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Article ; Online: Different endoscopic treatments for small colorectal polyps

Xuanhan Li / He Zhu / Fudong Li / Ri Li / Hong Xu

Frontiers in Medicine, Vol

A systematic review, pair-wise, and network meta-analysis

2023 Volume 10

Abstract: Background and study aimsIn recent years, cold snare polypectomy (CSP) has been increasingly used for small polyps (<10 mm) instead of hot snare polypectomy (HSP). However, evidence-based research regarding the effectiveness and safety of CSP and HSP are ...

Abstract	Background and study aimsIn recent years, cold snare polypectomy (CSP) has been increasingly used for small polyps (<10 mm) instead of hot snare polypectomy (HSP). However, evidence-based research regarding the effectiveness and safety of CSP and HSP are still lacking. Additionally, for 4–10 -mm non-pedunculated polyps, the polyp removal method is still controversial. Therefore, it is clinically significant to conduct pair-wise and network meta-analyses to assess such resection methods.MethodsWe searched PubMed, Embase, and the Cochrane library for randomized controlled trials (RCTs). Only studies that involved the resection of polyps <10 mm were included. Outcomes included the complete resection rate, polyp retrieval rate, procedure-related complications, and procedure times.ResultsOverall, 23 RCTs (5,352 patients) were identified. In meta-analysis compared CSP versus HSP for polyps <10 mm, CSP showed lower complete resection rate than HSP although with no statistically significant difference [odds ratio (OR): 0.77, 95% confidence interval (CI): 0.56–1.06]. CSP showed a lower risk of major post-polypectomy complications compared to HSP (OR: 0.28, 95% CI: 0.11–0.73). In the network meta-analysis for 4–10 mm non-pedunculated polyps, HSP, and endoscopic mucosal resection (EMR) showed a higher complete resection rate than CSP (OR: 2.7, 95% CI: 1.3–9.2 vs. OR: 2.6, 95% CI: 1.0–10) but a significantly longer time than CSP (WMD: 16.55 s, 95% CI [7.48 s, 25.25 s], p < 0.001), (WMD: 48.00 s, 95% CI [16.54 s, 79.46 s], p = 0.003). Underwater CSP ranked third for complete resection with no complications.ConclusionFor <10 mm polyps, CSP is safer than HSP, especially for patients taking antithrombotic drugs. For 4–10 mm non-pedunculated polyps, HSP, and EMR have higher complete resection rates than CSP.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022315575.
Keywords	colonic polyps ; cold snare polypectomy ; hot snare polypectomy ; therapeutics ; meta-analysis ; treatment outcome ; Medicine (General) ; R5-920
Subject code	571
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Platelets in Renal Disease.

Gomchok, Drolma / Ge, Ri-Li / Wuren, Tana

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: Kidney disease is a major global health concern, affecting millions of people. Nephrologists have shown interest in platelets because of coagulation disorders caused by renal diseases. With a better understanding of platelets, it has been found that ... ...

Abstract	Kidney disease is a major global health concern, affecting millions of people. Nephrologists have shown interest in platelets because of coagulation disorders caused by renal diseases. With a better understanding of platelets, it has been found that these anucleate and abundant blood cells not only play a role in hemostasis, but also have important functions in inflammation and immunity. Platelets are not only affected by kidney disease, but may also contribute to kidney disease progression by mediating inflammation and immune effects. This review summarizes the current evidence regarding platelet abnormalities in renal disease, and the multiple effects of platelets on kidney disease progression. The relationship between platelets and kidney disease is still being explored, and further research can provide mechanistic insights into the relationship between thrombosis, bleeding, and inflammation related to kidney disease, and elucidate targeted therapies for patients with kidney disease.
MeSH term(s)	Humans ; Immunity, Innate ; Blood Platelets ; Hemostasis ; Inflammation ; Kidney Diseases/complications ; Disease Progression
Language	English
Publishing date	2023-09-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914724
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Research progress on the effect of mitochondrial and endoplasmic reticulum stress caused by hypoxia during pregnancy on preeclampsia and intrauterine growth restriction].

Liu, Hui-Fang / Ge, Ri-Li / Wuren, Ta-Na

Sheng li xue bao : [Acta physiologica Sinica

2023 Volume 75, Issue 5, Page(s) 714–726

Abstract: Preeclampsia and intrauterine growth restriction (IUGR) of the fetus are the two most common pregnancy complications worldwide, affecting 5%-10% of pregnant women. Preeclampsia is associated with significantly increased maternal and fetal morbidity and ... ...

Abstract	Preeclampsia and intrauterine growth restriction (IUGR) of the fetus are the two most common pregnancy complications worldwide, affecting 5%-10% of pregnant women. Preeclampsia is associated with significantly increased maternal and fetal morbidity and mortality. Hypoxia-induced uteroplacental dysfunction is now recognized as a key pathological factor in preeclampsia and IUGR. Reduced oxygen supply (hypoxia) disrupts mitochondrial and endoplasmic reticulum (ER) function. Hypoxia has been shown to alter mitochondrial reactive oxygen species (ROS) homeostasis and induce ER stress. Hypoxia during pregnancy is associated with excessive production of ROS in the placenta, leading to oxidative stress. Oxidative stress occurs in a number of human diseases, including high blood pressure during pregnancy. Studies have shown that uterine placental tissue/cells in preeclampsia and IUGR show high levels of oxidative stress, which plays an important role in the pathogenesis of both the complications. This review summarizes the role of hypoxia-induced mitochondrial oxidative stress and ER stress in the pathogenesis of preeclampsia/IUGR and discusses the potential therapeutic strategies targeting oxidative stress to treat both the pregnancy complications.
MeSH term(s)	Pregnancy ; Female ; Humans ; Placenta ; Fetal Growth Retardation/etiology ; Pre-Eclampsia/etiology ; Pre-Eclampsia/pathology ; Reactive Oxygen Species ; Hypoxia/pathology ; Pregnancy Complications/pathology ; Endoplasmic Reticulum Stress
Chemical Substances	Reactive Oxygen Species
Language	Chinese
Publishing date	2023-11-02
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells.

Yan, Ranran / Cai, Hao / Zhou, Xiaofeng / Bao, Guodan / Bai, Zhenzhong / Ge, Ri-Li

Frontiers in endocrinology

2024 Volume 15, Page(s) 1344971

Abstract: Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence and affects approximately one-third of adults, owing to high-fat dietary habits and a sedentary lifestyle. The role of hypoxia-inducible factor 2α (HIF-2α) in NAFLD progression ... ...

Abstract	Non-alcoholic fatty liver disease (NAFLD) has a high global prevalence and affects approximately one-third of adults, owing to high-fat dietary habits and a sedentary lifestyle. The role of hypoxia-inducible factor 2α (HIF-2α) in NAFLD progression remains unknown. This study aimed to investigate the effects of chronic hypoxia on NAFLD progression by examining the role of hypoxia-inducible factor 2α (HIF-2α) activation and that of hepatic stellate cell (HSC)-derived myofibroblasts through glutaminolysis. We hypothesised that hypoxia exacerbates NAFLD by promoting HIF-2α upregulation and inhibiting phosphorylated yes-associated protein (YAP), and that increasing YAP expression enhances HSC-derived myofibroblasts. We studied patients with NAFLD living at high altitudes, as well as animal models and cultured cells. The results revealed significant increases in HSC-derived myofibroblasts and collagen accumulation caused by HIF-2α and YAP upregulation, both in patients and in a mouse model for hypoxia and NAFLD. HIF-2α and HIF-2α-dependent YAP downregulation reduced HSC activation and myofibroblast levels in persistent chronic hypoxia. Furthermore, hypoxia-induced HIF-2α upregulation promoted YAP and inhibited YAP phosphorylation, leading to glutaminase 1 (GLS1), SLC38A1, α-SMA, and Collagen-1 overexpression. Additionally, hypoxia restored mitochondrial adenosine triphosphate production and reactive oxygen species (ROS) overproduction. Thus, chronic hypoxia-induced HIF-2α activation enhances fibrosis and NAFLD progression by restoring mitochondrial ROS production and glutaminase-1-induced glutaminolysis, which is mediated through the inhibition of YAP phosphorylation and increased YAP nuclear translocation. In summary, HIF-2α plays a pivotal role in NAFLD progression during chronic hypoxia.
MeSH term(s)	Adult ; Animals ; Humans ; Mice ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Collagen Type I/metabolism ; Glutaminase/metabolism ; Glutamine/metabolism ; Hepatic Stellate Cells/metabolism ; Hypoxia/metabolism ; Liver Cirrhosis/metabolism ; Non-alcoholic Fatty Liver Disease/metabolism ; Phosphorylation ; Reactive Oxygen Species/metabolism ; YAP-Signaling Proteins
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Collagen Type I ; Glutaminase (EC 3.5.1.2) ; Glutamine (0RH81L854J) ; Reactive Oxygen Species ; YAP-Signaling Proteins ; Yap1 protein, mouse ; YAP1 protein, human ; endothelial PAS domain-containing protein 1 (1B37H0967P)
Language	English
Publishing date	2024-02-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2024.1344971
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Effects of human umbilical cord mesenchymal stem cells (MSCs)-derived exosomes on pulmonary vascular remodeling in hypoxic pulmonary hypertension].

Liu, Hong / Zhang, Yu-Wei / Zhang, Qing-Qing / Wang, Yu-Xiang / Ge, Ri-Li / Ma, Lan

Sheng li xue bao : [Acta physiologica Sinica

2024 Volume 76, Issue 1, Page(s) 33–44

Abstract: The present study aimed to investigate the effect of human umbilical cord mesenchymal stem cells (MSCs)-derived exosomes (MSCs-Exo) on mice with hypoxic pulmonary hypertension (HPH). MSCs were isolated and cultured from human umbilical cords under ... ...

Abstract	The present study aimed to investigate the effect of human umbilical cord mesenchymal stem cells (MSCs)-derived exosomes (MSCs-Exo) on mice with hypoxic pulmonary hypertension (HPH). MSCs were isolated and cultured from human umbilical cords under aseptic conditions, and exosomes were extracted from the supernatants and identified. Healthy SPF C57BL/6 mice were randomly divided into three groups: normoxic group, hypoxic group, and hypoxic+MSCs-Exo group. Mice in the hypoxic group and the hypoxic+MSCs-Exo group were maintained for 28 d at an equivalent altitude of 5 000 m in a hypobaric chamber to establish HPH mouse model. The mice in the hypoxic+MSCs-Exo group were injected with MSCs-Exo via tail vein before hypoxia and on days 1, 3, 5 and 9 of hypoxia, and the mice in the other two groups were injected with PBS. At the end of the experiment, echocardiography was performed to detect pulmonary arterial acceleration time/pulmonary arterial ejection time ratio (PAAT/PET), right ventricular free wall thickness, and right ventricular hypertrophy index RV/(LV+S). HE staining was performed to observe the lung tissue morphology. EVG staining was performed to observe elastic fiber hyperplasia. Immunohistochemistry was performed to detect α smooth muscle actin (α-SMA) expression in lung tissue. Immunofluorescence staining was used to detect macrophage infiltration in lung tissue. qPCR was performed to detect IL-1β and IL-33 in lung tissue, and cytometric bead array was performed to detect IL-10 secretion. Western blotting was used to detect the M1 macrophage marker iNOS, M2 macrophage marker Arg-1 and IL-33/ST2 pathway proteins in lung tissues. The results showed that hypoxia increased pulmonary artery pressure and pulmonary vascular remodeling, increased macrophage infiltration, IL-1β and IL-33 expression (P < 0.05) and upregulated the IL-33/ST2 pathway (P < 0.05). Compared with the hypoxic group, MSCs-Exo treatment increased PAAT/PET (P < 0.05), decreased right ventricular free wall thickness (P < 0.05), right ventricular hypertrophy index RV/(LV+S) (P < 0.05), α-SMA expression in small pulmonary vessels (P < 0.05), and inflammatory factors including IL-1β and IL-33 expression in lung tissue, however increased IL-10 secretion (P < 0.05). In addition, MSCs-Exo treatment upregulated Arg-1 and downregulated iNOS and IL-33/ST2 (P < 0.05). The results suggest that MSC-Exo may alleviate HPH through their immunomodulatory effects.
MeSH term(s)	Humans ; Animals ; Mice ; Mice, Inbred C57BL ; Hypertension, Pulmonary ; Interleukin-10 ; Interleukin-33 ; Exosomes ; Hypertrophy, Right Ventricular ; Interleukin-1 Receptor-Like 1 Protein ; Vascular Remodeling ; Hypoxia ; Mesenchymal Stem Cells ; Lung
Chemical Substances	Interleukin-10 (130068-27-8) ; Interleukin-33 ; Interleukin-1 Receptor-Like 1 Protein
Language	Chinese
Publishing date	2024-02-28
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 386: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Ubenimex combined with Albendazole for the treatment of

Zhou, Zhen / Huayu, Meiduo / Mu, Yalin / Tang, Feng / Ge, Ri-Li

Frontiers in veterinary science

2024 Volume 11, Page(s) 1320308

Abstract: Introduction: Alveolar echinococcosis (AE) is a parasitic disease caused by : Methods: In this study, the therapeutic effect of Ubenimex combined with Albendazole on AE was evaluated. Mice were intraperitoneally injected with : Results: The ... ...

Abstract	Introduction: Alveolar echinococcosis (AE) is a parasitic disease caused by Methods: In this study, the therapeutic effect of Ubenimex combined with Albendazole on AE was evaluated. Mice were intraperitoneally injected with Results: The results revealed that the combined treatment could inhibit the growth and infiltration of cysts in BALB/c mice infected with Discussion: This study suggests that the combined treatment with Ubenimex and Albendazole could be a potential therapeutic strategy for
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2024.1320308
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal

Zhou, Sisi / Yan, Jun / Song, Kang / Ge, Ri-Li

Biomedicines

2023 Volume 11, Issue 11

Abstract: Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha ( ...

Abstract	Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha (
Language	English
Publishing date	2023-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11112992
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bibliometric and visual analysis of machine learning-based research in acute kidney injury worldwide.

Yu, Xiang / Wu, RiLiGe / Ji, YuWei / Feng, Zhe

Frontiers in public health

2023 Volume 11, Page(s) 1136939

Abstract: Background: Acute kidney injury (AKI) is a serious clinical complication associated with adverse short-term and long-term outcomes. In recent years, with the rapid popularization of electronic health records and artificial intelligence machine learning ... ...

Abstract	Background: Acute kidney injury (AKI) is a serious clinical complication associated with adverse short-term and long-term outcomes. In recent years, with the rapid popularization of electronic health records and artificial intelligence machine learning technology, the detection rate and treatment of AKI have been greatly improved. At present, there are many studies in this field, and a large number of articles have been published, but we do not know much about the quality of research production in this field, as well as the focus and trend of current research. Methods: Based on the Web of Science Core Collection, studies reporting machine learning-based AKI research that were published from 2013 to 2022 were retrieved and collected after manual review. VOSviewer and other software were used for bibliometric visualization analysis, including publication trends, geographical distribution characteristics, journal distribution characteristics, author contributions, citations, funding source characteristics, and keyword clustering. Results: A total of 336 documents were analyzed. Since 2018, publications and citations have increased dramatically, with the United States (143) and China (101) as the main contributors. Regarding authors, Bihorac, A and Ozrazgat-Baslanti, T from the Kansas City Medical Center have published 10 articles. Regarding institutions, the University of California (18) had the most publications. Approximately 1/3 of the publications were published in Q1 and Q2 journals, of which Scientific Reports (19) was the most prolific journal. Tomašev et al.'s study that was published in 2019 has been widely cited by researchers. The results of cluster analysis of co-occurrence keywords suggest that the construction of AKI prediction model related to critical patients and sepsis patients is the research frontier, and XGBoost algorithm is also popular. Conclusion: This study first provides an updated perspective on machine learning-based AKI research, which may be beneficial for subsequent researchers to choose suitable journals and collaborators and may provide a more convenient and in-depth understanding of the research basis, hotspots and frontiers.
MeSH term(s)	Humans ; Artificial Intelligence ; Machine Learning ; Acute Kidney Injury ; Algorithms ; Bibliometrics
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1136939
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bibliometric and visual analysis of machine learning-based research in acute kidney injury worldwide

Xiang Yu / RiLiGe Wu / YuWei Ji / Zhe Feng

Frontiers in Public Health, Vol

2023 Volume 11

Abstract: BackgroundAcute kidney injury (AKI) is a serious clinical complication associated with adverse short-term and long-term outcomes. In recent years, with the rapid popularization of electronic health records and artificial intelligence machine learning ... ...

Abstract	BackgroundAcute kidney injury (AKI) is a serious clinical complication associated with adverse short-term and long-term outcomes. In recent years, with the rapid popularization of electronic health records and artificial intelligence machine learning technology, the detection rate and treatment of AKI have been greatly improved. At present, there are many studies in this field, and a large number of articles have been published, but we do not know much about the quality of research production in this field, as well as the focus and trend of current research.MethodsBased on the Web of Science Core Collection, studies reporting machine learning-based AKI research that were published from 2013 to 2022 were retrieved and collected after manual review. VOSviewer and other software were used for bibliometric visualization analysis, including publication trends, geographical distribution characteristics, journal distribution characteristics, author contributions, citations, funding source characteristics, and keyword clustering.ResultsA total of 336 documents were analyzed. Since 2018, publications and citations have increased dramatically, with the United States (143) and China (101) as the main contributors. Regarding authors, Bihorac, A and Ozrazgat-Baslanti, T from the Kansas City Medical Center have published 10 articles. Regarding institutions, the University of California (18) had the most publications. Approximately 1/3 of the publications were published in Q1 and Q2 journals, of which Scientific Reports (19) was the most prolific journal. Tomašev et al.'s study that was published in 2019 has been widely cited by researchers. The results of cluster analysis of co-occurrence keywords suggest that the construction of AKI prediction model related to critical patients and sepsis patients is the research frontier, and XGBoost algorithm is also popular.ConclusionThis study first provides an updated perspective on machine learning-based AKI research, which may be beneficial for subsequent researchers to choose ...
Keywords	machine learning ; acute kidney injury ; bibliometric analysis ; model ; critical care ; hotspot ; Public aspects of medicine ; RA1-1270
Subject code	001
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Factors affecting pulmonary arterial pressure in response to high-altitude hypoxic stress].

Zhou, Zhen / Tang, Feng / Ge, Ri-Li

Sheng li xue bao : [Acta physiologica Sinica

2022 Volume 75, Issue 1, Page(s) 130–136

Abstract: The alteration of pulmonary artery pressure is an important physiological indicator to reflect the organism's adaptation to acclimatization or the pathological injury in response to high-altitude hypoxic environment. The effects of hypoxic stress at ... ...

Abstract	The alteration of pulmonary artery pressure is an important physiological indicator to reflect the organism's adaptation to acclimatization or the pathological injury in response to high-altitude hypoxic environment. The effects of hypoxic stress at different altitudes for different time on pulmonary artery pressure are different. There are many factors involved in the changes of pulmonary artery pressure, such as the contraction of pulmonary arterial smooth muscle, hemodynamic changes, abnormal regulation of vascular activity and abnormal changes of cardiopulmonary function. Understanding of the regulatory factors of pulmonary artery pressure in hypoxic environment is crucial in clarifying the relevant mechanisms of hypoxic adaptation, acclimatization, prevention, diagnosis, treatment and prognosis of acute and chronic high-altitude diseases. In recent years, great progress has been made in the study regarding the factors affecting pulmonary artery pressure in response to high-altitude hypoxic stress. In this review, we discuss the regulatory factors and intervention measures of pulmonary arterial hypertension induced by hypoxia from the aspects of hemodynamics of circulatory system, vasoactive state and changes of cardiopulmonary function.
MeSH term(s)	Humans ; Altitude ; Arterial Pressure ; Acclimatization ; Hypoxia ; Muscle, Smooth
Language	Chinese
Publishing date	2022-11-03
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	604308-2
ISSN	0371-0874
ISSN	0371-0874
Database	MEDical Literature Analysis and Retrieval System OnLINE

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