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Article ; Online: TUMOR MARKERS EXPRESSION LEVELS IN GASTRIC CANCER PATIENT'S PERIPHERAL BLOOD BY RT-PCR ASSESSMENT.

Kawakami, Gabriel da Silva / Pereira, Marina Alessandra / Kubrusly, Márcia Saldanha / Carrasco, Alexis Germán Murillo / Ramos, Marcus Fernando Kodama Pertille / Ribeiro Júnior, Ulysses

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

2024 Volume 36, Page(s) e1789

Abstract: Background: Hematological recurrence is the second most frequent cause of failure in the treatment of gastric cancer. The detection of circulating tumor markers in peripheral blood by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) ...

Abstract	Background: Hematological recurrence is the second most frequent cause of failure in the treatment of gastric cancer. The detection of circulating tumor markers in peripheral blood by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) method may be a useful tool to predict recurrence and determine the patient's prognosis. However, no consensus has been reached regarding the association between the tumor markers level in peripheral blood and its impact on patient survival. Aims: To evaluate the expression of the circulating tumor markers CK20 and MUC1 in peripheral blood samples from patients with gastric cancer by qRT-PCR, and to verify the association of their expression levels with clinicopathological characteristics and survival. Methods: A total of 31 patients with gastric adenocarcinoma were prospectively included in this study. CK20 and MUC1 expression levels were analyzed from peripheral blood by the qRT-PCR technique. Results: There was no statistically significant (p>0.05) association between CK20 expression levels and clinical, pathological, and surgical features. Higher MUC1 expression levels were associated with female patients (p=0.01). There was a correlation between both gene levels (R=0.81, p<0.001), and CK20 level and tumor size (R=0.39, p=0.034). Conclusions: CK20 and MUC1 expression levels could be assessed by qRT-PCR from total peripheral blood samples of patients with gastric cancer. CK20 levels were correlated to MUC1 levels as well as to tumor size. There was no difference in disease-free survival and overall survival regarding both genetic markers expression in this series.
MeSH term(s)	Humans ; Female ; Reverse Transcriptase Polymerase Chain Reaction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Neoplastic Cells, Circulating/pathology ; Keratin-20/genetics ; Keratin-20/metabolism ; Biomarkers, Tumor/genetics
Chemical Substances	Keratin-20 ; Biomarkers, Tumor
Language	English
Publishing date	2024-02-05
Publishing country	Brazil
Document type	Journal Article
ISSN	2317-6326
ISSN (online)	2317-6326
DOI	10.1590/0102-672020230071e1789
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Article ; Online: PALLIATIVE GASTRECTOMY VERSUS GASTRIC BYPASS FOR SYMPTOMATIC CLINICAL STAGE IV GASTRIC CANCER: A PROPENSITY SCORE MATCHING ANALYSIS.

Pinto, Sterphany Ohana Soares Azevêdo / Pereira, Marina Alessandra / Ribeiro Junior, Ulysses / D'Albuquerque, Luiz Augusto Carneiro / Ramos, Marcus Fernando Kodama Pertille

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

2024 Volume 36, Page(s) e1790

Abstract: Background: Patients with clinical stage IV gastric cancer may require palliative procedures to manage complications such as obstruction. However, there is no consensus on whether performing palliative gastrectomy compared to gastric bypass brings ... ...

Abstract	Background: Patients with clinical stage IV gastric cancer may require palliative procedures to manage complications such as obstruction. However, there is no consensus on whether performing palliative gastrectomy compared to gastric bypass brings benefits in terms of survival. Aims: To compare the overall survival of patients with distal obstructive gastric cancer undergoing palliative surgical treatment, using propensity score matching analysis. Methods: Patients who underwent palliative bypass surgery (gastrojejunostomy or partitioning) and resection between the years 2009 and 2023 were retrospectively selected. Initial and postoperative clinicopathological variables were collected. Results: 150 patients were initially included. The derived group (n=91) presented more locally invasive disease (p<0.01), greater degree of obstruction (p<0.01), and worse clinical status (p<0.01), while the resected ones (n= 59) presented more distant metastasis (p<0.01). After matching, 35 patients remained in each group. There was no difference in the incidence of postoperative complications, but the derived group had higher 90-day mortality (p<0.01). Overall survival was 16.9 and 4.5 months for the resected and derived groups, respectively (p<0.01). After multivariate analysis, hypoalbuminemia (hazard ratio - HR=2.02, 95% confidence interval - 95%CI 1.17-3.48; p=0.01), absence of adjuvant chemotherapy (HR=5.97; 95%CI 3.03-11.7; p<0.01), and gastric bypass (HR=3,28; 95%CI 1.8-5.95; p<0.01) were associated with worse survival. Conclusions: Palliative gastrectomy was associated with greater survival and lower postoperative morbidity compared to gastric bypass. This may be due to better local control of the disease, with lower risks of complications and better effectiveness of chemotherapy.
MeSH term(s)	Humans ; Gastric Bypass ; Retrospective Studies ; Stomach Neoplasms/surgery ; Stomach Neoplasms/pathology ; Propensity Score ; Gastrectomy
Language	English
Publishing date	2024-02-05
Publishing country	Brazil
Document type	Journal Article
ISSN	2317-6326
ISSN (online)	2317-6326
DOI	10.1590/0102-672020230072e1790
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Article ; Online: ROBOTIC ASSISTED VERSUS LAPAROSCOPIC DISTAL PANCREATECTOMY: A RETROSPECTIVE STUDY.

Jureidini, Ricardo / Namur, Guilherme Naccache / Ribeiro, Thiago Costa / Bacchella, Telesforo / Stolzemburg, Lucas / Jukemura, José / Ribeiro Junior, Ulysses / Cecconello, Ivan

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

2023 Volume 36, Page(s) e1783

Abstract: Background: Minimally invasive distal pancreatectomy (MIDP) is associated with less blood loss and faster functional recovery. However, the benefits of robotic assisted distal pancreatectomy (RDP) over laparoscopic distal pancreatectomy (LDP) are ... ...

Abstract	Background: Minimally invasive distal pancreatectomy (MIDP) is associated with less blood loss and faster functional recovery. However, the benefits of robotic assisted distal pancreatectomy (RDP) over laparoscopic distal pancreatectomy (LDP) are unknown. Aims: To compare RDP versus LDP for surgical treatment of benign lesions, pre-malignant and borderline malignant pancreatic neoplasias. Methods: This is a retrospective study comparing LDP with RDP. Main outcomes were overall morbidity and overall costs. Secondary outcomes were pancreatic fistula (PF), infectious complications, readmission, operative time (OT) and length of hospital stay (LOS). Results: Thirty patients submitted to LDP and 29 submitted to RDP were included in the study. There was no difference regarding preoperative characteristics. There was no difference regarding overall complications (RDP - 72,4% versus LDP - 80%, p=0,49). Costs were superior for patients submitted to RDP (RDP=US$ 6,688 versus LDP=US$ 6,149, p=0,02), mostly due to higher costs of surgical materials (RDP=US$ 2,364 versus LDP=1,421, p=0,00005). Twenty-one patients submitted to RDP and 24 to LDP developed pancreatic fistula (PF), but only 4 RDP and 7 LDP experienced infectious complications associated with PF. OT (RDP=224 min. versus LDP=213 min., p=0.36) was similar, as well as conversion to open procedure (1 RDP and 2 LDP). Conclusions: The postoperative morbidity of robotic distal pancreatectomy is comparable to laparoscopic distal pancreatectomy. However, the costs of robotic distal pancreatectomy are slightly higher.
MeSH term(s)	Humans ; Robotic Surgical Procedures/methods ; Retrospective Studies ; Pancreatic Fistula/etiology ; Pancreatic Fistula/surgery ; Pancreatectomy/methods ; Laparoscopy/methods ; Treatment Outcome ; Pancreatic Neoplasms/surgery ; Length of Stay ; Postoperative Complications/epidemiology
Language	English
Publishing date	2023-12-08
Publishing country	Brazil
Document type	Journal Article
ISSN	2317-6326
ISSN (online)	2317-6326
DOI	10.1590/0102-672020230065e1783
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Article ; Online: CHARACTERIZATION OF THE PSYCHOLOGICAL TYPOLOGY IN ESOPHAGEAL CANCER PATIENTS.

Pinto, Stela Duarte / Rodriguez, Lórgio Henrique Diaz / Takeda, Flávio Roberto / Tacconi, Marcos Roberto / Sallum, Rubens Antonio Aissar / Cecconello, Ivan / Ribeiro Junior, Ulysses

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

2023 Volume 35, Page(s) e1715

Abstract: Background: Esophageal cancer is an environment-related disease, and the most important risk factors are alcohol intake and smoking, in addition to gastroesophageal reflux in obese patients. The characterization of the patients' personality can ... ...

Abstract	Background: Esophageal cancer is an environment-related disease, and the most important risk factors are alcohol intake and smoking, in addition to gastroesophageal reflux in obese patients. The characterization of the patients' personality can contribute to the perception of how everyone adapts to the social environment and what relationship one can establish with themselves and with others. Aim: The aim of this study was to identify the psychological typology in patients with esophageal cancer. Methods: The psychological typology of patients was defined using the Typological Assessment Questionnaire. In addition, the aspects of psychological assessment were studied to access the particularities of each patient, especially their reaction to the diagnosis and the meaning attributed to the disease. Results: A total of 90 patients with esophageal cancer, aged over 18 years, who completed high school, and were interviewed at the first medical appointment, were included. The introverted attitude was predominant (83.33%). The most common psychological type was introverted sensation, with feeling as a secondary function (43.3%), and the second most frequent was introverted feeling, with sensation as a secondary function (24.4%). From this psychological assessment, a variety of defensive mechanisms were found to minimize distress. Most patients made use of adaptive defenses in the face of the illness process. Conclusion: The identification of the psychological typology allows the most effective assistance in directing the peculiar needs of each patient. In addition, it contributes to the care team to individualize treatments based on specific psychological characteristics.
MeSH term(s)	Adult ; Humans ; Esophageal Neoplasms/psychology
Language	English
Publishing date	2023-01-09
Publishing country	Brazil
Document type	Journal Article
ISSN	2317-6326
ISSN (online)	2317-6326
DOI	10.1590/0102-672020220002e1715
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Article ; Online: ROBOTIC-ASSISTED VERSUS LAPAROSCOPIC INCISIONAL HERNIA REPAIR: DIFFERENCES IN DIRECT COSTS FROM A BRAZILIAN PUBLIC INSTITUTE PERSPECTIVE.

Costa, Thiago Nogueira / Tustumi, Francisco / Ferros, Lucas Sousa Maia / Colonno, Bárbara Buccelli / Abdalla, Ricardo Zugaib / Ribeiro-Junior, Ulysses / Cecconello, Ivan

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

2023 Volume 35, Page(s) e1714

Abstract: Background: Robotic-assisted surgery research has grown dramatically in the past two decades and the advantages over traditional videolaparoscopy have been extensively debated. For hernias, the robotic system can increase intraoperative strategies, ... ...

Abstract	Background: Robotic-assisted surgery research has grown dramatically in the past two decades and the advantages over traditional videolaparoscopy have been extensively debated. For hernias, the robotic system can increase intraoperative strategies, especially in complex hernias or incisional hernias. Aims: This study aimed to compare the direct cost differences between robotic and laparoscopic hernia repair and determine each source of expenditure that may be related to the increased costs in a robotic program from the perspective of a Brazilian public institution. Methods: This study investigated the differences in direct costs from the data generated from a trial protocol (ReBEC: RBR-5s6mnrf). Patients with incisional hernia were randomly assigned to receive laparoscopic ventral incisional hernia repair (LVIHR) or robotic ventral incisional hernia repair (RVIHR). The direct medical costs of hernia treatment were described in the Brazilian currency (R$). Results: A total of 19 patients submitted to LVIHR were compared with 18 submitted to RVIHR. The amount spent on operation room time (RVIHR: 2,447.91±644.79; LVIHR: 1,989.67±763.00; p=0.030), inhaled medical gases in operating room (RVIHR: 270.57±211.51; LVIHR: 84.55±252.34; p=0.023), human resources in operating room (RVIHR: 3,164.43±894.97; LVIHR: 2,120.16±663.78; p<0.001), material resources (RVIHR: 3,204.32±351.55; LVIHR: 736.51±972.32; p<0.001), and medications (RVIHR: 823.40±175.47; LVIHR: 288.50±352.55; p<0.001) for RVIHR was higher than that for LVIHR, implying a higher total cost to RVIHR (RVIHR: 14,712.24±3,520.82; LVIHR: 10,295.95±3,453.59; p<0.001). No significant difference was noted in costs related to the hospital stay, human resources in intensive care unit and ward, diagnostic tests, and meshes. Conclusion: Robotic system adds a significant overall cost to traditional laparoscopic hernia repair. The cost of the medical and robotic devices and longer operative times are the main factors driving the difference in costs.
MeSH term(s)	Humans ; Incisional Hernia/surgery ; Robotic Surgical Procedures/methods ; Brazil ; Hernia, Ventral/surgery ; Laparoscopy/methods ; Herniorrhaphy/methods ; Surgical Mesh
Language	English
Publishing date	2023-01-09
Publishing country	Brazil
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2317-6326
ISSN (online)	2317-6326
DOI	10.1590/0102-672020220002e1714
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Article ; Online: FAILURE TO RESCUE AFTER GASTRECTOMY: A NEW INDICATOR OF SURGICAL QUALITY.

Hong, Stefany / Pereira, Marina Alessandra / Dias, André Roncon / Ribeiro Junior, Ulysses / D'Albuquerque, Luiz Augusto Carneiro / Ramos, Marcus Fernando Kodama Pertille

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

2023 Volume 36, Page(s) e1774

Abstract: Background: The main treatment modality for gastric cancer is surgical resection with lymphadenectomy. Despite advances in perioperative care, major surgical complications can occur in up to 20% of cases. To determine the quality of surgical care ... ...

Abstract	Background: The main treatment modality for gastric cancer is surgical resection with lymphadenectomy. Despite advances in perioperative care, major surgical complications can occur in up to 20% of cases. To determine the quality of surgical care employed, a new indicator called failure to rescue (FTR) was proposed, which assesses the percentage of patients who die after complications occur. Aims: To assess the rate of FTR after gastrectomy and factors associated with its occurrence. Methods: Patients with gastric cancer who underwent gastrectomy with curative intent were retrospectively evaluated. According to the occurrence of postoperative complications, patients were divided into FTR group (grade V complications) and rescued group (grade III/IV complications). Results: Among the 731 patients, 114 had major complications. Of these patients, 76 (66.7%) were successfully treated for the complication (rescued group), while 38 (33.3%) died (FTR group). Patients in the FTR group were older (p=0.008; p<0.05), had lower levels of hemoglobin (p=0.021; p<0.05) and albumin (p=0.002; p<0.05), and a higher frequency of ASA III/IV (p=0.033; p<0.05). There were no differences between the groups regarding surgical and pathological characteristics. Clinical complications had a higher mortality rate (40.0% vs 30.4%), with pulmonary complications (50.2%) and infections (46.2%) being the most lethal. Patients with major complications grade III/IV had worse survival than those without complications. Conclusions: The FTR rate was 33.3%. Advanced age, worse performance, and nutritional parameters were associated with FTR.
MeSH term(s)	Humans ; Retrospective Studies ; Stomach Neoplasms/surgery ; Postoperative Complications/etiology ; Gastrectomy/adverse effects ; Hospital Mortality ; Risk Factors
Language	English
Publishing date	2023-11-13
Publishing country	Brazil
Document type	Journal Article
ISSN	2317-6326
ISSN (online)	2317-6326
DOI	10.1590/0102-672020230056e1774
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Article ; Online: Economic evaluations of colorectal cancer screening: A systematic review and quality assessment.

Ramos, Marcela Castro / Passone, Julio Augusto de Lima / Lopes, Ana Carolina de Freitas / Safatle-Ribeiro, Adriana Vaz / Ribeiro Júnior, Ulysses / de Soárez, Patrícia Coelho

Clinics (Sao Paulo, Brazil)

2023 Volume 78, Page(s) 100203

Abstract: Colorectal Cancer (CRC) is the third most common type of cancer worldwide and ranks second in mortality. Screening programs for early detection and treatment have been implemented in several countries. Economic evaluations are an important tool to ... ...

Abstract	Colorectal Cancer (CRC) is the third most common type of cancer worldwide and ranks second in mortality. Screening programs for early detection and treatment have been implemented in several countries. Economic evaluations are an important tool to support decision-making about reimbursement and coverage decisions in health systems and, therefore, to support efficient resource allocation. The article aims to review the up-to-date evidence on economic evaluations of CRC screening strategies. MEDLINE, EMBASE, Web of Science, SCOPUS, SciELO, Lilacs, CRD databases, and lists of references were reviewed to identify relevant literature regarding full economic evaluations of CRC screening in asymptomatic average-risk individuals over 40 years old. Searches were conducted with no restriction to language, setting, or date. Qualitative syntheses described CRC screening strategies and comparators (baseline context), study designs, key parameter inputs and incremental cost-effectiveness ratios. Seventy-nine articles were included. Most of the studies were from high-income countries and a third-party payer perspective. Markov models were predominantly used, although microsimulation has been increasingly adopted in the last 15 years. The authors found 88 different screening strategies for CRC, which differed in the type of technique, the interval of screening, and the strategy, i.e., isolated or combined. The annual fecal immunochemical test was the most predominant screening strategy. All studies reported cost-effective results in their scenarios compared to no screening scenarios. One-quarter of the publications reported cost-saving results. It is still necessary to develop future economic evaluations in Low- and Middle-Income Countries (LMICs), which account for the high burden of disease.
MeSH term(s)	Humans ; Adult ; Cost-Benefit Analysis ; Early Detection of Cancer ; Colorectal Neoplasms/diagnosis
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2182801-5
ISSN	1980-5322 ; 1807-5932
ISSN (online)	1980-5322
ISSN	1807-5932
DOI	10.1016/j.clinsp.2023.100203
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Article ; Online: PERIOPERATIVE CARE IN DIGESTIVE SURGERY: THE ERAS AND ACERTO PROTOCOLS - BRAZILIAN COLLEGE OF DIGESTIVE SURGERY POSITION PAPER.

Aguilar-Nascimento, José Eduardo de / Ribeiro Junior, Ulysses / Portari-Filho, Pedro Eder / Salomão, Alberto Bicudo / Caporossi, Cervantes / Colleoni Neto, Ramiro / Waitzberg, Dan Linetzky / Campos, Antonio Carlos Ligocki

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

2024 Volume 37, Page(s) e1794

Abstract: Background: The concept introduced by protocols of enhanced recovery after surgery modifies perioperative traditional care in digestive surgery. The integration of these modern recommendations components during the perioperative period is of great ... ...

Abstract	Background: The concept introduced by protocols of enhanced recovery after surgery modifies perioperative traditional care in digestive surgery. The integration of these modern recommendations components during the perioperative period is of great importance to ensure fewer postoperative complications, reduced length of hospital stay, and decreased surgical costs. Aims: To emphasize the most important points of a multimodal perioperative care protocol. Methods: Careful analysis of each recommendation of both ERAS and ACERTO protocols, justifying their inclusion in the multimodal care recommended for digestive surgery patients. Results: Enhanced recovery programs (ERPs) such as ERAS and ACERTO protocols are a cornerstone in modern perioperative care. Nutritional therapy is fundamental in digestive surgery, and thus, both preoperative and postoperative nutrition care are key to ensuring fewer postoperative complications and reducing the length of hospital stay. The concept of prehabilitation is another key element in ERPs. The handling of crystalloid fluids in a perfect balance is vital. Fluid overload can delay the recovery of patients and increase postoperative complications. Abbreviation of preoperative fasting for two hours before anesthesia is now accepted by various guidelines of both surgical and anesthesiology societies. Combined with early postoperative refeeding, these prescriptions are not only safe but can also enhance the recovery of patients undergoing digestive procedures. Conclusions: This position paper from the Brazilian College of Digestive Surgery strongly emphasizes that the implementation of ERPs in digestive surgery represents a paradigm shift in perioperative care, transcending traditional practices and embracing an intelligent approach to patient well-being.
MeSH term(s)	Humans ; Digestive System Surgical Procedures/methods ; Perioperative Care/methods ; Perioperative Care/standards ; Brazil ; Enhanced Recovery After Surgery/standards ; Clinical Protocols
Language	English
Publishing date	2024-05-06
Publishing country	Brazil
Document type	Journal Article ; Practice Guideline
ISSN	2317-6326
ISSN (online)	2317-6326
DOI	10.1590/0102-672020240001e1794
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Article ; Online: Feasibility and Colonoscopy Yield Using the Fecal Immunochemical Test (FIT)-Based Colorectal Cancer Screening in a Latin America Country.

Sorbello, Mauricio Paulin / Ribeiro Júnior, Ulysses / Eluf-Neto, José / Pfuetzenreiter, Vinicius / da Silva E Sousa Júnior, Afonso Henrique / Kawaguti, Fábio Shiguehissa / Cohen, Diane Dede / de Mello, Evandro Sobroza / Nahas, Sergio Carlos / Safatle-Ribeiro, Adriana Vaz

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2024

Abstract: Background & aims: Organized colorectal cancer (CRC) screening is not widely practiced in Latin America and the results of regional studies may help overcome barriers for implementation of national screening programs. We aimed to describe the ... ...

Abstract	Background & aims: Organized colorectal cancer (CRC) screening is not widely practiced in Latin America and the results of regional studies may help overcome barriers for implementation of national screening programs. We aimed to describe the implementation and findings of a fecal immunochemical test (FIT)-based program in Brazil. Methods: In a prospective population-based study, asymptomatic individuals (50-75 years old) from Sao Paulo city were invited to undergo FIT for CRC screening. Participants with positive FIT (≥10 μg Hb/g feces) were referred for colonoscopy. Subjects were classified into groups according to the presence of CRC, precursor lesions, and other benign findings, possibly related to bleeding. Results: Of a total of 9881 subjects, 7.8% had positive FIT and colonoscopy compliance was 68.9% (n = 535). Boston scale was considered adequate in 99% and cecal intubation rate was 99.4%. CRC was diagnosed in 5.9% of the cases, adenoma in 63.2%, advanced adenoma in 31.4%, and advanced neoplasia in 33.0%. Age was positively associated with CRC (P = .03). Higher FIT concentrations were associated with increased detection of CRC (P < .008), advanced adenoma (P < .001), and advanced neoplasia (P < .001). Conclusions: Implementation of a FIT-based CRC screening program was feasible in a low-resource setting, and there was a high yield for neoplasia in individuals with a positive FIT. This approach could be used as a model to plan and disseminate organized CRC screening more broadly in Brazil and Latin America.
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2024.01.033
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Article ; Online: Prognostic Value of Bone Marrow Uptake Using 18F-FDG PET/CT Scans in Solid Neoplasms.

Tustumi, Francisco / Albenda, David Gutiérrez / Perrotta, Fernando Simionato / Sallum, Rubens Antonio Aissar / Ribeiro Junior, Ulysses / Buchpiguel, Carlos Alberto / Duarte, Paulo Schiavom

Journal of imaging

2022 Volume 8, Issue 11

Abstract: Background: Fluorine-18-fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) uptake is known to increase in infective and inflammatory conditions. Systemic inflammation plays a role in oncologic prognosis. ... ...

Abstract	Background: Fluorine-18-fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) uptake is known to increase in infective and inflammatory conditions. Systemic inflammation plays a role in oncologic prognosis. Consequently, bone marrow increased uptake in oncology patients could potentially depict the systemic cancer burden. Methods: A single institute cohort analysis and a systematic review were performed, evaluating the prognostic role of 18F-FDG uptake in the bone marrow in solid neoplasms before treatment. The cohort included 113 esophageal cancer patients (adenocarcinoma or squamous cell carcinoma). The systematic review was based on 18 studies evaluating solid neoplasms, including gynecological, lung, pleura, breast, pancreas, head and neck, esophagus, stomach, colorectal, and anus. Results: Bone marrow 18F-FDG uptake in esophageal cancer was not correlated with staging, pathological response, and survival. High bone marrow uptake was related to advanced staging in colorectal, head and neck, and breast cancer, but not in lung cancer. Bone marrow 18F-FDG uptake was significantly associated with survival rates for lung, head and neck, breast, gastric, colorectal, pancreatic, and gynecological neoplasms but was not significantly associated with survival in pediatric neuroblastoma and esophageal cancer. Conclusion: 18F-FDG bone marrow uptake in PET/CT has prognostic value in several solid neoplasms, including lung, gastric, colorectal, head and neck, breast, pancreas, and gynecological cancers. However, future studies are still needed to define the role of bone marrow role in cancer prognostication.
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2824270-1
ISSN	2313-433X ; 2313-433X
ISSN (online)	2313-433X
ISSN	2313-433X
DOI	10.3390/jimaging8110297
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