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  1. Article ; Online: Histopathology of growth hormone-secreting pituitary tumors: State of the art and new perspectives.

    Guaraldi, Federica / Ambrosi, Francesca / Ricci, Costantino / Di Sciascio, Luisa / Asioli, Sofia

    Best practice & research. Clinical endocrinology & metabolism

    2024  Volume 38, Issue 3, Page(s) 101894

    Abstract: Somatotroph (GH) adenomas/PitNETs typically arise from adenohypophysis and are biochemically active, leading to acromegaly and gigantism. More rarely, they present with ectopic origin and do not present overt biochemical or clinical features (silent ... ...

    Abstract Somatotroph (GH) adenomas/PitNETs typically arise from adenohypophysis and are biochemically active, leading to acromegaly and gigantism. More rarely, they present with ectopic origin and do not present overt biochemical or clinical features (silent variants). Histopathological examination should consider the clinical and radiological background, and include multiple steps assessing tumor morphology, pituitary transcription factors (PTFs), hormone secretion, proliferation markers, granulation, and somatostatin receptors (STRs), aimed at depicting as better as possible tumor origin (in case of non-functioning and/or metastatic tumor), and clinical behavior, including response to treatment. GH-secreting tumors are part of the Pit-1 family tumors and can secrete GH only (pure somatotrophs) or co-secrete prolactin (mixed tumors; in this case, various histological subtypes have been identified). Each subtype presents unique radiological, biochemical, and clinical characteristic. Therefore, the integration of biochemical, clinical, radiological, and histopathological elements is fundamental for proper diagnosis and management of pituitary adenomas/PitNETs, to be performed in referral Centers. In more recent times, the importance of genetic and epigenetic evaluation in the characterization of pituitary tumors (i.e., early identification of aggressive variants) has been outlined by some large studies, with the intention of improving targeted treatments.
    MeSH term(s) Humans ; Growth Hormone-Secreting Pituitary Adenoma/pathology ; Growth Hormone-Secreting Pituitary Adenoma/genetics ; Growth Hormone-Secreting Pituitary Adenoma/metabolism ; Adenoma/pathology ; Adenoma/genetics ; Adenoma/metabolism ; Pituitary Neoplasms/pathology ; Pituitary Neoplasms/metabolism ; Pituitary Neoplasms/genetics
    Language English
    Publishing date 2024-04-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052339-7
    ISSN 1878-1594 ; 1532-1908 ; 1521-690X
    ISSN (online) 1878-1594 ; 1532-1908
    ISSN 1521-690X
    DOI 10.1016/j.beem.2024.101894
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  2. Article: Confocal Assessment of Pigmented-Mucosal Lesions: A Monocentric, Retrospective Evaluation of Lip and Genital Area.

    Coco, Valeria / Cappilli, Simone / Di Stefani, Alessandro / Ricci, Costantino / Perino, Francesca / Di Nardo, Lucia / Longo, Caterina / Peris, Ketty

    Dermatology practical & conceptual

    2024  Volume 14, Issue 1

    Abstract: Introduction: Pigmentation of lip and/or genitalia is mainly due to the development of benign melanotic macules, with a less occurrence of melanocytic and other non-melanocytic lesions. Mucosal melanoma has worse prognosis compared with cutaneous ... ...

    Abstract Introduction: Pigmentation of lip and/or genitalia is mainly due to the development of benign melanotic macules, with a less occurrence of melanocytic and other non-melanocytic lesions. Mucosal melanoma has worse prognosis compared with cutaneous counterpart, hence identification of atypical features for an early diagnosis is crucial.
    Objectives: The aim of this study was to report further data of confocal features characterizing pigmented mucosal lesions of genital area and of the lips and test the diagnostic role of the reflectance confocal microscopy (RCM)lip score.
    Methods: Clinical, dermoscopic and RCM images of histologically proven pigmented lesions, involving the genital area (vulva or glans penis) and lip, were retrospectively reviewed. RCM images were evaluated for malignant criteria, and statistical analysis was conducted for categorical variables.
    Results: Seventy pigmented lesions were included in the study and divided into two groups based on the body area location: lip (17) and genital area (53). Architectural disarray (P = 0.002), dendritic (P = 0.031) and roundish cells in epidermis (P < 0.0001), interpapillary dendritic cells (P = 0.039) and junctional atypical cells (P = 0.002) were associated to genital melanoma. Melanoma involving the lip was characterized by roundish cells in epidermis, a criterion found in one labial benign lesion, only (P = 0.005). Main limitations of the study are the inclusion of low melanomas and the presence of epidermal dendritic cells in melanosis and melanoma, as a confusing factor in imaging.
    Conclusions: Dermatologists should consider confocal microscopy as an adjunctive tool to dermoscopy in the differential diagnosis of pigmented mucosal lesions, especially in presence of clinical and dermoscopic findings suspicious for malignancy.
    Language English
    Publishing date 2024-01-01
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 2685397-8
    ISSN 2160-9381
    ISSN 2160-9381
    DOI 10.5826/dpc.1401a28
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  3. Article ; Online: Depicting dermoscopic and confocal findings in patients with Gorlin-Goltz Syndrome.

    Dika, Emi / Lambertini, Martina / Veronesi, Giulia / Misciali, Cosimo / Ricci, Costantino / Longo, Caterina

    Italian journal of dermatology and venereology

    2023  Volume 158, Issue 6, Page(s) 500–501

    MeSH term(s) Humans ; Basal Cell Nevus Syndrome/diagnostic imaging ; Patients
    Language English
    Publishing date 2023-11-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.23.07623-5
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  4. Article ; Online: The Tricky Blue.

    Pepe, Francesca / Corti, Barbara / Ricci, Costantino / Schiavi, Costantino / Roda, Matilde / Barisani, Alessia / Vaccari, Sabina

    Indian journal of dermatology

    2023  Volume 67, Issue 6, Page(s) 817–819

    Language English
    Publishing date 2023-03-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.ijd_769_22
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  5. Article ; Online: Trapezius Muscle and the Cutaneous Branches of Spinal Nerves: Sonographic/Anatomic Discussion of Myofascial Pain and Superficial Injections.

    Ricci, Vincenzo / Ricci, Costantino / Mezian, Kamal / Naňka, Ondřej / Özçakar, Levent

    Pain medicine (Malden, Mass.)

    2022  Volume 24, Issue 3, Page(s) 221–225

    MeSH term(s) Humans ; Superficial Back Muscles ; Myofascial Pain Syndromes ; Spinal Nerves ; Ultrasonography ; Pain
    Language English
    Publishing date 2022-08-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnac125
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  6. Article ; Online: From histo-anatomy to sonography in lymphedema: EURO-MUSCULUS/USPRM approach.

    Ricci, Vincenzo / Ricci, Costantino / Gervasoni, Fabrizio / Andreoli, Arnaldo / Özçakar, Levent

    European journal of physical and rehabilitation medicine

    2021  Volume 58, Issue 1, Page(s) 108–117

    Abstract: Lymphedema is a disorder characterized by the accumulation of protein-rich lymphatic fluid in the cutaneous and subcutaneous tissue. Based on the underlying causes, it is classified into primary and secondary forms. The use of ultrasound has recently ... ...

    Abstract Lymphedema is a disorder characterized by the accumulation of protein-rich lymphatic fluid in the cutaneous and subcutaneous tissue. Based on the underlying causes, it is classified into primary and secondary forms. The use of ultrasound has recently become widespread in the field of lymphedema - especially for its diagnosis and treatment planning. In this study, we briefly reviewed the anatomy and histology of the skin and subcutaneous tissue - to propose a standardized ultrasound assessment of the superficial tissues in patients with upper-/lower-limb lymphedema. We believe that identification of the sono-histological patterns of the dermo-epidermal complex and subcutaneous tissue has place to serve as a simple and reproducible strategy to evaluate their edema diseases that are often subject to an inaccurate diagnosis in daily clinical practice.
    MeSH term(s) Humans ; Lymphedema/diagnostic imaging ; Lymphedema/etiology ; Ultrasonography
    Language English
    Publishing date 2021-04-16
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2426908-6
    ISSN 1973-9095 ; 1973-9087
    ISSN (online) 1973-9095
    ISSN 1973-9087
    DOI 10.23736/S1973-9087.21.06853-2
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  7. Article ; Online: From Histoanatomy to Sonography in Myofascial Pain Syndrome: A EURO-MUSCULUS/USPRM Approach.

    Ricci, Vincenzo / Ricci, Costantino / Gervasoni, Fabrizio / Cocco, Giulio / Andreoli, Arnaldo / Özçakar, Levent

    American journal of physical medicine & rehabilitation

    2022  Volume 102, Issue 1, Page(s) 92–97

    Abstract: Abstract: Myofascial pain is a common clinical condition, whereby accurate physical examination is usually considered as the cornerstone to identify/diagnose the "trigger point complex," that is, the characteristic finding of this syndrome. Considering ... ...

    Abstract Abstract: Myofascial pain is a common clinical condition, whereby accurate physical examination is usually considered as the cornerstone to identify/diagnose the "trigger point complex," that is, the characteristic finding of this syndrome. Considering the emerging role of ultrasound examination as the natural extension of physical assessment for musculoskeletal disorders, we briefly revise the histological/anatomical features of trigger points and propose a standardized, multistep sonographic approach to myofascial pain. We also imply that the integrated clinical-ultrasound evaluation could be considered as a potential tool to discriminate different phases/subsets of this challenging pathology.
    MeSH term(s) Humans ; Myofascial Pain Syndromes/diagnostic imaging ; Trigger Points/diagnostic imaging ; Musculoskeletal System ; Ultrasonography ; Fibromyalgia ; Pain
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000001975
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  8. Article ; Online: Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis.

    Ricci, Costantino / Dika, Emi / Ambrosi, Francesca / Lambertini, Martina / Veronesi, Giulia / Barbara, Corti

    International journal of molecular sciences

    2022  Volume 23, Issue 11

    Abstract: Cutaneous melanoma (cM) is the deadliest of all primary skin cancers. Its prognosis is strongly influenced by the stage at diagnosis, with early stages having a good prognosis and being potentially treatable with surgery alone; advanced stages display a ... ...

    Abstract Cutaneous melanoma (cM) is the deadliest of all primary skin cancers. Its prognosis is strongly influenced by the stage at diagnosis, with early stages having a good prognosis and being potentially treatable with surgery alone; advanced stages display a much worse prognosis, with a high rate of recurrence and metastasis. For this reason, the accurate and early diagnosis of cM is crucial-misdiagnosis may have extremely dangerous consequences for the patient and drastically reduce their chances of survival. Although the histological exam remains the "gold standard" for the diagnosis of cM, a continuously increasing number of immunohistochemical markers that could help in diagnosis, prognostic characterization, and appropriate therapeutical choices are identified every day, with some of them becoming part of routine practice. This review aims to discuss and summarize all the data related to the immunohistochemical analyses that are potentially useful for the diagnosis of cM, thus rendering it easier to appropriately applicate to routine practice. We will discuss these topics, as well as the role of these molecules in the biology of cM and potential impact on diagnosis and treatment, integrating the literature data with the experience of our surgical pathology department.
    MeSH term(s) Humans ; Immunohistochemistry ; Melanoma/pathology ; Skin Neoplasms/pathology ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2022-05-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23115911
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  9. Article ; Online: Line-field confocal optical coherence tomography (LC-OCT) in Hailey-Hailey disease: another brick in the wall.

    Di Stefani, Alessandro / Cappilli, Simone / Ricci, Costantino / Costantini, Alessio / Paradisi, Andrea / Peris, Ketty

    International journal of dermatology

    2022  Volume 62, Issue 3, Page(s) e178–e179

    MeSH term(s) Humans ; Pemphigus, Benign Familial ; Tomography, Optical Coherence ; Microscopy, Confocal/methods
    Language English
    Publishing date 2022-10-17
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16462
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  10. Article ; Online: Histopathology and high-resolution ultrasound imaging for peripheral nerve (injuries).

    Ricci, Vincenzo / Ricci, Costantino / Cocco, Giulio / Gervasoni, Fabrizio / Donati, Danilo / Farì, Giacomo / Özçakar, Levent

    Journal of neurology

    2022  Volume 269, Issue 7, Page(s) 3663–3675

    Abstract: Background: Neuropathies are commonplace in clinical practice and ultrasound assessment of the peripheral nerves is increasingly becoming a valuable diagnostic tool to support the physical and electrophysiological examinations. In the pertinent ... ...

    Abstract Background: Neuropathies are commonplace in clinical practice and ultrasound assessment of the peripheral nerves is increasingly becoming a valuable diagnostic tool to support the physical and electrophysiological examinations. In the pertinent literature, several sonographic approaches have been proposed to evaluate the peripheral nerve tissue-mainly based on (semi)-quantitative measures.
    Objective: To define a standardized sonographic approach aiming to evaluate the different sono-histological sections of the peripheral nerve also in a qualitative way.
    Methods: Using high-frequency ultrasound probes and high-level ultrasound machines, we matched the histopathological features of the peripheral nerve (in acute and chronic phase) and the different sonographic patterns. Moreover, high-sensitive power Doppler assessments have been performed to assess the microcirculation of the peripheral nerve in physiological and pathological conditions.
    Results: Modern ultrasound equipment allows a "real-time dissection" of the peripheral nerve evaluating the sonographic patterns of its different histological compartments in physiological and pathological conditions. Moreover, high-sensitive power Doppler allows clear visualization of the microcirculation of the peripheral nerve both in the acute and chronic phases of the neuropathy.
    Conclusion: In clinical practice, using adequate technological equipment, (semi)-quantitative measurements of the peripheral nerve can be coupled with different sonographic patterns of its histological components-both in the acute and chronic phase of the peripheral neuropathy. This way, better/prompt diagnosis and optimal management of the patients would be possible.
    MeSH term(s) Electrophysiological Phenomena ; Humans ; Peripheral Nerve Injuries ; Peripheral Nerves/diagnostic imaging ; Ultrasonography/methods ; Ultrasonography, Doppler
    Language English
    Publishing date 2022-01-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-022-10988-1
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