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Article ; Online: How we deal with

Antonello, Roberta Maria / Riccardi, Niccolò

Frontiers in bioscience (Scholar edition)

2022 Volume 14, Issue 1, Page(s) 1

Abstract: Among central nervous system (CNS) infections (e.g., meningitis, brain abscess, ventriculitis, transverse myelitis), those caused ... ...

Abstract	Among central nervous system (CNS) infections (e.g., meningitis, brain abscess, ventriculitis, transverse myelitis), those caused by
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Central Nervous System Infections/drug therapy ; Humans ; Meningitis/drug therapy ; Methicillin-Resistant Staphylococcus aureus ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-02-21
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2565100-6
ISSN	1945-0524 ; 1945-0516
ISSN (online)	1945-0524
ISSN	1945-0516
DOI	10.31083/j.fbs1401001
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Zs.A 7071: Show issues

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Article ; Online: "The blinding disease". The history of trachoma in Italians between the 19th and 20th centuries: colonial or national blindness?

Martini, Mariano / Riccardi, Niccolò / Simonetti, Omar / Orsini, Davide / Samassa, Francesco / Parodi, Alessandra

Pathogens and global health

2024 , Page(s) 1–6

Abstract: Trachoma is one of the oldest known causes of blindness in humans and it is caused by the intracellular Gram-negative ... ...

Abstract	Trachoma is one of the oldest known causes of blindness in humans and it is caused by the intracellular Gram-negative bacterium
Language	English
Publishing date	2024-04-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2625162-0
ISSN	2047-7732 ; 2047-7724
ISSN (online)	2047-7732
ISSN	2047-7724
DOI	10.1080/20477724.2024.2342623
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Ud II Zs.196: Show issues

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Article: Early Intra-Abdominal Bacterial Infections after Orthotopic Liver Transplantation: A Narrative Review for Clinicians.

Taddei, Riccardo / Riccardi, Niccolò / Tiseo, Giusy / Galfo, Valentina / Biancofiore, Giandomenico

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Despite recent advances in the transplant field, infectious complications after orthotopic liver transplantation (OLT) are major causes of morbidity and mortality. Bacterial intra-abdominal infections (IAIs) are predominant during the first month post- ... ...

Abstract	Despite recent advances in the transplant field, infectious complications after orthotopic liver transplantation (OLT) are major causes of morbidity and mortality. Bacterial intra-abdominal infections (IAIs) are predominant during the first month post-transplantation and affect patient and graft survival. Recently, the emergence of multidrug resistant bacteria has generated great concern in OLT patients. We performed this narrative review of the literature in order to propose a "ready-to-use" flowchart for reasoned empirical antibiotic therapy in the case of suspected post-OLT IAIs. The review was ultimately organized into four sections: "Epidemiology and predisposing factors for IAI"; "Surgical-site infections and perioperative prophylaxis"; "MDRO colonization and infections"; and "Reasoned-empirical antibiotic therapy in early intra-abdominal infections post OLT and source control". Multidisciplinary teamwork is warranted to individualize strategies for the prevention and treatment of IAIs in OLT recipients, taking into account each patient's risk factors, the surgical characteristics, and the local bacterial epidemiology.
Language	English
Publishing date	2023-08-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12081316
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Article ; Online: Pharyngeal and cutaneous diphtheria: a tail of a refugee.

Galfo, Valentina / Riccardi, Niccolò / Leonildi, Alessandro / Falcone, Marco / Barnini, Simona

Infection

2023 Volume 51, Issue 5, Page(s) 1599–1600

MeSH term(s)	Humans ; Diphtheria/diagnosis ; Refugees
Language	English
Publishing date	2023-01-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	185104-4
ISSN	1439-0973 ; 0300-8126 ; 0173-2129
ISSN (online)	1439-0973
ISSN	0300-8126 ; 0173-2129
DOI	10.1007/s15010-023-01990-4
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Zs.A 881: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 528: Show issues

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Article ; Online: Synergistic properties of linezolid against Enterococcus spp. isolates: a systematic review from in vitro studies.

Antonello, Roberta Maria / Riccardi, Niccolò / Saderi, Laura / Sotgiu, Giovanni

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2023 Volume 43, Issue 1, Page(s) 17–31

Abstract: Purpose: Vancomycin-resistant enterococci (VRE) are a leading cause of hospital-acquired infections with limited therapeutic options. Combination of at least two antimicrobials is a possible strategy to obtain rapid and sustained bactericidal effects ... ...

Abstract	Purpose: Vancomycin-resistant enterococci (VRE) are a leading cause of hospital-acquired infections with limited therapeutic options. Combination of at least two antimicrobials is a possible strategy to obtain rapid and sustained bactericidal effects and overcome the emergence of resistance. We revised the literature on linezolid synergistic properties from in vitro studies to assess its activity in combination with molecules belonging to other antibiotic classes against Enterococcus spp. Methods: We performed a systematic review of the literature from three peer-reviewed databases including papers evaluating linezolid synergistic properties in vitro against Enterococcus spp. isolates. Results: We included 206 Enterococcus spp. isolates (92 E. faecalis, 90 E. faecium, 2 E. gallinarum, 3 E. casseliflavus, 19 Enterococcus spp.) from 24 studies. When an isolate was tested with different combinations, each combination was considered independently for further analysis. The most frequent interaction was indifferent effect (247/343, 72% of total interactions). The highest synergism rates were observed when linezolid was tested in combination with rifampin (10/49, 20.4% of interactions) and fosfomycin (16/84, 19.0%, of interactions). Antagonistic effect accounted for 7/343 (2.0%) of total interactions. Conclusion: Our study reported overall limited synergistic in vitro properties of linezolid with other antibiotics when tested against Enterococcus spp. The clinical choice of linezolid in combination with other antibiotics should be guided by reasoned empiric therapy in the suspicion of a polymicrobial infection or targeted therapy on microbiological results, rather than on an intended synergistic effect of the linezolid-based combination.
MeSH term(s)	Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Enterococcus faecalis ; Enterococcus faecium ; Fosfomycin/pharmacology ; Fosfomycin/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/microbiology ; Linezolid/pharmacology ; Linezolid/therapeutic use ; Microbial Sensitivity Tests ; Rifampin/pharmacology ; Rifampin/therapeutic use ; Vancomycin-Resistant Enterococci
Chemical Substances	Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE) ; Linezolid (ISQ9I6J12J) ; Rifampin (VJT6J7R4TR)
Language	English
Publishing date	2023-11-17
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-023-04704-8
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Zs.A 1732: Show issues

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Article ; Online: Daptomycin synergistic properties from in vitro and in vivo studies: a systematic review.

Antonello, Roberta Maria / Canetti, Diana / Riccardi, Niccolò

The Journal of antimicrobial chemotherapy

2022 Volume 78, Issue 1, Page(s) 52–77

Abstract: Introduction: Daptomycin is a bactericidal lipopeptide antibiotic approved for the treatment of systemic infections (i.e. skin and soft tissue infections, bloodstream infections, infective endocarditis) caused by Gram-positive cocci. It is often ... ...

Abstract	Introduction: Daptomycin is a bactericidal lipopeptide antibiotic approved for the treatment of systemic infections (i.e. skin and soft tissue infections, bloodstream infections, infective endocarditis) caused by Gram-positive cocci. It is often prescribed in association with a partner drug to increase its bactericidal effect and to prevent the emergence of resistant strains during treatment; however, its synergistic properties are still under evaluation. Methods: We performed a systematic review to offer clinicians an updated overview of daptomycin synergistic properties from in vitro and in vivo studies. Moreover, we reported all in vitro and in vivo data evaluating daptomycin in combination with other antibiotic agents, subdivided by antibiotic classes, and a summary graph presenting the most favourable combinations at a glance. Results: A total of 92 studies and 1087 isolates (723 Staphylococcus aureus, 68 Staphylococcus epidermidis, 179 Enterococcus faecium, 105 Enterococcus faecalis, 12 Enterococcus durans) were included. Synergism accounted for 30.9% of total interactions, while indifferent effect was the most frequently observed interaction (41.9%). Antagonistic effect accounted for 0.7% of total interactions. The highest synergistic rates against S. aureus were observed with daptomycin in combination with fosfomycin (55.6%). For S. epidermidis and Enterococcus spp., the most effective combinations were daptomycin plus ceftobiprole (50%) and daptomycin plus fosfomycin (63.6%) or rifampicin (62.8%), respectively. Future perspectives: We believe this systematic review could be useful for the future updates of guidelines on systemic infections where daptomycin plays a key role.
MeSH term(s)	Humans ; Daptomycin/pharmacology ; Daptomycin/therapeutic use ; Fosfomycin/pharmacology ; Staphylococcus aureus ; Drug Synergism ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Gram-Positive Bacterial Infections/drug therapy
Chemical Substances	Daptomycin (NWQ5N31VKK) ; Fosfomycin (2N81MY12TE) ; Anti-Bacterial Agents
Language	English
Publishing date	2022-10-12
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkac346
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Vaccination for SARS-CoV-2 in Hematological Patients.

Riccardi, Niccolò / Falcone, Marco / Yahav, Dafna

Acta haematologica

2022 Volume 145, Issue 3, Page(s) 257–266

Abstract: Patients with specific hematological malignancies (HM) are at increased risk for severe disease and death from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In healthy subjects, vaccination against SARS-CoV-2 has been ... ...

Abstract	Patients with specific hematological malignancies (HM) are at increased risk for severe disease and death from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In healthy subjects, vaccination against SARS-CoV-2 has been demonstrated to be highly effective in disease prevention; however, immunocompromised patients were largely excluded from vaccine randomized controlled trials. In this review, we overview available non-randomized studies addressing effectiveness and safety of several coronavirus disease 2019 (COVID-19) vaccines in patients with HM. Overall, COVID-19 vaccines are safe in patients with HM, with adverse events similar to those in the general population. Though serology testing is not recommended as a test to evaluate vaccine effectiveness, a correlation between higher antibody levels and protection against infection has been reported. Studies evaluating humoral response to COVID-19 vaccine in HM patients demonstrate low immunogenicity, mainly in patients with lymphoproliferative disorders, as well as with certain drugs, including mainly anti-CD20 antibodies, Bruton tyrosine kinase inhibitors, and also ruxolitinib and venetoclax. Seropositivity rates of patients with non-Hodgkin lymphoma and chronic lymphocytic leukemia following mRNA vaccination reach 40%-50%. T-cell responses to vaccination are also impaired among these patients. Better humoral response rates are reported in multiple myeloma patients and hematopoietic stem-cell transplant, reaching ∼75%-80%, but not in patients following chimeric antigen receptor T-cell therapy. Patients with chronic myeloid leukemia and myeloproliferative diseases have high response rate to vaccination. Third mRNA vaccine dose is currently recommended to all HM patients. Alternative approaches for vaccination and prevention in patients unable to mount an immune response following full vaccination are provided in the review.
MeSH term(s)	Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/therapy ; Humans ; Randomized Controlled Trials as Topic ; SARS-CoV-2 ; Vaccination ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000523753
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Ud II Zs.145: Show issues

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Article ; Online: Fifty years after the eradication of Malaria in Italy. The long pathway toward this great goal and the current health risks of imported malaria.

Martini, Mariano / Angheben, Andrea / Riccardi, Niccolò / Orsini, Davide

Pathogens and global health

2021 Volume 115, Issue 4, Page(s) 215–223

Abstract: Fifty years ago, Italy was declared a malaria-free country by the World Health Organization (WHO). In remembering this important anniversary, the authors of this paper describe the long journey that led to this goal. In the century following the ... ...

Abstract	Fifty years ago, Italy was declared a malaria-free country by the World Health Organization (WHO). In remembering this important anniversary, the authors of this paper describe the long journey that led to this goal. In the century following the unification of Italy, malaria was one of the main public health problems. At the end of the 19th century, malaria cases amounted to 2 million, with 15,000-20,000 deaths per year. This manuscript examines the state of public and social health in Italy from the end of the 19th century to the beginning of the 20th century, with particular regard to the government's measures for the prevention, prophylaxis and treatment of malaria. The authors describe the main findings of Italian malariologists during the period under review, from the identification of
MeSH term(s)	Animals ; Anopheles ; Goals ; Humans ; Italy/epidemiology ; Malaria/epidemiology ; Malaria/prevention & control ; Malaria/transmission ; Mosquito Vectors
Language	English
Publishing date	2021-03-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2625162-0
ISSN	2047-7732 ; 2047-7724
ISSN (online)	2047-7732
ISSN	2047-7724
DOI	10.1080/20477724.2021.1894394
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Article ; Online: Edoardo Maragliano (1849-1940) and the immunogenicity of the tubercle bacillus: the pathway of a great italian physician.

Martini, Mariano / Riccardi, Niccolò / Maragliano, Edoardo / Brigo, Francesco

Journal of preventive medicine and hygiene

2021 Volume 62, Issue 2, Page(s) E552–E554

Abstract: Edoardo Maragliano (1849-1940) was an Italian physician; he played a central role in medicine's "renaissance" in Italy and Europe. After beginning his academic career as a professor of pathology, he became full professor of internal medicine in 1881. ... ...

Abstract	Edoardo Maragliano (1849-1940) was an Italian physician; he played a central role in medicine's "renaissance" in Italy and Europe. After beginning his academic career as a professor of pathology, he became full professor of internal medicine in 1881. While he studied all fields of internal medicine, his research focused mainly on tuberculosis. Thanks to his experiments in the medical clinic, Maragliano announced the possibility of immunization against Mycobacterium tuberculosis. Although criticized for using an inactivated vaccine, Maragliano continued to advocate vaccination with any type of vaccine. Maragliano keenly contributed to the still ongoing process of understanding the difficult interaction between Mycobacterium tuberculosis and the infected host.
MeSH term(s)	Bacillus ; History, 19th Century ; Humans ; Immunogenicity, Vaccine ; Italy ; Mycobacterium tuberculosis ; Physicians ; Tuberculosis/prevention & control ; Tuberculosis Vaccines/immunology
Chemical Substances	Tuberculosis Vaccines
Language	English
Publishing date	2021-07-30
Publishing country	Italy
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	1102926-2
ISSN	2421-4248 ; 1121-2233
ISSN (online)	2421-4248
ISSN	1121-2233
DOI	10.15167/2421-4248/jpmh2021.62.2.2095
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Zs.B 990: Show issues

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Article ; Online: The possible impact of SARS-COV-2 on neglected tropical diseases in Europe: the out of spotlights emerging of schistosomiasis.

Mantica, Guglielmo / Martini, Mariano / Riccardi, NICCOLò

Journal of preventive medicine and hygiene

2021 Volume 62, Issue 1, Page(s) E3–E4

MeSH term(s)	COVID-19 ; Europe ; Humans ; Neglected Diseases ; SARS-CoV-2 ; Schistosomiasis/diagnosis ; Tropical Medicine
Language	English
Publishing date	2021-04-29
Publishing country	Italy
Document type	Letter
ZDB-ID	1102926-2
ISSN	2421-4248 ; 1121-2233
ISSN (online)	2421-4248
ISSN	1121-2233
DOI	10.15167/2421-4248/jpmh2021.62.1.1867
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