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  1. Article ; Online: Epidemiology of immune thrombocytopenia: study of adult patients at a referral hematology service in Northeastern Brazil.

    Kubrusly, Bruna Sobreira / Kubrusly, Elsie Sobreira / Rocha, Hermano Alexandre Lima / Júnior, Antonio Brazil Viana / Kubrusly, Marcela Sobreira / Ribeiro, Lucas Loiola Ponte Albuquerque / Ribeiro, Rosângela de Albuquerque / Duarte, Fernando Barroso

    Hematology, transfusion and cell therapy

    2023  

    Abstract: Immune thrombocytopenia (ITP) is an acquired bleeding disorder observed in the clinical practice. Little is known about its epidemiology in Brazil. The present study was conducted at a hematology referral center which covers a population of over 8 ... ...

    Abstract Immune thrombocytopenia (ITP) is an acquired bleeding disorder observed in the clinical practice. Little is known about its epidemiology in Brazil. The present study was conducted at a hematology referral center which covers a population of over 8 million in 184 municipalities in the state of Ceará. The purpose of this study was to draw a demographic profile of adult ITP patients with regard to sex, age, geographical origin and distribution across the state, and the proportion of secondary ITP. Following ethics committee approval, information was collected with an ad hoc instrument. The sample consisted of 187 adult ITP patients attending the Walter Cantídio University Hospital in 2015. The median follow-up time was 67 months (range: 1 month to 29 years). Female sex (n = 154; 82.35 %) was strongly prevalent in all age brackets, with an overall female/male ratio of 4.7:1. The median age was 41 ± 16.1 with an interquartile range of 29-55.5 years; there was no difference between the genders. Secondary ITP (18/187; 9.6 %) displayed a bimodal distribution and a linear increase between 38 and >68 years of age. The results of this survey on the epidemiology of ITP in Brazil suggest that ethnic and geographical factors may have a great impact on age and sex distribution and on the distribution of secondary ITP.
    Language English
    Publishing date 2023-11-17
    Publishing country Brazil
    Document type Journal Article
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2023.09.2363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Changing recombinant factor VIII to plasma-derived factor VIII during immune tolerance induction.

    Dias, Maíse Moreira / Mesquita Camelo, Ricardo / de Magalhães, Laura Peixoto / Lemos Jardim, Letícia / Gonçalves de Oliveira, Andrea / Ribeiro, Rosângela de Albuquerque / Karla Brognoli Franco, Vivian / Callado, Fábia Michelle Rodrigues de Araújo / Lorenzato, Cláudia Santos / Rezende, Suely Meireles

    Pediatric hematology and oncology

    2023  Volume 41, Issue 1, Page(s) 74–80

    MeSH term(s) Humans ; Factor VIII/therapeutic use ; Hemophilia A/drug therapy ; Plasma ; Immune Tolerance ; Recombinant Proteins
    Chemical Substances Factor VIII (9001-27-8) ; Recombinant Proteins
    Language English
    Publishing date 2023-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 632914-7
    ISSN 1521-0669 ; 0888-0018
    ISSN (online) 1521-0669
    ISSN 0888-0018
    DOI 10.1080/08880018.2023.2182853
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Factor VIII prophylactic therapy reduces neurological complications in patients with Hemophilia A.

    Fernandes, José Marcelino Aragão / Gondim, Francisco de Assis Aquino / Dias, Antônia Maria Negreiro / Ribeiro, Rosângela de Albuquerque / Ferreira Filho, Luiz Ivando Pires / Pinto, Vicente de Paulo Teixeira

    Arquivos de neuro-psiquiatria

    2021  Volume 79, Issue 12, Page(s) 1116–1122

    Abstract: Background: Bleeding in hemophiliacs can cause complications in the central and peripheral nervous system (CNS and PNS). The incidence of intracranial hemorrhage has reduced after the introduction of prophylactic treatment with factor VIII or IX, but ... ...

    Abstract Background: Bleeding in hemophiliacs can cause complications in the central and peripheral nervous system (CNS and PNS). The incidence of intracranial hemorrhage has reduced after the introduction of prophylactic treatment with factor VIII or IX, but the benefits of this therapy have not yet been evaluated on PNS complications.
    Objective: The aim of this study was to determine the prevalence of neurological complications in hemophiliacs and verify the effect of prophylactic therapy in these patients, including PNS disorders.
    Methods: We retrospectively evaluated the prevalence of CNS and PNS disorders caused by bleeding in hemophiliacs seen at the Hemocentro Regional Norte, Ceará, Brazil, from 1992 to 2018, and we compared the incidence in different periods (before and after the introduction of prophylactic treatment in 2011).
    Results: Of 75 hemophilia A patients evaluated (4.61/100.000 population), 13.3% (n=10) had either CNS (n=5) or PNS (n=5) disorders secondary to bleeding. Patients submitted to factor VIII replacement prophylactic therapy were less likely to have CNS events: from 1992 to 2011, 5 of 63 patients had CNS disease, while from 2011 to 2018, there were no new cases (p=0.0181). From 2011 to 2018, 5 PNS events occurred in patients without prophylactic therapy, whereas none occurred in those covered by prophylactic therapy (5/20 versus 0/29, p=0.0081).
    Conclusions: The prevalence of neurological complications in hemophiliacs in our cohort is similar to other studies. Similar to CNS, prophylactic therapy also reduces the risk of PNS complications. This is the first report in the literature showing this benefit.
    MeSH term(s) Brazil ; Central Nervous System ; Factor VIII ; Hemophilia A/complications ; Hemorrhage ; Humans ; Nervous System Diseases/etiology ; Nervous System Diseases/prevention & control ; Peripheral Nervous System/physiopathology ; Retrospective Studies
    Chemical Substances Factor VIII (9001-27-8)
    Language English
    Publishing date 2021-11-30
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1590/0004-282X-ANP-2020-0467
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  4. Article ; Online: Proposal of treatment algorithm for immune thromocytopenia in adult patients of a hematology service at a referral center in Northeastern Brazil.

    Ribeiro, Rosângela de Albuquerque / Galiza Neto, Gentil Claudino de / Furtado, Amanda da Silva / Ribeiro, Lucas Loiola Ponte Albuquerque / Kubrusly, Marcela Sobreira / Kubrusly, Elsie Sobreira

    Hematology, transfusion and cell therapy

    2019  Volume 41, Issue 3, Page(s) 253–261

    Abstract: Introduction: The management of adult (≥18 years) immune thrombocytopenia patients relies on platelet count, the risk of bleeding and presence of bleeding.: Objective: Confirming the diagnosis of immune thrombocytopenia and the start of therapy, our ... ...

    Abstract Introduction: The management of adult (≥18 years) immune thrombocytopenia patients relies on platelet count, the risk of bleeding and presence of bleeding.
    Objective: Confirming the diagnosis of immune thrombocytopenia and the start of therapy, our hematology service, a referral center, favors the establishment of this algorithm to treat those patients.
    Results: Presentation, recently diagnosed or recurrence - group 1: life-threatening bleeding: high-dose intravenous immunoglobulins with methylprednisolone or dexamethasone. Hospitalization and platelet transfusion are considered. Group 2: Platelets <30×10
    Language English
    Publishing date 2019-02-16
    Publishing country Brazil
    Document type Journal Article ; Review
    ISSN 2531-1387
    ISSN (online) 2531-1387
    DOI 10.1016/j.htct.2018.10.005
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  5. Article: Factor VIII prophylactic therapy reduces neurological complications in patients with Hemophilia A

    FERNANDES, José Marcelino Aragão / GONDIM, Francisco de Assis Aquino / DIAS, Antônia Maria Negreiro / RIBEIRO, Rosângela de Albuquerque / FERREIRA, Luiz Ivando Pires / PINTO, Vicente de Paulo Teixeira

    Arquivos de Neuro-Psiquiatria

    2021  Volume 79, Issue 12, Page(s) 1116–1112

    Abstract: Background: Bleeding in hemophiliacs can cause complications in the central and peripheral nervous system (CNS and PNS). The incidence of intracranial hemorrhage has reduced after the introduction of prophylactic treatment with factor VIII or IX, but the ...

    Abstract Background: Bleeding in hemophiliacs can cause complications in the central and peripheral nervous system (CNS and PNS). The incidence of intracranial hemorrhage has reduced after the introduction of prophylactic treatment with factor VIII or IX, but the benefits of this therapy have not yet been evaluated on PNS complications. Objective: The aim of this study was to determine the prevalence of neurological complications in hemophiliacs and verify the effect of prophylactic therapy in these patients, including PNS disorders. Methods: We retrospectively evaluated the prevalence of CNS and PNS disorders caused by bleeding in hemophiliacs seen at the Hemocentro Regional Norte, Ceará, Brazil, from 1992 to 2018, and we compared the incidence in different periods (before and after the introduction of prophylactic treatment in 2011). Results: Of 75 hemophilia A patients evaluated (4.61/100.000 population), 13.3% (n=10) had either CNS (n=5) or PNS (n=5) disorders secondary to bleeding. Patients submitted to factor VIII replacement prophylactic therapy were less likely to have CNS events: from 1992 to 2011, 5 of 63 patients had CNS disease, while from 2011 to 2018, there were no new cases (p=0.0181). From 2011 to 2018, 5 PNS events occurred in patients without prophylactic therapy, whereas none occurred in those covered by prophylactic therapy (5/20 versus 0/29, p=0.0081). Conclusions: The prevalence of neurological complications in hemophiliacs in our cohort is similar to other studies. Similar to CNS, prophylactic therapy also reduces the risk of PNS complications. This is the first report in the literature showing this benefit.
    Keywords Hemophilia A ; Intracranial Hemorrhages ; Peripheral Nervous System Diseases ; Hemofilia A ; Hemorragias Intracranianas ; Doenças do Sistema Nervoso Periférico
    Language English
    Publishing date 2021-12-01
    Publisher Thieme Revinter Publicações Ltda.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 418916-4
    ISSN 1678-4227 ; 0004-282X
    ISSN (online) 1678-4227
    ISSN 0004-282X
    DOI 10.1590/0004-282X-ANP-2020-0467
    Database Thieme publisher's database

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  6. Article ; Online: Hemophilia B acquired through liver transplantation.

    Brunetta, Denise Menezes / Carneiro-Silva, Fabiana Aguiar / Vasconcelos, João Batista Marinho / Ribeiro, Rosângela de Albuquerque / Mesquita, Denissa Ferreira Gomes / Coelho, Gustavo Rego / Barroso-Duarte, Fernando / Garcia, José Huygens Parente

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2016  Volume 22, Issue 2, Page(s) 254–256

    MeSH term(s) Blood Coagulation ; End Stage Liver Disease/complications ; End Stage Liver Disease/surgery ; Hemophilia B/etiology ; Hemophilia B/therapy ; Hepatitis C/complications ; Humans ; Immunosuppression/methods ; Liver Cirrhosis/complications ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Partial Thromboplastin Time ; Prothrombin Time
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.24364
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