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Book ; Thesis: Analysis of the role of stabilin-1 in tumour growoth and its functions in tumour-associated macrophages

Riabov, Vladimir

2011

Author's details	vorgelegt von Vladimir Riabov
Language	English
Size	112 Bl. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Heidelberg, Univ., Diss., 2011
HBZ-ID	HT017174031
Database	Catalogue ZB MED Medicine, Health

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Book ; Online: Simulating the Time Projection Chamber responses at the MPD detector using Generative Adversarial Networks

Maevskiy, A. / Ratnikov, F. / Zinchenko, A. / Riabov, V.

2020

Abstract: High energy physics experiments rely heavily on the detailed detector simulation models in many tasks. Running these detailed models typically requires a notable amount of the computing time available to the experiments. In this work, we demonstrate a ... ...

Abstract	High energy physics experiments rely heavily on the detailed detector simulation models in many tasks. Running these detailed models typically requires a notable amount of the computing time available to the experiments. In this work, we demonstrate a new approach to speed up the simulation of the Time Projection Chamber tracker of the MPD experiment at the NICA accelerator complex. Our method is based on a Generative Adversarial Network - a deep learning technique allowing for implicit estimation of the population distribution for a given set of objects. This approach lets us learn and then sample from the distribution of raw detector responses, conditioned on the parameters of the charged particle tracks. To evaluate the quality of the proposed model, we integrate a prototype into the MPD software stack and demonstrate that it produces high-quality events similar to the detailed simulator, with a speed-up of at least an order of magnitude. The prototype is trained on the responses from the inner part of the detector and, once expanded to the full detector, should be ready for use in physics tasks. Comment: This is a post-peer-review, pre-copyedit version of an article published in Eur. Phys. J. C. The final authenticated version is available online at: http://dx.doi.org/10.1140/epjc/s10052-021-09366-4
Keywords	Physics - Instrumentation and Detectors ; Computer Science - Machine Learning ; High Energy Physics - Experiment
Publishing date	2020-12-08
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: Generative Adversarial Networks for the fast simulation of the Time Projection Chamber responses at the MPD detector

Maevskiy, A. / Ratnikov, F. / Zinchenko, A. / Riabov, V. / Sukhorosov, A. / Evdokimov, D.

2022

Abstract: The detailed detector simulation models are vital for the successful operation of modern high-energy physics experiments. In most cases, such detailed models require a significant amount of computing resources to run. Often this may not be afforded and ... ...

Abstract	The detailed detector simulation models are vital for the successful operation of modern high-energy physics experiments. In most cases, such detailed models require a significant amount of computing resources to run. Often this may not be afforded and less resource-intensive approaches are desired. In this work, we demonstrate the applicability of Generative Adversarial Networks (GAN) as the basis for such fast-simulation models for the case of the Time Projection Chamber (TPC) at the MPD detector at the NICA accelerator complex. Our prototype GAN-based model of TPC works more than an order of magnitude faster compared to the detailed simulation without any noticeable drop in the quality of the high-level reconstruction characteristics for the generated data. Approaches with direct and indirect quality metrics optimization are compared. Comment: Submitted for the proceedings of ACAT2021, https://indico.cern.ch/event/855454/contributions/4596732/
Keywords	Physics - Instrumentation and Detectors ; Computer Science - Machine Learning
Publishing date	2022-03-30
Publishing country	us
Document type	Book ; Online
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Article: [Mechanisms of sound reception and conduction in a dolphin].

Riabov, V A

Biofizika

2014 Volume 59, Issue 3, Page(s) 579–590

Abstract: Morphology of a lower jaw, model and behavioral experiments are discussed with the aim of exploring the mechanisms of sound reception and conduction to the dolphin's lower jaw canals taking into account known concepts of acoustics and a theory of group ... ...

Abstract	Morphology of a lower jaw, model and behavioral experiments are discussed with the aim of exploring the mechanisms of sound reception and conduction to the dolphin's lower jaw canals taking into account known concepts of acoustics and a theory of group antennas. It is shown that the left and right row of mental foramens with the respective mandibular canal and tissues of the canals are forming the new outer ear and the new external auditory canal by which the sound (in frequency band of 0.1-160 kHz) is transmitted into the middle ear, in contrast to the dolphin's non-functional outer ear. This new external ear is created by nature as a receiving array of the traveling wave antenna located in the throat of the acoustical horn (a corresponding mandibular canal). The results give reason to assume the presence of similar new outer ear in Odontoceti.
MeSH term(s)	Animals ; Bone Conduction/physiology ; Bottle-Nosed Dolphin/anatomy & histology ; Bottle-Nosed Dolphin/physiology ; Ear, External/anatomy & histology ; Ear, External/physiology ; Ear, Middle/anatomy & histology ; Ear, Middle/physiology ; Mandible/anatomy & histology ; Mandible/physiology
Language	Russian
Publishing date	2014-05
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	280283-1
ISSN	0006-3029
ISSN	0006-3029
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Article ; Online: Hyperglycemia Induces Inflammatory Response of Human Macrophages to CD163-Mediated Scavenging of Hemoglobin-Haptoglobin Complexes.

Matuschik, Laura / Riabov, Vladimir / Schmuttermaier, Christina / Sevastyanova, Tatyana / Weiss, Christel / Klüter, Harald / Kzhyshkowska, Julia

International journal of molecular sciences

2022 Volume 23, Issue 3

Abstract: Hyperglycemia, a hallmark of diabetes, can induce inflammatory programming of macrophages. The macrophage scavenger receptor CD163 internalizes and degrades hemoglobin-haptoglobin (Hb-Hp) complexes built due to intravascular hemolysis. Clinical studies ... ...

Abstract	Hyperglycemia, a hallmark of diabetes, can induce inflammatory programming of macrophages. The macrophage scavenger receptor CD163 internalizes and degrades hemoglobin-haptoglobin (Hb-Hp) complexes built due to intravascular hemolysis. Clinical studies have demonstrated a correlation between impaired scavenging of Hb-Hp complexes via CD163 and diabetic vascular complications. Our aim was to identify whether hyperglycemia is able to amplify inflammation via Hb-Hp complex interactions with the immune system. M(IFNγ), M(IL-4), and control M0 macrophages were differentiated out of primary human monocytes in normo- (5 mM) and hyperglycemic (25 mM) conditions. CD163 gene expression was decreased 5.53 times in M(IFNγ) with a further decrease of 1.99 times in hyperglycemia. Hyperglycemia suppressed CD163 surface expression in M(IFNγ) (1.43 times). Flow cytometry demonstrated no impairment of Hb-Hp uptake in hyperglycemia. However, hyperglycemia induced an inflammatory response of M(IFNγ) to Hb-Hp1-1 and Hb-Hp2-2 uptake with different dynamics. Hb-Hp1-1 uptake stimulated IL-6 release (3.03 times) after 6 h but suppressed secretion (5.78 times) after 24 h. Contrarily, Hb-Hp2-2 uptake did not affect IL-6 release after 6h but increased secretion after 24 h (3.06 times). Our data show that hyperglycemia induces an inflammatory response of innate immune cells to Hb-Hp1-1 and Hb-Hp2-2 uptake, converting the silent Hb-Hp complex clearance that prevents vascular damage into an inflammatory process, hereby increasing the susceptibility of diabetic patients to vascular complications.
MeSH term(s)	Antigens, CD/metabolism ; Antigens, Differentiation, Myelomonocytic/metabolism ; Cells, Cultured ; Diabetic Angiopathies/metabolism ; Endocytosis/physiology ; Haptoglobins/metabolism ; Hemoglobins/metabolism ; Hemolysis/physiology ; Humans ; Hyperglycemia/metabolism ; Inflammation/metabolism ; Macrophages/metabolism ; Monocytes/metabolism ; Receptors, Cell Surface/metabolism ; Receptors, Scavenger/metabolism
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD163 antigen ; Haptoglobins ; Hemoglobins ; Receptors, Cell Surface ; Receptors, Scavenger ; haptoglobin-hemoglobin complex
Language	English
Publishing date	2022-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23031385
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Titanium induces pro-inflammatory and tissue-destructive responses in primary human macrophages.

Gudima, Alexandru / Hesselbarth, David / Li, Guanhao / Riabov, Vladimir / Michel, Julia / Liu, Quan / Schmuttermaier, Christina / Jiao, Zhen / Sticht, Carsten / Jawhar, Ahmed / Obertacke, Udo / Klüter, Harald / Vrana, Nihal Engin / Kzhyshkowska, Julia

Journal of leukocyte biology

2024

Abstract: Implants and medical devices are efficient and practical therapeutic solutions for a multitude of pathologies. Titanium and titanium alloys are used in orthopedics, dentistry, and cardiology. Despite very good mechanical properties, and corrosion ... ...

Abstract	Implants and medical devices are efficient and practical therapeutic solutions for a multitude of pathologies. Titanium and titanium alloys are used in orthopedics, dentistry, and cardiology. Despite very good mechanical properties, and corrosion resistance titanium implants can fail due to inflammatory or tissue-degradation related complications. Macrophages are major immune cells that control acceptance of failure of the implant. In this study, for the first time, we have performed a systematic analysis of the response of differentially activated human macrophages (M(Control), M(IFNγ) and M(IL-4)) to the polished and porous titanium surfaces in order to identify the detrimental effect of titanium leading to the tissue destruction and chronic inflammation. Transcriptome analysis revealed that the highest number of differences between titanium and control settings are found in M(IL-4) that model healing type of macrophages. RT-qPCR analysis confirmed that both polished and porous titanium affected expression of cytokines, chitinases/chitinase-like proteins and matrix metalloproteinases. Titanium-induced release and activation of MMP7 by macrophages was enhanced by fibroblasts in both juxtacrine and paracrine cell interaction models. Production of titanium-induced MMPs and cytokines associated with chronic inflammation were independent of the presence of Staphylococcus aureus. MMP7, one of the most pronounced tissue-destroying factor and chitinase-like protein YKL-40 were expressed in CD68+ macrophages in peri-implant tissues of patients with orthopedic implants. In summary, we demonstrated that titanium induces pro-inflammatory and tissue-destructing responses mainly in healing macrophages, and the detrimental effects of titanium surfaces on implant-adjacent macrophages are independent on the bacterial contamination.
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1093/jleuko/qiae072
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Article: [Mental foramens and dolphin hearing].

Riabov, V O

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)

2010 Volume 56, Issue 3, Page(s) 98–103

Abstract: Detection thresholds of short broadband acoustic impulses with an energy maximum on frequencies 8, 16, 30 and 100 kHz was measured in the dolphin (Tursiops truncatus p.) with using techniques of behavioral responses in the indoor pool. At acoustic ... ...

Abstract	Detection thresholds of short broadband acoustic impulses with an energy maximum on frequencies 8, 16, 30 and 100 kHz was measured in the dolphin (Tursiops truncatus p.) with using techniques of behavioral responses in the indoor pool. At acoustic shielding of mental foramens, detection thresholds of these impulses worsen on 30, 34, 40 and 50 dB, respectively. The new original results obtained experimentally prove that mental foramens are the unique sound-conducting pathway for sounds of about 6-160 kHz frequency band (in consideration of stimulus broadbandness). In this connection the assumption that morphological structures of the lower jaw represent a specialized peripheral part of the dolphin hearing, which was based on studying of morphology and results of modelling, receives additional experimental confirmation. The mental foramens play part of external auditory canals and conduct all frequency range of the hearing of dolphin into fat body of the mandibular canal. Via fat body sounds transmit to a lateral side of an acoustical bone and into the middle and inner ear. From morphology similarity, it is possible to assume presence of the similar sound-conducting mechanism in Odontoceti.
MeSH term(s)	Acoustic Stimulation ; Adipose Tissue/physiology ; Animals ; Auditory Pathways/anatomy & histology ; Auditory Pathways/physiology ; Auditory Threshold/physiology ; Bottle-Nosed Dolphin/anatomy & histology ; Bottle-Nosed Dolphin/physiology ; Hearing/physiology ; Mandible/anatomy & histology ; Mandible/physiology ; Perceptual Masking
Language	Ukrainian
Publishing date	2010
Publishing country	Ukraine
Document type	English Abstract ; Journal Article
ZDB-ID	420438-4
ISSN	2522-9028 ; 0015-3311 ; 0201-8489
ISSN	2522-9028 ; 0015-3311 ; 0201-8489
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival.

Yin, Shui-Ping / Gao, Yi / Xie, Xu-Shi / Xu, Dan-Dan / Riabov, Vladimir / Du, Wei-Dong

Oncology letters

2020 Volume 19, Issue 3, Page(s) 2404–2412

Abstract: The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its ... ...

Abstract	The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not been evaluated. The present study investigated the expression of stabilin-1 and its association with clinicopathological parameters in patients with gastric cancer. The expression of stabilin-1 was evaluated by immunohistochemical staining of gastric cancer tissue samples of 371 Chinese patients with primary gastric adenocarcinoma. Confocal laser scanning microscopy was used to determine the cellular source of stabilin-1 in the gastric cancer tissues using anti-CD68, anti-CD163, anti-stabilin-1 and anti-secreted protein acidic and rich in cysteine antibodies. A higher number of stabilin-1-positive cells were observed in the cancer tissues of primary gastric adenocarcinoma compared with adjacent non-cancerous tissues of primary gastric adenocarcinoma (P<0.001); the majority of stabilin-1-positve cells were CD68
Language	English
Publishing date	2020-01-16
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2020.11310
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Silico Pan-Cancer Analysis Reveals Prognostic Role of the Erythroferrone (ERFE) Gene in Human Malignancies.

Xu, Qingyu / Altrock, Eva / Schmitt, Nanni / Streuer, Alexander / Rapp, Felicitas / Nowak, Verena / Obländer, Julia / Weimer, Nadine / Palme, Iris / Göl, Melda / Hofmann, Wolf-Karsten / Nowak, Daniel / Riabov, Vladimir

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: The erythroferrone gene ( ...

Abstract	The erythroferrone gene (
MeSH term(s)	Humans ; Prognosis ; Peptide Hormones/genetics ; Hepcidins/metabolism ; Neoplasms/genetics ; Myelodysplastic Syndromes ; Tumor Microenvironment
Chemical Substances	Peptide Hormones ; Hepcidins
Language	English
Publishing date	2023-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021725
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Article: [Characteristics of the acoustic field of interfering reflections and the echolocation hearing of the dolphin].

Riabov, V A

Biofizika

2008 Volume 53, Issue 3, Page(s) 504–512

Abstract: A model of the acoustic field of interfering reflections from steel cylinders was developed. Analysis of the model showed the availability of great potential resources for a decrease of the influence of unwanted echoes and hence for increasing the signal- ...

Abstract	A model of the acoustic field of interfering reflections from steel cylinders was developed. Analysis of the model showed the availability of great potential resources for a decrease of the influence of unwanted echoes and hence for increasing the signal-to-clatter ratio. The conformity of the available models of the echolocation hearing of the dolphin to the acoustic field of the clatter was considered. The participation of mandidle mental foramens in conducting the echo to the cochlea was considered. In this case the hearing aperture is determined by the dimensions of mental foramens, while the hearing base is determined by the distance between the mental foramens of the left and right mandible halves. There are good reasons to believe that the optimal dimensions of the aperture and the base of echolocation hearing of Odontoceti essentially increase the effectiveness of defense of their sonar from reverberation.
MeSH term(s)	Animals ; Bone Conduction ; Discrimination (Psychology) ; Dolphins/physiology ; Echolocation/physiology ; Hearing/physiology ; Jaw/anatomy & histology ; Models, Biological ; Sound Localization/physiology
Language	Russian
Publishing date	2008-05
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	280283-1
ISSN	0006-3029
ISSN	0006-3029
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