate isolates were selected from a 2014 ... ...

    Abstract Nafithromycin (WCK 4873), a novel antimicrobial agent of the lactone ketolide class, is currently in phase 2 development for treatment of community-acquired bacterial pneumonia (CABP). A total of 4,739 nonduplicate isolates were selected from a 2014 global surveillance program at medical institutions located in 43 countries within the United States, Europe, Latin America, and the Asia-Pacific region. Nafithromycin and comparator agents were used for susceptibility testing by reference broth microdilution methods. Nafithromycin was active against
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Community-Acquired Infections/drug therapy ; Drug Resistance, Multiple, Bacterial ; Haemophilus influenzae/drug effects ; Haemophilus influenzae/isolation & purification ; Humans ; Ketolides/pharmacology ; Lactones/pharmacology ; Microbial Sensitivity Tests ; Moraxella (Branhamella) catarrhalis/drug effects ; Moraxella (Branhamella) catarrhalis/isolation & purification ; Pneumonia, Bacterial/drug therapy ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/isolation & purification ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/isolation & purification ; Streptococcus pyogenes/drug effects ; Streptococcus pyogenes/isolation & purification ; United States
    Chemical Substances Anti-Bacterial Agents ; Ketolides ; Lactones ; nafithromycin (75F74Y2R70)
    Language English
    Publishing date 2017-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01230-17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Erratum for Pfaller et al., "

    Pfaller, M A / Sader, H S / Rhomberg, P R / Flamm, R K

    Antimicrobial agents and chemotherapy

    2018  Volume 62, Issue 2

    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02383-17
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  9. Article ; Online: Activity of omadacycline tested against Enterobacteriaceae causing urinary tract infections from a global surveillance program (2014).

    Pfaller, M A / Rhomberg, P R / Huband, M D / Flamm, R K

    Diagnostic microbiology and infectious disease

    2018  Volume 91, Issue 2, Page(s) 179–183

    Abstract: Omadacycline is an aminomethylcycline with in vitro activity against many gram-negative pathogens. Omadacycline and comparators were tested against Enterobacteriaceae from urinary tract infections (UTIs) selected from a 2014 global surveillance program ... ...

    Abstract Omadacycline is an aminomethylcycline with in vitro activity against many gram-negative pathogens. Omadacycline and comparators were tested against Enterobacteriaceae from urinary tract infections (UTIs) selected from a 2014 global surveillance program and compared to results of isolates from 2010 surveillance. The omadacycline MIC
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Cohort Studies ; Enterobacteriaceae/drug effects ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Humans ; Microbial Sensitivity Tests ; Tetracyclines/pharmacology ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/microbiology
    Chemical Substances Anti-Bacterial Agents ; Tetracyclines ; omadacycline (090IP5RV8F)
    Language English
    Publishing date 2018-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2018.01.019
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    Zs.A 1845: Show issues Location:
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  10. Article ; Online: In Vitro

    Pfaller, M A / Sader, H S / Rhomberg, P R / Flamm, R K

    Antimicrobial agents and chemotherapy

    2017  Volume 61, Issue 4

    Abstract: ... ...

    Abstract The
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Europe ; Fluoroquinolones/pharmacology ; Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Streptococcus pneumoniae/drug effects ; United States
    Chemical Substances Anti-Bacterial Agents ; Fluoroquinolones ; delafloxacin (6315412YVF)
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.02609-16
    Database MEDical Literature Analysis and Retrieval System OnLINE

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